Advancement of Phenolic Acids in Drug Discovery

Fundamentals and Applications

1st Edition - June 19, 2024
Editors: Naresh Kumar, Nidhi Goel, Jesus Simal Gandara
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 5 3 8 - 0
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 5 3 9 - 7

Advancement of Phenolic Acids in Drug Discovery: Fundamental and Applications offers comprehensive coverage of the ADMET profiles of phenolic acids, their extraction method an… Read more

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Advancement of Phenolic Acids in Drug Discovery: Fundamental and Applications offers comprehensive coverage of the ADMET profiles of phenolic acids, their extraction method and prospects for drug design and development. Chapters overview phenolic acids and their characterization, discuss the role of phenolic acids in plant systems, present sources and detailed extraction methods of phenolic acids, and cover phenolic acid mechanisms of action as it relates to several key diseases and health conditions, including their role as antioxidant agents, anti-inflammatory and analgesic drugs, anti-microbial drugs, anti-viral drugs, anti-cancer drugs, diabetes and metabolic dysfunctions, neurological disorders, cardiovascular diseases. The book’s final chapters cover nanoscience aspects of phenolic acids, biomedical applications, and concludes with challenges and opportunities presented by phenolic acids. This is the ideal reference for researchers in the fields of drug development, both in academia and corporate settings. Researchers of related areas like food science and medicinal chemistry will also benefit from this in-depth profiling of therapeutical properties of phenolic acids.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Chapter 1. Phenolic acids: a brief overview
Abstract
1.1 Introduction
1.2 Biosynthesis and its regulation
1.3 Bioavailability and metabolism
1.4 Concluding remarks
Acknowledgments
References
Chapter 2. Sources and extraction methods of phenolic acids
Abstract
2.1 Introduction
2.2 Sources of phenolic acids
2.3 Classical and modern extraction methods
2.4 Factors affecting the extraction
2.5 Current scenario and future trends
2.6 Concluding remarks
References
Further reading
Chapter 3. Role of phenolic acids in plant system
Abstract
3.1 Introduction
3.2 Phenolic compounds
3.3 Biosynthesis of phenolic acids
3.4 Function of phenolic acids in plant system
3.5 Conclusions
References
Chapter 4A. Antioxidant methods, in vitro and in vivo studies of phenolic acids
Abstract
4A.1 Introduction
4A.2 Relationship between structure-antioxidant activities of phenolic acids
4A.3 Commonly used methods for antioxidant potential of phenolic acids
4A.4 Antioxidant capacity of phenolic acids and extracts rich in phenolic acids
4A.5 Clinical studies
4A.6 Applications, future trends, and concluding remarks
Acknowledgments
References
Chapter 4B. Phenolic acids as potent antioxidant agents
Abstract
4B.1 Introduction
4B.2 Free radicals and oxidative stress
4B.3 Oxidative stress and diseases
4B.4 Antioxidant enzymes and their mechanisms
4B.5 Nonenzymatic antioxidants and their action mechanisms
4B.6 Antioxidant potential of phenolic acids
4B.7 Conclusion
References
Chapter 5. Progressive approach of phenolic acids toward the advancement of antimicrobial drugs
Abstract
5.1 Background and introduction
5.2 Mechanism of antimicrobial action of phenolic acids
5.3 Phenolic acids toward the advancement of antimicrobial drugs
5.4 Enhancing phenolic acids use in antimicrobial drug development
5.5 New technologies for antimicrobial agents’ development
5.6 Antimicrobial use of phenolic acids and phenolic acid-rich extracts in other industries
5.7 Major challenges to the use of phenolic acids in antimicrobial drug development
5.8 Future perspectives and concluding remarks
References
Chapter 6. Promising role of phenolic acids as antimalarial and antiviral drugs
Abstract
6.1 Introduction
6.2 Phenolic acids as potential antimalarial agents
6.3 Phenolic acids as potential antiviral agents
6.4 Conclusions
References
Chapter 7. Development of phenolic acids-based system as anticancer drugs
Abstract
7.1 Introduction
7.2 Occurrence and intake of phenolic acids
7.3 Phenolic acids as anticancer agents
7.4 Drug delivery systems with phenolic acids
7.5 Conclusion and future perspective
Acknowledgments
Conflicts of interest
References
Chapter 8. Utility of phenolic acids in neurological disorders
Abstract
8.1 Introduction
8.2 Phenolic acids action on nervous system population
8.3 Major activities of phenolic acids against neurological disorders
8.4 Integration of phenolic acids in neuroprotective drugs development process
8.5 Major strategies to enhance bioefficacy of phenolic acids as neuroprotectants
8.6 New perspective on the neuroprotective effects of phenolic acids
8.7 Conclusions
References
Chapter 9. Role of Aronia’s phenolic acids in the treatment of diabetes mellitus
Abstract
9.1 Introduction
9.2 Botanical and genetic characteristics
9.3 Phytochemical composition
9.4 Antioxidant activity
9.5 What is diabetes mellitus?
9.6 Evaluation of the effects of Aronia anthocyanins on type 2 diabetes
9.7 Conclusions and future perspectives
References
Chapter 10. Role of phenolic acids in treatment and prevention of cardiovascular diseases
Abstract
10.1 Introduction
10.2 Cardiovascular diseases, prevalence, risk factors, and physiopathology
10.3 Potential mechanisms involved in cardiovascular health benefits of phenolic acids
10.4 Bioavailability of phenolic acids and gut microbiota interactions
10.5 Evidence on cardiovascular effects of phenolic acids
10.6 Clinical trials
10.7 Conclusions and future perspectives
Acknowledgments
References
Further reading
Chapter 11. Development of phenolic acid–based nanoparticles and nanomedicines
Abstract
Abbreviations
11.1 Phenolic acids at a glance
11.2 Nanodelivery systems for phenolic acids encapsulation, protection, and delivery
11.3 Improving the properties of phenolic acids by means of encapsulation into biomaterials
11.4 Other useful aspects of phenolic acids: toward a sustainable and green trend in the synthesis of nanoparticles
11.5 Conclusions
References
Chapter 12. Valorization of phenolic compounds delivery through lactic acid fermentation of fruit and vegetable juices: innovations, challenges, and gaps
Abstract
12.1 Introduction
12.2 Vegetable and fruits as sources of phenolic compounds
12.3 Lactic acid fermentation of juices from vegetables and fruits
12.4 Ameriolation of phenolic compounds production and bioavailability through lactic acid fermentation of fruits and vegetable juices
12.5 Challenges and gaps of phenolic delivery through lactic acid fermentation of vegetable and fruit juice
References
Chapter 13. Development of metal–phenolic acid network for biomedical usages
Abstract
13.1 Introduction
13.2 Iron–phenolic acid complexes
13.3 Gold–phenolic acid complexes
13.4 Cobalt–phenolic acid complex
13.5 Silver–phenolic acid complexes
13.6 Copper–phenolic acid complexes
13.7 Future perspectives and conclusion
References
Chapter 14. Grand challenges and opportunities for phenolic acids
Abstract
14.1 Introduction
14.2 Enhanced production and extraction of phenolic acids via plants
14.3 Enhanced production and extraction of phenolic acids via microorganisms
14.4 Increasing the bioavailability of phenolic acids
14.5 Ensuring the long-term preservation and stability improvement of phenolic acids
14.6 Conclusions
Acknowledgments
References
Index

