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Elsevier

Books in Life sciences

  • Epigenetics and DNA Damage

    • 1st Edition
    • Volume 33
    • Miriam Galvonas Jasiulionis
    • English
    Although scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still poorly understood. Comprehending how these processes are connected in time and space and play out in developmental processes may reveal novel directions for new research and disease treatment. Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research.

  • A Pharmacology Primer

    Techniques for More Effective and Strategic Drug Discovery
    • 6th Edition
    • Terry P. Kenakin
    • English
    A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Sixth Edition features the latest research surrounding the application of pharmacology in drug discovery in an effort to equip readers with a deeper understanding of complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for anyone involved in drug discovery. This edition has been reorganized for better flow and clarity and includes material on new technologies for screening (virtual, DNA encoded libraires, fragment-based) and a major section on phenotypic (target agnostic) screening for new leads and determination of drug targets. With full color illustrations as well as new examples throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery or pharmacologic research. New material includes a discussion of the determination of target engagement, including numerous new ways to demonstrate the physical interaction of molecules with drug targets and new drug candidates such a mRNA, gene therapy, antibodies and information on CRISPR and genomics.

  • Technologies to Recover Polyphenols from AgroFood By-products and Wastes

    • 1st Edition
    • Elisabete M.C. Alexandre + 2 more
    • English
    Technologies to Recover Polyphenols from AgroFood By-products and Wastes: Applications in Different Fields covers the most used technologies to extract and recover polyphenols from all kinds of by-products and wastes generated by the food industry, restaurant and agricultural sectors. Polyphenols are characterized by different AgroFood by-products and waste sources, hence this book explores the practical applications of these polyphenols in the development of functional foods and pharmaceutical and cosmetic products. Containing definitions, case studies, applications, literature reviews, and coverage of recent developments, this book will be a welcomed resource for food scientists, including those working in sustainability, agriculture and engineering.

  • Hazardous and Trace Materials in Soil and Plants

    Sources, Effects, and Management
    • 1st Edition
    • M. Naeem + 4 more
    • English
    Hazardous and Trace Materials in Soil and Plants: Sources, Effects and Management explores the latest advancements in reducing, avoiding and eliminating soil contaminants that challenge the health and safety of agricultural plants. With a focus on minimizing the production of those hazardous substances, controlling their distribution and ensuring safe utilization, the book explores each contributing area and provides insights toward improved, sustainable and secure production. This is an excellent reference resource on both current research and future directions from laboratory research to field applications. The combined impacts of climate change and industrialization have led to increased and diversified threats to the health of the soil in which our food crops are grown, as well as in the plants themselves. This dual-hazard scenario is increasingly recognized as a threat to not just the environment, but to global food security as agricultural soils contaminated with pollutants alter plant metabolism, thus resulting in reduced crop quality and production quantity.

  • Nonlinear Control for Blood Glucose Regulation of Diabetic Patients: An LMI Approach

    • 1st Edition
    • Anirudh Nath + 2 more
    • English
    Nonlinear Control for Blood Glucose Regulation of Diabetic Patients: An LMI-Based Approach exposes readers to the various existing mathematical models that define the dynamics of glucose-insulin for Type 1 diabetes patients. After providing insights into the mathematical model of patients, the authors discuss the need and emergence of new control techniques that can lead to further development of an artificial pancreas. The book presents various nonlinear control techniques to address the challenges that Type 1 diabetic patients face in maintaining their blood glucose level in the safe range (70-180 mg/dl). The closed-loop solution provided by the artificial pancreas depends mainly on the effectiveness of the control algorithm, which acts as the brain of the system. APS control algorithms require a mathematical model of the gluco-regulatory system of the T1D patients for their design. Since the gluco-regulatory system is inherently nonlinear and largely affected by external disturbances and parametric uncertainty, developing an accurate model is very difficult.

  • Metals and Metalloids in Soil-Plant-Water Systems

    Phytophysiology and Remediation Techniques
    • 1st Edition
    • Tariq Aftab + 1 more
    • English
    Metals and Metalloids in Soil-Plant-Water Systems: Phytophysiology and Remediation Techniques examines the impact of metal/metalloid contamination on the plant lifecycle, along with microbes present in soil. Highlighting uptake and translocation, the book also examines antioxidant, photosynthesis and growth characteristics of plants grown in metal contaminated soil. Beginning with an introduction to different sources of soil and water pollution, chapters assess the environmental cytotoxicity pollution impact on plants, as well as how the generation of reactive oxygen and nitrogen species in plant tissues is affected. The book also discusses various soil remediation methodologies, including the potential applications of metal oxidizing microbes and nanomaterials. This is an essential resource for researchers and students interested in plant physiology, soil science, environmental science and agriculture.

