Handbook of Gastrointestinal Motility and Disorders of Gut-Brain Interactions

2nd Edition - June 20, 2023
Editors: Satish S.C. Rao, Henry Parkman, Richard McCallum
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 9 1 1 - 6
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 9 1 0 - 9

Handbook of Gastrointestinal Motility and Disorders of Gut-Brain Interactions, Second Edition fills the void in GI literature for a short and concise go-to book for disorders… Read more

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Handbook of Gastrointestinal Motility and Disorders of Gut-Brain Interactions, Second Edition fills the void in GI literature for a short and concise go-to book for disorders of GI motility and gut and brain interactions. This exceptionally illustrated reference contains all the information needed for the latest knowledge on adults as well as adolescent and pediatric GI motility disorders, each systematically arranged by disorder and gut anatomy for easy reference. Each chapter includes extensive color pictures of each test as well as descriptions of how to perform and interpret the motility tests and how to incorporate them into patient care decisions.

Current advances in the field have led the way for new updates. A new section dedicated to systemic disorders and special topics, including gut autonomic disorders, cannabis and the gut, eating disorders, pediatric and adolescent disorders, nutritional therapies, and psychological management is included. This is the perfect book for those who encounter the common problems of dysphagia, heartburn, nausea, vomiting, gastroparesis, abdominal pain, gas and bloating, irritable bowel syndrome, constipation, and fecal incontinence and rare disorders in daily practice, including practicing physicians, gastroenterologists, motility laboratory personnel, surgeons and internists

