Skip to main content
Elsevier

Books in Pharmacology

Elsevier's Pharmacology collection studies how drugs interact with biological systems to improve health and treat disease. It covers pharmacodynamics, exploring drug effects on biology, and pharmacokinetics, studying how the body affects drugs. Branches like Pharmacogenetics. Essential for pharmacologists, this collection offers invaluable insights into drug interactions, efficacy, and safety, crucial for advancing drug development and improving patient outcomes.

  • The Alkaloids

    Chemistry and Physiology
    • 1st Edition
    • R. H. F. Manske
    • English
    The Alkaloids: Chemistry and Physiology, Volume V: Pharmacology deals with the chemistry and pharmacology of the alkaloids. This book discusses the general pharmacology of morphine, cryptopine-like compounds, toad poisons, and respiratory stimulants. The appraisal of the utility of alkaloids as antimalarials, uterine stimulants, metabolism of cocaine, and optical isomerism-activity relationship are also elaborated. This publication likewise covers the parasympathetic blocking agents as mydriatics, methods of measuring mydriatic activity, alkaloids exhibiting curariform activity, and minor alkaloids of unknown structure. Other topics include the fate of morphine, tropane group, factors affecting cocaine anesthesia, and sympathomimetic mydriatics. This volume is intended for chemists and pharmacologists concerned with alkaloids.

  • The Alkaloids

    Chemistry and Physiology
    • 1st Edition
    • R. H. F. Manske
    • English
    The Alkaloids: Chemistry and Physiology, Volume X focuses on the structure of alkaloids. This book discusses the occurrence of glycoalkaloids and alkamines, jerveratrum alkaloids, and erythrophleum alkaloids containing a C-4 carbomethoxy group. The mass spectra of lycopodium alkaloids, alkaloids of the Calabar bean, and benzyltetrahydroisoq... alkaloids with three oxygenated substituents are also elaborated. This publication likewise covers the biogenesis of benzylisoquinoline alkaloids, simple indole bases, biogenesis of the picralima alkaloids, and stereochemistry of the uncarines. Other topics include plants and their contained alkaloids, lycodine and related alkaloids, and a-naphthaphenanthrid... alkaloids. This volume is suitable for chemists and specialists working in the field of alkaloid chemistry.

  • The Alkaloids

    Chemistry and Physiology
    • 1st Edition
    • R. H. F. Manske
    • English
    The Alkaloids: Chemistry and Physiology, Volume VI: Supplement to Volumes I and II updates the chemistry of the alkaloids by linking developments to the content of earlier volumes. This book discusses the taxonomic position of the alkaloids in plants, external factors governing alkaloid formation, pyrrolidine alkaloids, and structure of the necines. The alkaloids of the pomegranate root bark, alkaloids of Sedum spp, structure of dioscorine, and reactions of morphine and codeine are also elaborated. This publication likewise covers the chemistry of colchicine, alkaloids derived from dibenzofuran, and biological effects of the amaryllidaceae alkaloids. This volume is a good reference for chemists and specialists conducting work on alkaloids.

  • Biochemical and Molecular Aspects of Selected Cancers

    • 1st Edition
    • Thomas G. Pretlow + 1 more
    • English
    Biochemical and Molecular Aspects of Selected Cancers, Volume I provides an overview of important topics and prototypes in cancer research. The book consists of papers provided by outstanding investigators in diverse disciplines in different areas of cancer research. This volume focuses on topics relevant to cancers in humans. It covers such topics as tumor-suppressor genes and human neoplasia; protein kinase C in neoplastic cells; and extracellular matrix interactions with tumor-progressing cells: tumor versus cell type-specific mechanisms. Structural and functional characteristics of human melanoma; steroid hormones and hormone receptors in neoplastic diseases; and patterns and significance of genetic changes in neuroblastomas are expounded as well. Oncologists, biochemists, cytologists, and other researchers in allied fields will find the book invaluable.