  • Helicase Enzymes Part B

    • 1st Edition
    • English
    Methods in Enzymology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Post-transcriptional Gene Regulation in Human Disease

    • 1st Edition
    • Volume 32
    • Buddhi Prakash Jain + 2 more
    • English
    Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail.

  • The Temporal Lobe

    • 1st Edition
    • Volume 187
    • English
    The Temporal Lobe, Volume 187 covers the exponential growth of studies on the relationships between brain and language/cognition, many of which involved the temporal lobe. This volume summarizes research on the anatomy and function of the temporal lobe under both normal and pathological conditions. In addition, it discusses the interactions of the temporal lobe with other brain structures. The book highlights the role of the temporal lobe in language processing as well as vision, object, face recognition and processing. The book also discusses the temporal lobe's role in reading, speech and the processing of color, music, action and memory. Temporal lobe disorders, assessments and treatments are also covered, including encephalitis, Alzheimer’s, epilepsy, Korsakov’s syndrome, and more.

  • Respiratory Neurobiology

    Physiology and Clinical Disorders, Part I
    • 1st Edition
    • Volume 188
    • English
    Respiratory Neurobiology: Physiology and Clinical Disorders, Part One, Volume 188 is one of two volumes on the neurology of breathing. This volume focuses on the neurophysiology of breathing, while the second volume focuses on pathologies attributable to abnormalities of the neural control of breathing, breathing problems that may occur in neurological diseases, and the neurological complications of respiratory diseases.

  • Imaging of Headache, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 40-3
    • Sangam Kanekar
    • English
    In this issue of Neurologic Clinics, guest editor Dr. Sangam Kanekar brings his considerable expertise to the topic of Imaging of Headache. Top experts in the field cover key topics such as headache attributed to disorder of the cranium and base of the skull; role of CT and MRI in evaluation of headache due to paranasal sinus and teeth disorder; imaging of painful ophthalmologic disorders; role of MRI and CT in the evaluation of headache in pregnancy and postpartum period; assessment and imaging of pediatric and adolescent headache; and more.

  • Synergistic Approaches for Bioremediation of Environmental Pollutants: Recent Advances and Challenges

    • 1st Edition
    • Riti Thapar Kapoor + 1 more
    • English
    Synergistic Approaches for Bioremediation of Environmental Pollutants: Recent Advances and Challenges focuses on the exploitation of various biological treatment technologies and their use to treat toxic contaminants present in industrial effluent and in restoring contaminated sites, which lacks in a more comprehensive manner in existing titles on similar topics available on the global market. The book comprises advanced biotechnologies and updated information, along with sustainable waste management developments and future directions for researchers and scientists working in the field of microbiology.

  • 3D Lung Models for Regenerating Lung Tissue

    • 1st Edition
    • Gunilla Westergren-Thorsson + 1 more
    • English
    3D Lung Models for Regenerating Lung Tissue is a comprehensive summary on the current state of art 3D lung models and novel techniques that can be used to regenerate lung tissue. Written by experts in the field, readers can expect to learn more about 3D lung models, novel techniques including bioprinting and advanced imaging techniques, as well as important knowledge about the complexity of the lung and its extracellular matrix composition. Structured into 15 different chapters, the book spans from the original 2D cell culture model on plastic, to advanced 3D lung models such as using human extracellular matrix protein. In addition, the last chapters cover new techniques including 3D printing, bioprinting, and artificial intelligence that can be used to drive the field forward and some future perspectives. This highly topical book with chapters on everything from the complexity of the lung and its microenvironment to cutting-edge 3D lung models, represents an exciting body of work that can be used by researchers during study design, grant writing, as teaching material, or to stay updated with the progression of the field.

  • Hepatobiliary Cancers: Translational Advances and Molecular Medicine

    • 1st Edition
    • Volume 156
    • English
    Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies.

  • "Venomous" Bites from "Non-Venomous" Snakes

    • 2nd Edition
    • Scott A Weinstein + 2 more
    • English
    "Venomous" Bites from "Non-Venomous" Snakes, Second Edition thoroughly examines the potential hazards associated with bites by non-front-fanged snakes (popularly, but inaccurately, called "rear-fanged snakes"). This diverse group contains approximately 80% of living snake species (approximately 2,900 species). A large proportion of these snakes were previously assigned to the family Colubridae but, as a consequence of expanding systematics investigations, have been split into multiple families and subfamilies. Many of these snakes produce venoms or oral secretions that contain toxins and other biologically active substances. A large variety of non–front-fanged snakes figure in the pet industry, yet little documented information or formal study of their potential medical importance has been published. Therefore, although the possible medical importance of many of these species has been subjected to speculation since the mid-19th century, there is a limited amount of useful descriptive information regarding the real hazard (or lack thereof) of this wide variety of snakes. The first edition of this book provided "one-stop shopping" by offering information regarding their possible toxicity and clinical relevance as well as recommendations for medical management of their bites. The second edition expands and updates the content with detailed information about the effects and medical management of bites by a broad representation of non–front-fanged species. The hypothetical venomous nature of some lizards considered as non-venomous such as the Komodo monitor or dragon and their allies, as well as the medical effects of their bites, is also examined. The dynamic taxonomy of advanced snakes is updated, and the bases for some of these fluid changes are discussed. Likewise, terminology is also updated in order to reflect the ongoing debates regarding the definition of "venom" and the balanced reinforcement of nonmedical criteria used to define the biological basis of the term "venomous."

