Pharmacology in Drug Discovery and Development
Understanding Drug Response
- 3rd Edition - May 21, 2024
- Imprint: Academic Press
- Author: Terry P. Kenakin
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 4 1 2 4 - 9
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 4 1 2 5 - 6
Pharmacology in Drug Discovery and Development: Understanding Drug Response, Third Edition is an introductory resource that illustrates how pharmacology can be used to furnish t… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quotePharmacology in Drug Discovery and Development: Understanding Drug Response, Third Edition is an introductory resource that illustrates how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization.
The updates to the Third Edition include a new section converting “descriptive” data into “predictive” data through comparison to mathematical models, expansion on enzymes, drug metabolites and drug–drug interactions, and two new chapters. The newly developed companion website hosts further educational resources to complement the book. As in previous editions, this new edition includes numerous valuable chapter summaries, detailed references, practical examples, and case studies throughout.
- Fully updated, including two new chapters on the science of finding drug molecules
- Introduces the discipline to a scientist new to the area
- Demonstrates the value of pharmacology in the drug discovery process
- Presents a wide variety of techniques in simple terms
- Includes interactive exercises in the companion website
Scientists coming new into the drug discovery area, Appropriate to undergraduate students in Pharmaceutical Science courses and health professions in general, Lab technicians and corporate based researchers coming in new to drug discovery
1. Pharmacology: The Chemical Control of Physiology
2. Drug Affinity and Efficacy
3. Predicting Agonist Effect
4. Drug Antagonism: Orthosteric Drug Effects
5. Allosteric Drug Effects
6. Enzymes as Drug Targets
7. Pharmacokinetics I: Permeation and Metabolism
8. Pharmacokinetics II: Distribution and Multiple Dosing
9. In Vivo Pharmacology
10. Safety Pharmacology
11. The science of Finding Drug Molecules I: Validating and Screening drug targets
12. The Science of Finding Drug Molecules II: Demonstrating Target Engagement and Therapeutic Value
Appendix
A. Answers to Chapter Questions
B. Derivations and Proofs
2. Drug Affinity and Efficacy
3. Predicting Agonist Effect
4. Drug Antagonism: Orthosteric Drug Effects
5. Allosteric Drug Effects
6. Enzymes as Drug Targets
7. Pharmacokinetics I: Permeation and Metabolism
8. Pharmacokinetics II: Distribution and Multiple Dosing
9. In Vivo Pharmacology
10. Safety Pharmacology
11. The science of Finding Drug Molecules I: Validating and Screening drug targets
12. The Science of Finding Drug Molecules II: Demonstrating Target Engagement and Therapeutic Value
Appendix
A. Answers to Chapter Questions
B. Derivations and Proofs
- Edition: 3
- Published: May 21, 2024
- No. of pages (Paperback): 444
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443141249
- eBook ISBN: 9780443141256
TK
Terry P. Kenakin
Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.
Affiliations and expertise
Professor, Pharmacology, University of North Carolina, USARead Pharmacology in Drug Discovery and Development on ScienceDirect