Immunopharmacology
- 1st Edition, Volume 66 - March 5, 2013
- Editor: David J Webb
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 2 8 2 8 0 - 2
- Hardback ISBN:9 7 8 - 0 - 1 2 - 4 0 4 7 1 7 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 4 0 5 1 8 4 - 3
This new volume of Advances in Pharmacology explores the current state of Alzheimer's disease research and therapeutics. Chapters cover such topics as the B cell targeted the… Read more
This new volume of Advances in Pharmacology explores the current state of Alzheimer's disease research and therapeutics. Chapters cover such topics as the B cell targeted therapies, Lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.
- Explores the current state of Alzheimer's disease research and therapeutics
- Chapters cover a variety of topics such as the B cell targeted therapies, lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin
- With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike
Pharmacologists, immunologists, and biochemists
Preface
Contributors
Chapter One. Redefining Approaches to Asthma: Developing Targeted Biologic Therapies
Abstract
1. Introduction
2. Human Asthma Biology
3. Pharmacokinetics and Pharmacodynamics of Asthma Biologics
4. Clinical Study Design for Asthma Biologics
5. Conclusion
Acknowledgments
References
Chapter Two. Protein Therapeutics Targeted at the TNF Superfamily
Abstract
1. Introduction
2. The TNF and TNF Receptor Superfamilies
3. Antibody and Receptor-Based Drugs
4. Clinical Responses to TNF Inhibitors
5. Targeting Other TNFSF Pathways
6. Conclusion
Acknowledgments
References
Chapter Three. Immunopharmacology of Lipid A Mimetics
Abstract
1. Introduction
2. LPS Receptor Complex
3. TLR4 Signaling
4. Endotoxin
5. Structure of LPS
6. Lipid A: The “Endotoxic Principle”
7. Diversity of Lipid A in Nature
8. Synthetic Lipid A
9. TRIF-Selective Signaling
10. Conclusion
References
Chapter Four. The Biology of Thymic Stromal Lymphopoietin (TSLP)
Abstract
1. Introduction
2. TSLP Signaling
3. TSLP-Responsive Cells
4. TSLP-Associated Diseases
5. Conclusion
Acknowledgments
References
Chapter Five. Eicosanoids in Metabolic Syndrome
Abstract
1. Introduction
2. Lipid Metabolism in Control of Eicosanoid Synthesis
3. Metabolism of Eicosanoids in MetS
4. Eicosanoids in Sepsis and Drug Metabolism
5. Eicosanoids and MetS Diseases
6. Therapies in the Treatment of NAFLD
7. Conclusion
Acknowledgments
References
Chapter Six. The Yin and Yang of Protein Kinase C-theta (PKCθ): A Novel Drug Target for Selective Immunosuppression
Abstract
1. Introduction
2. History, Structure and Expression of PKCθ
3. Specialized Functions of PKCθ in Conventional T Cells: The Yin
4. The Differential Role of PKCθ in Immune Responses
5. PKCθ and the Immunological Synapse
6. PKCθ, CD28 Costimulation, and T Cell Anergy
7. Unique Function of PKCθ in Regulatory T Cell Development and Function: The Yang
8. PKCθ in Human Disease
9. Is PKCθ a Promising Drug Target?
10. Conclusion and Future Perspectives
Acknowledgments
References
Index
- Edition: 1
- Volume: 66
- Published: March 5, 2013
- Language: English
Read Immunopharmacology on ScienceDirect