  • Parathyroid Hormone

    • 1st Edition
    • Volume 120
    • English
    Vitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Application of Biofilms in Applied Microbiology

    • 1st Edition
    • Maulin P. Shah
    • English
    Application of Biofilms in Applied Microbiology gives a complete overview on the structure, physiology and application of biofilms produced by microbes, along with their potential application in biotechnology. Sections cover new technologies for biofilm study, physiology of microorganisms in biofilms, bacterial biofilms, biofilm development, and fungal biofilms, summarizing various technologies available for biofilm study. Subsequent chapters describe biofilm developments with Bacillus subtillis, Escherichia coli, and Pseudomonas putida, along with several chapters on the study of microbial biofilm and their advantages and disadvantages in the area of environmental biotechnology. The book closes with a chapter on the rapid development of new sequencing technologies and the use of metagenomics, thus revealing the great diversity of microbial life and enabling the emergence of a new perspective on population dynamics.

  • Fish Roe

    Biochemistry, Products, and Safety
    • 1st Edition
    • Alaa El-Din A. (Aladin) Bekhit
    • English
    Provides comprehensive coverage of the components available in fish roe and highlights their biological and nutritional effects as well as their sensory and safety attributes. Fish Roe: Biochemistry, Products, and Safety describes various components available in fish roe and introduces their biological and nutritional effects. In addition to addressing biological and nutritional effects, this book also explores fish roe products and their safety while also providing coverage of the bioactives that are naturally available in fish roe or generated during processing, thereby outlining the maximum benefits that can be obtained from this natural resource. Beginning with the introduction of fish roe production procedures worldwide, this book further explores the processing of traditional fish roe products from Europe, Asia, and the Middle East, where fish roe is frequently consumed. This book also discusses the sensory and safety attributes of fish roe and will be a comprehensive reference for food scientists, chemists, food process engineers, developers, researchers, and students in the field of seafood science.

  • Methods in Stem Cell Biology - Part B

    • 1st Edition
    • Volume 171
    • English
    Methods in Cancer Stem Cell Biology: Part B, Volume 171 in the Methods in Cell Biology series highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including Orthotopic brain tumor models derived from glioblastoma stem-like cells, RNA sequencing in hematopoietic stem cells, Generation of inducible pluripotent stem cells from human dermal fibroblasts, In vitro preparation of dental pulp stem cell grafts combined with biocompatible scaffolds for tissue engineering, Gene expression knockdown in chronic myeloid leukemia stem cells, Identification and isolation of slow-cycling GSCs, Assessment of CD133, EpCAM, and much more.

  • Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary

    • 1st Edition
    • Volume 95
    • English
    Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades, and since the first article on P450 was published in 1962. Chapters in this new release include Multiple conformations of cytochromes P450 and the relevance to predicting SAR, Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and more. Additional section cover Atypical kinetics of cytochrome P450 enzymes in drug metabolism, Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites, Use of engineered cytochrome P450s for accelerating drug discovery and development, Assessing cytochrome P450 function using genetically engineered mouse models, Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions, and much more. Research on many forms of P450s has been extended into different fields, from molecules to in vivo situations because pharmacologists and toxicologists appreciate and are attracted to the potential therapeutics. The purpose of this volume is to collect a comprehensive description of major progress to date, to discuss possible future directions, and to invite young researchers to join this important and exciting world of P450.

  • Early Nutrition and Long-Term Health

    Mechanisms, Consequences, and Opportunities
    • 2nd Edition
    • Jose M Saavedra + 1 more
    • English
    Early Nutrition and Long-Term Health: Mechanisms, Consequences, and Opportunities, Second Edition updates and expands upon the content in the first edition and adds focus on actionable and modifiable aspects of nutrition that have an impact on long-term health and disease. Part I examines the associations and the mechanisms of early life nutrition on growth as well as the development of cognitive, metabolic, immune, and dietary patterns and behaviors. Part II reviews the associations and impact of early life nutrition on non-communicable disease as well as their societal and economic impact. Part III focuses on the dietary and nutritional needs and approaches to optimizing the different stages of nutrition, from conception to the second year of life. Nutritionists, pediatricians, academics with research interest in this area, and food industry and healthcare professionals working in infant/child product and services, as well as students studying related disciplines, will benefit from this updated reference.

