Antimicrobial Peptides

Challenges and Future Perspectives

1st Edition - November 23, 2022
Editors: K. Sreejith, K. Ajesh
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 6 8 2 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 3 2 0 - 2

Antimicrobial Peptides: Challenges and Future Perspectives covers the latest developments about antimicrobial peptides in the scenario of drug resistance. The book is divided i… Read more

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Antimicrobial Peptides: Challenges and Future Perspectives covers the latest developments about antimicrobial peptides in the scenario of drug resistance. The book is divided into 16 chapters arranged in sequence and preceded by chapters on historical developments and their role as regulatory molecules in innate defense mechanism. Emphasis is given to purification techniques and characterization suitable for interdisciplinary research. Chapters provide an inventory of various antimicrobial peptides, from a diverse array of organisms such as bacteria, fungi, insects, amphibians, plants and mammals. A section on marine ecosystem broadens readers understanding on marine based antimicrobial peptides.

Additional sections provide an informative overview on peptides with antiviral properties and those targeting multi-drug resistant bacteria. Recent reports and mechanism on resistance against antimicrobial peptides are also provided, along with key insights into the challenges and future perspectives of peptide drug development.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
1. Historical developments of antimicrobial peptide research
Abstract
1.1 Introduction
1.2 History and development of antimicrobial peptides
1.3 Antimicrobial peptides as host innate defense barricade
1.4 Peptide-based database: barn house for AMPs
1.5 Current timeline of antimicrobial peptide approvals
1.6 Chemical developments in AMPs
1.7 Antimicrobial peptides modification for medical application
1.8 Antimicrobial peptides modification for industrial applications
1.9 An interdisciplinary upgrade to AMPs
1.10 Conclusion
References
2. Biosynthesis of peptide antibiotics and innate immunity
Abstract
2.1 Introduction
2.2 Antimicrobial peptides in innate immunity
2.3 Biosynthesis of nonribosomal and ribosomal peptides
2.4 Summary and conclusion
References
3. Antimicrobial peptides: features and modes of action
Abstract
3.1 Introduction
3.2 Historical perspective
3.3 Features of antimicrobial peptides
3.4 Biosynthesis and regulation
3.5 Some common families of antimicrobial peptides
3.6 Relationship of structure with function
3.7 Modes of action
3.8 Multifaceted roles of antimicrobial peptides
3.9 Limitations and challenges
3.10 Conclusion
References
4. Purification and characterization of antimicrobial peptides
Abstract
4.1 Purification techniques
4.2 Characterization techniques
References
5. Antimicrobial lipopeptides of bacterial origin—the molecules of future antimicrobial chemotherapy
Abstract
5.1 Introduction
5.2 Lipopeptides
5.3 Conclusion
References
6. Antimicrobial peptides of fungal origin
Abstract
6.1 Introduction
6.2 Fungi-producing antimicrobial peptides
6.3 Fungal peptides
6.4 Mode of action and biological activities
6.5 Mechanisms of synthesis
6.6 Detection methods of antimicrobial peptides
6.7 Peptide databases
6.8 Biotechnological applications
6.9 Summary and conclusions
Acknowledgments
References
7. Insect peptides with antimicrobial effects
Abstract
7.1 Introduction
7.2 The need for antimicrobial peptides
7.3 Classification of insect peptides
7.4 Mode of action
7.5 Concluding remarks
References
8. Amphibian host defense peptides
Abstract
8.1 Antimicrobial peptides: critical component of innate immune system
8.2 Antimicrobial peptide from amphibians
8.3 Conclusion
References
9. Plant-derived antimicrobial peptides
Abstract
9.1 General characteristics of bioactive peptides derived from plants
9.2 Antimicrobial peptides derived from different plant families
9.3 Extraction and identification of plant antimicrobial peptides
9.4 Perspectives in technological and therapeutic applications
9.5 Concluding remarks
References
10. Mammalian antimicrobial peptides
Abstract
10.1 Introduction
10.2 History of antimicrobial peptides
10.3 Mammalian antimicrobial peptides as first-line defense against invading microbes
10.4 Classification of mammalian antimicrobial peptides
10.5 Common mechanism of action of mammalian antimicrobial peptides
10.6 Clinical applications of antimicrobial peptides
10.7 Current and future prospects and challenges in developing antimicrobial peptides
References
11. Antimicrobial peptides from marine environment
Abstract
11.1 Introduction
11.2 Antimicrobial peptides from marine invertebrates
11.3 Antimicrobial peptides from marine microorganisms
11.4 Antimicrobial peptides from marine vertebrates
11.5 Antimicrobial peptides from marine algae
11.6 Conclusions
References
12. Peptides with antiviral activities
Abstract
12.1 Introduction
12.2 Viral life cycle
12.3 Peptides as viral inhibitors
12.4 Mechanism of inhibition
12.5 Peptides as therapeutics
12.6 Challenges and future scope
Acknowledgments
References
13. Antimicrobial peptide antibiotics against multidrug-resistant ESKAPE pathogens
Abstract
13.1 Introduction
13.2 Antibiotic resistance of ESKAPE pathogens
13.3 Strategies to combat the ESKAPE pathogens
13.4 Advantages and disadvantages of cationic antimicrobial peptides
13.5 Antimicrobial peptides to stop ESKAPE pathogens
13.6 Mechanisms of bacterial killing by antimicrobial peptides
13.7 Efficacies in animal models and clinical use of antimicrobial peptides
13.8 Concluding remarks
Acknowledgment
References
14. Antimicrobial peptide resistance and scope of computational biology in antimicrobial peptide research
Abstract
14.1 Introduction
14.2 Antimicrobial peptide resistance in gram-positive bacteria
14.3 Mechanisms of antimicrobial peptides resistance in gram-negative bacteria
14.4 Scope of computational biology in antimicrobial peptide research
14.5 Conclusion
References
15. Recent advances and challenges in peptide drug development
Abstract
15.1 Introduction
15.2 Historical overview of peptide drug development
15.3 Basic drawbacks of peptide drugs
15.4 Present approaches toward the discovery of protein–protein modulators
15.5 Peptides and protein–protein interactions
15.6 Innovations and computational methods for peptide–protein interactions
15.7 Conclusion
References
16. Future perspective of peptide antibiotic market
Abstract
16.1 Introduction
16.2 Global antimicrobial peptides market overview
16.3 Applications of antimicrobial peptide
16.4 Important parameters of market analysis
16.5 Drivers and restraints of the peptide antibiotics market
16.6 Conclusion
References
Index

