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Exosome Communication
Advances in Research and Therapeutics for Health and Disease
- 1st Edition - November 15, 2024
- Authors: Dilapathi Gugulothu, Dharmendra Kumar Khatri, Lalitkumar K. Vora, William C.S. Cho
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 9 0 5 2 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 9 0 5 3 - 4
Exosome Communication: Advances in Research and Therapeutics for Health and Disease is a reference tailored for pharmaceutical scientists and covers the key qualities of exosom… Read more
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Request a sales quoteExosome Communication: Advances in Research and Therapeutics for Health and Disease is a reference tailored for pharmaceutical scientists and covers the key qualities of exosomes as drug delivery vehicles. Exosomes are intracellular membrane-based vesicles with diverse compositions, offering advantages over other drug delivery systems like liposomes and polymeric nanoparticles due to their non-immunogenic nature. This book provides a comprehensive exploration of exosomes, starting with their history and development, understanding extracellular vesicles and biogenesis, and techniques for isolation and characterization. It also delves into cargo loading, release strategies, and their potential applications in diagnostics and various diseases, including antigen-specific delivery, gene delivery, and vaccine delivery, highlighting how engineering exosomes can enhance therapeutic efficacy. The book also addresses critical considerations like quality control, heterogeneity reduction, regulatory and ethical aspects, clinical trials, and scale-up manufacturing. By providing a comprehensive and detailed overview of exosome-based therapeutics' potential, "Exosome Communication: Advances in Research and Therapeutics for Health and Disease" serves as a valuable reference for those interested in exploring exosomes' applications in drug delivery and therapeutics.
1. Introduction: History and Development of Exosomes Nanovesicles
2. Exploring Extracellular Vesicles: Understanding Exosomes and Beyond
3. Exosome Isolation Techniques: Methods, Protocols, and Best Practices
4. Improving Cargo Loading and Release Strategies for Exosomes Nanovesicles
5. Exosome Characterization Techniques, Composition Analysis and Contents of Exosomes Nanovesicles: Methods and Interpretation
6. Quality Control, Minimizing Heterogeneity and Enhancing Yield in Exosome Isolation and Production
7. Inhibition of Cell-Cell Communication in Exosomes
8. Modifications of Exosomes Nanovesicles for Targeted drug delivery
9. Challenges for the Development of Exosome Nanovesicle-Based Formulations for Drug Delivery and Assessing Toxicity
10. Diagnostic Potential and Biomarkers Potential of Exosome Nanovesicles
11. Exosomes in Immunology
12. Exosomes in Protein and Peptide Delivery
13. Exosomes Nanovesicles in Antigen-Specific Antibody Delivery, Gene Delivery, and Vaccine Delivery
14. Theranostic Potential of Exosomes in Neurodegenerative Diseases
15. Exosomes in Cancer Therapeutic Delivery
16. Potential Role of Microbial-derived Exosomes in Human Health and Diseases
17. Current Applications of New Generations of Exosomes Nanovesicles
18. Clinical Trials and Translational Research in Exosome Nanovesicle Therapeutics
19. Scale-up and Manufacturing of Exosome-based Therapeutics
20. Regulatory and Ethical Considerations in Exosome-Based Therapeutics
2. Exploring Extracellular Vesicles: Understanding Exosomes and Beyond
3. Exosome Isolation Techniques: Methods, Protocols, and Best Practices
4. Improving Cargo Loading and Release Strategies for Exosomes Nanovesicles
5. Exosome Characterization Techniques, Composition Analysis and Contents of Exosomes Nanovesicles: Methods and Interpretation
6. Quality Control, Minimizing Heterogeneity and Enhancing Yield in Exosome Isolation and Production
7. Inhibition of Cell-Cell Communication in Exosomes
8. Modifications of Exosomes Nanovesicles for Targeted drug delivery
9. Challenges for the Development of Exosome Nanovesicle-Based Formulations for Drug Delivery and Assessing Toxicity
10. Diagnostic Potential and Biomarkers Potential of Exosome Nanovesicles
11. Exosomes in Immunology
12. Exosomes in Protein and Peptide Delivery
13. Exosomes Nanovesicles in Antigen-Specific Antibody Delivery, Gene Delivery, and Vaccine Delivery
14. Theranostic Potential of Exosomes in Neurodegenerative Diseases
15. Exosomes in Cancer Therapeutic Delivery
16. Potential Role of Microbial-derived Exosomes in Human Health and Diseases
17. Current Applications of New Generations of Exosomes Nanovesicles
18. Clinical Trials and Translational Research in Exosome Nanovesicle Therapeutics
19. Scale-up and Manufacturing of Exosome-based Therapeutics
20. Regulatory and Ethical Considerations in Exosome-Based Therapeutics
- No. of pages: 450
- Language: English
- Edition: 1
- Published: November 15, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780443290527
- eBook ISBN: 9780443290534
DG
Dilapathi Gugulothu
Dr. Gugulothu is an Assistant Professor in the Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, India. His doctoral dissertation work was in Pharmaceutics involved exploring nanotechnology in enhancing the biological activity of curcumin and ellagic acid independently or in combination with synthetic analogues in various diseases like malaria, diabetes, ulcerative colitis and H.pylori infection. Currently he is working on exploring natural mucilages as a pharmaceutical excipient for development of novel drug delivery systems for treatment of Parkinson’s disease and diabetes, Exosome delivery, nanofibers for drug delivery, functional Graphen oxide Nanoparticles for treatment of cancer. Furthermore, he is working on development of analytical methods for APIs.
