Esophageal Disease and the Role of the Microbiome
- 1st Edition - November 23, 2022
- Imprint: Academic Press
- Editor: David A. Johnson
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 0 7 0 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 0 7 1 - 8
Esophageal Diseases and the Role of the Microbiome provides evidence on biomic influence in esophageal diseases. The book builds on the translational information on H pylori for ul… Read more
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Request a sales quoteEsophageal Diseases and the Role of the Microbiome provides evidence on biomic influence in esophageal diseases. The book builds on the translational information on H pylori for ulcer disease as well as the explosive focus on biomic influence in virtually all areas of esophageal diseases. This important reference will help translational researchers by providing scientific understanding and hypothesis generation that is needed for furthering this field of study. It will also provide clinicians with disease management options for esophageal diseases (for GERD and PPI options/side effects) and present cutting-edge science to promote provider/patient understanding and options.
- Delivers a translational understanding of new paradigms for esophageal disease
- Explains the effects of microbiome balance in the esophagus
- Suggests potential treatment options of esophageal dysbiosis
Both basic science researchers and gastroenterologists, Primary care physicians dealing with GERD/esophageal disease
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Introduction
- Chapter 1: Is acid the cornerstone factor in gastroesophageal reflux disease and its related complications?
- Abstract
- Conflict of interest disclosures
- Introduction—A brief history of gastric acid
- Evidence that acid causes esophageal injury
- Acid and heartburn
- Bile acids, esophageal injury, and heartburn
- Conclusions
- Future directions
- References
- Chapter 2: Cytokines and immune modulators—Effects on esophageal inflammation
- Abstract
- Introduction
- Esophageal mucosal defense systems
- Immune-mediated response in animal models and humans with acute reflux esophagitis
- Cytokines: Initiators of the immune-mediated response in acute reflux esophagitis
- Cytokines: Initiators of epithelial repair responses in acute reflux esophagitis
- Cytokines: Potential disruptors of the physical epithelial barrier in acute reflux esophagitis
- Hypoxia-inducible factor-2α: Central role in the squamous cell cytokine response in acute reflux esophagitis
- Role of the immune system in reflux esophagitis
- Esophageal innate immunity and toll-like receptors
- Activation of the innate immune system during reflux esophagitis
- TLR2 signaling in esophageal squamous mucosa
- TLR4 signaling in esophageal squamous mucosa
- Esophageal adaptive immunity and T cell phenotypes
- Conclusions
- Future directions
- COI disclosures
- References
- Chapter 3: Acid suppression and effects on the gastrointestinal microbiome
- Abstract
- Introduction
- Animal studies
- Human studies
- Disease associations
- Summary
- Future priorities
- References
- Chapter 4: Esophageal dysbiosis and pathogenesis of gastroesophageal reflux disease
- Abstract
- Author contributions
- Conflicts of interest
- Introduction
- Traditional view of GERD progression
- Revised mechanism for GERD pathogenesis
- Microbiome changes
- Inflammatory pathway
- Conclusions
- Future directions
- References
- Chapter 5: Gastroesophageal reflux disease and the role of Helicobacter pylori
- Abstract
- Conflict of interest disclosure
- Introduction
- Pathogenesis of GERD
- Biologic links/plausibility
- Epidemiology/outcomes
- Conclusions
- Future directions
- References
- Chapter 6: Esophageal dysbiosis and neoplasia: Moving from Barrett's esophagus to adenocarcinoma
- Abstract
- Introduction
- Development of microbiome research contributes to a new concept of health and disease
- Risk and environmental factors altering the risk of EAC-progression
- Microbial alterations in the esophagus linked to histopathological changes
- Microbes influencing BE- and EAC-pathogenesis
- Esophageal microbiome: current techniques of sampling and analysis need to be improved
- Conclusion
- Future directions
- COI disclosures
- References
- Chapter 7: Esophageal dysbiosis and esophageal squamous cell carcinoma
- Abstract
- Introduction
- Esophageal dysbiosis in Esophageal squamous cell carcinoma
- Esophageal microbiome: Environmental exposures and carcinogen metabolism
- Oral microbiome, Oral health, and Esophageal squamous cell carcinoma
- Role of the gastric microenvironment in Esophageal squamous cell carcinoma
- Limitations of current research
- Conclusions
- Future directions
- COI disclosures
- References
- Chapter 8: Esophageal dysbiosis and eosinophilic esophagitis—Bacteria to blame?