K. Sreejith

He is also the Research Director of Kannur University since 2018. Dr. Sreejith has received MPhil in Biophysics and PhD in Biochemistry from Mahatma Gandhi University, Kerala, India. He has more than 19 years of teaching and research experience. His area of research is antimicrobial peptides and proteins, anti inflammatory compounds and cancer biology. Since 2008, his team has contributed extensively in the aforementioned area with publications appearing in the Journal of Applied Microbiology, Applied Biochemistry and Biotechnology, Peptides, Mycopathologia. He has presented papers in the II International conference on antimicrobial research, Lisbon, Portugal-2012 and European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), Amsterdam (Netherlands) in 2016. He is a life member of Indian Peptide Society (IPS). Since 2003 he has been serving Kannur University in its Board of studies in Microbiology as a member and from 2010 onwards he is the Chairman. He is having collaboration with researchers, Dr Sudarslal, Professor, School of Biotechnology, Amrita Vishwa Vidyapeetham, Kerala, India, and Dr C Arunan, School of Chemical Sciences, Mahatma Gandhi University, Kerala, India

Affiliations and expertise

Professor, Department of Biotechnology and Microbiology, Kannur University, Kerala, India

K. Ajesh

He has completed his masters in Microbiology from Kuvempu University, Karnataka, India and received PhD in Microbiology from Kannur University, Kerala India. His area of research is peptide antibiotics, biofilms, drug resistance and Phage therapy. He has more than five years of teaching and research experience. His contribution in antimicrobial peptides and drug resistance appeared in various journals including-peptides, Journal of Applied microbiology, Applied Biochemistry & Biotechnology, Mycopathologia. He has been Board of studies member in Microbiology (2014-18) and Chairman, Board of Examiners in Biotechnology and Microbiology (2012-15), Kannur University. He is a reviewer of Journal of Bacteriology and Mycology. He is a member of Indian Peptide Society (IPS), Indian Initiative for Management of Antibiotic Resistance (IIMAR) and International Society for Viruses of Microorganisms (ISVM).

Affiliations and expertise

Faculty, Department of Biotechnology and Microbiology, Kannur University, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

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