Cover
Title page
Table of Contents
Copyright
Dedication
Contributors
About the editors
Foreword
Preface
Acknowledgments
Section A: Esophageal disorders
Chapter 1: Understanding esophageal symptoms: Dysphagia, heartburn, and chest pain
Abstract
Conflict of interest
Introduction
Obstructive symptoms
Perceptive symptoms
Functional esophageal disorders
Conclusion
Board-style questions
References
Chapter 2: Gastroesophageal reflux disease (GERD)
Abstract
Financial support
Conflict of interest
Definition/symptoms
Epidemiology
Pathophysiology of GERD
Lower esophageal sphincter, the antireflux barrier
Gastroesophageal reflux mechanisms
Pathogenesis of symptoms in GERD
Diagnostic and treatment strategies of GERD
PPI-resistant GERD
Role of reflux inhibitors in the treatment of reflux disease
Conclusion
Questions for GERD chapter by Dr. Mittal
Key questions
References
Chapter 3: Achalasia and esophagogastric junction outflow obstruction
Abstract
Definition
Epidemiology
Pathophysiology
Diagnosis
Treatment
Summary of treatment and follow-up
Conclusions
Questions
References
Chapter 4: Esophageal spasm and hypercontractile motility disorders
Abstract
Introduction
Distal esophageal spasm
Hypercontractile esophagus
Conclusions
Questions and answers
References
Chapter 5: Oropharyngeal dysphagia and cricopharyngeal disorders
Abstract
Background
Swallowing mechanisms
Swallowing control
Swallowing musculature
Presentation
Diagnosis
Management
Conclusions
Questions
Answers
References
Chapter 6: Esophageal hypersensitivity
Abstract
Definition
Hypersensitivity in esophageal disorders
Epidemiology
Pathophysiology
Diagnosis
Clinical presentation
Treatment
Multiple choice questions
References
Section B: Gastric disorders
Chapter 7: Understanding symptoms of gastric dysmotility: Nausea, vomiting, abdominal pain, postprandial fullness, and early satiety
Abstract
Introduction
Nausea and vomiting
Abdominal pain
Postprandial fullness and early satiety
Bloating and abdominal distention
Other signs and symptoms associated with gastric dysmotility
Conclusion
Board-style questions
References
Chapter 8: Gastroparesis
Abstract
Definition
Epidemiology
Pathophysiology
Proteomics and RNA expression studies
Diagnosis
Treatment
Evaluation and treatment algorithms
Board review questions
References
Chapter 9: Functional dyspepsia
Abstract
Definitions
Epidemiology
Pathophysiology
Treatment
Conclusion
MCQ
References
Chapter 10: Dumping syndrome
Abstract
Disclosures
Introduction
Symptoms
Epidemiology
Pathophysiology of dumping syndrome
Differential diagnosis
Diagnosis
Treatment modalities
Addendum
Conclusions
MCQ
References
Chapter 11: Cyclic vomiting syndrome and cannabinoid hyperemesis syndrome
Abstract
Introduction
History and epidemiology
Clinical features
Pathophysiology
Diagnosis
Treatment
Conclusion
“Board review” questions
References
Chapter 12: Rumination syndrome
Abstract
Definition
Introduction
Epidemiology
Pathophysiology
Diagnosis
Treatment
Conclusion
Questions
References
Section C: Small intestinal disorders
Chapter 13: Understanding small intestinal dysmotility symptoms: Bloating, distension, and gas
Abstract
Grant support
Disclosures
Bloating, distension, and gas: Definitions
Epidemiology and general clinical features
Pathophysiology
Diagnosis
Treatment
Conclusion
Questions
References
Chapter 14: Chronic intestinal pseudo-obstruction
Abstract
Introduction
Epidemiology
Etiology
Clinical presentation
Diagnosis
Diagnostic evaluation of chronic intestinal pseudo-obstruction
Treatment
Conclusion
Review questions
References
Chapter 15: Intestinal bacterial, fungal, and methanogen overgrowth
Abstract
Introduction
Diagnosis of SIBO, IMO and SIFO
Management of bacterial, archaeal, and fungal overgrowth
Conclusions
Questions
References
Chapter 16: Food intolerances
Abstract
Definition/symptoms
Board review style questions (3-5 MCQ) with answers
References
Section D: Colonic and anorectal disorders
Chapter 17: Understanding colonic symptoms: Constipation, diarrhea, and fecal incontinence
Abstract
Introduction
Constipation
Diarrhea
Fecal incontinence
Constipation
Chronic Diarrhea
Fecal incontinence
References
Chapter 18: Irritable bowel syndrome
Abstract
Overview
Pathophysiology
Diagnosis
Epidemiology
Treatment
Questions for IBS
References
Chapter 19: Chronic constipation
Abstract
Introduction
Definition/symptoms
Epidemiology
Pathophysiology
Diagnosis
Treatment
Fiber supplementation
Osmotic and stimulant laxatives
Prescription medications
5-HT4 agonists
Future treatments
Conclusions
MCQ’s
References
Chapter 20: Dyssynergic defecation and constipation
Abstract
Definition
Epidemiology
Economic cost
Psychological impact
Etiology
Pathophysiology
Diagnosis
Management of dyssynergic defecation
Practice questions
References
Chapter 21: Fecal incontinence
Abstract
Definition and presenting symptoms
Epidemiology and risk factors
Physiology of continence
Etiology and pathophysiology of fecal incontinence
Clinical evaluation
Diagnostic testing
Management
Conclusions
MCQs—Fecal Incontinence, Chapter 21—S. Mark Scott, PhD, Henriette Heinrich, PD Dr. Med
References
Chapter 22: Anorectal disorders: Fecal impaction, structural disorders of the pelvic floor and anorectal pain syndromes
Abstract
Introduction
Fecal impaction
Structural disorders of the pelvic floor (e.g., rectocele, rectal prolapse and descending perineum syndrome)
Anorectal pain syndromes
Board review style questions
References
Section E: Systemic disorders and special topics
Chapter 23: Diabetes and the gut
Abstract
Introduction
Esophagus
Stomach
Small and large intestine
Conclusion
Review questions
References
Chapter 24: Neurology and the gut: Autonomic neuropathy and dysautonomia
Abstract
Introduction
Autonomic innervation of the gut
Disorders of gastrointestinal dysautonomia
Overview of diabetes and DAN
Parkinson's disease (PD)
Postural orthostatic tachycardia syndrome (POTS)
Conclusion
Multiple choice questions
References
Chapter 25: Scleroderma, Ehlers-Danlos syndrome and other rheumatological conditions and the gut
Abstract
Scleroderma
Ehlers-Danlos syndrome
Other rheumatological diseases
Review questions
References
Chapter 26: Opioid-induced bowel disorder and narcotic bowel syndrome
Abstract
Introduction
Opioid-induced bowel disorders
Narcotic bowel syndrome
Opioid-induced constipation: Multiple choice questions
References
Chapter 27: Cannabis and the GI tract
Abstract
Introduction
Cannabis plant: species, strains, and route of use
Endocannabinoid system and the GI tract
Food intake and obesity
Nausea and vomiting
Functional chest pain
Irritable bowel syndrome
Inflammatory bowel disease
Nonalcoholic fatty liver disease (NAFLD) and fibrosis in chronic liver disease
Cannabis and pancreatic diseases
Conclusions and future directions
MCQs
References
Chapter 28: Eating disorders: Understanding their symptoms, mechanisms, and relevance to gastrointestinal functional and motility disorders
Abstract
Definition/symptoms
Pathophysiology
Diagnosis
Treatment
Conclusion
Review questions
References
Chapter 29: Pediatric and adolescent GI motility disorders and management
Abstract
Introduction
Gastroesophageal reflux disease (GERD)
Gastroparesis
Cyclic vomiting syndrome
Rumination syndrome
Functional abdominal pain disorders
Pediatric intestinal pseudo-obstruction
Pathogenesis
Functional constipation
Questions
References
Chapter 30: Nutritional therapies for GI motility disorders
Abstract
Heartburn and gastroesophageal reflux disease (GERD)
Gastroparesis
Functional bowel disorders
Summary
MCQs
References
Chapter 31: Centrally mediated abdominal pain syndrome: Causes and treatments
Abstract
Introduction
Diagnostic criteria
Epidemiology
Pathophysiology
Conclusion
Multiple-choice questions
References
Chapter 32: Psychological evaluation and treatment of gastrointestinal motility and functional disorders: Including cognitive behavioral therapy
Abstract
Introduction
Biopsychosocial conceptualization
Psychological evaluation
Psychological treatment
Conclusion
Questions
References
Index

