Books in Biochemical pharmacology

Drug Metabolism in Diseases

2nd Edition
October 1, 2025
Wen Xie
English

Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development, now in second edition, provides pharmaceutical scientists and biologists with the needed foundational knowledge required to understand the interplay between diseases and physiological conditions, how they impact drug metabolism and disposition, and its implications in personalized treatment. The book has been expanded with six new chapters, and completely updated with the scientific findings since the first edition published in 2016. The new chapters in the book cover drug metabolism in metabolic syndrome , transplant patients, geriatric patients, the developmental regulation of drug metabolism and disposition, the effect of gut microbiota on xenobiotic and endobiotic metabolism, the regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways, and drug metabolism in HIV patients. All other chapters in the first edition like drug metabolism in pregnancy, pediatric patients, patients of cardiovascular disease, and kidney diseases were completely updated to include the latest research results and references. Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development is a comprehensive reference on the mutual effect between drug metabolism and diseases, which has great implications in precision medicine and therapeutic development. Pharmaceutical scientists and drug metabolism researchers in academia and corporate R&D departments will benefit from the expanded coverage provided by expert authors. Research physicians interested in better understand the impact of diseases in drug metabolism will also benefit from the comprehensive overview of the area.

Pharmacological Targets in Metabolic Diseases

1st Edition
September 1, 2025
Marcos Roberto de Oliveira
English

Pharmacological Targets in Metabolic Diseases: Challenges and Opportunities is a complete reference on possible drug development targets to be leveraged in therapeutic developments. Covering both signaling pathways and specific proteins, the book presents ways to modulate the molecular and cellular alterations observed in metabolic diseases and disorders through the application of new or classical drugs. The comprehensive coverage starts by providing an overview of metabolic diseases and disorders, biological alterations, and pharmacological targets. This section covers targets at both molecular, and subcellular and cellular levels. The next section in the book is focused on pharmaceutical targeting of organs, including a dedicated chapter to the gut-brain axis. Next comes a thorough review of the current advances in metabolic syndrome research. Section VI is focused on inborn errors of metabolism, and is followed by a section devoted to natural molecules and their pharmacological potential to treat these conditions. The Editor introduces next a whole section dedicated to the role of the microbiota in metabolic diseases therapeutics. The following sections cover the impact of aging, nanotechnology, the environment, and finally diagnostic techniques in metabolic diseases and disorders. Pharmacological Targets in Metabolic Diseases: Challenges and Opportunities meet the needs of pharmacology researchers looking for a comprehensive and authoritative source of information on possible therapeutic targets to threat these conditions. Research physicians, nutritionists, and biologists can benefit from the detailed information provided at the different levels of targets identified to treat metabolic diseases and conditions.

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

2nd Edition
February 18, 2025
Mahendra Rai
English
eBook
9 7 8 0 4 4 3 2 9 0 4 5 9

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components, Second Edition offers pharmaceutical and life sciences researchers an overview on the most relevant studies for fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses, and fungi using natural products. This new edition expands the coverage of uses of traditional medicinal plants to against MDR, includes new chapters on the potential of plant-derived bioactive compounds for reversal of multidrug resistances, covers the use of flavonoids to combat microbes and cancer, and the use of nanoparticles as drug delivery vehicle.The need to combat multidrug-resistant microorganisms is an urgent one. This book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components, and more, to aid researchers in effective antimicrobial drug discovery.

Exosome Communication

1st Edition
November 15, 2024
Dalapathi Gugulothu + 3 more
English
Paperback
9 7 8 0 4 4 3 2 9 0 5 2 7
eBook
9 7 8 0 4 4 3 2 9 0 5 3 4

Exosome Communication: Advances in Research and Therapeutics for Health and Disease serves as a crucial reference for pharmaceutical scientists, focusing on the key qualities of exosomes as drug delivery vehicles. Exosomes are intracellular membrane-based vesicles with diverse compositions, offering significant advantages over traditional drug delivery systems such as liposomes and polymeric nanoparticles, due to their nonimmunogenic nature. This book provides a comprehensive exploration of exosomes, starting with their history and development, understanding extracellular vesicles and biogenesis, and techniques for isolation and characterization. This book also addresses critical considerations like quality control, heterogeneity reduction, regulatory and ethical aspects, clinical trials, and scale-up manufacturing.

