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TRP Channels as Therapeutic Targets

Advances in Basic Science and Clinical Use

  • 2nd Edition - August 22, 2024
  • Latest edition
  • Editor: Arpad Szallasi
  • Language: English

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. C… Read more

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Description

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. Chapters are completely updated, withe new topics on TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation. This is a great reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline will also find this book helpful for biologic principles of action.

Key features

  • Presents the perspectives of several life science research specialties on the topic
  • Provides a comprehensive picture of the TRP field, from TRP channel dysfunction through TRP drug discovery and development to clinical trials and everyday medical practice
  • Represents an updated and complete reference

Readership

Research and development scientists in the pharmaceutical industry. Clinicians interested in new drugs in the pipeline

Table of contents

1. A brief introduction to trp channel biology

2. The crystal structure of trp channels: implications for drug discovery

3. TRP channel dysfunction in hereditary diseases ("TRP channelopathies")

4. Altered trp channel expression in acquired disease

5. TRP gene polymorphism and disease risk

6. Targeting trpv1 channels for pain relief

7. Trpa1 antagonists for pain relief

8. TRP channels and migraine

9. Emerging pain targets: trpm and trpc channels

10. Trp channels in bladder disorders

11. TRP channels in respiratory diseases

12. TRP channels: emerging targets in covid and its complications

13. TRP channels and cerebrovascular diseases

14. Targeting TRP channels for relief from itch

15. TRP channels in dermatological disorders

16. TRP channels in hypertension

17. TRP channels in diabetes, obesity, and metabolic syndrome

18. TRP channels cardiovascular disease

19. TRP channels and digestive disease

20. TRP channels and cancer

21. TRP channels for anxiety relief and for improving mental health

22. TRP channels and neurodegenerative disorders

23. Mucolipidosis

24. TRP channels and renal disease

25. TRP channels and arthritis

26. TRP channels and thermoregulation: therapeutic opportunities

Review quotes

"...a comprehensive, current overview of the TRP channel field, especially in the context of pathologies in which TRP channels could be involved, and consequently, their potential as targets for therapeutic intervention....The book would best serve an audience with advanced degrees in biomedical research and drug discovery....The editor is widely published on the subject of TRP channels and is a recognized expert in the field....Includes excellent chapters on structural insights into TRP channel function gained from recent advances in the use of cryogenic EM, clear explanation of the biophysics behind the thermal regulation of several TRP channels, and what genomics has to say about the potential for TRP channels as therapeutic targets....[It] is the most recent, and it contains useful information not available in the other books." ©Doody's Book Review Service, 2025, R. Kyle Palmer, PhD (Opertech Bio)

Product details

  • Edition: 2
  • Latest edition
  • Published: August 23, 2024
  • Language: English

About the editor

AS

Arpad Szallasi

Arpad Szallasi is a leading expert on the roles of TRP channels in health and disease. He was the first to provide a biochemical proof for the existence of the vanilloid (capsaicin) receptor, now known as TRPV1. Currently, he holds a Professor position at the 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary. His research focuses on targeting of TRP channels for therapeutic purposes, with special emphasis on pain and inflammation. Arpad Szallasi obtained his MD degree Summa cum Laude from the Medical University School of Debrecen, Hungary (1984). He received his PhD degree in Pharmacology from the Karolinska Institute, Stockholm, Sweden (1995). Arpad Szallasi held several research positions both in academia (Karolinska Institute, Washington University, St. Louis, MO) and industry (Menarini Ricerche Sud, Pomezia, Italy) before pursuing a carrier in diagnostic pathology. Arpad Szallasi is a past President for the New Jersey Association of Blood Bank Professional and a former medical advisor to the American Red Cross.
Affiliations and expertise
Professor, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary

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