  • Role of Chitosan and Chitosan-Based Nanomaterials in Plant Sciences

    • 1st Edition
    • Santosh Kumar + 1 more
    • English
    Role of Chitosan and Chitosan-Based Nanomaterials in Plant Sciences explores the physiological, morphological, biochemical and molecular regulation of chitosan and chitosan-based nanoparticles in plants in normal conditions, as well as during different stresses, and their probable mechanism of operation in the tolerance mechanism. The book stimulates further research in the field of chitosan and will foster further interests for researchers, academicians and scientists worldwide. Nanotechnology is being used widely in all disciplines of science and technology, including plant sciences. Chitosan has widely been reported as a beneficial organic compound for the growth and developments of plants and it plays a protective role for the plants against abiotic and biotic stresses. Yet there are very few books available that deal exclusively with Chitosan and Chitosan based nanoparticles impacts on plants respectively.

  • Targeted Nanomedicine for Breast Cancer Therapy

    • 1st Edition
    • Shivani Rai Paliwal + 1 more
    • English
    Targeted Nanomedicine for Breast Cancer Therapy provides a compilation of treatment approaches for breast cancer, including conventional receptor targeting methods and novel strategies like stimuli responsive methods and tumor micro-environment responsive strategies. This book compiles the most important information on the state-of-the-art therapeutics, including breast cancer biomarkers and design principles of bio-responsive nanosystems. Presented in two parts, sections cover basic and receptor mediated targeting approaches and examine tumor microenvironment mediated approaches. This is a useful book for pharmaceutical scientists and basic and clinical scientists working in the research area of breast cancer and drug discovery both from academics and industry.Worldwide, breast cancer is the most common cancer in women, however, breast cancer therapy is always challenging. This book aims to help researchers remain updated on the most targeted nanomedicine research available.

  • Autophagy and Metabolism

    Potential Target for Cancer Therapy
    • 1st Edition
    • Dhruv Kumar + 1 more
    • English
    Autophagy and Metabolism: Potential Target for Cancer Therapy presents updates on autophagy in cancer metabolism and how it can be used to develop new, more efficient treatments. Written by experts in the field, the book presents recent research and explains how to translate it to the clinical setting. Sections discuss tumor cell metabolism and autophagy as therapeutic targets, autophagy regulation in cancer, signaling pathways in metabolic dysregulation in solid tumors, metabolic stress and cell death pathways, and the role of the tumor microenvironment. In addition, topics cover combined targeting autophagy, metabolism for cancer therapy, and the autophagy effect on immune cell metabolism. This will be a valuable resource for researchers, oncologists, graduate students, and members of the biomedical field who are interested in learning more about the interaction between autophagy and cancer metabolism.

  • Helicase Enzymes Part A

    • 1st Edition
    • Volume 672
    • English
    Methods in Enzymology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Storage of Cereal Grains and Their Products

    • 5th Edition
    • Kurt A. Rosentrater
    • English
    Storage of Grains and Their Products, Fifth Edition, presents the most authoritative reference on the principles and practices of storing and handling grains and their products. Divided into four main sections, the book covers the range of storage systems available in both the developed and developing world, the practicalities of the design and implementation of grain storage systems, looking in detail at handling, cleaning, drying, aeration, instrumentation amongst other topics, specific threats to stored grains, pulses, oils and pseudocereals from chemicals, rodents, insects and biosecurity, and the economics of grain storage, government regulations and future considerations. Professionals responsible for the storage and handling of grains will find this book a great resource, however, it will also be of interest to academic researchers and postgraduate students in both cereal science and food processing.

  • Advances in Agronomy

    • 1st Edition
    • Volume 175
    • Donald L. Sparks
    • English
    Advances in Agronomy, Volume 175, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

  • Advances in Applied Microbiology

    • 119th Edition
    • Geoffrey M. Gadd + 1 more
    • English
    Advances in Applied Microbiology, Volume 119 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topics of microbiology.

  • Design, Principle and Application of Self-Assembled Nanobiomaterials in Biology and Medicine

    • 1st Edition
    • Alok Pandya + 2 more
    • English
    Design, Principle and Application of Self-Assembled Nanobiomaterials in Biology and Medicine discusses recent advances in science and technology using nanoscale units that show the novel concept of combining nanotechnology with various research disciplines within both the biomedical and medicine fields. Self-assembly of molecules, macromolecules, and polymers is a fascinating strategy for the construction of various desired nanofabrication in chemistry, biology, and medicine for advanced applications. It has a number of advantages: (1) It is involving atomic-level modification of molecular structure using bond formation advanced techniques of synthetic chemistry. (2) It draws from the enormous wealth of examples in biology for the development of complex, functional structures. (3) It can incorporate biological structures directly as components in the final systems. (4) It requires that the target self-assembled structures be thermodynamically most stable with relatively defect-free and self-healing. In this book, we cover the various emerging self-assembled nanostructured objects including molecular machines, nano-cars molecular rotors, nanoparticles, nanosheets, nanotubes, nanowires, nano-flakes, nano-cubes, nano-disks, nanorings, DNA origami, transmembrane channels, and vesicles. These self-assembled materials are used for sensing, drug delivery, molecular recognition, tissue engineering energy generation, and molecular tuning.