Affiliations and expertise
Delhi Institute of Pharmaceutical Sciences and Research, IndiaDK
Dharmendra Kumar Khatri
Dr. Dharmendra Kumar Khatri is an Assistant Professor in the department of pharmacology & toxicology department at NIPER Hyderabad, India. The major research area of his interest is the elucidation of the pathogenic mechanism of Parkinson’s disease. Specifically, a multidisciplinary approach is employed to investigate the cellular and molecular mechanism underlying the pathogenic degeneration of specific neuronal populations in the PD brain and their theranostic potential. Drug screening of novel molecules isolated from plant sources or synthetic congeners, and targeted drug delivery systems for their neuroprotective and neuronal regeneration properties using animal and cellular models.
Affiliations and expertise
NIPER Hyderabad, indiaLV
Lalitkumar K. Vora
Dr. Lalitkumar K. Vora is a Lecturer at the School of Pharmacy, Queen’s University, Belfast, UK. He completed his PhD (Pharmaceutics) in 2017 from the Institute of Chemical Technology (ICT), Mumbai, and then he did postdoctoral research on microneedle technologies at Queen’s University. He has 150 international publications, 10 book chapters, and 2 granted patents. To date, he has presented over 120 peer-reviewed studies at various international conferences. His research interests include polymeric delivery for biologics, long-acting drug delivery, and microneedle-assisted noninvasive drug/vaccine delivery and diagnosis.
Affiliations and expertise
Lecturer, School of Pharmacy, Queen’s University, Belfast, UKWC
William C.S. Cho
William C.S. Cho, PhD, RCMP, FHKIMLS, FHKSMDS, Chartered Scientist (UK), FIBMS (UK). Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China. Dr. Cho’s primary research interests focus on cancer research to discover biomarkers for cancer diagnosis, treatment prediction, and prognosis. As a seasoned researcher, Dr. Cho has conducted cancer research using molecular biology, proteomics, genomics, immunology, bioinformatics, and next-generation sequencing technologies. Dr. Cho has published more than 600 peer-reviewed papers (Lancet, Lancet Oncology, Annals of Oncology, Lancet Gastroenterology & Hepatology, Advanced Science, Nature Communications, PNAS, Molecular Cancer, Journal of Thoracic Oncology, Journal of the National Cancer Institute, Journal of Extracellular Vesicles, Clinical Cancer Research, Clinical Chemistry, Theranostics, etc.) covering cancer biomarkers, proteomics, noncoding RNA, traditional Chinese medicine, and dozens of books (including An Omics Perspective on Cancer Research, MicroRNAs in Cancer Translational Research, Drug Repurposing in Cancer Therapy: Approaches and Applications, Supportive Cancer Care with Chinese Medicine, etc.). The cumulative impact factor of journals exceeds 4000, and the papers have been cited >25,000 times. Dr. Cho is listed among the top 2% of the most influential scientists in the world. In addition, Dr. Cho has served as a research grant reviewer for many international research funds, including the Hope Funds for Cancer Research (United States), Cancer Research (United Kingdom), National Medical Research Council (Singapore), etc.
Affiliations and expertise
Queen Elizabeth Hospital, Hong Kong