  • The Biological Action of Physical Medicine

    Controlling the Human Body's Information System
    • 1st Edition
    • Jan Zbigniew Szopinski
    • English
    The Biological Action of Physical Medicine: Controlling the Human Body's Information System challenges the contemporary way of thinking of diagnostics and therapy "from the outside." Drawing on 30 years of independent comprehensive research, this reference provides a universal and scientifically acceptable physiological theory, explaining the mode of action of methods of physical medicine as well as the underlying physiological mechanisms. Scientific research described in this book explains the universal neurophysiological foundation of all the respective methods, including organ electrodermal diagnostics (OED), thermotherapy (heat, cryostimulation), phototherapy (infrared, ultraviolet, laser), ultrasound therapy, electrotherapy (from transcutaneous electric nerve stimulation to electromagnetic field therapies), magnetotherapy, and mechanical nerve stimulation (acupuncture, reflexive massage, cupping, high-pressure hydrotherapy). A better understanding of physical medicine's modes of action not only insures better clinical results, but also illuminates pain mechanisms and our understanding of the functioning of the nervous system.

  • Integrative Anatomy and Pathophysiology in TCM Cardiology

    • 1st Edition
    • Anika Niambi Al-Shura
    • English
    Integrative Anatomy and Pathophysiology in Traditional Chinese Medicine Cardiology covers the structure, function, and pathology of the cardiovascular system from the TCM and western medical perspectives. It focuses specifically on western medicine anatomy and pathophysiology, along with TCM aspects of essence, qi, blood and body fluid concepts, production, and function to explain cardiovascular system dysfunction, its independent role and dependent interactions with the functions of other organ systems. This book is designed for US-based licensed TCM practitioners as well as cardiology researchers.

  • The Eye in Systemic Disease

    • 2nd Edition
    • Jack J. Kanski + 1 more
    • English
    The Eye in Systemic Disease, Second Edition presents an overview of the relationship of the eye and medicine. The book details the systemic aspects of diseases. The topics discussed include various eye conditions such as conjunctivitis, episcleritis, keratitis, keratoconjunctivitis sicca, and cataract. Endocrine, circulatory, rheumatological, neurological, pulmonary, and blood disorders are covered as well. Physicians and students of medicine and pathology will find the book very useful.

  • Physical Examination in Cardiovascular Chinese Medicine

    • 1st Edition
    • Anika Niambi Al-Shura
    • English
    Physical Examination in Cardiovascular Chinese Medicine details the basics of how to take and record cardiac patient history and triage vitals, then apply the basic western and TCM methods for examining cardiovascular patients in the clinic. It outlines the basic procedure for creating intake questions and then examining the cardiovascular patient using both western and TCM techniques. This book is intended for US-based licensed TCM practitioners as well as cardiology researchers.

  • A Pharmacology Primer

    Techniques for More Effective and Strategic Drug Discovery
    • 4th Edition
    • Terry P. Kenakin
    • English
    A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research.

  • Side Effects of Drugs Annual

    A worldwide yearly survey of new data in adverse drug reactions
    • 1st Edition
    • Volume 35
    • Jeffrey K Aronson
    • English
    The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then as a yearly update to the voluminous encyclopedia, Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of adverse drug reactions and interactions. An international team of specialists has contributed to the informative Annual by critically interpreting it and by pointing to whatever is misleading.

  • Emerging Targets and Therapeutics in the Treatment of Psychostimulant Abuse

    • 1st Edition
    • Volume 69
    • Linda P. Dwoskin
    • English
    This new volume of Advances in Pharmacology presents the emerging targets and therapeutics in the treatment of psychostimulant abuse. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

  • Cellular and Molecular Pathobiology of Cardiovascular Disease

    • 1st Edition
    • Monte Willis + 2 more
    • English
    Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology.

  • Platelets and Aspirin-Induced Asthma

    Pathogenesis and Melatonin
    • 1st Edition
    • Helen Evsyukova
    • English
    Platelets and Aspirin-Induced Asthma is the first book to be published that reflects research conducted on aspirin-induced asthma pathogenesis. It is examined through positions of neuroimmunoendocrine interactions in organism. The Melatonin hormone plays a key role, being the regulator and coordinator of complicated and interrelated biological processes. This new concept of aspirin-induced asthma pathogenesis suggests new methods for treatment of this disease by means of correcting the melatonin content in the patient’s organism. Investigations into the mechanisms of aspirin-induced asthma as a pathology of melatonin producing cells of platelets helps to determine high-risk groups and develop preventive measures and adequate therapy.