Satish S.C. Rao

Dr. Rao is professor at Georgia Regents University as well as chief of Gastroenterology/Hepatology and founding director of the Digestive Health Center and the GI Service Line. He is leading an initiative to expand the university’s capabilities in treating digestive disorders that includes a new Digestive Health Center and neurogastroenterology and motility suite. He is working with colleagues in surgery, urology, otolaryngology, and neurology to create a model system of interdisciplinary care for GI motility patients. Dr. Rao is past president of the American Neurogastroenterology and Motility Society. He received the 3 highest honors from the American Gastroenterological Association: The Distinguished Clinician Award, the Masters Award for Outstanding Clinical Research, and the Distinguished Educator Award. He received the Auxiliary Research Award from the American College of Gastroenterology and several international awards for his research and teaching. He is cochair of AGA Council on Neurogastroenterology and GI Motility.

Affiliations and expertise

J . Harold Harrison MD, Distinguished University Chair in Gastroenterology, Professor of Medicine and Director, Neurogastroenterology/Motility, Director, Digestive Health Clinical Research Center, Medical College of Georgia, Augusta University, Augusta, GA, USA

Henry Parkman

Dr. Parkman has been actively involved in studying GI motility at Temple University School of Medicine at the basic science and clinical levels. His clinical focus has been treating patients with GI motility disorders. Clinically, Dr. Parkman oversees the GI Motility Laboratory. His clinical laboratory has developed expertise in a comprehensive array of GI motility tests for clinical evaluation of patients. Dr. Parkman was funded for 10 years with an NIH K24 Midcareer Investigator Award in Patient-Oriented Research where he mentored young investigators in clinical research. Dr. Parkman is currently a funded member of the NIH Gastroparesis Clinical Research Consortium. During his presidency of the American Neurogastroenterological and Motility Society, Dr. Parkman helped standardize the radionuclide gastric emptying study resulting in a standardized test. He remains active with an initiative to develop a patient-reported outcome (PRO) for gastroparesis that meets the approval of the Food and Drug Administration (FDA).

Affiliations and expertise

Stanley Lorber Chair in Gastroenterology Professor of Medicine, Director, GI Motility Laboratory, Gastroenterology Section, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States Vice Chair of Research, Department of Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States

Richard McCallum

Dr. McCallum is a professor and founding chairman of the Department of Internal Medicine, Texas Tech University Health Sciences Center. He also serves as director of the Center for Neurogastroenterology and GI Motility and Functional Bowel Disorders. He is a pioneer in gut electrophysiology and developed the concept of electrical “pacing” of the stomach to treat gastroparesis and nausea and vomiting, particularly related to diabetes mellitus. He has contributed to major advances in understanding and management of cyclic vomiting syndrome in adults, “dumping syndrome,” and rumination syndrome and has revolutionized the field of gastroparesis and functional dyspepsia by developing and reporting a new technique to non-surgically obtain gastric smooth muscle tissue by endoscopic ultrasound biopsy. Dr. McCallum was recently awarded funding from the International Foundation for Functional Gastrointestinal Diseases (IFFDG) to study a new therapy, transcutaneous electrical stimulation, in patients with nausea, vomiting, and idiopathic gastroparesis.

Affiliations and expertise

Professor of Medicine and Founding Chair, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas, Director of GI Research and Director of the Center for Neurogastroenterology and GI Motility, Gastroenterology/Hepatology and Nutrition, Honorary Professor, University of Queensland, Brisbane, Australia

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Handbook of Gastrointestinal Motility and Disorders of Gut-Brain Interactions

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Institutional subscription on ScienceDirect

Satish S.C. Rao

Henry Parkman

Richard McCallum