  • The Paradox of the Immune System

    Protection, Chronic Inflammation, Autoimmune Disease, Cancer, and Pandemics
    • 1st Edition
    • Louis J. Catania
    • English
    The Paradox of the Immune System: Protection, Inflammation, Autoimmune Disease and Beyond provides a provocative approach to immunology as a "double-edged sword." While it is our greatest protector, it is also the cause of chronic inflammation that leads to autoimmune disease, cancer and infectious diseases like COVID-19. Sections cover the basic science of immunology and its intimate genetic associations, biomedical hypotheses asserting immunology as the basis of all human diseases, and elaborate on immunology as "the enemy within us." This engaging, original approach to a science so personal provides new and invaluable understanding on the bioscience that controls our lives.

  • Histopathology Atlas of Acute Radiation Syndrome and Delayed Effects in Rhesus Macaques

    Kidney, Lung, Heart, Intestine and Mesenteric Lymph Node
    • 1st Edition
    • George Parker
    • English
    Histopathology Atlas of Acute Radiation Syndrome and Delayed Effects in Rhesus Macaques: Kidney, Lung, Heart, Intestine and Mesenteric Lymph Node provides a thoroughly illustrated review of the tissue damage and reparative changes associated with standardized irradiation doses in rhesus macaques. In addition to time-sequenced, routinely stained histologic sections, the book presents results of numerous histochemical, immunohistochemical and chromogenic in-situ stains that provide insights into the pathogenesis of radiation-associated tissue injury and repair. This book is compiled and written by a board-certified veterinary pathologist with more than 40 years of experience in the interpretation of experimentally induced tissue alterations in laboratory animals. This is an important resource for researchers in the field of animal science radiation injury, including radiation oncologists and individuals involved in disaster preparedness related to accidental or deliberate radiation exposure in large populations.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 109
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 109, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release focusing on Biomarkers of dysfunctional visceral fat, Immunoassay Design and Biotin Interference, Orexin/Hypocretin and Major Psychiatric Disorders and more.

  • Emerging Sources and Applications of Alternative Proteins

    • 1st Edition
    • Volume 101
    • English
    Protein nutrition and sustainability is a global challenge. Emerging Sources and Applications of Food Proteins provides the latest progresses about research and applications of emerging alternative proteins. Topics covered in this volume include rapeseed (canola) proteins, pulse proteins, insect proteins, fungal proteins, artificial meat, and new applications in bioactive peptides, nanotechnology, 3D printing, meat alternatives, with a focus on the consumer trend and practical applications.

  • Promoting Responsive Feeding During Breastfeeding, Bottle-Feeding, and the Introduction to Solid Foods

    • 1st Edition
    • Alison Ventura
    • English
    Promoting Responsive Feeding During Breastfeeding, Bottle-Feeding, and the Introduction to Solid Foods　addresses how caregiver feeding practices and styles shape the quality and outcome of feeding interactions during infancy. Emphasis is placed on　how　the quality and nature of caregiver-child interactions during breastfeeding, bottle-feeding,　and the introduction to solid foods　shape the development of children’s eating behaviors, growth trajectories and chronic disease risk. The book also considers the potential influence of broader contextual factors on early feeding interactions, including how psychological, social, cultural and economic factors may influence caregivers’ abilities to implement feeding recommendations.

  • Integrative Strategies for Bioremediation of Environmental Contaminants, Volume 2

    Avenues to a Cleaner Society
    • 1st Edition
    • Riti Thapar Kapoor + 1 more
    • English
    Integrative Strategies for Bioremediation of Environmental Contaminants, Volume Two: Avenues to a Cleaner Society focuses on the exploitation of various biological treatment technologies and their use to treat toxic contaminants present in industrial effluent to restore contaminated sites. The book includes coverage of combined treatments of microbes for reuse of wastewater and contaminated soil to successfully achieve eco-restoration, environment protection and sustainable development. In 14 chapters, this reference compiles current and advanced biotechnologies as well as future directions for research. This is a valuable resource for researchers in microbiology, biotechnology, environmental engineering and environmental science, and all those who wish to broaden their knowledge in the field of applied microbiology to develop sustainable waste management.

