Senescence, Senotherapeutics and Mitochondria
- 1st Edition, Volume 136 - July 10, 2023
- Imprint: Academic Press
- Editors: Ufuk Cakatay, Mehmet Can Atayik
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 8 8 8 6 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 8 8 8 7 - 9
Senescence, Senotherapeutics and Mitochondria, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implicati… Read more
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Request a sales quoteSenescence, Senotherapeutics and Mitochondria, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions, Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives, Mitochondria in cell senescence: Friend or Foe?, The role of mitochondria and mitophagy in cell senescence, Small molecules targeting mitochondrial dysfunction for potential senotheraputics, Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Mitochondrial targeting peptides and probes, Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases, and much more.
Other sections cover Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, Melatonin as mitochondria-targeted drugs, Coenzyme Q-related compounds to maintain healthy mitochondria during aging, Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics, and more.
- Updates on how mitochondria are closely related to the survival of senescent cells using either mitochondria-targeted senolytic or redox modulator senomorphic strategies
- Differentiates itself from other books with its multidisciplinary perspectives and multidimensional clinical approaches
- Offers a novel perspective on both the basic and clinical sciences for a wide group of well-established academicians, students and researchers in medicinal chemistry, gerontology, geriatrics, oncology, pharmacology, pathology, bioinformatics, sports science and nutritional sciences
Well-established academicians and students and researchers in medicinal chemistry, gerontology, geriatrics, oncology, pharmacology, pathology, bioinformatics, sports science, and nutritional sciences
- Cover image
- Title page
- Table of Contents
- Advances in PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY
- Copyright
- Contributors
- Preface
- References
- Chapter One: Cellular senescence in aging: Molecular basis, implications and therapeutic interventions
- Abstract
- 1 Introduction
- 2 Cellular senescence
- 3 Molecular basis of senescence
- 4 Features of senescence
- 5 Implications of senescence in development, physiology and aging
- 6 Organelle crosstalk contributes to cellular senescence
- 7 Targeting senescent cells
- 8 Conclusions
- Acknowledgment
- References
- Further reading
- Chapter Two: Mitochondria in cell senescence: A Friend or Foe
- Abstract
- Abbreviations
- 1 Cell senescence and physiological/pathophysiological roles
- 2 Mitochondrial morphology and metabolic reprograming in cell senescence
- 3 Mitochondrial reform in the cell senescence
- 4 Mitochondria-targeted senotherapies
- 5 Conclusion
- References
- Chapter Three: The role of mitochondria and mitophagy in cell senescence
- Abstract
- 1 Introduction
- 2 Cell Senescence
- 3 Autophagy and Senescence
- 4 Autophagy and Metabolic Diseases
- 5 Mitophagy and Senescence
- 6 Mitophagy and Diseases
- 7 Cross Talk between Key players
- References
- Chapter Four: Mitochondria-associated cellular senescence mechanisms: Biochemical and pharmacological perspectives
- Abstract
- 1 Prologue
- 2 Biochemical aspect of mitochondria-related senescence
- 3 Pharmacological aspect of mitochondria-related senescence
- 4 TPP-based (lipophilic cation-linked) mitochondria targeted compounds
- 5 TPP-free mitochondria-targeted antioxidant compounds
- 6 Mitochondria-targeted cardiolipin penetrating peptides
- 7 Mitochondria-targeted signal peptides
- 8 Mitochondria targeted vesicular nanocarrier systems
- 9 Mitochondria targeted BCL-2 family protein inhibitors
- 10 Mitochondria-targeted biguanides
- 11 Facilitative membrane transport
- 12 Conclusion and future perspectives
- References
- Chapter Five: Changing ROS, NAD and AMP: A path to longevity via mitochondrial therapeutics
- Abstract
- 1 Role of mitochondria in senescence regulation
- 2 Life-extending interventions that affect mitochondrial metabolism
- 3 Ambiguities associated with senotherapeutics that affect mitochondria
- 4 Conclusions and perspectives
- References
- Chapter Six: Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases
- Abstract
- 1 Introduction
- 2 MDPs in skeletal muscle and ageing
- 3 MDPs in ageing-associated neurodegenerative diseases and cognition
- 4 Conclusion and future perspectives
- References
- Chapter Seven: Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction
- Abstract
- 1 Introduction
- 2 Types of senescence caused by mitochondria dysfunction
- 3 Senotherapeutics
- 4 Senolytics
- 5 Senomorphics
- 6 Geroprotectors and other senotherapeutics
- 7 Conclusion and future perspectives
- Acknowledgments
- References
- Chapter Eight: Melatonin as mitochondria-targeted drug
- Abstract
- 1 Introduction
- 2 Melatonin synthesis in mitochondria and associations with diseases
- 3 Physiological effects of melatonin
- 4 Melatonin: a mitochondrial targeting molecule
- 5 Conclusions
- Conflicts of interest
- References
- Chapter Nine: Coenzyme Q-related compounds to maintain healthy mitochondria during aging
- Abstract
- 1 Introduction: the key role of mitochondria in aging
- 2 Two main roles for CoQ in mitochondrial homeostasis
- 3 Deficiency in CoQ leads to mitochondrial dysfunction
- 4 The high hydrophobicity of CoQ10, a problem for its transport and distribution
- 5 Structure and antioxidant function of CoQ and mitochondrial targeted CoQ-related compounds
- 6 Antiaging effects of CoQ-related compounds
- 7 Conclusions
- References
- Chapter Ten: Targeting mitochondrial dysfunction to salvage cellular senescence for managing neurodegeneration
- Abstract
- 1 Introduction
- 2 Cellular senescence
- 3 Cell senescence signaling pathway
- 4 The link between senescence and mitochondrial dysfunction
- 5 Senescence in neurodegenerative diseases
- 6 Pharmacologically targeting mitochondria in neurodegenerative diseases
- 7 Conclusion
- References
- Chapter Eleven: Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics
- Abstract
- 1 Introduction
- 2 The concept of pathophysiological pleiotropy
- 3 Pathophysiological pleiotropy – a fundamental principle of senescence
- 4 Neurodegeneration from the perspective of pathophysiological pleiotropy and cellular senescence
- 5 Gut in neurodegeneration – a broader scope of the EPC network in neurodegeneration
- 6 Microbiota-mitochondria crosstalk
- 7 Microbiota-mitochondria crosstalk in the context of cellular senescence
- 8 Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics
- 9 Conclusion
- References
- Chapter Twelve: Therapeutic targeting of mitochondria–proteostasis axis by antioxidant polysaccharides in neurodegeneration
- Abstract
- Abbreviations
- 1 Introduction
- 2 Regulation of mitochondrial pathways by antineurodegenerative polysaccharides
- 3 Regulation of proteostasis pathways by antineurodegenerative polysaccharides
- 4 Targeting mitochondria–proteostasis axis as a strategy against neurodegeneration
- 5 Conclusions
- Acknowledgments
- References
- Chapter Thirteen: Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders
- Abstract
- 1 Severity and causes of neurodegenerative disorders
- 2 Factors influencing neurodegenerative diseases
- 3 Hypertension
- 4 Cerebrovascular blood flow
- 5 Cerebral metabolism
- 6 Mitochondrial function
- 7 Mitochondrial metabolic modifications associated with senescence
- 8 Exploring mitochondrial dysfunctions in aging-related neurodegenerative disorders
- 9 Mitochondrial defects in Alzheimer’s disease
- 10 Mitochondrial dysfunction in Parkinson’s disease
- 11 Mitochondrial alteration leads to a progression of Huntington’s disease
- 12 Function of mitochondria in Amyotrophic lateral sclerosis
- 13 Applications of natural compounds in common neurodegenerative disorders
- 14 Phytocompounds in clinical trials for neurodegenerative disorders
- 15 Strategies to improve mitochondrial activity in neurodegenerative disorder
- 16 Conclusion
- References
- Edition: 1
- Volume: 136
- Published: July 10, 2023
- No. of pages (Hardback): 468
- No. of pages (eBook): 304
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443188862
- eBook ISBN: 9780443188879
UC
Ufuk Cakatay
Ufuk Çakatay (May 09, 1965 –) is a Turkish biochemist and biogerontologist. He is a full professor of medical biochemistry at Istanbul-University Cerrahpaşa in Istanbul, Turkey. He has a long-standing interest in oxidative protein damage, redox signaling, and biomarkers of proteostasis. Much less is known about the relationship between redox signaling events and senescent cells. However, it has been shown that the number of senescent cells in many tissues increases with age and that senescent cells are found in various age-related diseases. The development of experimental animal models for age-related disorders and the optimization of various bioanalytical techniques for the assessment of redox status in aging tissue are among his major research interests. Professor Çakatay has authored more than 100 publications in several leading journals, including research papers, book chapters, editorials, and invited reviews on free radical biology, aging, diabetes, redox signaling, and senotherapeutics. He has been a guest editor, reviewer, and editorial board member for more than 50 journals. In addition, Professor Çakatay has a keen interest in mentoring medical students and promoting their research careers. He has received several prestigious awards, including the Top Reviewer Award from Elsevier Science Publishing, and was a former member of the Animal Research and Ethics Committee of Istanbul University.
Affiliations and expertise
Cerrahpasa Faculty of Medicine, Department of Medical Biochemistry, Istanbul University-Cerrahpasa, Istanbul, TurkeyMC
Mehmet Can Atayik
Dr. Atayik is currently working in the Department of General Surgery at Hacettepe University Faculty of Medicine. He has been working as a scientist and researcher with Prof. Ufuk Çakatay since 2017. His research interests are in the fields of aging, age-related disorders, redox biology, oncogenetics, melatonin, mitochondria, surgical advances, and developing novel techniques for modern surgery. Dr. Atayik has conducted clinical research and experimental studies. He has published many scientific papers, such as research papers, narrative reviews, and book chapters, and has worked as an author, referee, editorial assistant, and guest editor, and editor in many prominent publishing houses. He was awarded the Young Investigator Presentation Prize at the VIII. International Congress of Molecular Medicine, which was held in Istanbul, Turkey, in November 2021.
Affiliations and expertise
Scientist and Researcher, Department of General Surgery, Hacettepe University Faculty of Medicine, TurkeyRead Senescence, Senotherapeutics and Mitochondria on ScienceDirect