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Structure and Intrinsic Disorder in Enzymology
- 1st Edition - November 17, 2022
- Imprint: Academic Press
- Editors: Munishwar Nath Gupta, Vladimir N. Uversky
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 5 3 3 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 5 3 4 - 4
Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics and functions of intrinsically disordere… Read more
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Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics and functions of intrinsically disordered enzymes, along with valuable notes and technical insights powering new research in this emerging field. Here, more than twenty international experts examine protein flexibility and cryo-enzymology, hierarchies of intrinsic disorder, methods for measurement of disorder in proteins, bioinformatics tools for predictions of structure, disorder and function, protein promiscuity, protein moonlighting, globular enzymes, intrinsic disorder and allosteric regulation, protein crowding, intrinsic disorder in post-translational, and much more.
Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial and pharmaceutical labs.
- Unifies the roles of intrinsic disorder and structure in the functioning of enzymes and proteins
- Examines a range of enzyme and protein characteristics, their relationship to intrinsic disorder, and methods for study
- Features chapter contributions from international leaders in the field
Basic and translational researchers in biochemistry, biotechnology, molecular biology, cellular biology, genetics, pathology, chemistry, and pharmaceutical science; life science researchers; developmental biologists; clinicians and graduate students in the biosciences
1. Enzymology: Early insights
M N Gupta and Vladimir N. Uversky
2. Deep mutational scanning to probe specificity determinants.
Raghavan Varadarajan
3. Protein flexibility and cryo-enzymology: The trade-off between stability andcatalytic rates
Vladimir N. Uversky and Munishwar Gupta
4. Thermodynamic Perspective of Protein Disorder and Phase Separation: Model Systems
B. Montgomery Pettitt Pettitt
5. Structure and disorder: Protein functions depend on this new binary transforming lock-and-key into structure-function continuum
Vladimir N. Uversky and M N Gupta
6. Methods for measuring structural disorder in proteins
Sonia Longhi
7. Prediction of protein structure and intrinsic disorder in the era of deep learning
Zsuzsanna Dosztányi
8. Roles of Intrinsically Disordered Regions in Phosphoinositide 3-Kinase Biocatalysis
Vrushank Dave
9. Many faces of protein promiscuity: Not just broad specificity of proteins
M N Gupta and Vladimir N. Uversky
10. Role Of Plasticity And Disorder In Protein Moonlighting: Blurring Of Lines Between Biocatalysts And Other Biologically Active Proteins
M N Gupta and Vladimir N. Uversky
11. Molten globular enzymes
Vladimir N. Uversky
12. Intrinsic disorder and allosteric regulation
Zhirong Liu
13. Macromolecular Crowding: How it Affects Protein Structure, Disorder, and Catalysis
M N Gupta and Vladimir N. Uversky
14. Intrinsic disorder and post-translational modifications: An evolutionary perspective
Paul M. Harrison
15. The roles of prion-like domains in amyloid formation, phase separation, and solubility
Eric D. Ross
16. IDPRs of membrane proteins influence membrane curvature
Jeanne Stachowiak
17. How binding to surfaces affects disorder.
Diego Masone
- Edition: 1
- Published: November 17, 2022
- Imprint: Academic Press
- Language: English
MG
Munishwar Nath Gupta
Dr. Munishwar Nath Gupta earned his PhD from Indian Institute of Science, Bengaluru, and completed post-doctoral positions at Massachusetts Institute of Technology (USA), University of Minnesota (USA), Lund University (Sweden), and University of Technology of Compiegne (France). He has taught chemistry, biochemistry, and biotechnology at the Indian Institute of Technology, Delhi, between 1975-2016. He was awarded the National Science Talent fellowship (India) and Fellowships of National Academy of Sciences and Indian National Science Academy. He has edited three books on thermostability of enzymes, non-aqueous enzymology and affinity-based separation methods. He was an Associate Editor of Biocatalysis and Biotransformation (Taylor and Francis) and the founding and former editor-in-chief of Sustainable Chemical Processes (Springer). He’s served on editorial boards of several national and international journals and acted as a consultant to Novozyme (Denmark), Dabur (India), and other international companies.
Affiliations and expertise
Former Emeritus Professor, Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Delhi, IndiaVU
Vladimir N. Uversky
Prof. Vladimir N. Uversky, PhD, DSc, FRSB, FRSC, FAIMBE, Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF), is a pioneer in the field of protein intrinsic disorder. He has made a number of groundbreaking contributions in the field of protein folding, misfolding, and intrinsic disorder. He obtained his academic degrees from Moscow Institute of Physics and Technology (Ph.D., in 1991) and from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences (D.Sc., in 1998). He spent his early career working mostly on protein folding at the Institute of Protein Research and the Institute for Biological Instrumentation (Russia). In 1998, moved to the University of California Santa Cruz. In 2004, joined the Indiana University−Purdue University Indianapolis as a Senior Research Professor. Since 2010, Professor Uversky is with USF, where he works on various aspects of protein intrinsic disorder phenomenon and on analysis of protein folding and misfolding processes. Prof. Uversky has authored over 1250 scientific publications and edited several books and book series on protein structure, function, folding, misfolding, and intrinsic disorder. He is also serving as an editor in a number of scientific journals. He was a co-founder of the Intrinsically Disordered Proteins Subgroup at the Biophysical Society and the Intrinsically Disordered Proteins Gordon Research Conference. Prof. Uversky collaborated with more than 12,500 colleagues from more than 2,750 research organizations in 89 countries/territories.
Affiliations and expertise
PhD, DSc, FRSB, FRSC, FAIMBE, Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South FloridaRead Structure and Intrinsic Disorder in Enzymology on ScienceDirect