  • Diabetes Digital Health and Telehealth

    • 1st Edition
    • David C. Klonoff + 2 more
    • English
    Diabetes Digital Health and Telehealth explains, from technologic, economic and sociologic standpoints how digital health and telehealth have come to dominate the management of diabetes. The book also includes information on improved telemedicine tools and platforms for communicating with patients, reviewing medical records, and interpreting data from wearable devices. In addition, evolving wearable sensors such as continuous glucose monitors, closed loop automated insulin delivery systems, cuffless blood pressure monitors, exercise monitors and smart insulin pens are covered.

  • Biocatalysis in Green Solvents

    • 1st Edition
    • Pedro Lozano
    • English
    Biocatalysis in Green Solvents offers a pragmatic overview and instruction in biocatalysis and enzymology of green solvents for sustainable industries and medicine, running from concept to application. Here, international experts in the field discuss structure-function relationships of enzymes in ionic liquids (ILs) and examine how enzymes act as selective catalysts for fine biochemical synthesis in non-aqueous environments. Several integral green biochemical processes of biocatalytic transformation and pure product separation are described in detail. Application focused chapters discuss the role of biocatalysis in creating and implementing deep eutectic solvents, biomass derived solvents, sub and supercritical fluids, carbon dioxide biphasic systems, and enzymatic membrane reactors, as well as applying these biocatalytic processes in drug discovery and production.

  • Immunopathology, Diagnosis and Treatment of HPV induced Malignancies

    • 1st Edition
    • Prashant Khare + 1 more
    • English
    Immunopathology, Diagnosis and Treatment of HPV induced Malignancies focuses on the human papilloma virus infection and associated cancers. In ten chapters, the book explains the deep knowledge about molecular mechanism in HPV pathogenesis and recent advanced tools applied in the field of HPV induced cancer and cures. In a nutshell, the book gives new insights and the associated challenges involved in the identification of promising drug and vaccine targets, current diagnostic tools, and advancements in current therapies against HPV induced cancers and other malignancies.

  • Krause and Mahan’s Food and the Nutrition Care Process

    • 16th Edition
    • Janice L Raymond + 1 more
    • English
    **Selected for 2026 Doody's Core Titles as an Essential Purchase in Nutrition**Provide optimal nutritional care with the latest guidelines to evidence-based practice! Krause and Mahan’s Food & the Nutrition Care Process, 16th Edition provides an all-in-one resource for the dietetics information you need to care for patients throughout the entire life cycle. With insight from clinical specialists, the book guides you through the steps of assessment, diagnosis and intervention, monitoring, and evaluation. It also covers nutrition in each stage of life, weight management, medical nutrition therapies for conditions and disorders, and the use of nutrition therapies in childhood. From a team of nutrition experts led by Janice L. Raymond and Kelly Morrow, this classic text has been trusted by nurses, nutritionists, and dieticians for since 1952.

  • Application of Sampling and Detection Methods in Agricultural Plant Biotechnology

    • 1st Edition
    • Ray Shillito + 1 more
    • English
    Application of Sampling and Detection Methods in Agricultural Plant Biotechnology describes detection methods for seed, plants and grain derived from biotechnology. This international handbook, based on a series of workshops carried out for governments in collaboration with ILSI and Co-published in partnership with the Cereals & Grains Association, provides the technical and practical information needed to develop, validate and use detection methods. This useful resource provides readers with the tools necessary to carry out reliable sampling, detection and interpretation of data.

  • Cellular Immunity in the Peritoneum

    • 1st Edition
    • Volume 371
    • English
    Adoptive Cell Transfer, Volume 371 in the International Review of Cell and Molecular Biology series highlights advances in the field, with this new volume presenting interesting chapters written by an international board of authors who expound on topics such as the Impact of tumor microenvironment on Adoptive Cell Transfer activity, Dendritic Cell Transfer, CAR-T Cell dysfunction and exhaustion, NK Cell-based cancer immunotherapy, Enabling CAR-T cells for solid tumors: rage against the suppressive tumor microenvironment, Improving Adoptive T-Cell therapy with cytokines administration, and What will (and should) be improved in Immunotherapy with CAR?

  • Forest Microbiology Vol.3_Tree Diseases and Pests

    Tree Diseases and Pests
    • 1st Edition
    • Fred O Asiegbu + 1 more
    • English
    Forest Microbiology: Tree Diseases and Pests, Volume Three in the Forest Microbiology series, provides an overview of major disease agents of trees, including viruses, phytoplasma, bacteria, fungi, nematodes and major insect pests. With a strong emphasis on genetics, biochemistry, physiology, evolutionary biology and population dynamics of the organisms involved, this book provides a comprehensive understanding on the health of forests. Sections cover important pest threats such as bark beetles, emerald ash borer, coffee borers, leaf cutting ants, cocoa mirids, and more. This volume highlights a range of emerging diseases of forest trees in temperate and tropic regions as well as information on habitats. Forest trees play crucial roles not only for mitigating effects of the climate change but also for their considerable economic and ecological value. Forest trees are equally vital as an alternative bioenergy source and play important roles in pollution abatement and the maintenance of biodiversity. Timber and its associated products from forest trees contribute substantially to the revenue generation of many countries of the world.

