Modulation of Oxidative Stress
Biochemical, Physiological and Pharmacological Aspects
- 1st Edition - August 4, 2023
- Imprint: Academic Press
- Editors: Luciano Saso, Alessandro Giuffre, Giuseppe Valacchi, Mauro Maccarrone
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 2 4 7 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 2 4 8 - 7
Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biologica… Read more
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Request a sales quoteModulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer’s disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids.
This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out.
- Provides the latest updates in the fast-developing field of REDOX biochemistry and pharmacology
- Presents content that is clear and easy to read
- Useful for researchers and instructors in many fields
Pharmacology, Pharmaceutical sciences, and Biochemistry researchers at PhD level and above
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1. Antioxidants as modulators of the ubiquitin–proteasome system against aging and proteinopathies
- Introduction
- Proteasome in aging and proteinopathies
- Antioxidants that affect proteasome function
- Concluding remarks
- Chapter 2. Cysteine thiol modifications—Oxidative (eu)stress perspective
- Introduction
- Cysteines: The archetypal regulatory amino acid
- The interplay between cysteine PTMs and oxidative stress—Protective or detrimental?
- S-oxidation
- S-glutathionylation
- S-nitrosation
- S-sulfenylation/persulfidation
- Modulation of cellular processes in response to oxidative stress
- Conclusions
- Abbreviations
- Chapter 3. Regulation of NRF2 signaling pathway and the hallmarks of aging: An overview
- Introduction
- NRF2 and KEAP1 structures and pathways
- NRF2 signaling in redox homeostasis and inflammation
- NRF2 and the hallmarks of aging
- NRF2 modulators
- Conclusions
- Chapter 4. Fluid redox biomarkers in neurological disease
- Introduction
- Redox biomarkers
- Alzheimer's disease
- Vascular dementia
- Parkinson's disease
- Concluding remarks
- Chapter 5. CCM proteins are key players in redox signaling and oxidative stress regulation in Cerebral Cavernous Malformations
- Introduction
- CCM proteins regulate redox signaling and oxidative stress in CCM
- Therapeutic perspectives
- Concluding remarks
- Chapter 6. The effect of maternal and early-life nutrition on redox homeostasis
- Introduction
- Oxidative stress signaling and embryonic development
- Maternal nutrition and the chronic disorders in later life
- Maternal undernutrition, intrauterine growth restriction, and redox homeostasis
- Maternal overnutrition and redox homeostasis
- Maternal nutrition, epigenetics, and oxidative stress
- Maternal iron and oxidative stress
- Concluding remarks
- Chapter 7. Mitochondria-associated membranes (MAMs) as modulators of oxidative stress in Alzheimer disease
- Introduction
- Structure and function of mitochondria-associated membranes
- MAMs and ROS production
- Alzheimer disease, oxidative stress, and MAMs
- MAMs as therapeutic target in AD
- Concluding remarks
- Abbreviations
- Chapter 8. Oxidative stress biomarkers in human health and disease
- Introduction
- Reactive oxygen species and oxidative stress
- Oxidative stress biomarkers
- Oxidative stress biomarkers and the mechanism of human diseases
- Conclusion and perspectives
- Chapter 9. Modulation of the antioxidant defense system against pathophysiological redox imbalance in cardiovascular diseases
- Introduction
- Modulation of the antioxidant defense system components
- Cardiovascular diseases and oxidative stress-related settings
- Concluding remarks
- Chapter 10. Modulation of cancer cell proliferation by interfering with metabolic ROS production
- Introduction
- Metabolic sources of ROS in cancer
- Signaling-linked sources of ROS in cancer
- ROS and glucose metabolism in cancer
- ROS and lipid metabolism in cancer
- ROS and amino acid metabolism in cancer
- Concluding remarks
- Chapter 11. Modulation of human hydrogen sulfide metabolism by physiological effectors
- Hydrogen sulfide in human pathophysiology
- Cellular targets of hydrogen sulfide
- Modulation of oxidative stress by hydrogen sulfide
- Hydrogen sulfide metabolism in human disease
- Modulation of H2S metabolism by physiological effectors
- Crosstalk between gasotransmitters and impact on oxidative stress
- Abbreviations
- Chapter 12. Intestinal redox regulation and inflammatory bowel disease
- Introduction
- Pathophysiology of IBD and its relation to redox disturbance
- Reactive species and their formation in the normal intestine
- Antioxidant mechanisms in the intestine
- Gene regulation of antioxidant systems
- Redox balance impacts the differentiation and proliferation of IECs
- Ferroptosis of IECs in IBD
- Mucus as an important component of the intestinal barrier
- Pharmaceutical modulation of oxidative stress in the treatment of IBD
- Concluding remarks
- Chapter 13. Applications of plant-derived products in photodynamic therapy
- Introduction
- Photodynamic therapy
- Plant-derived products in anticancer PDT
- Plant-derived products in aPDT
- Conclusion
- Chapter 14. Hopes and disappointments related to the use of flavonoids in therapeutical approaches
- Introduction—Antioxidant activities of flavonoids and beyond
- Flavonoids as anticancer compounds
- Antibacterial and antiviral effects of flavonoids
- The potential use of flavonoids in neurodegenerative diseases
- The case of the use of genistein in mucopolysaccharidoses
