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Books in Life sciences

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    • AI Technologies for Crop Breeding

      • 1st Edition
      • Jen-Tsung Chen
      • English
      AI Technologies for Crop Breeding offers the latest insights into the use of artificial intelligence models to improve plant health and production. Presenting applications of AI technologies in plant biology, biotechnology, and crop breeding, it explores practices for the mitigation of biotic and abiotic stressors as well as other plant growth challenges.AI-based technologies are expected to advance approaches to plant functional genomics and multiple omics, resulting in smarter and more efficient crop breeding for next-generation agriculture helping to address the challenges of the increasing human population and the globally changing climate. AI tools such as machine learning, particularly deep learning, have been applied to predict chief players in complicated biological networks, increasing the understanding of in-depth mechanisms of plant-pathogen and plant-environment interactions. Additionally, responses of plants facing stress can be modeled using AI technologies, and the resulting data are valuable not only to plant stress physiology but also for stress-resilient and disease-resistant crop breeding.This book introduces AI technologies for studying plant biology, focusing on machine learning and deep learning models for integrating multiple omics approaches and revealing the knowledge of plant functional genomes. Technological advancements and emerging applications of machine learning and deep learning in genomic selection, genome-wide association study (GWAS), phenotyping and constructing phenomics, and transcriptomics are also featured in this book.AI Technologies for Crop Breeding is an ideal reference for researchers, academics, and advanced-level students and professors in the fields of plant sciences, plant stress physiology, bioinformatics, systems biology, and crop breeding.

    • Advances in Immunology

      • 1st Edition
      • Volume 167
      • English
      Advances in Immunology, Volume 167, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Chapters in this new release include Recent Advances in Antifungal Immunity, Neuroimmunology beyond the CNS: nerve-macrophage interactions in peripheral tissues, Regulatory T cell functions in peripheral tissues, Alarmins in mucosal tissues and how they regulate health and disease, Ontogeny and function of microglia and nerve-associated macrophages, and Modulation of humoral immunity by γδ T cells.

    • Ketamine

      Fundamentals, Applications, Pharmacology, and Clinical Aspects
      • 1st Edition
      • Albert Dahan + 1 more
      • English
      Pharmacology of Ketamine: Fundamentals, Applications, Delivery Systems and Clinical Aspects explores the multifaceted properties of ketamine for diverse applications, delving into dosing strategies, routes of administration, and their pharmacological implications. The book begins with an introduction that underscores the need to bridge research and practice. It then delves into the pharmacological intricacies of ketamine, dissecting mechanisms and dosing strategies and exploring the diverse routes of administration and their impact on ketamine's metabolites.The book then explores the PK and PD characteristics of ketamine, followed by a deep dive into clinical applications emphasizing anesthesia, psychiatric therapy, and emerging treatments. The final part of the book covers addiction, toxicity, and future research perspectives. It will serve as a comprehensive reference tailored to the needs of both researchers and clinicians involved in the administration and study of ketamine.

    • Data-Driven Diagnostics and Disease Prediction with AI Optimization

      • 1st Edition
      • Shailendra Pratap Singh + 3 more
      • English
      Data-Driven Diagnostics and Disease Prediction with AI Optimization provides useful insights into model creation, data preparation, and ethical issues for healthcare applications. The book covers all the conventional and non-conventional methods related to this domain. It also discusses AI-based optimization techniques, Machine Learning models, and Advanced AI, offering practical insights, case studies, and optimization strategies to help data scientists and researchers efficiently employ AI in diagnostics and illness prediction in a world where precise diagnostics and early illness prediction may save lives and healthcare resources.