  • Membrane Electrodes in Drug-Substances Analysis

    • 1st Edition
    • Vasile V. Cosofret
    • J. D. R. Thomas
    • English
    Membrane Electrodes in Drug-Substances Analysis discusses the analytical control of drugs using ion-selective membrane electrodes. This book is divided into three parts, comprised of 18 chapters organized according to the topics they cover. The first part covers the general aspects of membrane electrodes, which includes topics such as theoretical considerations and the basic characteristics of membrane electrodes. Part II deals with the general methods of analysis using membrane electrodes, and Part III tackles the determination of drug-substances. This book will be of great use to researchers and professionals engaged in drug research.

  • The Nervous System

    Central Nervous System Drugs
    • 1st Edition
    • Walter S. Root + 1 more
    • English
    Physiological Pharmacology: A Comprehensive Treatise, Volume II: The Nervous System — Part B, Central Nervous System Drugs focuses on the effects of drugs on the functions of the central nervous system. The selection first offers information on depressant and anticonvulsant drugs. Topics include neurophysiological substrate of drug action; pharmacological properties of selected muscle relaxants; anticonvulsants and their mechanisms; and definitive seizure mechanisms. The book also takes a look at antitussive drugs and psychic energizers and antidepressant drugs. The publication examines emetic and antiemetic drugs, as well as neural mechanisms of emesis, emetic syndromes and agents, and antiemetic agents. The text also reviews the effects of drugs on the eyes and synoptic transmission in the central nervous system. Discussions focus on the effect of drugs used in the therapy of ocular disease; undesirable eye effects of ophthalmic and other drugs; and chemical transmitters in the central nervous system. The selection is a dependable reference for readers interested in the effects of drugs on the central nervous system.

  • Advances in Drug Research

    • 1st Edition
    • Volume 18
    • Bernard Testa
    • English
    Each volume in this distinguished series presents authoritative reviews, both generally, on topics of broad interest in drug research, and specifically, on novel and established therapeutic classes. Acknowledged experts contribute in areas such as drug design, clinical and molecular pharmacology, drug metabolism, and mechanisms of action. Reviewers have consistently praised Advances in Drug Research for its comprehensive and lucid summaries of up-to-date knowledge.

  • Advances in Immunopharmacology

    Proceeding of the Fourth International Conference on Immunopharmacology, Osaka, Japan, 16-19 May 1988
    • 1st Edition
    • J. W. Hadden
    • English
    The Fourth International Conference on Immunopharmacology took place in Osaka, Japan, May 1988. It was attended by over 900 participants from a variety of fields, illustrating the broad interest and wide-ranging applications of the subject. This Proceedings volume provides a comprehensive record of the Conference and is organized according to the sectional headings employed at the meeting. The topics covered include basic and clinical immunology, and preclinical and clinical aspects of immunopharmacology. The material presented is referenced and indexed throughout, and illustrated with photographs, diagrams and tables.

  • Handbook of Dental Pharmacology and Therapeutics

    • 1st Edition
    • Roy Goulding
    • English
    Handbook of Dental Pharmacology and Therapeutics is a supplement to lectures given in dental schools on the subject of pharmacology in dental practice. The author describes dental therapeutics and pharmacology including the prescription of drugs, legislation of dangerous drugs, posology (dosage), weights and measures, frequency, or administration. He explains the sedatives, hypnotics, and anticonvulsants: he notes that narcotics can depress (not uniformly) all the tissue in the human body. The author also describes the mode of action and the stages induced in general anesthesia; the classification, action, and the therapeutics of analgesics (antipyretics, opiates, synthetic opiates). An interesting subject concerns analeptics or restoratives to resurrect the dying that includes stimulants of the central nervous systems (ephedrine, amphetamine, strychnine). Visits to the dentists should include obtundents and counter-irritants that dull sensation to pain. The author notes that in drilling cavities, the sharper the bur, the less obtundent needed. The author also addresses other drugs (hemostatic, anticoagulants) and those acting on the cardiovascular system or on the blood vessels. This handbook can prove useful for dentists, dental aides, pharmacologists, practitioners of general medicine, as well as students of dental medicine.

