Senescence, Senotherapeutics and Mitochondria

1st Edition, Volume 136 - July 10, 2023
Editors: Ufuk Cakatay, Mehmet Can Atayik
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 8 8 6 - 2
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 8 8 7 - 9

Senescence, Senotherapeutics and Mitochondria, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implicati… Read more

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Senescence, Senotherapeutics and Mitochondria, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions, Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives, Mitochondria in cell senescence: Friend or Foe?, The role of mitochondria and mitophagy in cell senescence, Small molecules targeting mitochondrial dysfunction for potential senotheraputics, Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Mitochondrial targeting peptides and probes, Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases, and much more.

Other sections cover Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, Melatonin as mitochondria-targeted drugs, Coenzyme Q-related compounds to maintain healthy mitochondria during aging, Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics, and more.

Cover image
Title page
Table of Contents
Advances in PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY
Copyright
Contributors
Preface
References
Chapter One: Cellular senescence in aging: Molecular basis, implications and therapeutic interventions
Abstract
1 Introduction
2 Cellular senescence
3 Molecular basis of senescence
4 Features of senescence
5 Implications of senescence in development, physiology and aging
6 Organelle crosstalk contributes to cellular senescence
7 Targeting senescent cells
8 Conclusions
Acknowledgment
References
Further reading
Chapter Two: Mitochondria in cell senescence: A Friend or Foe
Abstract
Abbreviations
1 Cell senescence and physiological/pathophysiological roles
2 Mitochondrial morphology and metabolic reprograming in cell senescence
3 Mitochondrial reform in the cell senescence
4 Mitochondria-targeted senotherapies
5 Conclusion
References
Chapter Three: The role of mitochondria and mitophagy in cell senescence
Abstract
1 Introduction
2 Cell Senescence
3 Autophagy and Senescence
4 Autophagy and Metabolic Diseases
5 Mitophagy and Senescence
6 Mitophagy and Diseases
7 Cross Talk between Key players
References
Chapter Four: Mitochondria-associated cellular senescence mechanisms: Biochemical and pharmacological perspectives
Abstract
1 Prologue
2 Biochemical aspect of mitochondria-related senescence
3 Pharmacological aspect of mitochondria-related senescence
4 TPP-based (lipophilic cation-linked) mitochondria targeted compounds
5 TPP-free mitochondria-targeted antioxidant compounds
6 Mitochondria-targeted cardiolipin penetrating peptides
7 Mitochondria-targeted signal peptides
8 Mitochondria targeted vesicular nanocarrier systems
9 Mitochondria targeted BCL-2 family protein inhibitors
10 Mitochondria-targeted biguanides
11 Facilitative membrane transport
12 Conclusion and future perspectives
References
Chapter Five: Changing ROS, NAD and AMP: A path to longevity via mitochondrial therapeutics
Abstract
1 Role of mitochondria in senescence regulation
2 Life-extending interventions that affect mitochondrial metabolism
3 Ambiguities associated with senotherapeutics that affect mitochondria
4 Conclusions and perspectives
References
Chapter Six: Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases
Abstract
1 Introduction
2 MDPs in skeletal muscle and ageing
3 MDPs in ageing-associated neurodegenerative diseases and cognition
4 Conclusion and future perspectives
References
Chapter Seven: Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction
Abstract
1 Introduction
2 Types of senescence caused by mitochondria dysfunction
3 Senotherapeutics
4 Senolytics
5 Senomorphics
6 Geroprotectors and other senotherapeutics
7 Conclusion and future perspectives
Acknowledgments
References
Chapter Eight: Melatonin as mitochondria-targeted drug
Abstract
1 Introduction
2 Melatonin synthesis in mitochondria and associations with diseases
3 Physiological effects of melatonin
4 Melatonin: a mitochondrial targeting molecule
5 Conclusions
Conflicts of interest
References
Chapter Nine: Coenzyme Q-related compounds to maintain healthy mitochondria during aging
Abstract
1 Introduction: the key role of mitochondria in aging
2 Two main roles for CoQ in mitochondrial homeostasis
3 Deficiency in CoQ leads to mitochondrial dysfunction
4 The high hydrophobicity of CoQ10, a problem for its transport and distribution
5 Structure and antioxidant function of CoQ and mitochondrial targeted CoQ-related compounds
6 Antiaging effects of CoQ-related compounds
7 Conclusions
References
Chapter Ten: Targeting mitochondrial dysfunction to salvage cellular senescence for managing neurodegeneration
Abstract
1 Introduction
2 Cellular senescence
3 Cell senescence signaling pathway
4 The link between senescence and mitochondrial dysfunction
5 Senescence in neurodegenerative diseases
6 Pharmacologically targeting mitochondria in neurodegenerative diseases
7 Conclusion
References
Chapter Eleven: Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics
Abstract
1 Introduction
2 The concept of pathophysiological pleiotropy
3 Pathophysiological pleiotropy – a fundamental principle of senescence
4 Neurodegeneration from the perspective of pathophysiological pleiotropy and cellular senescence
5 Gut in neurodegeneration – a broader scope of the EPC network in neurodegeneration
6 Microbiota-mitochondria crosstalk
7 Microbiota-mitochondria crosstalk in the context of cellular senescence
8 Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics
9 Conclusion
References
Chapter Twelve: Therapeutic targeting of mitochondria–proteostasis axis by antioxidant polysaccharides in neurodegeneration
Abstract
Abbreviations
1 Introduction
2 Regulation of mitochondrial pathways by antineurodegenerative polysaccharides
3 Regulation of proteostasis pathways by antineurodegenerative polysaccharides
4 Targeting mitochondria–proteostasis axis as a strategy against neurodegeneration
5 Conclusions
Acknowledgments
References
Chapter Thirteen: Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders
Abstract
1 Severity and causes of neurodegenerative disorders
2 Factors influencing neurodegenerative diseases
3 Hypertension
4 Cerebrovascular blood flow
5 Cerebral metabolism
6 Mitochondrial function
7 Mitochondrial metabolic modifications associated with senescence
8 Exploring mitochondrial dysfunctions in aging-related neurodegenerative disorders
9 Mitochondrial defects in Alzheimer’s disease
10 Mitochondrial dysfunction in Parkinson’s disease
11 Mitochondrial alteration leads to a progression of Huntington’s disease
12 Function of mitochondria in Amyotrophic lateral sclerosis
13 Applications of natural compounds in common neurodegenerative disorders
14 Phytocompounds in clinical trials for neurodegenerative disorders
15 Strategies to improve mitochondrial activity in neurodegenerative disorder
16 Conclusion
References

Ufuk Cakatay

Ufuk Çakatay (May 09, 1965 –) is a Turkish biochemist and biogerontologist. He is a full professor of medical biochemistry at Istanbul-University Cerrahpaşa in Istanbul, Turkey. He has a long-standing interest in oxidative protein damage, redox signaling, and biomarkers of proteostasis. Much less is known about the relationship between redox signaling events and senescent cells. However, it has been shown that the number of senescent cells in many tissues increases with age and that senescent cells are found in various age-related diseases. The development of experimental animal models for age-related disorders and the optimization of various bioanalytical techniques for the assessment of redox status in aging tissue are among his major research interests. Professor Çakatay has authored more than 100 publications in several leading journals, including research papers, book chapters, editorials, and invited reviews on free radical biology, aging, diabetes, redox signaling, and senotherapeutics. He has been a guest editor, reviewer, and editorial board member for more than 50 journals. In addition, Professor Çakatay has a keen interest in mentoring medical students and promoting their research careers. He has received several prestigious awards, including the Top Reviewer Award from Elsevier Science Publishing, and was a former member of the Animal Research and Ethics Committee of Istanbul University.

Affiliations and expertise

Cerrahpasa Faculty of Medicine, Department of Medical Biochemistry, Istanbul University-Cerrahpasa, Istanbul, Turkey

Mehmet Can Atayik

Dr. Atayik is currently working in the Department of General Surgery at Hacettepe University Faculty of Medicine. He has been working as a scientist and researcher with Prof. Ufuk Çakatay since 2017. His research interests are in the fields of aging, age-related disorders, redox biology, oncogenetics, melatonin, mitochondria, surgical advances, and developing novel techniques for modern surgery. Dr. Atayik has conducted clinical research and experimental studies. He has published many scientific papers, such as research papers, narrative reviews, and book chapters, and has worked as an author, referee, editorial assistant, and guest editor, and editor in many prominent publishing houses. He was awarded the Young Investigator Presentation Prize at the VIII. International Congress of Molecular Medicine, which was held in Istanbul, Turkey, in November 2021.

Affiliations and expertise

Scientist and Researcher, Department of General Surgery, Hacettepe University Faculty of Medicine

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health