Handbook of Melatonin-Based Therapy and its Applications
- 1st Edition - October 1, 2025
- Imprint: Academic Press
- Editors: Alejandro Romero Martínez, Eva Ramos Alonso, Francisco López-Muñoz
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 3 0 2 4 0 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 0 2 4 1 - 1
Handbook of Melatonin-Based Therapy and its Applications provides pharmaceutical researchers and health professionals with a comprehensive reference on the applications of melato… Read more
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Handbook of Melatonin-Based Therapy and its Applications provides pharmaceutical researchers and health professionals with a comprehensive reference on the applications of melatonin in the therapeutic setting. Succinct, meticulously organized, and expertly written, this book addresses all essential aspects. It starts with an overview of safe use of melatonin, translational aspects, and its prospection. The next section of the book covers a variety of clinical applications, including dosage, pharmacokinetics and pharmacodynamic profiles, toxicity, and principles of action. The chapters in this section cover applications to both adults and pediatric patients suffering from conditions like skin cancers, GI issues, psychiatric, hepatic and ocular conditions.
This is a comprehensive resource for pharmaceutical scientists and health professionals involved in developing therapies and applying them to patients. Researchers in the fields of medicine, biology, neuroscience, and pharmacology conducting studies related to melatonin-based will benefit from insights into the latest research findings, clinical trials, and therapeutic approaches.
This is a comprehensive resource for pharmaceutical scientists and health professionals involved in developing therapies and applying them to patients. Researchers in the fields of medicine, biology, neuroscience, and pharmacology conducting studies related to melatonin-based will benefit from insights into the latest research findings, clinical trials, and therapeutic approaches.
- Covers the most significant clinical aspects where melatonin has been shown to be effective
- Summarizes research progress and therapeutic applications of melatonin
- Provides a platform for researchers from diverse fields to collaborate and advance our understanding of the field
Pharmacology and Pharmaceutical Science researchers and practitioners
1. Physiology and Safety of melatonin
2. Translational melatonin in preclinical models
3. Melatonin and COVID-19
4. Obtaining phytomelatonin and other bio(logical)-melatonin: sources and therapeutic applications
5. Melatonin as a Therapy for Neonatal Encephalopathy: The journey to clinical trials
6. Melatonin Gastroprotection by melatonin: an emerging concept and underlying mechanisms
7. Melatonin as a therapeutic in the skin
8. The use of melatonin in oxidative stress of the newborn
9. Synergistic impact of melatonin on colorectal cancer
10. Melatonin in Oncology: Unveiling its Potential in Prostate Cancer
11. The use of melatonin in pediatric perioperative care
12. Exploring melatonin as a therapeutic approach for mustard vesicants
13. Epigenetic Modulation by Melatonin: Clinical Implications and Therapeutic Prospects
14. Why Melatonin Administration might be harmful during the mounting of a defense response
15. New galenic formulations of melatonin and therapeutic applications
16. Melatonin, sleep and mood disorders
17. Melatonin and neurodegenerative diseases
18. Melatonin and autism spectrum disorders
19. Melatonin and andrology
20. Melatonin and hepatic injury
21. Melatonin treatment against experimental optic Neuritis and glaucoma
2. Translational melatonin in preclinical models
3. Melatonin and COVID-19
4. Obtaining phytomelatonin and other bio(logical)-melatonin: sources and therapeutic applications
5. Melatonin as a Therapy for Neonatal Encephalopathy: The journey to clinical trials
6. Melatonin Gastroprotection by melatonin: an emerging concept and underlying mechanisms
7. Melatonin as a therapeutic in the skin
8. The use of melatonin in oxidative stress of the newborn
9. Synergistic impact of melatonin on colorectal cancer
10. Melatonin in Oncology: Unveiling its Potential in Prostate Cancer
11. The use of melatonin in pediatric perioperative care
12. Exploring melatonin as a therapeutic approach for mustard vesicants
13. Epigenetic Modulation by Melatonin: Clinical Implications and Therapeutic Prospects
14. Why Melatonin Administration might be harmful during the mounting of a defense response
15. New galenic formulations of melatonin and therapeutic applications
16. Melatonin, sleep and mood disorders
17. Melatonin and neurodegenerative diseases
18. Melatonin and autism spectrum disorders
19. Melatonin and andrology
20. Melatonin and hepatic injury
21. Melatonin treatment against experimental optic Neuritis and glaucoma
- Edition: 1
- Published: October 1, 2025
- Imprint: Academic Press
- Language: English
AR
Alejandro Romero Martínez
Alejandro Romero Martínez, PhD in Biological
Sciences from the University of Vigo
(2000), is a Tenured Professor in Toxicology
at the University Complutense of Madrid.
His research activity has resulted in 105
Journal Citation Reports (JCR) articles (h-index
38). He is also the coauthor of 12 international
book chapters and 4 national. Moreover,
he coauthors >50 international and
>40 national congress communications and
2 patents. He has supervised two doctoral
theses. He is a member of 4 editorial
committees and has acted as reviewer/
evaluator of 72 international journals in his
specialty with JCR relative quality index. He
combines his interest and background on
molecular toxicology and neuroprotection
studies of new molecules with therapeutic
interest against neurodegeneration and focuses
on novel melatonin-based therapies.
He has made important contributions in
cell/molecular biology of new multitarget
compounds synthesized against key targets
in Alzheimer’s disease and advances in the
knowledge of melatonin as a pleiotropic
agent against several pathologies and
mechanisms of toxicity. Dr. Martinez led the
MELVES project (medical countermeasures
program SYP41804) to test melatonin as a
potential health support measure for treatment
and prophylaxis. Remarkably, the
Spanish Ministry of Defence-General Directorate
of Armament and Material/SDG
PLATIN has displayed interest by selecting
his project. He has collaborated as an
external reviewer for the Czech Science
Foundation and Medical Research Council’s
Developmental Pathway Funding Scheme
(DPFS). Moreover, he is a member of the
Spanish Association of Toxicology (AETOX)
since January 2011, and certified as a European
Registered Toxicologist (ERT).
Affiliations and expertise
Professor, Department of Toxicology, Complutense University of Madrid, Madrid, SpainEA
Eva Ramos Alonso
Dr. Eva Ramos Alonso graduated in pharmacy and received her PhD in 2010 with first-class honors. She is tenured professor in Toxicology. She acquired a wide experience in alternative research to animal experimentation, with in silico techniques and in vitro tests applied to assess the safety or toxicological profile, as well as, the efficacy of a wide variety of chemical products and new molecules with therapeutic interest.
Affiliations and expertise
Universidad Complutense de Madrid, Madrid, SpainFL
Francisco López-Muñoz
Dr. Francisco López-Muñoz is PhD degree in Medicine (Complutense University of Madrid) and specialist in Pharmaceutical Medicine. Currently, he is a Full Professor of Pharmacology, Vice-Chancellor of Research and Science, Chairman of the Research Ethics Committee at Camilo José Cela University (Madrid), and a research fellow at “Hospital 12 de Octubre” Research Institute (Madrid, Spain). He is editor/author of 32 books and author of 800 scientific articles and chapters related to psychopharmacology, 197 of them with JCR impact factor (h-index 47).
Affiliations and expertise
Camilo José Cela University, Madrid, Spain