Immunopharmacology

Preface

Contributors

Chapter One. Redefining Approaches to Asthma: Developing Targeted Biologic Therapies

Abstract

1. Introduction

2. Human Asthma Biology

3. Pharmacokinetics and Pharmacodynamics of Asthma Biologics

4. Clinical Study Design for Asthma Biologics

5. Conclusion

Acknowledgments

References

Chapter Two. Protein Therapeutics Targeted at the TNF Superfamily

Abstract

1. Introduction

2. The TNF and TNF Receptor Superfamilies

3. Antibody and Receptor-Based Drugs

4. Clinical Responses to TNF Inhibitors

5. Targeting Other TNFSF Pathways

6. Conclusion

Acknowledgments

References

Chapter Three. Immunopharmacology of Lipid A Mimetics

Abstract

1. Introduction

2. LPS Receptor Complex

3. TLR4 Signaling

4. Endotoxin

5. Structure of LPS

6. Lipid A: The “Endotoxic Principle”

7. Diversity of Lipid A in Nature

8. Synthetic Lipid A

9. TRIF-Selective Signaling

10. Conclusion

References

Chapter Four. The Biology of Thymic Stromal Lymphopoietin (TSLP)

Abstract

1. Introduction

2. TSLP Signaling

3. TSLP-Responsive Cells

4. TSLP-Associated Diseases

5. Conclusion

Acknowledgments

References

Chapter Five. Eicosanoids in Metabolic Syndrome

Abstract

1. Introduction

2. Lipid Metabolism in Control of Eicosanoid Synthesis

3. Metabolism of Eicosanoids in MetS

4. Eicosanoids in Sepsis and Drug Metabolism

5. Eicosanoids and MetS Diseases

6. Therapies in the Treatment of NAFLD

7. Conclusion

Acknowledgments

References

Chapter Six. The Yin and Yang of Protein Kinase C-theta (PKCθ): A Novel Drug Target for Selective Immunosuppression

Abstract

1. Introduction

2. History, Structure and Expression of PKCθ

3. Specialized Functions of PKCθ in Conventional T Cells: The Yin

4. The Differential Role of PKCθ in Immune Responses

5. PKCθ and the Immunological Synapse

6. PKCθ, CD28 Costimulation, and T Cell Anergy

7. Unique Function of PKCθ in Regulatory T Cell Development and Function: The Yang

8. PKCθ in Human Disease

9. Is PKCθ a Promising Drug Target?

10. Conclusion and Future Perspectives

Acknowledgments

References

Index