
Antimicrobial Peptides
Challenges and Future Perspectives
- 1st Edition - November 23, 2022
- Editors: K. Sreejith, K. Ajesh
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 6 8 2 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 0 3 2 0 - 2
Antimicrobial Peptides: Challenges and Future Perspectives covers the latest developments about antimicrobial peptides in the scenario of drug resistance. The book is divided i… Read more

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Request a sales quoteAntimicrobial Peptides: Challenges and Future Perspectives covers the latest developments about antimicrobial peptides in the scenario of drug resistance. The book is divided into 16 chapters arranged in sequence and preceded by chapters on historical developments and their role as regulatory molecules in innate defense mechanism. Emphasis is given to purification techniques and characterization suitable for interdisciplinary research. Chapters provide an inventory of various antimicrobial peptides, from a diverse array of organisms such as bacteria, fungi, insects, amphibians, plants and mammals. A section on marine ecosystem broadens readers understanding on marine based antimicrobial peptides.
Additional sections provide an informative overview on peptides with antiviral properties and those targeting multi-drug resistant bacteria. Recent reports and mechanism on resistance against antimicrobial peptides are also provided, along with key insights into the challenges and future perspectives of peptide drug development.
- Emphasizes antimicrobial peptides targeting various human viruses and multidrug resistant bacteria
- Written by internationally recognized experts who provide readers with a wide and useful perspective
- Provides in-depth resources for undertaking a research work in antimicrobial peptides with the inclusion of chapters on purification techniques and structural details
- Addresses the possibility and availability of peptide antibiotics in the global drug market
- Serves as a complete resource from the discovery to drug development of peptide antibiotics
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- 1. Historical developments of antimicrobial peptide research
- Abstract
- 1.1 Introduction
- 1.2 History and development of antimicrobial peptides
- 1.3 Antimicrobial peptides as host innate defense barricade
- 1.4 Peptide-based database: barn house for AMPs
- 1.5 Current timeline of antimicrobial peptide approvals
- 1.6 Chemical developments in AMPs
- 1.7 Antimicrobial peptides modification for medical application
- 1.8 Antimicrobial peptides modification for industrial applications
- 1.9 An interdisciplinary upgrade to AMPs
- 1.10 Conclusion
- References
- 2. Biosynthesis of peptide antibiotics and innate immunity
- Abstract
- 2.1 Introduction
- 2.2 Antimicrobial peptides in innate immunity
- 2.3 Biosynthesis of nonribosomal and ribosomal peptides
- 2.4 Summary and conclusion
- References
- 3. Antimicrobial peptides: features and modes of action
- Abstract
- 3.1 Introduction
- 3.2 Historical perspective
- 3.3 Features of antimicrobial peptides
- 3.4 Biosynthesis and regulation
- 3.5 Some common families of antimicrobial peptides
- 3.6 Relationship of structure with function
- 3.7 Modes of action
- 3.8 Multifaceted roles of antimicrobial peptides
- 3.9 Limitations and challenges
- 3.10 Conclusion
- References
- 4. Purification and characterization of antimicrobial peptides
- Abstract
- 4.1 Purification techniques
- 4.2 Characterization techniques
- References
- 5. Antimicrobial lipopeptides of bacterial origin—the molecules of future antimicrobial chemotherapy
- Abstract
- 5.1 Introduction
- 5.2 Lipopeptides
- 5.3 Conclusion
- References
- 6. Antimicrobial peptides of fungal origin
- Abstract
- 6.1 Introduction
- 6.2 Fungi-producing antimicrobial peptides
- 6.3 Fungal peptides
- 6.4 Mode of action and biological activities
- 6.5 Mechanisms of synthesis
- 6.6 Detection methods of antimicrobial peptides
- 6.7 Peptide databases
- 6.8 Biotechnological applications
- 6.9 Summary and conclusions
- Acknowledgments
- References
- 7. Insect peptides with antimicrobial effects
- Abstract
- 7.1 Introduction
- 7.2 The need for antimicrobial peptides
- 7.3 Classification of insect peptides
- 7.4 Mode of action
- 7.5 Concluding remarks
- References
- 8. Amphibian host defense peptides
- Abstract
- 8.1 Antimicrobial peptides: critical component of innate immune system
- 8.2 Antimicrobial peptide from amphibians
- 8.3 Conclusion
- References
- 9. Plant-derived antimicrobial peptides
- Abstract
- 9.1 General characteristics of bioactive peptides derived from plants
- 9.2 Antimicrobial peptides derived from different plant families
- 9.3 Extraction and identification of plant antimicrobial peptides
- 9.4 Perspectives in technological and therapeutic applications
- 9.5 Concluding remarks
- References
- 10. Mammalian antimicrobial peptides
- Abstract
- 10.1 Introduction
- 10.2 History of antimicrobial peptides
- 10.3 Mammalian antimicrobial peptides as first-line defense against invading microbes
- 10.4 Classification of mammalian antimicrobial peptides
- 10.5 Common mechanism of action of mammalian antimicrobial peptides
- 10.6 Clinical applications of antimicrobial peptides
- 10.7 Current and future prospects and challenges in developing antimicrobial peptides
- References
- 11. Antimicrobial peptides from marine environment
- Abstract
- 11.1 Introduction
- 11.2 Antimicrobial peptides from marine invertebrates
- 11.3 Antimicrobial peptides from marine microorganisms
- 11.4 Antimicrobial peptides from marine vertebrates
- 11.5 Antimicrobial peptides from marine algae
- 11.6 Conclusions
- References
- 12. Peptides with antiviral activities
- Abstract
- 12.1 Introduction
- 12.2 Viral life cycle
- 12.3 Peptides as viral inhibitors
- 12.4 Mechanism of inhibition
- 12.5 Peptides as therapeutics
- 12.6 Challenges and future scope
- Acknowledgments
- References
- 13. Antimicrobial peptide antibiotics against multidrug-resistant ESKAPE pathogens
- Abstract
- 13.1 Introduction
- 13.2 Antibiotic resistance of ESKAPE pathogens
- 13.3 Strategies to combat the ESKAPE pathogens
- 13.4 Advantages and disadvantages of cationic antimicrobial peptides
- 13.5 Antimicrobial peptides to stop ESKAPE pathogens
- 13.6 Mechanisms of bacterial killing by antimicrobial peptides
- 13.7 Efficacies in animal models and clinical use of antimicrobial peptides
- 13.8 Concluding remarks
- Acknowledgment
- References
- 14. Antimicrobial peptide resistance and scope of computational biology in antimicrobial peptide research
- Abstract
- 14.1 Introduction
- 14.2 Antimicrobial peptide resistance in gram-positive bacteria
- 14.3 Mechanisms of antimicrobial peptides resistance in gram-negative bacteria
- 14.4 Scope of computational biology in antimicrobial peptide research
- 14.5 Conclusion
- References
- 15. Recent advances and challenges in peptide drug development
- Abstract
- 15.1 Introduction
- 15.2 Historical overview of peptide drug development
- 15.3 Basic drawbacks of peptide drugs
- 15.4 Present approaches toward the discovery of protein–protein modulators
- 15.5 Peptides and protein–protein interactions
- 15.6 Innovations and computational methods for peptide–protein interactions
- 15.7 Conclusion
- References
- 16. Future perspective of peptide antibiotic market
- Abstract
- 16.1 Introduction
- 16.2 Global antimicrobial peptides market overview
- 16.3 Applications of antimicrobial peptide
- 16.4 Important parameters of market analysis
- 16.5 Drivers and restraints of the peptide antibiotics market
- 16.6 Conclusion
- References
- Index
- No. of pages: 346
- Language: English
- Edition: 1
- Published: November 23, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323856829
- eBook ISBN: 9780323903202
KS
K. Sreejith
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