- Abstract
- Introduction
- Normal esophageal microbiome
- Potential modulators of the Esophageal microbiome in eosinophilic esophagitis
- Sampling methods used to study the microbiome in EoE
- EoE microbiome
- Data summary and pathophysiologic significance
- Conclusions
- Future directions
- COI
- References
- Chapter 9: Laryngopharyngeal reflux and dysbiosis
- Abstract
- Introduction—The gut microbiota and its influence
- Mechanisms for defense against laryngopharyngeal reflux
- Diagnosis of LPR
- Lifestyle factors
- Hypersensitivity
- Acid and nonacid esophageal reflux
- Esophageal and gastric adenocarcinoma
- Microbiota and bacterial overgrowth
- Treatment and proton pump inhibitors
- Conclusions
- Future directions
- COI and disclosures
- References
- Chapter 10: Esophageal dysbiosis and esophageal motility disorders
- Abstract
- Introduction
- Achalasia
- Chagas disease and megaesophagus
- Squamous cell carcinoma (SCC) in the setting of achalasia
- Esophageal hypermotility disorders
- Esophageal hypomotility disorders
- Future research
- Conflicts of interest
- References
- Chapter 11: Gastrointestinal microbiome: Evaluation of testing technologies
- Abstract
- Conflict of interest disclosures
- Bacteria in the foregut: From assumed sterility to the exploration of complex microbial communities
- Culture-dependent identification of microbial communities
- Culture-independent methods of studying the microbiome
- Conclusions
- Future directions
- References
- Chapter 12: Esophagogastric microbiome—Internal and external influences effecting variance
- Abstract
- Introduction
- Internal factors (Fig. 1)
- Oral and dental health
- Obesity
- External factors (Fig. 2)
- Antibiotics
- Prebiotics and probiotics
- Proton pump inhibitors
- Tobacco and alcohol
- Conclusions
- Future directions
- Author contributions
- Conflict of interest
- References
- Chapter 13: Esophageal dysbiosis—Correcting the paradox: Prebiotics, probiotics, or antibiotics?
- Abstract
- Author contributions
- Potential conflict of interest
- Introduction
- Prebiotics
- Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), and esophageal adenocarcinoma (EAC)
- Eosinophilic esophagitis (EoE)
- Limitations to the use and study of prebiotics
- Probiotics
- Gastroesophageal reflux disease
- Barrett's esophagus
- Cancer
- Candidiasis
- Eosinophilic esophagitis
- Antibiotics
- Bacteriocins
- Conclusions
- Future directions
- References
- Index
- Edition: 1
- Published: November 23, 2022
- Imprint: Academic Press
- No. of pages: 214
- Language: English
- Paperback ISBN: 9780323950701
- eBook ISBN: 9780323950718
DJ
David A. Johnson
Dr. Johnson MD, MACG, FASGE, MACP is Professor of Medicine and Chief of Gastroenterology at Eastern VA School of Medicine. He co-founded the National Medicare Carrier Advisory Committee. He served on the GI Multi-Society CRC Screening Task Force and ACG guidelines committee for CRC screening, and co-authored the national guidelines. He served on the American Board of Internal Medicine (Gastroenterology), Board of Examiners (2012-2017), and was reappointed to the Maintenance of Certification ABIM Board 2020-present. He has been honored with the highest award from the American College of Gastroenterology; the Berk/Fise Award for lifetime achievements, as well as the William D Carey ACG Governors award to lifetime contributions to gastroenterology. He is the physician who worked with Virginia State Senator Emily Couric to put through the historic legislation to mandate colon cancer screening with colonoscopy as the preferred standard. This initiative has set the model for other states which have followed with similar legislation.
Affiliations and expertise
Professor of Medicine and Chief of Gastroenterology, Eastern Virgina Medical School, Norfolk, VA, United StatesRead Esophageal Disease and the Role of the Microbiome on ScienceDirect