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Elsevier

Books in Clinical pharmacology therapeutics

This collection covers drug efficacy, safety, and personalized treatment strategies across various medical conditions. Supporting clinicians, pharmacologists, and researchers, it features evidence-based guidelines, therapeutic innovations, and adverse effect management that optimize patient outcomes and support clinical decision-making.

  • Biofunctional Cosmetics for Health

    Exploring Nature’s Ingredients for Safety, Efficacy, and Sustainability
    • 1st Edition
    • Alexandros Tsoupras + 1 more
    • English
    Bio-functional Cosmetics for Health: Exploring Nature’s Ingredients for Safety, Efficacy, and Sustainability bridges the gap between cosmetics, nutraceuticals, and pharmaceuticals, providing the latest research for developing health-promoting cosmeceuticals and nutricosmetics from various food sources and food waste. From medicinal plants, teas, cacao, coffee, fruits, vegetables, plant oils, nuts, and cereals to marine microorganisms, fungi, insects, crustaceans, and more, this book takes a close look into the safety, efficacy and sourcing of bioactives from these food sources and how they can be sustainably used as ingredients to create bio-functional cosmetics, cosmeceuticals and nutricosmetics.Reade... will gain insight on the anti-inflammatory, antioxidant, anti-aging, and anti-cancer properties of bioactive ingredients in cosmetics and will also be informed on the latest regulatory and safety issues and R&D trends for the application of bioactives in functional cosmetics and cosmeceutical products.

  • Handbook of Melatonin-Based Therapy and its Applications

    • 1st Edition
    • Alejandro Romero Martínez + 2 more
    • English
    Handbook of Melatonin-Based Therapy and its Applications provides pharmaceutical researchers and health professionals with a comprehensive reference on the applications of melatonin in the therapeutic setting. Succinct, meticulously organized, and expertly written, this book addresses all essential aspects. It starts with an overview of safe use of melatonin, translational aspects, and its prospection. The next section of the book covers a variety of clinical applications, including dosage, pharmacokinetics and pharmacodynamic profiles, toxicity, and principles of action. The chapters in this section cover applications to both adults and pediatric patients suffering from conditions like skin cancers, GI issues, psychiatric, hepatic and ocular conditions.This is a comprehensive resource for pharmaceutical scientists and health professionals involved in developing therapies and applying them to patients. Researchers in the fields of medicine, biology, neuroscience, and pharmacology conducting studies related to melatonin-based will benefit from insights into the latest research findings, clinical trials, and therapeutic approaches.

  • Ketamine

    Fundamentals, Applications, Pharmacology, and Clinical Aspects
    • 1st Edition
    • Albert Dahan + 1 more
    • English
    Pharmacology of Ketamine: Fundamentals, Applications, Delivery Systems and Clinical Aspects explores the multifaceted properties of ketamine for diverse applications, delving into dosing strategies, routes of administration, and their pharmacological implications. The book begins with an introduction that underscores the need to bridge research and practice. It then delves into the pharmacological intricacies of ketamine, dissecting mechanisms and dosing strategies and exploring the diverse routes of administration and their impact on ketamine's metabolites.The book then explores the PK and PD characteristics of ketamine, followed by a deep dive into clinical applications emphasizing anesthesia, psychiatric therapy, and emerging treatments. The final part of the book covers addiction, toxicity, and future research perspectives. It will serve as a comprehensive reference tailored to the needs of both researchers and clinicians involved in the administration and study of ketamine.