  • Trends in Receptor Research

    Proceedings of the 8th Camerino-Noordwijkerhout Symposium, Camerino, Italy, 8-12 September 1991
    • 1st Edition
    • Volume 18
    • P. Angeli
    • English
    The 8th Camerino-Noordwijker... Symposium has continued along its traditional path of interdisciplinary cooperation. Chemists, biochemists, pharmacologists, biophysicists and physiologists are all involved in the task of improving our knowledge of the mechanisms of drug-receptor interaction and of the heterogeneous nature of biological molecules. In this volume, leading researchers have contributed state of the art information on receptor chemistry. Newest developments are covered with particular reference to receptors of the nervous system; SAR studies; receptor isolation; receptor cloning; receptor topography; biomedical consequences of occupancy; receptor regulation and receptor theory. This will be of great interest to pharmacologists, biochemists and medicinal chemists, as well as a valuable source of reference for medical students and postgraduate students in related fields.

  • Advances in Drug Research

    • 1st Edition
    • Volume 19
    • Bernard Testa
    • English
    Each volume in this distinguished series presents authoritative reviews on topics of broad interest in drug research and on novel and established therapeutic classes. Acknowledged experts contribute in areas such as drug design, clinical and molecular pharmacology, drug metabolism, and mechanisms of action. Reviewers have consistently praised Advances in Drug Research for its comprehensive and lucid summaries of up-to-date knowledge.

  • Methods in Behavioral Pharmacology

    • 1st Edition
    • Volume 10
    • F. van Haaren
    • English
    Methods in Behavioral Pharmacology is unique in offering a complete description and critical evaluation of most, if not all, methods available to study the effects of drugs on behavior. It stands apart in that it is not limited to the analysis of a particular class of pharmacological agents in a limited number of paradigms. Methods in Behavioral Pharmacology covers all paradigms without reference to specific pharmacological compounds.The book provides a comprehensive overview of the methodology used to study the behavioral effects of legal and illegal drugs. It also provides an in-depth presentation of dependent variables, their quantification and a critical evaluation of their advantages and disadvantages. An excellent work, contributed to by well-known experts in the different fields of behavioral pharmacology.

  • Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells

    • 1st Edition
    • T.E. Gram
    • English
    Research has shown that the lung is capable of metabolically activating xenobiotics into intermediates that can covalently bind to pulmonary tissue. Further, it has been shown that the lung consists of many distinct cell types with the ability to take up and sequester metabolically unchanged drugs and chemicals that are ultimately toxic in effect. This volume reflects the extent of these developments and provides a state-of-the art reference in a rapidly evolving field incorporating both drug metabolism and pulmonary toxicology research.

  • Metal Toxicology

    Approaches and Methods
    • 1st Edition
    • Robert A. Goyer
    • English
    Metal Toxicology addresses the effects of metals on human health, as well as their mechanisms of toxicity. Unlike most books on metal toxicity which are organized by individual metals, this book is arranged inan organ-by-organ basis. It deals with unifying mechanisms of metal toxicity within a given tissue, and with exposure of a tissue to more than one metal at a time.

  • Advances in Immunopharmacology

    Proceedings of the Second International Conference on Immunopharmacology, July 1982, Washington, USA
    • 1st Edition
    • J. W. Hadden + 1 more
    • English
    The second of two volumes covering the most recent developments in this new field. Like the previous volume, this book brings together the two fields of immunology and pharmacology, and offers a review format for advances in basic aspects, as well as an update in discussion format of therapy-related advances.

