Advancement of Phenolic Acids in Drug Discovery
Fundamentals and Applications
- 1st Edition - June 19, 2024
- Editors: Naresh Kumar, Nidhi Goel, Jesus Simal Gandara
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 8 5 3 8 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 8 5 3 9 - 7
Advancement of Phenolic Acids in Drug Discovery: Fundamental and Applications offers comprehensive coverage of the ADMET profiles of phenolic acids, their extraction method an… Read more
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Request a sales quoteAdvancement of Phenolic Acids in Drug Discovery: Fundamental and Applications offers comprehensive coverage of the ADMET profiles of phenolic acids, their extraction method and prospects for drug design and development. Chapters overview phenolic acids and their characterization, discuss the role of phenolic acids in plant systems, present sources and detailed extraction methods of phenolic acids, and cover phenolic acid mechanisms of action as it relates to several key diseases and health conditions, including their role as antioxidant agents, anti-inflammatory and analgesic drugs, anti-microbial drugs, anti-viral drugs, anti-cancer drugs, diabetes and metabolic dysfunctions, neurological disorders, cardiovascular diseases. The book’s final chapters cover nanoscience aspects of phenolic acids, biomedical applications, and concludes with challenges and opportunities presented by phenolic acids. This is the ideal reference for researchers in the fields of drug development, both in academia and corporate settings. Researchers of related areas like food science and medicinal chemistry will also benefit from this in-depth profiling of therapeutical properties of phenolic acids.
- Highlights fundamental concepts with advanced exploration of phenolic acids
- Provides in-depth coverage on the design and development of novel drugs from natural phenolic acids
- Reviews the changing role of phenolic acids
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Chapter 1. Phenolic acids: a brief overview
- Abstract
- 1.1 Introduction
- 1.2 Biosynthesis and its regulation
- 1.3 Bioavailability and metabolism
- 1.4 Concluding remarks
- Acknowledgments
- References
- Chapter 2. Sources and extraction methods of phenolic acids
- Abstract
- 2.1 Introduction
- 2.2 Sources of phenolic acids
- 2.3 Classical and modern extraction methods
- 2.4 Factors affecting the extraction
- 2.5 Current scenario and future trends
- 2.6 Concluding remarks
- References
- Further reading
- Chapter 3. Role of phenolic acids in plant system
- Abstract
- 3.1 Introduction
- 3.2 Phenolic compounds
- 3.3 Biosynthesis of phenolic acids
- 3.4 Function of phenolic acids in plant system
- 3.5 Conclusions
- References
- Chapter 4A. Antioxidant methods, in vitro and in vivo studies of phenolic acids
- Abstract
- 4A.1 Introduction
- 4A.2 Relationship between structure-antioxidant activities of phenolic acids
- 4A.3 Commonly used methods for antioxidant potential of phenolic acids
- 4A.4 Antioxidant capacity of phenolic acids and extracts rich in phenolic acids
- 4A.5 Clinical studies
- 4A.6 Applications, future trends, and concluding remarks
- Acknowledgments
- References
- Chapter 4B. Phenolic acids as potent antioxidant agents
- Abstract
- 4B.1 Introduction
- 4B.2 Free radicals and oxidative stress
- 4B.3 Oxidative stress and diseases
- 4B.4 Antioxidant enzymes and their mechanisms
- 4B.5 Nonenzymatic antioxidants and their action mechanisms
- 4B.6 Antioxidant potential of phenolic acids
- 4B.7 Conclusion
- References
- Chapter 5. Progressive approach of phenolic acids toward the advancement of antimicrobial drugs
- Abstract
- 5.1 Background and introduction
- 5.2 Mechanism of antimicrobial action of phenolic acids
- 5.3 Phenolic acids toward the advancement of antimicrobial drugs
- 5.4 Enhancing phenolic acids use in antimicrobial drug development
- 5.5 New technologies for antimicrobial agents’ development
- 5.6 Antimicrobial use of phenolic acids and phenolic acid-rich extracts in other industries
- 5.7 Major challenges to the use of phenolic acids in antimicrobial drug development
- 5.8 Future perspectives and concluding remarks
- References
- Chapter 6. Promising role of phenolic acids as antimalarial and antiviral drugs
- Abstract
- 6.1 Introduction
- 6.2 Phenolic acids as potential antimalarial agents
- 6.3 Phenolic acids as potential antiviral agents
- 6.4 Conclusions
- References
- Chapter 7. Development of phenolic acids-based system as anticancer drugs
- Abstract
- 7.1 Introduction
- 7.2 Occurrence and intake of phenolic acids
- 7.3 Phenolic acids as anticancer agents
- 7.4 Drug delivery systems with phenolic acids
- 7.5 Conclusion and future perspective
- Acknowledgments
- Conflicts of interest
- References
- Chapter 8. Utility of phenolic acids in neurological disorders
- Abstract
- 8.1 Introduction
- 8.2 Phenolic acids action on nervous system population
- 8.3 Major activities of phenolic acids against neurological disorders
- 8.4 Integration of phenolic acids in neuroprotective drugs development process
- 8.5 Major strategies to enhance bioefficacy of phenolic acids as neuroprotectants
- 8.6 New perspective on the neuroprotective effects of phenolic acids
- 8.7 Conclusions
- References
- Chapter 9. Role of Aronia’s phenolic acids in the treatment of diabetes mellitus
- Abstract
- 9.1 Introduction
- 9.2 Botanical and genetic characteristics
- 9.3 Phytochemical composition
- 9.4 Antioxidant activity
- 9.5 What is diabetes mellitus?