  • mRNA Therapeutics

    Foundations, Innovations, and Clinical Applications
    • 1st Edition
    • Anya Hillery
    • English
    mRNA Therapeutics: Foundations, Innovations and Clinical Applications aims to provide a comprehensive text that covers all aspects of mRNA therapeutics, from the foundational science that underpins this disruptive new drug class, through the scientific and technological breakthroughs crucial for therapeutic success, to the current clinical applications and the innovative advances driving future directions. The book begins with foundational knowledge covering mRNA biology, the immune system, and vaccines. The second section addresses the major challenges associated with mRNA as a therapeutic modality, and the molecular engineering innovations and delivery technologies that have allowed these hurdles to be largely overcome. The third section describes the current and future clinical applications of mRNA therapeutics that are transforming, or are poised to transform, medicine and health. This includes the use of mRNA vaccines for COVID-19 and other infectious diseases, as well as mRNA's role in revolutionizing cancer immunotherapy, covering immunostimulants, cancer vaccines including personalized neoantigen vaccines, and CAR T cell technologies. Additional chapters describe the use of mRNA therapeutics for protein replacement therapy and gene-editing, as well as newer mRNA constructs, including self-amplifying mRNA. The final section addresses the safety and regulatory considerations of mRNA therapeutics, along with broader cultural issues including vaccine hesitancy, global vaccine inequality, and pandemic preparedness. Currently, mRNA texts either provide personal accounts from key players involved in COVID-19 vaccine development, with limited scientific depth, or focus on highly specialized, more esoteric applications of mRNA in advanced molecular biology. This book aims to bridge this gap by providing a scientifically rigorous and wide-ranging exploration of mRNA's role in therapeutics. This pioneering textbook serves as a vital addition to the academic canon, providing an essential tool for the current and next generation of students, scientists, researchers and professionals in a wide variety of related disciplines including molecular biology, biomedical engineering, pharmaceutical science, oncology, and the health sciences.

  • Therapeutic Drug Monitoring

    Newer Drugs and Biomarkers
    • 2nd Edition
    • Amitava Dasgupta
    • English
    Therapeutic Drug Monitoring: Newer Drugs and Biomarkers, Second Edition is an updated reference on TDM analytical techniques in diverse clinical settings. This new edition reviews exciting new developments in the area, including seven new chapters covering immunoassay design and applications, combined chromatographic techniques in therapeutic monitoring, drug monitoring in alternative specimens, pharmacogenomics of anticancer drugs, pharmacogenomics testing for patient management, selected antifungal agents, pharmacodynamic monitoring, and therapeutic drug monitoring of selected anticoagulants. All remaining chapters in the first edition were thoroughly revised and updated.This book is the ideal reference for clinical pathologists, pharmacologists, and toxicologists involved with TDM. Scientists working in diagnostic companies, developing reagents for monitoring therapeutic drugs will also find relevant information in this book.

  • Pharmacogenomics

    From Discovery to Clinical Implementation
    • 1st Edition
    • Showkat Ahmad Ganie + 3 more
    • English
    Pharmacogenomics: From Discovery to Clinical Implementation is a complete reference aimed at building a solid foundation of the key concepts in this fast-moving knowledge area. The book's chapters over the foundational aspects of pharmacogenomics, including drug metabolism, drug discovery, development, and testing, and then detail studies of key health conditions and the potential therapeutic applications of pharmacogenomics. Diseases covered include diabetes, cardiovascular diseases, psychiatric disease, cancer, pulmonary and respiratory diseases, viral diseases, gastroenterology, autoimmune diseases, immunosuppressants, and, finally, an overview of computational resources. This is the perfect resource for pharmaceutical science graduate students to learn the key concepts of the area. However, researchers and graduate students in the related fields of genetics, pharmacoepidemiology... molecular biology, and medicinal chemistry will also benefit from the structured approach of the book.

  • Standardizing Pharmacology: Assays and Hormones

    Discoveries in Pharmacology, Volume 2
    • 2nd Edition
    • Michael J. Parnham + 2 more
    • English
    Standardizing Pharmacology: Assays and Hormones, Volume Two in the Discoveries in Pharmacology series, presents selected articles from historic discoveries that are enhanced with commentary from contemporary scholars who present discussions on the importance of each chapter, along with an updated bibliography on the subject and contributions from a Nobel Prize winner and other pioneers in pharmacology. Academic and industry researchers in pharmacology and medicine, as well as advanced students will find this series a useful teaching tool and launch to new discoveries. Sections cover key discoveries in receptor theory, pharmacological methods and the development of hormone therapy, including J. Parascandola on the development of receptor theory, R.S. Yalow on radioimmunoassay, M. van Rossum and J.T L.A. Hurkmans on bioassays, M. Tausk on androgen therapy and C. Djerassi on oral contraceptives, with commentaries from experts such as T. Hökfelt and V.C. Jordan.

  • Lantibiotics as Alternative Therapeutics

    • 1st Edition
    • Sanket Joshi + 3 more
    • English
    Lantibiotics as Alternative Therapeutics explores alternative therapeutics, lantibiotics and other novel drugs. This book provides concrete information to readers regarding lantibiotics and various types of antimicrobial peptides with their mode of actions in treating various multidrug resistant organisms. It explains various techniques that are involved in analyzing antimicrobial peptides and their mode of actions. The development of antibiotic resistance has now reached a point of crisis where innovative methods and application of novel compounds and methods are required to prevent the spread of drug resistant infections. Novel compounds exhibit different modes of action to the currently used mechanism of therapeutics in order to combat against the resistant organisms. Lantibiotics hold considerable potential as a consequence of their unusual structure, unique mechanisms of action and their potency against multi-drug resistant bacteria. This book will be useful for pharmaceutical industry scientists and researchers in microbial and biomedical research as well as graduate and advanced students in microbiology, medical biotechnology, health, and pharmaceutical sciences.

  • Recent Developments in Anti-Inflammatory Therapy

    • 1st Edition
    • Parteek Prasher + 4 more
    • English
    Advances in Anti-inflammatory Therapy explores the cutting-edge in anti-inflammation therapy in clear and concise language, with insights from academia and industry. Sections cover key regulatory pathways that mediate acute and chronic inflammation and disease onset. Further chapters are devoted to advanced anti-inflammatory pharmaceuticals, including chemical moieties, pharmacophores, APIs, natural products, herbal therapies, molecular nanomedicine and advanced drug delivery vectors. Systematically planned chapters and illustrations enable potential readers to gain essential insights on the most recent advancements in the field. Arranged with systematic chapters covering a broad range of inflammatory diseases, discussions on past, current and future therapeutics and advanced anti-inflammatory pharmaceuticals, this book will be useful to a wide range of researchers, especially medicinal chemists, drug design experts, and biological and translational researchers working in the field of inflammation.

  • Tamoxifen Tales

    Suggestions for Scientific Survival
    • 1st Edition
    • V. Craig Jordan
    • English
    Tamoxifen Tales: Suggestions for Scientific Survival presents a case study describing the academic journey of teams behind major advances in medical sciences, highlighting lessons learned that are applicable to the next generation of scientists. This book provides a manual on the successful mentoring of young scientists, including stories describing how training experience shaped careers to become leaders in academia and the pharmaceutical industry. The book documents Professor V. Craig Jordan’s 50-year career in medical sciences that led to the discovery and development of Selective Estrogen Receptor Modulators (SERMs), which became the standard of women’s healthcare around the world. Additionally, it illustrates the versatility of a scientist with a commitment to serving societies. This important resource will be a useful and interesting book for established medical scientists, research mentors and advanced students wanting to chart a successful and impactful research career.

  • Atkinson's Principles of Clinical Pharmacology

    • 4th Edition
    • Shiew-Mei Huang + 3 more
    • English
    **Selected for Doody’s Core Titles® 2024 in Pharmacology**Atkins... Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology.

  • Clinical Pharmacology During Pregnancy

    • 2nd Edition
    • Donald Mattison + 1 more
    • English
    Clinical Pharmacology During Pregnancy, Second Edition is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals involved in the care of women during pregnancy. The book focuses on the impact of pregnancy on drug disposition and includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy. This update includes substantially expanded sections on the ethics of pharmacological research in pregnancy and physiologic changes, along with new sections on patient reported outcomes in pregnancy, delivery and postnatal care, and the use of pharmacokinetic and pharmacodynamic approaches to estimate maternal, placental and fetal dosing. The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are also covered, as are research issues, including clinical trial design and ethical considerations.