    • Artificial Metalloproteins

      • 1st Edition
      • Volume 720
      • English
      Artificial Metalloproteins covers artificial metalloproteins (ArMs) and how they have emerged as powerful vehicles with which to control, implement, and leverage the unique reactivity and spectroscopic properties of their bound metal ions. Chapters in this release include Incorporating Non-Native Cofactors into Heme Proteins, Designing 4-Helix Bundles to Bind Porphyrin/Porphyrin-... Cofactors, Cobalt-Substituted Hemoprotein Expression, Rationally designed directed evolution of cytochrome P450 enzymes, De novo design of a switchable a-helical hemoprotein, Primary Coordination Sphere Part B: Unnatural Metal-Binding Sites Beyond the Heme, and more.Other sections cover Unnatural Amino Acid Incorporation for Creating Artificial Metalloenzymes, Development of a PQQ-Dependent Artificial Metalloprotein, Evolutionary Engineering of a Rhodium Complex-Linked Artificial Metalloenzyme, Design and Application of Nonheme Iron Enzymes, Part C: Secondary Sphere Modulation for Metallocofactor Activation, Designing Artificial Metalloenzymes by Engineering the Primary and Secondary Coordination Sphere in Native Protein Scaffolds, and much more.

    • Advances in Clinical Chemistry

      • 1st Edition
      • Volume 129
      • English
      Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

    • Fungal and Protozoan Carbonic Anhydrases

      • 1st Edition
      • Volume 57
      • English
      Fungal and Protozoan Carbonic Anhydrases, Volume 57 in The Enzymes series, explores recent advancements in the study of fungal and protozoan carbonic anhydrases (CAs). This volume presents a comprehensive collection of chapters covering various aspects of these enzymes, including an overview of fungal and protozoan CAs (genetics, molecular biology, and phylogenetics), the structure and function of fungal α-carbonic anhydrases, and an in-depth look at β-carbonic anhydrases in Saccharomyces cerevisiae, Candida spp., and Cryptococcus neoformans.Additiona... chapters delve into the Malassezia spp. and Sordaria macrospora CAs, as well as protozoan CAs from Plasmodium falciparum, Trypanosoma cruzi, Leishmania spp., Toxoplasma gondii, and Entamoeba histolytica. The volume also addresses the challenges in developing selective fungal and protozoal CA inhibitors as anti-infective agents, providing insights into their potential biomedical applications.

    • Advanced Cancer Research Protocols

      • 1st Edition
      • Volume 198
      • English
      Advanced Cancer Research Protocols, Volume 198 is a comprehensive and cutting-edge resource dedicated to the latest methodologies and protocols in the field of cancer research. Topics in this new release include Introduction to Cancer Biology and Current Research Trends, Cell Culture Techniques for Cancer Research, Practical Approaches to Advanced Molecular Biology Techniques, High-throughput sequencing Technologies for Cancer Genomics, Epigenetic Analysis in Cancer Research, Proteomics and Metabolomics in Cancer Biomarker Discovery, In vivo Cancer Modeling Using Mouse Models, and much more.Other sections highlight advances in Advanced Imaging Techniques for Cancer Research, Cancer Stem Cell Analysis and Targeting, Immunotherapy and Cancer Vaccine Development, Gene Editing Techniques in Cancer Research, Single-Cell Analysis in Cancer Research, Liquid Biopsy and Circulating Tumor Cell Analysis, and Exploring the Tumor Microenvironment in Solid Cancer: From Biology to Therapy.

    • Fundamentals of Brain Organoids for Neurological Diseases

      • 1st Edition
      • Balachandar Vellingiri + 1 more
      • English
      Researchers use brain organoids to study the formation of neural tissues, investigate the processes involved in brain development, and gain a better understanding of neurological disorders and diseases. Brain organoids are particularly useful in studying developmental disorders, neurodegenerative diseases, and infectious diseases that affect the brain. Fundamental of Brain Organoids for Neurological Diseases provides a practical resource for researchers on how to utilize and apply brain organoids. This book is organized into nine distinct sections, guiding the reader through each step from advanced overview of what organoids are to the use of brain organoids in various neurodevelopmental disorders and neurodegenerative diseases. In later sections, this book reviews the necessary methods involved in organoid development including the elements and challenges involved. This book will serve as a valuable tool for researchers, helping to advance the understanding of brain biology and disease mechanisms.

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