  • Advances in Drug Research

    • 1st Edition
    • Volume 17
    • Bernard Testa
    • English
    This volume comprises five authoritative reviews on timely topics in drug research. The first two chapters deal with chemotherapeutic agents (selective antiviral agents and cepham antibiotics) and subsequent chapters deal with the cardiovascular system and topics in neuropharmacology.

  • Classes of Pesticides

    • 1st Edition
    • Wayland J. Hayes Jr.
    • English
    Handbook of Pesticide Toxicology, Volume 3: Classes of Pesticides focuses on the properties, toxicity, classes, and reactions of pesticides. The selection first offers information on carbamate insecticides, nitro compounds and related phenolic pesticides, and synthetic organic rodenticides. Discussions focus on miscellaneous synthetic organic rodenticides, fluoroacetic acid and its derivatives, mononitrophenols, dinitrophenols, classification of carbamates, and toxicology of anticholinesterase carbamates. The book then examines herbicides and fungicides and related compounds. Topics include nitrogen heterocyclic fungicides not otherwise classified, hydrazines, hydrozones, and diazo fungicides, anilino and nitrobenzenoid fungicides, antibiotics and botanicals, organic phosphorus herbicides, carbamate herbicides, and herbicidal oils and simple aliphatics. The publication elaborates on miscellaneous pesticides, including repellents, synthetic molluscicides, inhibitors of chitin synthesis, chemosterilants, and synthetic acaricides. The selection is a valuable source of data for researchers interested in pesticide toxicology.

  • International Symposium on the Treatment of Carcinoma of the Prostate, Berlin, November 13 to 15, 1969

    Life Science Monographs
    • 1st Edition
    • G. Raspé + 1 more
    • English
    International Symposium on the Treatment of Carcinoma of the Prostate, Berlin, November 13 to 15, 1969 presents a resolution to the doubts and uncertainty in the treatment of carcinoma and formulate a new policy for handling. It discusses the basis of hormonal treatment of prostatic cancer. The focus of study is the pharmacological aspects of prostate cancer treatment. Some of the topics covered in the book are the metabolism of testosterone in the prostate, the use of stilbestrol diphosphate in treating prostate cancer, the pathology of prostate cancer, and the cardiovascular complications of the disease. The subjects on orchiectomy and adrenalectomy are covered. The modern radiotherapy is discussed. The text identifies the use of radioactive isotopes. An analysis of the irradiation of the hypophysis is presented. A chapter of the volume is devoted to the cytotoxic agents in prostate carcinoma treatment. Another section of the book focuses on application of cryo-therapy. The book will provide useful information to doctors, oncologists, radiologists, students and researchers.

  • Unexpected Reactions to Modern Therapeutics

    Antibiotics
    • 1st Edition
    • Leo Schindel
    • English
    Unexpected Reactions to Modern Therapeutics: Antibiotics discusses the side-effects of antibiotics, specifically the allergic reactions of the skin and mucous membranes to penicillin. This book contains 12 chapters that address the specific organ reaction to penicillin and the complications of the gastro-intestinal tract after ingestion of chloramphenicol. Some of the topics covered in the book are the inhibition of the bone marrow function and blood changes after receiving doses of chloramphenicol; lesions of the skin and mucous membranes after applying tetracyclines; changes in the hemopoietic system, liver function, and structure after medication of oxy-tetracycline. Other chapters deal with the analysis of antibiotic resistant bacteria and the physiological adverse effects of neomycin. An analysis of the side-effects of erythromycin is provided. The concluding chapters describe the nephrotoxic effects of bacitracin and the epidermal effects of fumagillin. The book can provide useful information to doctors, pharmacologists, students, and researchers.

  • Salt and Water Balance

    Proceedings of the Third International Pharmacological Meeting July 24–30, 1966
    • 1st Edition
    • K. H. Beyer + 1 more
    • English
    Salt and Water Balance, Volume 8 presents the proceedings of the 3rd International Pharmacological Meeting, held in Sao Paulo, Brazil, on July 24–30, 1966. This book features the modulation of renal control of electrolyte and water balance, which is the most effective approach of handling most clinical problems wherein fluid retention needs to be reduced. Comprised of 10 chapters, this compilation of papers starts with an overview of the diuretic agents that are effective diuretic therapy. This text then describes the active transport, which proceeds at the expense of energy against the combined chemical and electrical gradients in the case of electrolytes. Other chapters consider the historical importance in therapy and the mechanisms of action of mercurial diuretics. This book discusses as well the complications and unwanted side effects of diuretic therapy. The final chapter deals with the hemodynamic mechanisms and their possible influence on the tubular function. This book is a valuable resource for physicians, health care professionals, and patients.