  • Nano-Pharmacokinetics and Theranostics

    Advancing Cancer Therapy
    • 1st Edition
    • Nanasaheb D. Thorat + 1 more
    • English
    Nano-Pharmacokinetic... and Theranostics: Advancing Cancer Therapy addresses from a comprehensive and multidisciplinary approach the translational aspects and clinical perspectives of nano-pharmacokinetic... using cancer as a model disease. Nano-pharmacokinetic... is emerging as an important sub discipline of nanoscience and medical sciences because of the increasing safety issues of nanosystems on living organisms. This book reports the dynamics of nanosystems in living organisms for better understanding of nanotoxicity, pharmacology, biochemistry, physiology and medicine perspectives. It further examines current progress of state-of-the art pharmacokinetics mechanisms, which will be of great help to develop more clinical-oriented nanosystems with a wide safety margin. The book is divided into three sections: the first section focuses on the concept of pharmacokinetics with state-of-the-art Nano-Pharmacokinetic... (NPK). The second section looks at the engineering of nanoparticles and pharmacokinetics clinical development. The final section focuses on Nano-Pharmacokinetic... and Theranostics, elaborating the basic question of how pharmacokinetics of nanomaterials relate to their end applications such as cancer therapy. Nano-Pharmacokinetic... and Theranostics: Advancing Cancer Therapy will be useful to researchers in the field of nanoparticle based targeted drug delivery including pharmaceutical scientists, material scientists, chemists, nanotechnologists, biomedical scientists, and clinicians.

  • Inflammation and Natural Products

    • 1st Edition
    • Sreeraj Gopi + 3 more
    • English
    Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries.

  • Saffron

    The Age-Old Panacea in a New Light
    • 1st Edition
    • Maryam Sarwat + 1 more
    • English
    Saffron: The Age-Old Panacea in a New Light is the first book to detail the functions and effect of saffron in medicinal situations. This book explores the medicinal aspects of saffron and the effect saffron imparts on various diseases of the central nervous system, cardiovascular system, digestive system, locomotor system, urogenital system, eye, skin, and immune system, along with their mechanism of action. This perpetual bulb found mainly in Asia and Europe, Iran, India and Mediterranean countries has been shown to reduce seizures, delay convulsions, and as a neuroprotective agent against cerebral ischemia, brain damage, and Alzheimer's and Parkinson's disease. In addition, it also reduces depression, hypnosis and anxiety and enhances learning and memory skills.

  • Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases

    The Chemical and Pharmacological Basis of their Action
    • 1st Edition
    • Solomon Habtemariam
    • English
    Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases: The Chemical and Pharmacological Basis of their Action focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants—rather than just the nutritional composition of certain foods. The book provides up-to-date information on acclaimed antidiabetic super fruits, spices and other food ingredients. Sections cover diabetes and obesity at the global level, the physiological control of carbohydrate and lipid metabolism, the pathophysiology of type-2 diabetes, the chemistry and pharmacology of a variety of spices, and much more. This book will be invaluable for research scientists and students in the medical and pharmaceutical sciences, medicinal chemistry, herbal medicine, drug discovery/developmen... nutrition science, and for herbal practitioners and those from the nutraceutical and pharm industries.

  • Pharmacogenomics

    Challenges and Opportunities in Therapeutic Implementation
    • 2nd Edition
    • Yui-Wing Francis Lam + 1 more
    • English
    Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation, Second Edition, provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of pharmacogenomics from academic, regulatory, pharmaceutical, socio-ethical and economic perspectives. While emphasis is on the limitations in moving the science into drug development and direct therapeutic applications, this book also focuses on clinical areas with successful applications and important initiatives that have the ability to further advance the discipline. New chapters cover important topics such as pharmacogenomic data technologies, clinical testing strategies, cost-effectiveness, and pharmacogenomic education and practice guidelines. The importance of ethnicity is also discussed, which highlights phar,acogenomic diversity across Latin American populations.With chapters written by interdisciplinary experts and insights into the future direction of the field, this book is an indispensable resource for academic and industry scientists, graduate students and clinicians engaged in pharmacogenomics research and therapeutic implementation.

  • Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

    • 1st Edition
    • Surendra Nimesh + 2 more
    • English
    Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 56
    • English
    Progress in Medicinal Chemistry, Volume 56 provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a potential new era for Chagas Disease drug discovery, and imaging in drug development. Specific chapters cover timely topics, such as the development of LRRK2 inhibitors for the treatment of Parkinson's, and recent discoveries and developments in TRPA1 modulators. Users will find a comprehensive resource on the topic of medicinal chemistry that also discusses avenues for the acceleration of drug discovery programs.

  • Individualized Drug Therapy for Patients

    Basic Foundations, Relevant Software and Clinical Applications
    • 1st Edition
    • Roger W Jelliffe + 1 more
    • English
    Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose. The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 55
    • English
    Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a new era for Chagas Disease drug discovery? and imaging in drug development.

  • Meyler's Side Effects of Drugs

    The International Encyclopedia of Adverse Drug Reactions and Interactions
    • 16th Edition
    • Jeffrey K. Aronson
    • English
    Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, Sixteenth Edition, Seven Volume Set builds on the success of the 15 previous editions, providing an extensively reorganized and expanded resource that now comprises more than 1,500 individual drug articles with the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature, making this a must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company. The online version of the book provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking, and fully downloadable and printable full-text, HTML or PDF articles.

  • Recent Advances in Medicinal Chemistry, Volume 1

    • 1st Edition
    • Atta-ur Rahman + 2 more
    • English
    Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more.

  • Drugs During Pregnancy and Lactation

    Treatment Options and Risk Assessment
    • 3rd Edition
    • Christof Schaefer + 2 more
    • English
    Drugs During Pregnancy and Lactation, Third Edition is a quick and reliable reference for all those working in disciplines related to fertility, pregnancy, lactation, child health and human genetics who prescribe or deliver medicinal products, and to those who evaluate health and safety risks. Each chapter contains twofold information regarding drugs that are appropriate for prescription during pregnancy and an assessment of the risk of a drug when exposure during pregnancy has already occurred. Thoroughly updated with current regulations, references to the latest pharmacological data, and new medicinal products, this edition is a comprehensive resource covering latest knowledge and findings related to drugs during lactation and pregnancy.

  • Biased Signaling in Physiology, Pharmacology and Therapeutics

    • 1st Edition
    • Brian J Arey
    • English
    Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-depen... activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.

  • Handbook of Dental Pharmacology and Therapeutics

    • 1st Edition
    • Roy Goulding
    • English
    Handbook of Dental Pharmacology and Therapeutics is a supplement to lectures given in dental schools on the subject of pharmacology in dental practice. The author describes dental therapeutics and pharmacology including the prescription of drugs, legislation of dangerous drugs, posology (dosage), weights and measures, frequency, or administration. He explains the sedatives, hypnotics, and anticonvulsants: he notes that narcotics can depress (not uniformly) all the tissue in the human body. The author also describes the mode of action and the stages induced in general anesthesia; the classification, action, and the therapeutics of analgesics (antipyretics, opiates, synthetic opiates). An interesting subject concerns analeptics or restoratives to resurrect the dying that includes stimulants of the central nervous systems (ephedrine, amphetamine, strychnine). Visits to the dentists should include obtundents and counter-irritants that dull sensation to pain. The author notes that in drilling cavities, the sharper the bur, the less obtundent needed. The author also addresses other drugs (hemostatic, anticoagulants) and those acting on the cardiovascular system or on the blood vessels. This handbook can prove useful for dentists, dental aides, pharmacologists, practitioners of general medicine, as well as students of dental medicine.

  • Trends in Receptor Research

    Proceedings of the 8th Camerino-Noordwijkerhout Symposium, Camerino, Italy, 8-12 September 1991
    • 1st Edition
    • Volume 18
    • P. Angeli
    • English
    The 8th Camerino-Noordwijker... Symposium has continued along its traditional path of interdisciplinary cooperation. Chemists, biochemists, pharmacologists, biophysicists and physiologists are all involved in the task of improving our knowledge of the mechanisms of drug-receptor interaction and of the heterogeneous nature of biological molecules. In this volume, leading researchers have contributed state of the art information on receptor chemistry. Newest developments are covered with particular reference to receptors of the nervous system; SAR studies; receptor isolation; receptor cloning; receptor topography; biomedical consequences of occupancy; receptor regulation and receptor theory. This will be of great interest to pharmacologists, biochemists and medicinal chemists, as well as a valuable source of reference for medical students and postgraduate students in related fields.