TRP Channels as Therapeutic Targets

2nd Edition
August 22, 2024
Arpad Szallasi
English
Hardback
9 7 8 0 4 4 3 1 8 6 5 3 0
eBook
9 7 8 0 4 4 3 1 8 6 5 4 7

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. Chapters are completely updated, withe new topics on TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation. This is a great reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline will also find this book helpful for biologic principles of action.

Advancement of Phenolic Acids in Drug Discovery

1st Edition
June 19, 2024
Naresh Kumar + 2 more
English
Paperback
9 7 8 0 4 4 3 1 8 5 3 8 0
eBook
9 7 8 0 4 4 3 1 8 5 3 9 7

Advancement of Phenolic Acids in Drug Discovery: Fundamental and Applications offers comprehensive coverage of the ADMET profiles of phenolic acids, their extraction method and prospects for drug design and development. Chapters overview phenolic acids and their characterization, discuss the role of phenolic acids in plant systems, present sources and detailed extraction methods of phenolic acids, and cover phenolic acid mechanisms of action as it relates to several key diseases and health conditions, including their role as antioxidant agents, anti-inflammatory and analgesic drugs, anti-microbial drugs, anti-viral drugs, anti-cancer drugs, diabetes and metabolic dysfunctions, neurological disorders, cardiovascular diseases. The book’s final chapters cover nanoscience aspects of phenolic acids, biomedical applications, and concludes with challenges and opportunities presented by phenolic acids. This is the ideal reference for researchers in the fields of drug development, both in academia and corporate settings. Researchers of related areas like food science and medicinal chemistry will also benefit from this in-depth profiling of therapeutical properties of phenolic acids.

Progress and Prospect of Nanocarriers

1st Edition
May 6, 2024
Sushil K. Kashaw + 2 more
English
Paperback
9 7 8 0 1 2 8 1 9 9 7 9 4
eBook
9 7 8 0 3 2 3 9 0 3 1 1 0

Progress and Prospect of Nanocarriers: Design, Concept, and Recent Advances examines the different nanocarriers that are currently being developed for specific applications in biomedical drug delivery, disease management, diagnosis and therapy. Nanosized drug delivery systems have gained tremendous amounts of clinical interest due to their effective bio-distribution and enhanced pharmacokinetic and selective targeting capability which results in high therapeutic potential, low side effects, and the generation of cost-effective drug delivery systems. Numerous effective nanocarriers have been evolving, including polymeric nanoparticles, liposomes, microspheres, dendrimers, and carbon nanotubes.This book is a helpful reference for scientists and students in the fields of drug delivery, biomaterials and nanomedicine, as well as scientists and engineers in industrial disciplines of drug delivery and drug formulation.

Modulation of Oxidative Stress

1st Edition
August 4, 2023
Luciano Saso + 3 more
English
Paperback
9 7 8 0 4 4 3 1 9 2 4 7 0
eBook
9 7 8 0 4 4 3 1 9 2 4 8 7

Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer’s disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids. This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out.

Anti-Aging Pharmacology

1st Edition
December 7, 2022
Vitaly Koltover
English
Paperback
9 7 8 0 1 2 8 2 3 6 7 9 6
eBook
9 7 8 0 1 2 8 2 3 6 8 0 2

**Association of American Publishers (AAP) PROSE Award Finalist in Clinical Medicine, 2024**Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm.This book contains the work of the world’s leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice.

Discoveries in Pharmacology - Volume 1 - Nervous System and Hormones

2nd Edition
September 9, 2022
Clive Page + 2 more
English
Hardback
9 7 8 0 3 2 3 8 5 5 1 9 8
eBook
9 7 8 0 3 2 3 8 5 5 2 0 4

Discoveries in Pharmacology: Volume 1: Nervous system and hormones (2nd Ed.) presents selected articles from the historic Discoveries in Pharmacology series enhanced with commentary from contemporary scholars about the reception and importance of the chapter along with an updated bibliography on the subject with contributions from a Nobel Prize winner and other pioneers in Pharmacology. The Discoveries in Pharmacology series brought acknowledged experts in their fields together to provide first-hand accounts of important pharmacological discoveries discussing the scientific background and stories behind these pivotal moments. They allow a true understanding of the means by which pharmacological discoveries are made. This volume brings forth discussions on key discoveries in psycho- and neuro-pharmacology, haemodynamics, and hormones including chapters on antipsychotic agents by Nobel winner Anders Carlsson, Willy Haefely on benzodiazepine, and butyrophenone-type neuroleptics by P. A. J. Janssen and J. P. Tollenaere. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area will find this series a useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.

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