  • A New Era of Catecholamines in the Laboratory and Clinic

    • 1st Edition
    • Volume 68
    • Lee E. Eiden
    • English
    This new volume of Advances in Pharmacology presents catecholamine symposium proceedings. Chapters cover such topics as cellular dynamics of catecholamine release and re-uptake, catecholamines in mood regulation and imaging catecholamine transporters. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

  • Cystoscopy and Urography

    • 2nd Edition
    • Jas. B. MacAlpine
    • English
    Cystoscopy and Urography, Second Edition presents the significant advances in instrumentation and application of cytoscopy and urography. This book is organized into two parts encompassing 27 chapters. This edition adds six additional chapters from the first edition; three of these concern urography. The three other chapters survey pelvic resorption, excretion urography, and pyeloscopy. Other chapters deal with fistula of the bladder, funnel-neck deformity of the bladder, and congenital abnormalities of the kidney and ureter. This book also covers the topics of renal tuberculosis, purpura, and a description of endoscopic prostatic surgery. This book is of value to surgeons and urologists.

  • Global Clinical Trials for Alzheimer's Disease

    Design, Implementation, and Standardization
    • 1st Edition
    • Menghis Bairu + 1 more
    • English
    Global Clinical Trials for Alzheimer’s Disease is a handy one-stop reference for researchers and physicians planning and conducting global clinical trials in this area. This book addresses important considerations that may arise during the successful design and execution of these trials, including site selection, local regulatory issues, pharmacogenomics, ethical matters and much more. Given the saturation of traditional clinical trial markets and the worldwide progression of Alzheimer’s disease, there is a need to focus on clinical trials in emerging markets and developing countries. This book provides you with a practical approach to recognizing the opportunities and tackling the challenges that are present during the planning and execution of global clinical trials for Alzheimer’s disease.

  • Gene Therapy of Cancer

    Translational Approaches from Preclinical Studies to Clinical Implementation
    • 3rd Edition
    • Edmund C. Lattime + 1 more
    • English
    Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response.

  • Novel Psychoactive Substances

    Classification, Pharmacology and Toxicology
    • 1st Edition
    • Paul I. Dargan + 1 more
    • English
    Novel Psychoactive Substances: Classification, Pharmacology and Toxicology provides readers with background on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." This book also covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance followed by a discussion of the acute and chronic harm or toxicity associated with the substance. Written by international experts in the field, this multi-authored book is a valuable reference for scientists, clinicians, academics, and regulatory and law enforcement professionals.

  • Antiviral Agents

    • 1st Edition
    • Volume 67
    • Erik De Clercq
    • English
    This new volume of Advances in Pharmacology explores the current state of antiviral agents. Chapters cover such topics as virus entry inhibitors, interferon-free drug combinations, and antiviral agents for HSV. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

  • Protein Kinase Inhibitors in Research and Medicine

    • 1st Edition
    • Volume 548
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers protein kinase inhibitors in research and medicine, and includes chapters on such topics as fragment-based screening, broad kinome profiling of kinase inhibitors, and designing drug-resistant kinase alleles.

  • Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

    • 1st Edition
    • Mahendra Rai + 1 more
    • English
    Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components offers scientists a single source aimed at fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses and fungi using natural products. This essential reference discusses herbal extracts and essential oils used or under investigation to treat MDR infections, as well as those containing antimicrobial activity that could be of potential interest in future studies against MDR microorganisms. The need to combat multidrug-resistant microorganisms is an urgent one and this book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components and more to aid researchers in effective antimicrobial drug discovery

  • Immunopharmacology

    • 1st Edition
    • Volume 66
    • David J Webb
    • English
    This new volume of Advances in Pharmacology explores the current state of Alzheimer's disease research and therapeutics. Chapters cover such topics as the B cell targeted therapies, Lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

  • Pharmacogenomics

    Challenges and Opportunities in Therapeutic Implementation
    • 1st Edition
    • Yui-Wing Francis Lam + 1 more
    • English
    Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.