  • Clinical Pharmacology During Pregnancy

    • 1st Edition
    • English
    Clinical Pharmacology During Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy. The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are covered, as are research issues, including clinical trial design and ethical considerations.

  • Principles of Clinical Pharmacology

    • 3rd Edition
    • Shiew-Mei Huang + 2 more
    • English
    Principles of Clinical Pharmacology is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science. The Third Edition has been endorsed by the American Society for Clinical Pharmacology and Therapeutics

  • Meyler's Side Effects of Drugs Used in Anesthesia

    • 1st Edition
    • Jeffrey K. Aronson
    • English
    Elsevier now offers a series of derivative works based on the acclaimed Meylers Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing physician or health care clinician. A safe and efficient anesthesia practice requires appropriate drug knowledge. Catastrophes under anesthesia have focused attention on the interaction between drugs, including prescribed and non-prescribed medications, including interactions with vitamins, herbal preparations, traditional remedies, and food supplements.This book summarizes the adverse effects of a large range of drugs used in anesthesia. The material is drawn from the 15th edition of the internationally renowned encyclopedia, Meyler’s Side Effects of Drugs, and the latest volumes in the companion series, Side Effects of Drugs Annuals.This volume is critical for any health professional involved in the administration of anesthesia.

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 38
    • English
    Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

  • Bridging Hippocrates and Huang Ti, Volume 1

    A Comparative Thesaurus of Traditional Chinese and Western Urology, Andrology and Sexology
    • 1st Edition
    • P. Marandola + 2 more
    • English
    Western Medicine as seen today has a strong scientific basis in its development. The pathogenesis of most diseases and their symptomatology and physical signs are well studied and understood. The management of patients is based on firm understanding of these disease processes. In contrast, Traditional Chinese Medicine came about through the experience of many generations of practitioners over thousands of years. Undoubtedly, many of these treatments have proved to be effective in their own way, however, firm scientific basis is still lacking.While most Western Medicine advocates control of disease by eradication of pathogens and surgical removal of diseased organs as in the case of cancer, Traditional Chinese Medicine seeks to improve resistance against disease. There is probably a great wealth of therapeutic value in Traditional Chinese Medicine, which has not been discovered or explored fully. By combining the knowledge of both Western and Traditional Chinese Medicine, one might be able to improve the results of efficacy of treatments and the survival of patients. The integration of Medicine from East and West will take time to evolve and will need interested physicians from different parts of the world to work closely together to realize such a possibility.This book is an attempt to bridge the medical world of two great and ancient civilizations in their approach to the treatment of disease. It is informative with a detailed account of the history of medical development. It is highly recommended for those medical practitioners from both East and West who are interested to explore alternative medicine and research new areas of the medical frontier.

  • Side Effects of Drugs Annual

    A world-wide yearly survey of new data and trends in adverse drug reactions
    • 1st Edition
    • Volume 26
    • English
    The Side Effects of Drugs Annual was first published in 1977. It has been published continuously since then, as a yearly update to the encyclopaedic volume Meyler's Side Effects of Drugs. Each new Annual provides clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists have contributed to the Annuals by selecting critically from each year's publications all that is truly new and informative, by critically interpreting it, and by pointing out whatever is misleading. The use of the book is enhanced by separate indexes, allowing the reader to enter the text via the drug name, adverse effect, or drug interaction.Special features of the Annuals are the Side Effects of Drugs Essay, usually written by a guest author, and the special reviews: short articles, within the different chapters, that give extra attention to topics of current interest.The Essay in Annual 26 is entitled 'How safe is cannabis?' (by Professor L.L. Iversen) and there is a Historical Essay entitled 'From thalidomide to pharmacovigilance: a personal account' (by Professor D.J. Finney).The special reviews in this volume include, among others: The cognitive effects of Ecstasy Antipsychotic drugs and weight gain Vigabatrin-related visual abnormalities Managing the adverse effects of morphine The cardiotoxic effects of antihistamines Inhaled corticosteroids and growth inhibition in children Bioterrorism and its prevention through immunization