  • Microbial Crosstalk with Immune System

    New Insights in Therapeutics
    • 1st Edition
    • Asmita Das
    • English
    Our body is not sterile and harbors enumerable microflora that are now being understood to play a complex role in immune regulation and shaping of the immune system in a continuous and dynamic way. In 8 chapters, Microbial Crosstalk with Immune System: New Insights in Therapeutics provides an overall introduction with special focus on how the immune system which is specifically geared to get rid of non-self-antigens, allows numerous microbes to colonize the human body. In the presence of microbes there are several observations that suggest that there are multiple roles that are played by these microbes in tumor progression and shaping of our immune system which is explained at length in subsequent chapters. Microbial Crosstalk with Immune System: New Insights in Therapeutics discusses the emerging mechanisms of immune-therapeutics as well as its limitations while emphasizing the potential role of microbes in shaping immune-therapeutic and evolving novel strategies to deal with any limitations.

  • Circadian and Visual Neuroscience

    • 1st Edition
    • Volume 273
    • English
    Circadian and Visual Neuroscience, Volume 273 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on topics including Optical set-ups, Psychophysics of Luminance and Color Vision, Psychophysics of non-visual photoreception PRC/IRC/DRC/Spectral Sensitivity, Circadian and visual photometry, Modelling (retina), Modelling (circadian), Techniques for examining vision at the cellular level, Advanced techniques for characterizing the world hyperspectrally, Circadian physiology in mice: Melanopsin, Circadian physiology in mice: Color and cones, Translational aspects of animal studies, Retinal clocks, Primate non-visual physiology, Light and mood in animal models, and much more.

  • Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics

    • 1st Edition
    • Sunny Ohia + 1 more
    • English
    Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics provides a review of the basic anatomy, physiology, biochemistry and pathology of the eye with a focus drug therapy, drug delivery and use of therapeutic medical miniature devices. An understanding of the pharmacological actions of drugs acting on the eye requires the student and health care practitioner to learn additional principles in basic and clinical sciences that are unique to this organ. As a sensory organ, the eye is relatively inaccessible to the systemic circulation due to the blood-vitreous, blood-aqueous and blood-retinal barriers. Consequently, the administration of drugs for therapeutic effects in the eye necessitates an understanding of physico-chemical properties of the molecules and pharmacokinetic principles involved in the access to its site of action via topical, intracameral and intravitreal administration. This book includes information on the general principles of pharmacokinetics and pharmacodynamics of drugs as it pertains to the eye and in combating ocular disorders and diseases. Using a disease-themed approach, the book discusses basic and clinical pharmacological principles involved in the therapy of these diseases including the ocular side effect of systemically-adminis... drugs, drugs used in ophthalmic surgery and miscellaneous agents, the therapeutic utility of biologics, drug conjugates, combination products, gene and cellular therapy are also covered. Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics is useful as a primary and secondary source of reference for up-to-date information about the pharmacological mechanisms of action, pharmacokinetics, side effects, drug-drug interactions and therapeutic indications of drugs for pharmacologists, pharmaceutical scientists, students in the health care disciplines (nursing, pharmacy, optometry, medical), and practitioners in optometry and ophthalmology.

  • Essentials of Medical Biochemistry

    With Clinical Cases
    • 3rd Edition
    • Chung Eun Ha + 1 more
    • English
    Essentials of Medical Biochemistry, Third Edition offers a condensed, yet detailed overview of clinical biochemistry, spanning fundamentals and relevant physiologic and pathophysiologic concepts. Pivotal clinical case studies aid in understanding basic science in the context of diagnosis and treatment of human diseases, and the text illuminates key topics in molecular immunology and hemostasis. Users will find fundamental concepts aiding students and professionals in biochemistry, medicine, and other healthcare disciplines. The text is a useful refresher that will help users meet USMLE and other professional licensing examination requirements, providing thorough introductions, key points, multicolored illustrations of chemical structures and figures, fact-filled tables, and recommended reading lists. This Third Edition has been fully updated to address evolving techniques in the biological sciences, including genomics, metabolomics, transcriptomics, epigenomics, proteomics, and gene therapy, among other methods. In addition, each chapter has been fully revised for current science and now features learning objectives and chapter summaries, supplemental reading, and 5 clinical case based multiple choice questions. New clinical cases have been added throughout.

