Polycystic Ovary Syndrome
Basic Science to Clinical Advances Across the Lifespan
- 1st Edition - November 17, 2022
- Imprint: Elsevier
- Editors: Rehana Rehman, Aisha Sheikh
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 7 9 3 2 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 7 9 3 3 - 0
Providing a holistic, global approach to all aspects of PCOS, Polycystic Ovary Syndrome: Basic Science to Clinical Advances Across the Lifespan offers authoritative guidance on the… Read more
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Request a sales quoteProviding a holistic, global approach to all aspects of PCOS, Polycystic Ovary Syndrome: Basic Science to Clinical Advances Across the Lifespan offers authoritative guidance on the diagnosis, treatment, and management of this challenging syndrome. It presents a coherent, evidence-based approach to diagnosis, as well as recommendations for clinical practice grounded in recent advances in basic sciences. Unique in the field, this practical resource provides decision-making tools for endocrinologists, fertility specialists, gynecologists, and internists who diagnose and treat patients with this complex chronic condition.
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Covers all aspects of PCOS and management across the lifespan, including short- and long-term metabolic, endocrine, and psychological challenges.
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Offers an integrative approach to the understanding of pathophysiology and management of PCOS in adult women and adolescent girls with a focus on genetics, microRNAs, and risk factors.
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Includes clinical, hormonal and metabolic features as well as diagnostic criteria and PCOS phenotypes.
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Presents treatment and management options for common symptoms, hirsutism, menstrual irregularity, and conception planning, including a chapter on subfertility and the male PCOS equivalent. Includes coverage of standard comorbidities, as well as a section on global approaches to patients with PCOS that addresses unique concerns, practices, and stigmas associated with how different cultures approach the disorder.
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Addresses the use of complementary/alternative medicine, lifestyle modification, and behavioral therapy in managing PCOS.
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An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Endocrinologists, Fertility specialists, Gynecologists, Internists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Foreword
- Preface
- Dedication
- Acknowledgment
- List of Tables
- List of Illustrations
- Section I. Overview of Polycystic Ovary Syndrome
- 1. Introduction to polycystic ovary syndrome
- Introduction
- References
- 2. Polycystic ovary syndrome phenotypes
- Introduction
- Ethnic variations in PCOS prevalence and clinical presentation
- References
- 3. Polycystic ovary syndrome in adolescents
- Introduction
- Risk factors and pathogenesis of PCOS in adolescents
- Diagnostic challenges in adolescent PCOS
- Differential diagnosis of PCOS in adolescents
- Diagnosis of PCOS in adolescence
- Clinical presentation
- Quality of life in adolescents with PCOS
- Diagnostic approach to PCOS in adolescence
- Treatment strategies
- Summary
- References
- Section II. Pathogenesis and Clinical Presentation
- 4. Pathophysiology of polycystic ovary syndrome
- Pathophysiology of polycystic ovary syndrome
- Hormonal aberrations
- Vascular endothelial growth factor
- Vitamin D
- Epigenetics
- Genetics
- References
- 5. Interplay of adipocytokines with polycystic ovary syndrome
- Introduction
- Adiponectin
- Leptin
- Resistin
- Visfatin
- Chemerin
- Asprosin
- Conclusion
- References
- 6. Crosstalk between oxidative stress and chronic inflammation in pathogenesis of polycystic ovary syndrome
- Introduction: The role of oxidative stress and chronic inflammation in the pathogenesis of polycystic ovary syndrome
- The oxidant and antioxidant system
- Oxidative stress and chronic inflammation
- Oxidative stress and polycystic ovary syndrome
- Effects of reactive oxygen species on cellular functions in polycystic ovary syndrome patients
- Oxidative stress biomarkers detected in polycystic ovary syndrome
- Identification and prevention of OS enhancing factors
- Conclusion
- References
- 7. Polycystic ovary syndrome and subfertility: Ovulation dysregulation and fertility problems (clinical features and pathophysiology)
- Introduction
- Normal ovulation physiology
- Pathology in polycystic ovary syndrome
- Conclusion
- References
- 8. Clinical features and presentation of polycystic ovary syndrome
- Introduction
- Clinical features
- References