- Concluding remarks
- Chapter 15. Omega-3 nutritional intervention as therapeutic co-adjuvant approach to improve Rett syndrome clinical and biochemical features
- Introduction
- Rett syndrome: A multisystem pathology with genetic cause
- Rett syndrome: From gene therapy challenges to co-adjuvants of current therapeutic strategies
- Omega-3 polyunsaturated fatty acids
- The yin and yang of n-3 PUFAs
- n-3 PUFAs in Rett syndrome
- Concluding remarks
- Key terms
- Chapter 16. A glance on antioxidants: The role of sulfur amino acids in retinal disorders
- Retina and oxidative stress
- Oxidative stress and retinal diseases
- Sulfur-containing amino acids and impacts on oxidative stress in the retina
- Therapeutic approaches and effects with sulfur amino acids in retinal diseases
- Conclusions
- Chapter 17. Oxidative stress and antioxidant-based therapies in male infertility
- Introduction
- The role of oxidative/nitrosative stress and the ROS paradox
- Treatment of male infertility with antioxidant vitamins
- Concluding remarks
- Chapter 18. Modulation of oxidative stress in psoriasis: Pathophysiology and therapy
- Inflammation and redox balance/imbalance
- Lipid mediators in psoriasis
- Protein modifications and their consequences in psoriasis
- Medical and experimental treatment of psoriasis
- Lifestyle in psoriasis prevention
- Index
- Edition: 1
- Published: August 4, 2023
- No. of pages (Paperback): 306
- No. of pages (eBook): 390
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443192470
- eBook ISBN: 9780443192487
LS
Luciano Saso
Prof. Luciano Saso is a Professor of Pharmacology of the Faculty of Pharmacy and Medicine of Sapienza University of Rome, Italy. He is author of more than 350 original scientific articles published in peer reviewed international journals mainly in the field of pharmacological modulation of oxidative stress (H-index Google Scholar 62). He coordinated several international research projects and has been referee for many national and international funding agencies and international scientific journals in the last 25 years and he has been Editor and Guest Editor of Special Issues of different international journals.
Affiliations and expertise
Full Professor, Faculty of Pharmacy and Medicine, Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, ItalyAG
Alessandro Giuffre
Prof. Alessandro Giuffrè is a Senior Researcher of the National Research Council of Italy (Consiglio Nazionale delle Ricerche - CNR). Since 2020 he is Director of the CNR Institute of Molecular Biology and Pathology (IBPM) in Rome. Since he was awarded his PhD in Biochemistry in 1997, he has investigated the molecular mechanisms underlying the metabolism of O2, nitric oxide (NO), hydrogen sulfide (H2S) and related reactive species, with the ultimate goal of elucidating the role of these molecules in human physiology and pathophysiology. His research has focused on a variety of microbial and human enzymes and their ability to metabolize O2, NO and related species, as well as on the effects of NO on cellular bioenergetics. More recently his interests have extended also to H2S, another important small gaseous molecule with a key role in cell signaling. Currently, he has signed 95 articles in peer-reviewed International journals, with more than 3.500 citations.
Affiliations and expertise
Director, Institute of Molecular Biology and Pathology National Research Council, Rome, ItalyGV
Giuseppe Valacchi
Dr. Valacchi has been interested in evaluating the effect of exogenous and endogenous sources of oxidative stress on target organs, such as skin, GI tract and lung, and the signal pathways involved in the cellular responses to these insults with special focus on epithelial wound healing. In addition, he aims to study how new topical approaches (derived from natural and synthetic compounds) can ameliorate wound healing and tissue regeneration in both physiological and pathological situations. In the last 10 years he has also been pursuing research involved in understanding the role of oxidative stress in a rare disease, Rett Syndrome, defined as a neurodevelopment pathology, and in the aging processes and how dietary intervention can improve the clinical feature.
Affiliations and expertise
Professor, Regenerative Medicine, Department of Animal Science, North Carolina State University, USAMM
Mauro Maccarrone
Dr. Maccarrone is Professor and Chair of Biochemistry at the Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila (Italy). He is also Head of the Lipid Neurochemistry Unit at the European Center for Brain Research – IRCCS Santa Lucia Foundation, Rome. For his research activity he has received the “4th Royan International Research Award for Reproductive Biomedicine” (2003), the “2007 IACM Award for Basic Research”, the “2016 Mechoulam Award”, and the “2020 Tu Youyou Award”. Chair of the 2015 Gordon Research Conference on “Cannabinoid Function in the CNS”. Visiting Professor at Leiden University (Leiden Institute of Chemistry, The Netherlands) in 2017. Faculty member of The Lambert Center for the Study of Medicinal Cannabis and Hemp at Thomas Jefferson University in Philadelphia, since 2019. Visiting Professor at Cambridge University (Department of Psychology, U.K.) in 2019. Published more than 510 full papers, of which 60 with I.F. ≥ 9. He is listed among the Top Italian Scientists.
Affiliations and expertise
Professor and Chair of Biochemistry, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, ItalyRead Modulation of Oxidative Stress on ScienceDirect