  • Drug Stability for Pharmaceutical Scientists

    • 1st Edition
    • Thorsteinn Loftsson
    • English
    Drug Stability for Pharmaceutical Scientists is a clear and easy-to-follow guide on drug degradation in pharmaceutical formulation. This book features valuable content on both aqueous and solid drug solutions, the stability of proteins and peptides, acid-base catalyzed and solvent catalyzed reactions, how drug formulation can influence drug stability, the influence of external factors on reaction rates and much more. Full of examples of real-life formulation problems and step-by-step calculations, this book is the ideal resource for graduate students, as well as scientists in the pharmaceutical and related industries.

  • Nutritional Management of Renal Disease

    • 3rd Edition
    • Joel D. Kopple + 2 more
    • English
    This translational text offers in-depth reviews of the metabolic and nutritional disorders that are prevalent in patients with renal disease. Chapter topics address the growing epidemic of obesity and metabolic syndrome. Each chapter integrates basic and clinical approaches, from cell biology and genetics to diagnosis, patient management and treatment. Chapters in sections 4-7 include new illustrative case reports, and all chapters emphasize key concepts with chapter-ending summaries. New features also include the latest National Kidney Foundation Clinical Practice Guidelines on Nutrition in Chronic Renal Failure, the most recent scientific discoveries and the latest techniques for assessing nutritional status in renal disease, and literature reviews on patients who receive continuous veno-venous hemofiltration with or without dialysis.

  • Side Effects of Drugs Annual

    A worldwide yearly survey of new data in adverse drug reactions
    • 1st Edition
    • Volume 34
    • Jeffrey K Aronson
    • English
    The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then as a yearly update to the voluminous encyclopedia, Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of adverse drug reactions and interactions. An international team of specialists has contributed to the informative Annual by critically interpreting it and by pointing to whatever is misleading.

  • Clinical Pharmacology During Pregnancy

    • 1st Edition
    • English
    Clinical Pharmacology During Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy. The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are covered, as are research issues, including clinical trial design and ethical considerations.

  • Lithium and the Cell

    Pharmacology and Biochemistry
    • 1st Edition
    • Nicholas J. Birch
    • English
    This up-to-date compilation addresses the scientific problems of determining a mode of action of lithium and provides a cross-disciplinary perspective. In addition to psychiatrists interested in the therapeutic uses of lithium, it will also be of interest to biochemists using lithium as an inhibitor of phosphoinositide signaling, immunologists studying lymphocytes, and dermatologists studying viral replication in the skin.

  • T-Lymphocyte and Inflammatory Cell Research in Asthma

    • 1st Edition
    • G. Jolles + 2 more
    • English
    It is well established that asthma is an inflammatory disease of the airway mucosa and drugs like inhaled glucocorticoids are now commonly introduced early in therapy. A characteristic feature of this disease is the vast number of eosinophils in airway tissue, although many other migratory and resident inflammatory cells with the capacity to synthesize and release cytokines and putative asthma mediators are present in the inflamed mucosa. The cross-talk between lymphocytes and these cells and the role of cytokines in complex biological networks are currently areas of intense research.This volume gathers together chapters and discussions on the biology of immunocompetent and inflammatory cells, cellular interplay and communication, and on the relative importance of cells and mediators in disease.It should help contribute to further insights into the pathology of asthma and to the development of novel efficacious drugs for the treatment of asthma and related respiratory disorders.