- 9. Diagnostic criteria for polycystic ovary syndrome
- Introduction
- Diagnosis of polycystic ovary syndrome in adults
- National institutes of health criteria
- Androgen excess and polycystic ovary syndrome society criteria
- Diagnosis of polycystic ovary syndrome in postmenopausal females
- Diagnostic criteria
- Diagnosis in adolescents
- Challenges in the diagnosis of polycystic ovary syndrome in adolescents
- Diagnostic criteria in adolescents
- Referral to specialist
- Conclusion
- References
- 10. Polycystic ovary syndrome and metabolic syndrome: Risks in later life
- Introduction
- Polycystic ovary syndrome and obesity
- Polycystic ovary syndrome and insulin resistance
- Assessment of insulin resistance
- Polycystic ovary syndrome and metabolic syndrome
- Metabolic syndrome and polycystic ovary syndrome phenotype
- Abnormalities of glucose tolerance and diabetes in polycystic ovary syndrome
- Risks in later life
- Screening for metabolic syndrome
- Clinical implications
- Future research needs
- References
- 11. Polycystic ovary syndrome and mental health
- Introduction
- Depressive and anxiety disorder
- Body image and polycystic ovary syndrome
- The complex trio of culture, stigma, and polycystic ovary syndrome
- Sexuality and marital life
- Quality of life
- Coping strategies
- Eating disorders
- Bipolar affective disorder
- The complex relationship between obesity, polycystic ovary syndrome, and psychological issues
- Management of polycystic ovary syndrome
- Specific management for anxiety and depressive disorders
- Specific biologic interventions for mood disorder in polycystic ovary syndrome
- Referral to specialized psychiatric services
- Conclusion
- References
- 12. Polycystic ovary syndrome and nonalcoholic fatty liver disease
- Is there any link between polycystic ovary syndrome and nonalcoholic fatty liver disease?
- What is the plausible connection between polycystic ovary syndrome and nonalcoholic fatty liver disease?
- Conclusion
- References
- 13. Male polycystic ovary syndrome equivalent
- Introduction
- Findings in male relatives of females with PCOS
- Early-onset androgenic alopecia: A possible male PCOS equivalent marker?
- Conclusions and final remarks
- References
- Section III. Management of Polycystic Ovary Syndrome and Associated Comorbidities
- 14. Pharmacologic management of PCOS: Menstrual irregularities
- Definition
- Pathophysiology
- Implications of menstrual irregularities in PCOS patients
- Management of menstrual irregularities in polycystic ovary syndrome
- Summary
- References
- 15. Pharmacologic management for polycystic ovary syndrome: Hirsutism and acne
- Introduction
- Treatment of hirsutism
- Treatment of acne vulgaris
- Systemic therapy
- Devices and physical modalities for treating active acne
- Conclusion
- References
- 16. Pharmacologic management for polycystic ovary syndrome: Weight loss
- Significance of weight in polycystic ovary syndrome
- Weight management
- Pharmacologic interventions
- Bariatric surgery
- References
- 17. Role of insulin sensitizers in the management of polycystic ovary syndrome
- Introduction
- Mechanism of insulin sensitizers in PCOS
- Insulin sensitizers in polycystic ovary syndrome
- Comparative studies among various insulin sensitizers
- Conclusion
- References
- Reading list
- 18. Cardiovascular risk reduction in polycystic ovary syndrome
- Background
- Cardiovascular risk factors in polycystic ovary syndrome
- Polycystic ovary syndrome and cardiovascular diseases
- Cardiovascular risk management in polycystic ovary syndrome
- Primary prevention strategies for cardiovascular disease risk reduction in patients with polycystic ovary syndrome
- Conclusion
- References
- 19. Management of subfertility in polycystic ovary syndrome
- Introduction
- Physiologic principles of gonadotrophin ovarian stimulation
- Pathophysiology: The effect of polycystic ovary syndrome on fertility
- Investigations of infertility patients in polycystic ovary syndrome
- Principles of management of anovulatory infertility in polycystic ovary syndrome
- Management therapies
- Conclusion
- References
- 20. Management of associated risks of pregnancy in polycystic ovary syndrome
- Possible underlying mechanism of pathophysiologic changes in females with PCOS during pregnancy
- Risks associated with pregnancy in polycystic ovary syndrome
- Management of pregnancy complications in polycystic ovary syndrome patients
- Lifestyle modifications
- Metformin
- Myoinositol
- Conclusion
- References
- 21. Importance of lifestyle modifications
- Introduction
- How lifestyle interventions work
- Diet modification
- Exercise
- Behavioral strategies
- Vitamin D
- Environmental endocrine disruptors
- Summary
- References
- 22. Role of complementary and alternative medicine in polycystic ovary syndrome