  • Principles of Clinical Pharmacology

    • 1st Edition
    • Arthur J. Atkinson Jr. + 4 more
    • English
    The rate of introduction of new pharmaceutical products has increased rapidly over the past decade, and details learned about a particular drug become obsolete as it is replaced by newer agents. Principles of Clinical Pharmacology focuses on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. The coverage of these principles in this book will be of particular benefit to individuals engaged either in the teaching or study of sound therapeutic technique or in the investigation of pharmacological agents.

  • Histopathology of Preclinical Toxicity Studies

    Interpretation and Relevance in Drug Safety Evaluation
    • 2nd Edition
    • Peter Greaves
    • P. Greaves
    • English
    This book describes histopathological assessment of preclinical toxicology studies that are conducted to assess the safety of novel drugs. It discusses the implications of drug-induced changes that may be relevant to the critical early stages of the development of new therapeutic agents, notably prior to their first administration to humans and during early clinical trials. Covering virtually all aspects of drug-induced pathology in preclinical toxicity studies, the book is termed the 'gold standard' in the illustration of histopathology. This second revised edition continues to fill the gap for pathology literature relating to the development of new medicines and assessment of their safety based on preclinical studies. In addition to the updated references this edition contains many older references, some out of reach of modern computer based search tools.

  • Side Effects of Drugs Annual

    • 1st Edition
    • Volume 20
    • English
    The Side Effects of Drugs Annual has been published each year since 1977. It is designed to provide a critical and up-to-date account of new information related to adverse drug reactions and interactions from the clinician's point of view.Under the supervision of the series editors, an international team of expert authors have gathered together the latest information on adverse drug effects from the international literature. In addition to describing new reports of adverse drug effects, the authors have subjected those reports to critical analysis, setting them into context in terms of clinical relevance and importance, and cross-referring to previous reports where necessary. New adverse effects are reported and evaluated and previously reported adverse effects are re-evaluated in the light of the most recent information. A special feature is the reviews, in which selected adverse effects are discussed in depth. The use of the book is enhanced by two separate indexes, allowing the reader to enter the text by drug name, adverse effect name, or drug interaction.The Annual can be used independently or as a supplement to the standard encyclopaedic work in this field, Meyler's Side Effects of Drugs, of which, the http://www.elsevier.... Edition was published in December 2000.

  • XIVth International Symposium on Medicinal Chemistry

    • 1st Edition
    • Volume 28
    • F. Awouters
    • English
    Vaso-occlusive disorders including unstable angina, myocardial infarction, transient ischemic attacks, stroke and peripheral artery disease remain the major sources of morbidity and mortality in western civilization. Platelet activation and resulting platelet aggregation play a major role in the pathogenesis of these thromboembolic diseases. Recognition of the contribution of platelets to the pathophysiology of cardiovascular disease has provided impetus for the continued search for new antiplatelet agents. Hence, over the past two decades many strategies have been evaluated in the search for efficacious mechanisms to reduce platelet function. The medical need for more efficacious antithrombotic drugs and the growing understanding of the role of platelets in vascular injury have catalyzed the extensive evaluation of novel approaches to control platelet function. Along these lines, the volume therefore provides an in-depth assessment of ongoing clinical trials, new and clinically established agents, and other developments in this rapidly developing field.

  • Antidiabetic Agents: Recent Advances in their Molecular and Clinical Pharmacology

    • 1st Edition
    • Volume 27
    • English
    Volume 27, the first thematic volume in the Series, provides an overview of present knowledge with regard to the pharmacological and clinical aspects of antidiabetic drugs. It aims to stimulate further consideration of possible concepts in the development of new antidiabetic drugs.