  • Spontaneous Animal Models of Human Disease

    • 1st Edition
    • Volume 2
    • Edwin J. Andrews + 2 more
    • English
    This two-volume work gathers together the diverse information presently available on spontaneous animal models of human disease. In addition to providing a comprehensive review of existing models, the book presents many previous unpublished new models.The scope of this work is limited to spontaneous models. Neoplasia, infectious diseases including parasitism, and nutritionally induced or other types of experimental models have not been included. The sixteen parts of the book are alphabetically arranged according to organ system with over 230 authors contributing to the overall effort. In addition to many illustrations, the book features an extensive bibliography.

  • Biogenesis of Antibiotic Substances

    • 1st Edition
    • Zdenko Vanek
    • English
    Biogenesis of Antibiotic Substances covers the proceedings of a panel discussion on ""Basic Research and Practical Aspects of Antibiotic Production"" held during the Antibiotic Congress in Prague. This book is organized into 25 chapters that cover the regulating mechanisms of primary antibiotic metabolite biosynthesis. This text describes the relationship between secondary metabolite production and synthesis of cell matter or cell wall. The opening chapters describe the parasexual cycle and some of the ways in which the cycle may be used for strain improvement, as well as the applications of refined techniques of genetic recombination and the principles of biochemical genetics to the field of antibiotics. The next chapter deals with cultural and fermentative characteristics of A-type isolates obtained from progenitor and representative member strains of the Wisconsin Family of Strains of Penicillium chrysogenum. Considerable chapters are devoted to the metabolite biosynthesis, such as geodoxin and related compounds; secondary metabolism of penicillins, gibberellins, and griseofulvin in fungi; and tetracycline metabolites. The book goes on examining the stereochemical aspects of macrolide antibiotics. It also describes the biosynthetic pathways involving ring cleavage of carbocyclic compounds, as well as the biosynthesis of different peptide antibiotics and of actinomycins and its relationship to protein synthesis. The production of phenazines is also explained. Other chapters consider other metabolites, such as those that decarboxylate, the malonate, and the 3-nitropropionic acid. A discussion on the role of carbohydrates and phosphate in the biosynthesis of different types of antibiotics is included. Lastly, microbiological assay procedures for antibiotic research and influencing factors are presented.

  • Astrocytes

    Pharmacology and Function
    • 1st Edition
    • Bozzano G Luisa
    • English
    Interest in the functional roles of astrocytes in the nervous system has grown significantly as it is recognized that these cells not only have their own pharmacology but also release neuro- and vaso-active factors. This book relates astrocyte pharmacology to cell function for the first time, making it an attractive text across the neuroscience community.

  • Adenosine in the Nervous System

    • 1st Edition
    • Richard E. Stone
    • English
    This volume in a series on neuroscience provides an overview of the last 20 years of research into the biochemistry, physiology,pharmacol... and clinical therapeutic potential of adenosine and its analogues in the nervous system. Among the topics covered are adenosine transport in nervous systemtissues, adenosine production and metabolism and the electropharmacology of adenosine.

  • Origins of Resistance to Toxic Agents

    • 1st Edition
    • M Sevag
    • English
    Origins of Resistance to Toxic Agents contains the proceedings of the Symposium held in Washington, D.C. on March 25-27, 1954. Contributors theoretically explore the origins of drug resistance and related problems, based on the concept that the development of resistance to various toxic agents is associated with alterations and/or loss in enzyme proteins, and can explain the mutational and other processes. This text is organized into five sections encompassing 25 chapters and begins with an overview of the evolutionary aspects of resistance to antibacterial agents, herbicides, and insecticides. The book then discusses spontaneous and induced mutations to drug resistance in Escherichia coli, along with the mechanism of drug resistance in protozoa and bacteria, the physiological aspects of insect resistance to insecticides, and the enzymatic detoxication of DDT. The next chapters focus on the origins of tolerance and addiction to drugs and the problem of alcoholism; biochemical effects of narcotics and alcohol administration; tolerance and physical dependence to narcotics; and resistance and dependence in cancer cells. The book concludes by analyzing the significance of protein configuration to the specificity of biological interaction. This book is a valuable source of information for physicians, biochemists, pharmacologists, entomologists, plant physiologists, students of cancer, and those who are interested in the theory of the evolution of living matter.

Related subjects