  • Engineered Nanomaterials for Sustainable Agricultural Production, Soil Improvement and Stress Management

    • 1st Edition
    • Azamal Husen
    • English
    Engineered Nanomaterials for Sustainable Agricultural Production, Soil Improvement and Stress Management highlights the latest advances in applying this important technology within agriculture sectors for sustainable growth, production and protection. The book explores various smart engineered nanomaterials which are now being used as an important tool for improving growth and productivity of crops facing abiotic stresses, improving the health of the soil in which those crops are growing, and addressing stresses once the plant begins to produce food yield. The book includes insights into the use of nanoparticles as bactericides, fungicides and nanofertilizers. In addition, the book includes an international representation of authors who have crafted chapters with clarity, reviewing up-to-date literature with lucid illustrations. It will be an important resource for researchers, nanobiotechnologists... agriculturists and horticulturists who need a comprehensive reference guide.

  • Neurologie de l'adolescence

    • 1st Edition
    • Agathe Roubertie + 1 more
    • French
    L’adolescence est une période unique de transformation de l’individu. Sur le plan somatique, psychique et social, le passage de l’enfance à l’âge adulte est aussi l’occasion de troubles spécifiques ou dont l’expression revêt des aspects particuliers. Ainsi, dans le domaine de la neurologie, cela se traduit par des prévalences plus élevées de certaines affections, ainsi qu’un retentissement singulier sur la personne. Les troubles neurologiques peuvent en effet compromettre les facultés essentielles à l’autonomisation de l’individu, et ont un impact sur l’image que donne l’ado à ses pairs.Sans équivalent, cet ouvrage se justifie donc par les particularités de la prise en charge, les troubles affectant les ados (adolescentes et adolescents) de façon très différente des enfants (qui s’en remettent aux adultes) et des adultes (plus autonomes et responsables dans leur prise en charge).Traitant à la fois des maladies dont les prévalences sont élevées et des affections plus rares, l’ouvrage aborde cette problématique dans toute sa spécificité, en ne négligeant aucune dimension particulière du diagnostic, du traitement et de la prise en charge globale du jeune patient. Chaque chapitre exposera successivement les spécificités à l’adolescence des données épidémiologiques et cliniques (mode de présentation, pièges diagnostiques), puis les principaux diagnostics rencontrés et proposera une prise en charge adaptée à cet âge. La question de la transition des troubles neurologiques de l’enfant à l’âge adulte et de l’accompagnement de l’ado dans sa vie scolaire et sociale sont également abordés.Cet ouvrage s’adresse aux neurologues, pédiatres et neuropédiatres, ainsi qu’aux étudiants déjà entrés dans la spécialité.POINTS CLÉS - Toutes les pathologies touchant les ados, des plus fréquentes aux plus rares - Les spécificités de la prise en charge de l’ado - L’accompagnement de l’ado et la transition vers l’âge adulte

  • Carotenoids: Carotenoid and Apocarotenoid Biosynthesis, Metabolic Engineering and Synthetic Biology

    • 1st Edition
    • Volume 671
    • English
    Carotenoids: Carotenoid and Apocarotenoid Biosynthesis, Metabolic Engineering and Synthetic Biology, Volume 671, the latest release in the Methods of Enzymology series highlights new advances in the field with chapters on Metabolomics-based analysis of carotenoids and related metabolites in various species via quantitative trait loci and genome wide association mapping approaches, Using bacteria for functional analysis of genes encoding carotenoid biosynthetic enzymes, Rice Callus as a High Throughput Platform for Synthetic Biology and Metabolic Engineering of Carotenoids, Transient expression in Nicotiana benthamiana: A simple platform to investigate genes encoding carotenoid biosynthesis enzymes from diverse algal lineages, and much more. Additional chapters in this new release cover Protein-protein interaction techniques to investigate post-translational regulation of carotenogenesis, The isolation of sub-chromoplast structures from tomato and capsicum fruit, Carrot protoplasts as a suitable method for protein subcellular localization, High throughput production and characterization of carotenoid enzymes for structural and functional studies, Production and structural characterization of the cytochrome P450 enzymes in carotene ring hydroxylation, and more.

  • Applications of Nanovesicular Drug Delivery

    • 1st Edition
    • Amit Kumar Nayak + 3 more
    • English
    Applications of Nanovesicular Drug Delivery provides thorough insights and a complete and updated discussion on the preparation, properties and drug delivery applications of various nanovesicles. This volume will discuss target-specific drug application, such as ocular, transdermal, nasal, intravenous and oral delivery. This title is a valuable resource for academics, pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals and regulatory scientists actively involved in pharmaceutical products and process development of tailored-made polysaccharides in drug delivery applications. Recently, there have been a number of outstanding nanosystems in nanovesicular carrier-forms (such as nanoemulsions, self-nanoemulsifying systems, nanoliposomes, nanotransferosomes, etc.), that have been researched and developed for efficient drug delivery by many formulators, researchers and scientists. However, no previously published books have covered all these drug delivery nanovesicles collectively in a single resource.

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