Naresh Kumar

Dr. Naresh Kumar has earned his master’s and doctorate degrees in biotechnology from Himachal Pradesh University, Shimla and Indian Institute of Technology Roorkee, respectively. He has 6 years of postdoctoral experience at Indian Institute of Technology Roorkee and Indian Institute of Technology Indore. Dr. Kumar is currently working as an assistant professor at the Department of Biochemistry, Deshbandhu College, University of Delhi, Kalkaji, New Delhi, India. His current research focuses on natural products, chemical biology, computational biology, and drug discovery. With more than 12 years of research and 2 years of teaching experience, he is supervising several doctoral students. He contributed signi cantly to 21 peer-reviewed publications (his citations: >2200, h-index: 13, i10: 16) in addition to several invited book chapters with reputed international publishers. Dr. Kumar is editing books for Elsevier, Springer Nature, and Bentham Science. He also regularly reviews scienti c articles for a variety of international publishers. He has also received many prestigious fellowships and research awards.

Affiliations and expertise

Assistant professor at the Department of Biochemistry, Deshbandhu College, University of Delhi, Kalkaji, New Delhi, India.

Nidhi Goel

Dr. Nidhi Goel received her doctorate in Chemistry, Indian Institute of Technology Roorkee, India. After postdoctoral research from Indian Institute of Science Bangalore, Karnataka, India, she started her independent academic career as Assistant Professor, Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, India. Her research focuses on developing strategies, based on supramolecular building approaches, for rational construction of functional coordination polymers, Metal-Organic Frameworks and their prospective uses include magnetic, luminescence, and sensing applications. She is also working on drug design, medicinal chemistry natural products chemistry, and chemical biology. Dr. Goel has published more than fifty peer-reviewed research papers and book chapters in reputed international journals and books. She has 15 years research experience along with six years teaching experience at UG and PG level. She has been the Principal Investigator on three research projects from the Government of India. She is also a regular reviewer of a variety of international journals, and has also received several prestigious fellowships and research awards. Moreover, Dr. Goel is editing several books in CRC press Taylor & Francis group, Springer, and Elsevier. She is also acting as Guest Associate Editor in reputed journals.

Affiliations and expertise

Assistant Professor, Department of Chemistry, Institute of Science, Banaras Hindu University, Uttar Pradesh, India

Jesus Simal Gandara

Jesus Simal-Gandara is Full Prof in Nutrition and Food Science at the Faculty of Food Science and Technology, University of Vigo (Spain). He is Corresponding Member of the Royal Academy of Medicine and Surgery of Galicia (1991), Member of the Scientific Committee of the Spanish Agency for Consumption, Food Safety and Nutrition (2013-2016), Research Medal of the Royal Galician Academy of Sciences 2020 Antonio Casares Rodriguez (Chemistry and Geology), President of the International Association of Dietary Nutrition and Safety (2020), Full Member of the Royal Academy of Pharmacy of Galicia (2021), and Associate Editor in Food Science and Nutrition (Wiley) and Food Chemistry (Elsevier). He leads a research group of excellence, and was leading CIA3 - Environmental, Agricultural and Food Research Center (2008-2018). He was the Head of the Department of Analytical Chemistry and Food Science (2013-2018), and Vice-Chancellor for Internationalization at the University of Vigo (2018).

Affiliations and expertise

Professor in Nutrition and Food Science, Faculty of Food Science and Technology, University of Vigo, Spain

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Advancement of Phenolic Acids in Drug Discovery

Fundamentals and Applications

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Institutional subscription on ScienceDirect

Naresh Kumar

Nidhi Goel

Jesus Simal Gandara