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Drug Metabolism in Diseases
Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development
- 2nd Edition - October 1, 2025
- Editor: Wen Xie
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 9 2 8 9 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 9 2 9 0 - 3
Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development, now in second edition, provides pharmaceutical scient… Read more
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Request a sales quoteDrug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development, now in second edition, provides pharmaceutical scientists and biologists with the needed foundational knowledge required to understand the interplay between diseases and physiological conditions, how they impact drug metabolism and disposition, and its implications in personalized treatment. The book has been expanded with six new chapters, and completely updated with the scientific findings since the first edition published in 2016. The new chapters in the book cover drug metabolism in metabolic syndrome , transplant patients, geriatric patients, the developmental regulation of drug metabolism and disposition, the effect of gut microbiota on xenobiotic and endobiotic metabolism, the regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways, and drug metabolism in HIV patients. All other chapters in the first edition like drug metabolism in pregnancy, pediatric patients, patients of cardiovascular disease, and kidney diseases were completely updated to include the latest research results and references. Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development is a comprehensive reference on the mutual effect between drug metabolism and diseases, which has great implications in precision medicine and therapeutic development. Pharmaceutical scientists and drug metabolism researchers in academia and corporate R&D departments will benefit from the expanded coverage provided by expert authors. Research physicians interested in better understand the impact of diseases in drug metabolism will also benefit from the comprehensive overview of the area.
- Provides a comprehensive overview of how diseases and physiological conditions impact drug metabolism and disposition and its implications in personalized treatment
- Provides insights into leveraging drug metabolizing enzymes and transporters as therapeutic targets
- Includes six new chapters and updates across all content to provide a current and updated view on this rapidly evolving research topic
Academia basic science researchers who study drug metabolism and disposition; Pharmaceutical industry researchers who want to have a comprehensive understanding of drug absorption, distribution, metabolism, and excretion (ADME)
1. Introduction of drug metabolism and overview of disease effects on drug metabolism
2. Regulation of drug metabolizing enzymes by inflammation
3. Regulation of drug transporters by inflammation
4. Drug metabolism in metabolic syndrome
5. Drug metabolism in transplant patients
6. Drug metabolism in kidney diseases
7. Drug and fatty acid cytochrome P450 metabolism in critical care
8. Drug metabolism in patients of cardiovascular disease
9. Drug metabolism In pediatric patients
10. Drug metabolism in geriatric patients
11. Drug metabolism in pregnancy
12. Developmental regulation of drug metabolism and disposition
13. Effect of gut microbiota on xenobiotic and endobiotic metabolism
14. Regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways
15. Drug metabolism in HIV patients
16. Estrogen sulfotransferase in mediating disease-drug interactions, a case study
17. Xenobiotic receptors in the crosstalk between drug metabolism and energy metabolism
2. Regulation of drug metabolizing enzymes by inflammation
3. Regulation of drug transporters by inflammation
4. Drug metabolism in metabolic syndrome
5. Drug metabolism in transplant patients
6. Drug metabolism in kidney diseases
7. Drug and fatty acid cytochrome P450 metabolism in critical care
8. Drug metabolism in patients of cardiovascular disease
9. Drug metabolism In pediatric patients
10. Drug metabolism in geriatric patients
11. Drug metabolism in pregnancy
12. Developmental regulation of drug metabolism and disposition
13. Effect of gut microbiota on xenobiotic and endobiotic metabolism
14. Regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways
15. Drug metabolism in HIV patients
16. Estrogen sulfotransferase in mediating disease-drug interactions, a case study
17. Xenobiotic receptors in the crosstalk between drug metabolism and energy metabolism
- No. of pages: 450
- Language: English
- Edition: 2
- Published: October 1, 2025
- Imprint: Academic Press
- Hardback ISBN: 9780443292897
- eBook ISBN: 9780443292903
WX
Wen Xie
Professor of Pharmaceutical Sciences and Pharmacology, The Joseph Koslow Endowed Chair in Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA; Director of the Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
Affiliations and expertise
Professor of Pharmaceutical Sciences and Pharmacology, The Joseph Koslow Endowed Chair in Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA; Director of the Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA