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Inflammasome Biology

Fundamentals, Role in Disease States, and Therapeutic Opportunities

  • 1st Edition - November 23, 2022
  • Latest edition
  • Editor: Pablo Pelegrin
  • Language: English

Inflammasome Biology: Fundamentals, Role in Disease States, and Therapeutic Opportunities is a complete reference on the role of inflammasomes in health and disease. Sections… Read more

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Description

Inflammasome Biology: Fundamentals, Role in Disease States, and Therapeutic Opportunities is a complete reference on the role of inflammasomes in health and disease. Sections cover the different types of inflammasomes, including cellular signaling, structural and evolutive aspects, overview the role of inflammasomes in key diseases, microbial infections and human body systems conditions, cover the interplay between Inflammasomes and cell death processes, and discuss current therapeutic opportunities driven by inflammasome research, including targeting, blocking and inhibiting the development of inflammasomes through both synthetic and natural compounds.

This book is the perfect reference for cell biologists, immunologists and research clinicians to understand the foundations of inflammasomes and explore the therapeutic opportunities they present. Pharma researchers may also find this reference invaluable in devising new approaches to developing anti-inflammatory drugs.

Key features

  • Provides comprehensive coverage of the subject of inflammasome biology
  • Authored by leading experts worldwide
  • Provides biological insights that have both health implications and therapeutic potential

Readership

Cell Biologists, Immunologists at Masters level and above; Molecular biologists, Pharma researchers and several clinical specialties researchers

Table of contents

Part I – Fundamentals of Inflammasome Biology

1. Overview of inflammatory processes at cellular level

2. Inflammasome formation and triggers

3. Cellular signaling, molecular activation and regulation of the NLRP1 inflammasome

4. Cellular signaling, molecular activation and regulation of the NLRP3 inflammasome

5. Cellular signaling, molecular activation and regulation of the NLRP6 inflammasome

6. Cellular signaling, molecular activation and regulation of the NLRC4 inflammasome

7. Cellular signaling, molecular activation and regulation of the AIM2 inflammasome

8. Cellular signaling, molecular activation and regulation of the Pyrin inflammasome

9. Cellular signaling, molecular activation and regulation of the non-canonical inflammasome

10. Cellular signaling, molecular activation and regulation of auto-active inflammasomes

11. Autophagy and the inflammasome

12. Inflammasome effector functions

13. Inflammatory caspases

14. Structural aspects of inflammasomes

15. Evolutive aspects of inflammasomes

Part II – inflammasome role in disease processes

16. The inflammasome in cardiovascular diseases

17. Inflammasome implications in metabolic disorders

18. Inflammasome in venous thromboembolic disorders

19. Inflammasomes and neurodegenerative diseases

20. Inflammasome implication in diseases of the respiratory system

21. Inflammasomes and their regulation in oral disease

22. Inflammasomes in inflammatory bowel disease pathogenesis

23. Inflammasome induced inflammation and fibrosis in liver

24. Inflammasomes in sepsis

25. The Inflammasome in viral, bacterial and fungal infections

26. Autoinflammatory syndromes

27. The inflammasome in graft-versus-host disease

28. Implication of the inflammasomes in rheumatic diseases

29. The inflammasomes in kidney disease

30. Inflammasomes and cancer

31. Inflammasomes in the pathobiology of degenerative retinopathies.

Part III – Inflammasome crosstalk in Cell Death

32. Regulation of pyroptosis by inflammasomes.

33. Crosstalk between necroptosis and inflammasome.

34. Apoptosis and inflammasome regulation

35. Implication of inflammasomes regulating different types of cell death

36. Regulation of neutrophil NETosis by inflammasomes

Part IV – Therapeutic Opportunities

37. Therapeutic opportunities targeting the inflammasome

38. Development of selective inflammasome Inhibitors

39. Natural compounds blocking inflammasomes

40. Inhibitors targeting inflammasome effectors

41. Multi-inflammasome inhibitors

Product details

  • Edition: 1
  • Latest edition
  • Published: November 23, 2022
  • Language: English

About the editor

PP

Pablo Pelegrin

Dr. Pablo Pelegrin is the principal investigator of the molecular inflammation research group at the Murcia BioHealth Research Institute-Hospital “Virgen de la Arrixaca” in, Murcia, Spain. He has postdoctoral degrees from both the University of Manchester (UK), and from the University of Sheffield (UK). His PhD in developmental immunology was obtained with the University of Murcia. He is an honorary lecturer at the University of Manchester, and Editor of the Inflammasome Journal, published by De Gruyter Open. Dr. Pelegrin has researched the Inflammasome for the past 15 years and is one of the most prolific researchers in this multidisciplinary research area.
Affiliations and expertise
Principal Investigator, Molecular Inflammation Research Group, Murcia BioHealth Research Institute-Hospital “Virgen de la Arrixaca”, Murcia, Spain

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