- 9.6 Evaluation of the effects of Aronia anthocyanins on type 2 diabetes
- 9.7 Conclusions and future perspectives
- References
- Chapter 10. Role of phenolic acids in treatment and prevention of cardiovascular diseases
- Abstract
- 10.1 Introduction
- 10.2 Cardiovascular diseases, prevalence, risk factors, and physiopathology
- 10.3 Potential mechanisms involved in cardiovascular health benefits of phenolic acids
- 10.4 Bioavailability of phenolic acids and gut microbiota interactions
- 10.5 Evidence on cardiovascular effects of phenolic acids
- 10.6 Clinical trials
- 10.7 Conclusions and future perspectives
- Acknowledgments
- References
- Further reading
- Chapter 11. Development of phenolic acid–based nanoparticles and nanomedicines
- Abstract
- Abbreviations
- 11.1 Phenolic acids at a glance
- 11.2 Nanodelivery systems for phenolic acids encapsulation, protection, and delivery
- 11.3 Improving the properties of phenolic acids by means of encapsulation into biomaterials
- 11.4 Other useful aspects of phenolic acids: toward a sustainable and green trend in the synthesis of nanoparticles
- 11.5 Conclusions
- References
- Chapter 12. Valorization of phenolic compounds delivery through lactic acid fermentation of fruit and vegetable juices: innovations, challenges, and gaps
- Abstract
- 12.1 Introduction
- 12.2 Vegetable and fruits as sources of phenolic compounds
- 12.3 Lactic acid fermentation of juices from vegetables and fruits
- 12.4 Ameriolation of phenolic compounds production and bioavailability through lactic acid fermentation of fruits and vegetable juices
- 12.5 Challenges and gaps of phenolic delivery through lactic acid fermentation of vegetable and fruit juice
- References
- Chapter 13. Development of metal–phenolic acid network for biomedical usages
- Abstract
- 13.1 Introduction
- 13.2 Iron–phenolic acid complexes
- 13.3 Gold–phenolic acid complexes
- 13.4 Cobalt–phenolic acid complex
- 13.5 Silver–phenolic acid complexes
- 13.6 Copper–phenolic acid complexes
- 13.7 Future perspectives and conclusion
- References
- Chapter 14. Grand challenges and opportunities for phenolic acids
- Abstract
- 14.1 Introduction
- 14.2 Enhanced production and extraction of phenolic acids via plants
- 14.3 Enhanced production and extraction of phenolic acids via microorganisms
- 14.4 Increasing the bioavailability of phenolic acids
- 14.5 Ensuring the long-term preservation and stability improvement of phenolic acids
- 14.6 Conclusions
- Acknowledgments
- References
- Index
- No. of pages: 640
- Language: English
- Edition: 1
- Published: June 19, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780443185380
- eBook ISBN: 9780443185397
NK
Naresh Kumar
NG
Nidhi Goel
Dr. Nidhi Goel received her doctorate in Chemistry, Indian Institute of Technology Roorkee, India. After postdoctoral research from Indian Institute of Science Bangalore, Karnataka, India, she started her independent academic career as Assistant Professor, Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, India. Her research focuses on developing strategies, based on supramolecular building approaches, for rational construction of functional coordination polymers, Metal-Organic Frameworks and their prospective uses include magnetic, luminescence, and sensing applications. She is also working on drug design, medicinal chemistry natural products chemistry, and chemical biology. Dr. Goel has published more than fifty peer-reviewed research papers and book chapters in reputed international journals and books. She has 15 years research experience along with six years teaching experience at UG and PG level. She has been the Principal Investigator on three research projects from the Government of India. She is also a regular reviewer of a variety of international journals, and has also received several prestigious fellowships and research awards. Moreover, Dr. Goel is editing several books in CRC press Taylor & Francis group, Springer, and Elsevier. She is also acting as Guest Associate Editor in reputed journals.
JG