Reproducibility in Biomedical Research
Epistemological and Statistical Problems and the Future
- 2nd Edition - April 26, 2024
- Author: Erwin B. Montgomery Jr.
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 8 2 9 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 8 3 0 - 0
Reproducibility in Biomedical Research: Epistemological and Statistical Problems, Second Edition explores the ideas and conundrums inherent in scientific research. This second ed… Read more
Reproducibility in Biomedical Research: Epistemological and Statistical Problems, Second Edition explores the ideas and conundrums inherent in scientific research. This second edition addresses new challenges to reproducibility in biosciences, namely reproducibility of machine learning Artificial Intelligence (AI), reproducibility of translation from research to medical care, and the fundamental challenges to reproducibility. All current chapters are expanded to cover advances in the topics previously addressed. This book provides biomedical researchers with a framework to better understand the reproducibility challenges in the area. Newly introduced interactive exercises and updated case studies help students understand the fundamental concepts involved in the area.
- Includes four new chapters and updates across the book, covering recent developments of issues affecting reproducibility in biomedical research
- Covers reproducibility of results from machine learning AI algorithms
- Presents new case studies to illustrate challenges in related fields
- Includes a companion website with interactive exercises and summary tables
Graduate students and researchers in biomedical areas, Clinicians, policymakers, grant administrators
1. Introduction
2. The Problem of Irreproducibility
3. Validity of Biomedical Science, Reproducibility, and Irreproducibility
4. The Logic of Certainty versus the Logic of Discovery
5. The Logic of Probability and Statistics
6. Causation, Process Metaphor, and Reductionism
7. Case Studies in Clinical Biomedical Research 8. Case Studies in Basic Biomedical Research
9. Case Studies in Computational Biomedical Research
10. Case Studies in Machine Learning Artificial Intelligence (AI)
11. Reproducibility of translation from biomedical research to clinical care
12. Chaotic and Complex Systems, Statistics, and Far-from-Equilibrium Thermodynamics
13. The Nature of the Fundamental Challenges to Reproducibility in any Knowledge Discipline
14. Epilogue
15. Appendix: Types of lack of reproducibility
2. The Problem of Irreproducibility
3. Validity of Biomedical Science, Reproducibility, and Irreproducibility
4. The Logic of Certainty versus the Logic of Discovery
5. The Logic of Probability and Statistics
6. Causation, Process Metaphor, and Reductionism
7. Case Studies in Clinical Biomedical Research 8. Case Studies in Basic Biomedical Research
9. Case Studies in Computational Biomedical Research
10. Case Studies in Machine Learning Artificial Intelligence (AI)
11. Reproducibility of translation from biomedical research to clinical care
12. Chaotic and Complex Systems, Statistics, and Far-from-Equilibrium Thermodynamics
13. The Nature of the Fundamental Challenges to Reproducibility in any Knowledge Discipline
14. Epilogue
15. Appendix: Types of lack of reproducibility
- Edition: 2
- Published: April 26, 2024
- Language: English
EM
Erwin B. Montgomery Jr.
Dr. Montgomery has been an academic neurologist for over 40 years pursuing teaching, clinical and basic research at major academic medical centers. He has authored over 120 peer reviewed journal articles (available on PubMed) and 8 books on medicine (4 on the subject of Deep Brain Stimulation). The last two have been “Reproducibility in Biomedical Research” (Academic Press, 2024) and “The Ethics of Everyday Medicine” (Academic Press, 2023).
Affiliations and expertise
Emeritus Professor, Department of Medicine (Neurology), McMaster University, Hamilton, ON, CanadaRead Reproducibility in Biomedical Research on ScienceDirect