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Advances in Immunology
1st Edition - November 19, 2022
Editors: Frederick W. Alt, Kenneth Murphy
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 9 4 7 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 9 4 8 - 0
Advances in Immunology, Volume 156, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in… Read more
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Advances in Immunology, Volume 156, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology, with this volume covering self-referential immune recognition through C-type lectin receptors, genetic susceptibility to autoimmunity, activation and regulation of the cGAS-STING pathway and the implications of IL-15 trans-presentation on the immune response.
- Presents current developments and comprehensive reviews in immunology
- Provides the latest in a longstanding and respected serial on the subject matter
- Focuses on recent advances in the advancing area of the mechanisms involved in the evolution of regulatory T-cells in infection and Factor H and Properdin and their regulation
Immunologists and infectious disease specialists, cell biologists and hematologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: Self-referential immune recognition through C-type lectin receptors
- Abstract
- 1: Introduction
- 2: Development of functional CLRs
- 3: Dectin clusters
- 4: Recognition of various self-ligands through CLRs
- 5: Organogenesis
- 6: Perspectives
- Acknowledgments
- Conflict of interest disclosures
- References
- Chapter Two: Genetic susceptibility to autoimmunity—Current status and challenges
- Abstract
- 1: Introduction
- 2: Genetic architecture of autoimmune diseases
- 3: Genetic technology revolution in autoimmune diseases
- 4: Genetic susceptibility of autoimmune diseases—Recent progress
- 5: Genetic risk shared between autoimmune diseases
- 6: Genetic factors shared between autoimmune diseases and other diseases
- 7: From genetics research to translational medicine in autoimmunity
- 8: Concluding remarks
- Acknowledgments
- References
- Chapter Three: Recent advances in the activation and regulation of the cGAS-STING pathway
- Abstract
- 1: Introduction
- 2: An overview of the cGAS-STING pathway
- 3: Evolution of the cGAS-STING pathway and the CD-NTase family
- 4: Activation of cGAS
- 5: Activation of STING
- 6: Regulation of the cGAS-STING activation
- References
- Chapter Four: The implications of IL-15 trans-presentation on the immune response
- Abstract
- 1: Introduction
- 2: IL-15Rα recycles and presents IL-15 in trans to neighboring cells
- 3: IL-15Rα/IL-15 and IL-15Rα/IL-15L are ancient receptor/cytokine systems
- 4: Genetic organization of the IL15 gene and regulation of IL-15 production
- 5: Organization of the IL-15Rα locus complex includes an alternative exon that prevents cleavage of IL-15Rα from the cell membrane and facilitates trans-presentation of IL-15
- 6: Control of IL-15 transcription
- 7: Control of IL-15 translation
- 8: IL-15Rα and IL-15 must be expressed by the same cell for efficient trans-presentation
- 9: IL-15 signaling pathways
- 10: NKG2D signaling is coupled to the IL-15 signaling pathway
- 11: IL-15 trans-presentation is critical for NK-cell development and function
- 12: IL-15 trans-presentation and the differentiation of iNKT cells
- 13: IL-15 trans-presentation regulates homeostasis of CD4+ T lymphocytes
- 14: IL-15 trans-presentation plays a role in the development, homeostasis, and activation of dendritic epidermal T cells (DETCs)
- 15: The role of IL-15 in the homeostasis of γδ cells
- 16: IL-15 trans-presentation controls the expression and survival of CD44high CD8+ T cells
- 17: Dendritic cells and macrophages mediate the effect of IL-15 on CD8+ CD44high memory phenotype T cells
- 18: The effect of IL-15 trans-presentation from DCs to NK cells
- 19: IL-15-dependent IELs are a heterogeneous group of cells in the small and large intestine where they contribute to the first level of defense against infections
- 20: IL-15Rα trans-presents IL-15, thereby regulating tissue resident T cells and tissue specific destruction
- 21: IL-15 and autoimmune diseases
- 22: CD8+ CD122+ CD127- PD-1+ CD28+/− regulatory T cells are essential for the maintenance of T-cell homeostasis
- 23: IL-15 in cancer
- 24: Conclusions and therapeutic perspectives
- References
- No. of pages: 140
- Language: English
- Published: November 19, 2022
- Imprint: Academic Press
- Hardback ISBN: 9780323989473
- eBook ISBN: 9780323989480
FA
Frederick W. Alt
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
Affiliations and expertise
Investigator and Director, Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USAKM
Kenneth Murphy
Kenneth M. Murphy works in Washington University School of Medecine, USA.
Affiliations and expertise
Washington University School of Medecine, USA