- Introduction
- Etiology
- Treatment modalities
- Complementary and alternative medicine
- Role of medicinal herbs in the management of PCOS
- Role of functional foods in the management of PCOS
- Role of nuts intake in the management of PCOS
- References
- 23. Evidence-based recommendations for clinical practice (future directions: Research and practice)
- Introduction
- Questions for investigating and establishing quality standards for the diagnosis of PCOS
- Questions for understanding what works for improving treatments and interventions for PCOS
- Questions for identifying the mental and physical health comorbidity associated with PCOS
- Questions for exploring the contextual and social factors related to PCOS outcomes
- Questions for strengthening capacity building and organizational readiness for health systems responsive to the needs of populations with or at risk for PCOS
- Concluding remarks
- References
- Section IV. Global Approach to Polycystic Ovary Syndrome
- 24. Polycystic ovary syndrome in South Asians
- Genetics of PCOS in the South Asian population
- Metabolic disorders and other medical conditions in South Asians with PCOS
- PCOS fertility and pregnancy
- Physical characteristics of PCOS in South Asian females with PCOS and the impact on quality of life
- References
- 25. Situation analysis of polycystic ovary syndrome in Central and East Asia
- Understanding polycystic ovary syndrome in the region
- Factors influencing the prevalence, diagnosis, and management of PCOS
- Central Asia
- East Asia
- Conclusion
- References
- 26. Situational analysis of polycystic ovary syndrome in Southeast Asia
- Brunei
- Cambodia
- East Timor (Timor-Leste)
- Indonesia
- Laos
- Malaysia
- Myanmar
- Philippines
- Singapore
- Thailand
- Vietnam
- Conclusion
- References
- 27. Situation analysis of polycystic ovary syndrome in Western Asia
- Countries in the Northern region of Western Asia
- Countries in the fertile crescent of Western Asia
- Countries situated in the Arab peninsula
- References
- 28. Situation analysis, cultural beliefs, lifestyle, and the psychological impact of polycystic ovary syndrome in Europe
- Background
- Situation in Europe
- Cultural beliefs and implication of lifestyle in patients with PCOS
- Psychological impact
- References
- 29. Global approach to polycystic ovary syndrome in Africa
- Introduction
- Prevalence of polycystic ovary syndrome in Africa
- Clinical picture of polycystic ovary syndrome in Africans
- Treatment modalities for PCOS in Africa
- Recommendations and conclusions
- References
- 30. Polycystic ovary syndrome in North America
- North America
- Polycystic ovary syndrome–associated disorders in females in the United States
- Diagnosis
- Treatment (according to recommendations made by the ASRM)
- References
- Index
- Edition: 1
- Published: November 17, 2022
- Imprint: Elsevier
- No. of pages: 320
- Language: English
- Paperback ISBN: 9780323879323
- eBook ISBN: 9780323879330
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Rehana Rehman
Dr. Rehana Rehman has 20 years of teaching experience in the field of physiology. She is a well-recognized authority in the field of reproductive physiology and is working to identify treatable causes of infertility in collaboration with the Australian Concept Infertility Medical Centre. She has more than 200 publications in high impact national & international journal and 60 abstract presentations (oral and poster) in local and international conferences. Her book “Five Minutes to Wellness” is based on holistic review of all dimensions of wellness of medical students. She is a member of the Society for Endocrinology and the European Society of Human Reproduction & Endocrinology.
Affiliations and expertise
Associate Professor, Department of Biological & Biomedical Sciences, Aga Khan UniversityAS
Aisha Sheikh
Dr. Aisha Sheikh is a Consultant Endocrinologist. She is actively involved in medical education and research and she has published several research papers and book chapters. Dr. Sheikh is currently the Joint Secretary of Pakistan Endocrine Society. She has keen interest in antenatal Diabetes & Endocrinology and has played a key role in development of Gestational Diabetes Mellitus recommendations and action plans from the platform of the South Asian Federation of Endocrine Societies (SAFES). She has written book chapters, published her research findings, and presented her research at international meetings. She is a member of the Pakistan Endocrine Society and American Association of Clinical Endocrinologists.
Affiliations and expertise
Lecturer and Consultant Endocrinologist, Section of Endocrinology, Department of Medicine, The Aga Khan University, Stadium Road, KarachiRead Polycystic Ovary Syndrome on ScienceDirect