Drug Metabolism in Diseases
Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development
- 2nd Edition - October 1, 2025
- Imprint: Academic Press
- Editor: Wen Xie
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 9 2 8 9 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 9 2 9 0 - 3
Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development, Second Edition provides essential knowledge for pharma… Read more
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Request a sales quoteDrug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development, Second Edition provides essential knowledge for pharmaceutical scientists and biologists to understand the interplay between diseases and physiological conditions, impacting drug metabolism and its implications in personalized treatment. Expanded with six new chapters since the first edition, this updated book covers the latest scientific findings. Other important points include the book’s comprehensive reference on mutual effects between drug metabolism and diseases, implications in precision medicine, and therapeutic development. Pharmaceutical scientists, drug metabolism researchers, and research physicians will benefit from the expert insights provided.
- Provides a comprehensive overview of how diseases and physiological conditions impact drug metabolism and disposition
- Presents insights into leveraging drug metabolizing enzymes and transporters as therapeutic targets
- Updates across all content to provide a current and updated view on this rapidly evolving research topic
Academia basic science researchers who study drug metabolism and disposition; Pharmaceutical industry researchers who want to have a comprehensive understanding of drug absorption, distribution, metabolism, and excretion (ADME)
1. Introduction of drug metabolism and overview of disease effects on drug metabolism
2. Regulation of drug metabolizing enzymes by inflammation
3. Regulation of drug transporters by inflammation
4. Drug metabolism in metabolic syndrome
5. Drug metabolism in transplant patients
6. Drug metabolism in kidney diseases
7. Drug and fatty acid cytochrome P450 metabolism in critical care
8. Drug metabolism in patients of cardiovascular disease
9. Drug metabolism In pediatric patients
10. Drug metabolism in geriatric patients
11. Drug metabolism in pregnancy
12. Developmental regulation of drug metabolism and disposition
13. Effect of gut microbiota on xenobiotic and endobiotic metabolism
14. Regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways
15. Drug metabolism in HIV patients
16. Estrogen sulfotransferase in mediating disease-drug interactions, a case study
17. Xenobiotic receptors in the crosstalk between drug metabolism and energy metabolism
2. Regulation of drug metabolizing enzymes by inflammation
3. Regulation of drug transporters by inflammation
4. Drug metabolism in metabolic syndrome
5. Drug metabolism in transplant patients
6. Drug metabolism in kidney diseases
7. Drug and fatty acid cytochrome P450 metabolism in critical care
8. Drug metabolism in patients of cardiovascular disease
9. Drug metabolism In pediatric patients
10. Drug metabolism in geriatric patients
11. Drug metabolism in pregnancy
12. Developmental regulation of drug metabolism and disposition
13. Effect of gut microbiota on xenobiotic and endobiotic metabolism
14. Regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways
15. Drug metabolism in HIV patients
16. Estrogen sulfotransferase in mediating disease-drug interactions, a case study
17. Xenobiotic receptors in the crosstalk between drug metabolism and energy metabolism
- Edition: 2
- Published: October 1, 2025
- Imprint: Academic Press
- No. of pages: 450
- Language: English
- Hardback ISBN: 9780443292897
- eBook ISBN: 9780443292903
WX
Wen Xie
Professor of Pharmaceutical Sciences and Pharmacology, The Joseph Koslow Endowed Chair in Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA; Director of the Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
Affiliations and expertise
Professor of Pharmaceutical Sciences and Pharmacology, The Joseph Koslow Endowed Chair in Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA; Director of the Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA