Ionizing Radiation and the Immune Response - Part B
- 1st Edition, Volume 378 - July 10, 2023
- Editors: Lorenzo Galluzzi, Celine Mirjolet
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 8 4 3 2 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 8 4 3 3 - 8
Ionizing Radiation and the Immune Response, Part B, Volume 378 reviews the latest knowledge on the immune response induced by ionizing radiations. Specific chapters in this new… Read more
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Request a sales quoteIonizing Radiation and the Immune Response, Part B, Volume 378 reviews the latest knowledge on the immune response induced by ionizing radiations. Specific chapters in this new release include NK functions in radio-induced immune response, TRT and immune response, Radio-induced immune response and lipid metabolism, Effect of protons and heavy ions on immune response, Effect of flash therapy and mini beam on immune response, Radio-induced lymphopenia, CT to potentiate radio-induced immune response, Impact of RT on healthy tissues (inflammation), Radio-induced macrophagic response, To use nanoparticles and ionizing radiations to modulate immune response: opinion of the chemist, biologist and clinician, and much more.
Other sections cover the Role of Dendritic cells in radiation-induced immune response, the Relationship between the tumor microenvironment and the efficacy of the radiotherapy/immunotherapy combination, and Biomarkers of radiation induced response to optimize radio-immunotherapy combination.
- Covers the latest insights about the biological parameters modulating radio-induced immune response
- Provides an accurate review by selected experts of the impact on the immune response of radio-enhancer nanoparticles or chemotherapy targeting immunosuppressive immune cells
- Presents valuable information to clinicians to optimize radiotherapy and immunotherapy combinations
Radiation biologist, radiation oncologist and immunologists interested to use ionizing radiation to improve combination with immunotherapy
- Cover
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Dual impact of radiation therapy on tumor-targeting immune responses
- References
- Chapter One: Radio-induced lymphopenia in the era of anti-cancer immunotherapy
- Abstract
- 1: Introduction
- 2: Radio-induced lymphopenia (RIL)
- 3: Dynamics of RIL
- 4: RIL in the era of immunotherapies
- 5: How to implement efficient lymphocyte sparing radiotherapy?
- 6: Conclusion
- Acknowledgments
- References
- Chapter Two: Combining radiotherapy and NK cell-based therapies: The time has come
- Abstract
- 1: Introduction
- 2: Radiation therapy can improve the NK cell-mediated anti-tumor response
- 3: Radiation therapy can impair the NK cells anti-tumor response
- 4: Combining radiotherapy and NK cells targeted therapies to unleash their anti-tumor activity
- 5: Conclusion
- References
- Chapter Three: The role of dendritic cells in radiation-induced immune responses
- Abstract
- 1: Introduction
- 2: Critical DC populations in tumor immune responses
- 3: Radiation effects on dendritic cells in the treatment field
- 4: Summary
- 5: Conclusions
- References
- Chapter Four: Immunomodulatory effects of targeted radionuclide therapy
- Abstract
- 1: Introduction
- 2: Background
- 3: Radiation-induced DNA damage and the cGAS-STING signaling pathway
- 4: Antitumor immunity triggered by radiation-induced extracellular vesicles
- 5: TRT immunostimulatory effects
- 6: Concluding remarks
- Acknowledgments
- References
- Chapter Five: Opportunities and challenges of low-dose radiation to enable immunotherapy efficacy
- Abstract
- 1: Introduction
- 2: Immunotherapy in combination with high dose irradiation
- 3: Is high dose irradiation immune suppressive?
- 4: Low dose irradiation for tumor immune reprogramming
- 5: Development and clinical applications of LDRT combined with immunotherapy
- 6: Conclusions and future directions
- References
- Chapter Six: Radiation therapy-activated nanoparticle and immunotherapy: The next milestone in oncology?
- Abstract
- 1: Cancer treatment modalities and their respective action mechanisms
- 2: Current combinations of these therapies including RT
- 3: Interest and strategies to develop RT/NP/IT combination
- 4: Conclusion
- References
- Chapter Seven: Relationship between the tumor microenvironment and the efficacy of the combination of radiotherapy and immunotherapy
- Abstract
- 1: Introduction
- 2: Radiotherapy
- 3: Cancer immunotherapy
- 4: The rationale for combination immune checkpoint blockade and radiotherapy
- 5: Preclinical models combining immunotherapy and radiotherapy
- 6: Clinical trials combining immunotherapy and radiotherapy
- 7: Conclusion
- Conflict of interest
- References
- Chapter Eight: Recent advances in targeting myeloid-derived suppressor cells and their applications to radiotherapy
- Abstract
- Research Highlights
- 1: Introduction
- 2: Biological characteristics of MDSCs
- 3: DDSs mechanisms of actions
- 4: Conclusion and prospect
- References
- No. of pages: 277
- Language: English
- Edition: 1
- Volume: 378
- Published: July 10, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780443184321
- eBook ISBN: 9780443184338
LG
Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
Affiliations and expertise
Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USACM
Celine Mirjolet
Dr. Céline Mirjolet is a radiobiologist with in-depth knowledge of the impact of radiotherapy fractionation on the radiation-induced immune response and on the effectiveness of the radiotherapy and immunotherapy combination. She obtained a doctorate in radiobiology at the anti-cancer center of Nancy (France). She then moved to Brussels at the University of Belgium to study epigenetic mechanisms in transcriptional activity and cancer. For ten years, she has been working in the radiotherapy department of the Dijon cancer center in close collaboration with clinicians and physicists to develop translational research projects on the combination of immunotherapy and radiotherapy. She leads the preclinical research team in radiotherapy and radiobiology and her programs focus on the validation of preclinical concepts leading to the design of clinical trials.
Affiliations and expertise
Radiobiologist, CGFL Dijon, FranceRead Ionizing Radiation and the Immune Response - Part B on ScienceDirect