Microbiome in Neurological Disease
- 1st Edition, Volume 167 - November 23, 2022
- Imprint: Academic Press
- Editor: Tim Sampson
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 1 7 6 - 6
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 1 7 5 - 9
Microbiome in Neurological Disease, Volume 167 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting in… Read more
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Request a sales quoteMicrobiome in Neurological Disease, Volume 167 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Section in this new release cover Intersections of the microbiome and early neurodevelopment, Microbiome influences on neuro-immune interactions, The genomes of Parkinson’s disease, Experimental contributions of the microbiome to Parkinson’s disease, The foundations of microbiome contributions to Alzheimer’s disease, Immunologic pathways by which the gut microbiota influences Alzheimer’s disease, Role of the gut microbiome in Huntington’s Disease, and much more.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the International Review in Neurobiology series
- Updated release includes the latest information on Microbiome in Neurological Disease
Undergraduates, graduates, academics, and researchers in the field of microbiome in neurological disease
- Cover
- Title page
- Table of Contents
- Copyright
- Contributors
- Introduction: Unraveling the complex contributions of indigenous microbes to neurological health and disease
- Abstract
- We are not alone
- References
- Chapter One: Intersections of the microbiome and early neurodevelopment
- Abstract
- 1: Microbiota regulation of brain and behavior
- 2: Prenatal and early postnatal microbiota
- 3: Impact of microbiota on neurodevelopment: Considerations of the developmental origins of health and disease
- 4: Potential mechanisms of microbiota influences on neurodevelopment
- 5: Future directions
- References
- Chapter Two: Microbiome influences on neuro-immune interactions in neurodegenerative disease
- Abstract
- 1: Introduction
- 2: Microbiome influences on microglia
- 3: Microbiome influences on astrocytes
- 4: Microbiome influences on other immune cells
- 5: Gut microbiome studies in human populations
- 6: Gut microbiome studies in model organisms of aging or neurological disease
- 7: Blood brain barrier (BBB)
- 8: Vagus nerve
- 9: Mediators of gut/brain crosstalk
- 10: Therapeutic potential of probiotics and prebiotics to treat neurodegenerative disease
- 11: Future challenges/directions
- References
- Chapter Three: The many genomes of Parkinson's disease
- Abstract
- 1: Holistic view
- 2: Hologenome
- 3: PD and the microbiome
- 4: Concluding remarks
- References
- Chapter Four: Intestinal microbiota and neuroinflammation in Parkinson's disease: At the helm of the gut-brain axis
- Abstract
- 1: Introduction: Intestinal microbiota in health and disease
- 2: Microbial signatures and their significance in Parkinson's disease
- 3: Neuroprotection by short-chain fatty acids
- 4: Microbial effects on neuroinflammation
- 5: Environmental and dietary influences
- 6: Common medications and microbiota
- 7: Therapeutic strategies
- 8: Conclusions
- References
- Chapter Five: The emerging role of the microbiome in Alzheimer's disease
- Abstract
- 1: Alzheimer's disease
- 2: The gut microbiota influence health and disease in aging
- 3: The gut microbiota of patients with Alzheimer's disease
- 4: Antibiotics and Alzheimer's disease
- 5: The gut microbiota of murine models of Alzheimer's disease
- 6: The gut microbiota and the immune system in Alzheimer's disease
- 7: Interactions between the diet, the microbiota, and Alzheimer's disease
- 8: Prebiotics
- 9: Microbial mediators associated with Alzheimer's disease
- 10: Potential use of probiotics for the treatment of AD
- References
- Chapter Six: The microbiota-gut-brain axis in Huntington's disease
- Abstract
- 1: Microbiota-gut-brain axis
- 2: Gut microbiota disruption
- 3: Huntington's disease
- 4: The gut microbiota in HD
- 5: Gut microbiota and HD motor symptoms
- 6: Gut microbiota and HD-induced weight loss
- 7: Gut microbiota and cognition in HD
- 8: Gut microbiota and immune function in HD
- 9: Microbiota-gut-brain axis in HD
- 10: Gut microbiota and HD sexual dimorphism
- 11: Environment
- 12: Limitations
- 13: Conclusion
- References
- Chapter Seven: Role of the gut microbiome in multiple sclerosis: From etiology to therapeutics
- Abstract
- 1: Microbiome associations studies in MS
- 2: Mechanisms of gut dysbiosis
- 3: Influence of diet on the pathobiology of MS
- 4: Targeting gut bacteria to treat multiple sclerosis
- 5: Conclusions
- References
- Chapter Eight: Interactions between the gut microbiome and ketogenic diet in refractory epilepsy
- Abstract
- 1: Introduction to epilepsy
- 2: Increasing interest in the microbiome and epilepsy
- 3: Ketogenic diet and epilepsy
- 4: Ketogenic diet impact on epilepsy via gut microbiome
- 5: Potential mechanisms for microbial interactions with the ketogenic diet
- 6: Conclusion
- References
- Chapter Nine: Traumatic spinal cord injury and the contributions of the post-injury microbiome
- Abstract
- 1: Introduction
- 2: Remodeling of the gut microbiome after SCI
- 3: Interactions between the gut microbiome and SCI-induced neurogenic bowel
- 4: SCI-triggered local and systemic immune responses
- 5: Contributions of the microbiome to SCI-associated inflammation in humans
- 6: Microbiome contributions to SCI-associated inflammation in experimental models
- 7: SCI microbiome association with gut permeability after injury
- 8: Microbiome manipulations with therapeutic potential for SCI recovery
- 9: Looking broadly into the future at microbiome effects on SCI
- Acknowledgments
- References
- Edition: 1
- Volume: 167
- Published: November 23, 2022
- No. of pages (Hardback): 306
- No. of pages (eBook): 306
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780323991766
- eBook ISBN: 9780323991759
TS
Tim Sampson
Dr. Sampson’s primary research interests lie in understanding how the complex interactions between indigenous microbes and the host can shape neurological responses, during neurodegenerative disease and neurological injury. His academic career to date has uniquely positioned him with training across broad topics: microbiology, immunology, genetics, molecular biology, and biochemistry. Following postdoctoral studies at Caltech, with Dr. Sarkis Mazmanian, he utilized his background in bacterial genetics and host-pathogen interactions to explore how indigenous microbes influence Parkinson’s disease (PD). These activities have laid the foundation for his independent career exploring host-microbe interactions at the interface of PD, Alzheimer’s disease (AD) and other neurological illnesses--diseases historically studied within the context of the central nervous system.
Affiliations and expertise
Assistant Professor, Department of Cell Biology, Whitehead Biomedical Research Building, Emory University School of Medicine, GA, USARead Microbiome in Neurological Disease on ScienceDirect