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Translational Neuroimmunology, Volume 8
Multiple Sclerosis
- 1st Edition - June 16, 2023
- Editors: Nima Rezaei, Niloufar Yazdanpanah
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 8 5 7 8 - 6
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 8 5 7 9 - 3
Translational Neuroimmunology: Multiple Sclerosis provides an update on bench to bedside studies on Multiple Sclerosis as an autoimmune disease. Divided into twelve chapte… Read more
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Request a sales quoteTranslational Neuroimmunology: Multiple Sclerosis provides an update on bench to bedside studies on Multiple Sclerosis as an autoimmune disease. Divided into twelve chapters, the book begins with an in-depth introduction to the neuroimmunology and immunopathology of multiple sclerosis. Sections also provide content on genetics and epigenetics, the microbiome, diagnosis, and treatment of multiple sclerosis. Finally, various precision treatments are covered. All information is presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research.
- Provides an introduction on multiple sclerosis as an autoimmune disease, from bench to bedside
- Encourages the development of immunologic approaches to analyze the interaction and specific properties of nervous tissue elements during development and disease
- Focuses on understanding and therapeutically manipulating immunological responses to injury, degeneration and autoimmunity in the central nervous system
- Shows the changes in relevant immune and inflammatory reactions at the cellular and molecular level during the development of nervous system diseases
Clinical immunologists; neurologists, Rheumatologist; Endocrinologists; Microbiologists; Oncologists; Rheumatologists. Clinicians, research scientists, and industry partners.
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Series editor’s biography
- Abbreviations
- Chapter 1: Introduction to the neuroimmunology of multiple sclerosis
- Abstract
- 1: Introduction
- 2: Neuroimmunopathology
- 3: Diagnosis
- 4: Treatment
- 5: Conclusion
- References
- Chapter 2: Immunopathology of multiple sclerosis
- Abstract
- 1: Introduction
- 2: Natural history of multiple sclerosis
- 3: Etiopathogenesis
- 4: Biomarkers in MS disease
- 5: Conclusion
- References
- Chapter 3: Biomarkers in multiple sclerosis
- Abstract
- 1: Introduction
- 2: Disease-predictive biomarkers
- 3: Biomarkers of MS diagnosis
- 4: Biomarkers of MS prognosis
- 5: Biomarkers of disease activity
- 6: Response to treatment and side effects
- 7: Conclusion
- References
- Chapter 4: The neuroimmunology of fatigue in multiple sclerosis
- Abstract
- Conflict of interest
- 1: Introduction
- 2: Cellular, humoral, and other inflammatory markers and fatigue in multiple sclerosis
- 3: Central inflammation, hypothalamic dysfunction, and fatigue in multiple sclerosis
- 4: Conclusion
- References
- Chapter 5: Microbiome and multiple sclerosis
- Abstract
- 1: Introduction
- 2: Multiple sclerosis
- 3: The gut-brain axis
- 4: The gut microbiome and pathogenesis implication in multiple sclerosis
- 5: Immunological mechanisms involved in the pathophysiology of MS
- 6: Innate immune mechanisms in MS
- 7: Conclusion
- References
- Chapter 6: Associations and interactions with herpesviruses and parasites (helminths) in people with multiple sclerosis
- Abstract
- 1: Introduction
- 2: The pathophysiology of MS and infection
- 3: Human herpesviruses
- 4: Interactions of human herpesviruses with MS
- 5: Helminth infestations and associations with multiple sclerosis
- 6: Conclusion
- References
- Chapter 7: Cytotoxic T lymphocytes in multiple sclerosis: New targets for treatment?
- Abstract
- 1: Introduction
- 2: Characterization of granzymes: Triggering death pathways
- 3: Involvement of GzmB-derived CD4+ T lymphocytes in human diseases
- 4: Granzymes and cytotoxic T lymphocytes in multiple sclerosis
- 5: Conclusion
- References
- Chapter 8: Targeting leukocytes in multiple sclerosis: Therapeutic perspectives
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Therapeutic strategies for targeting neuroinflammation
- 3: Inducing antigen-specific tolerance
- 4: Targeting NK cells
- 5: Targeting B cells
- 6: Targeting myeloid cells: Macrophages, microglia, monocytes, and dendritic cells
- 7: Conclusion
- References
- Chapter 9: Sphingosine-1-phosphate, its receptors, and their role in multiple sclerosis
- Abstract
- 1: Introduction
- 2: Preclinical studies
- 3: Clinical trial results
- 4: Potential therapeutic opportunities
- 5: Conclusion
- References
- Chapter 10: Innate and adaptive immunomodulation by Bruton’s tyrosine kinase (BTK) inhibitors: An emerging treatment for multiple sclerosis
- Abstract
- 1: Introduction
- 2: The role of Bruton’s tyrosine kinase (BTK) in B cells and innate immunity
- 3: Effects of BTK inhibitors in experimental autoimmune and MS models
- 4: BTK inhibitors in the treatment of MS patients
- 5: Use of BTK inhibitors for targeting inflammatory/autoimmune diseases
- 6: Conclusion
- References
- Chapter 11: Monoclonal antibodies in multiple sclerosis treatment
- Abstract
- 1: Introduction
- 2: Multiple sclerosis
- 3: Monoclonal antibodies in MS treatment
- 4: Conclusion
- References
- Chapter 12: Immune-mediated cognition impairment in multiple sclerosis
- Abstract
- 1: Introduction
- 2: Cognitive impairment in MS and other neurological diseases
- 3: Inflammation and cognitive impairment
- 4: Synaptic plasticity and cognitive impairment in MS
- 5: Complement system and cognitive impairment in MS
- 6: Immune cells and cognitive impairment in MS
- 7: The role of cytokines in cognitive impairment in MS
- 8: Conclusion
- References
- Chapter 13: Activation of complement: A potent biomarker in multiple sclerosis
- Abstract
- 1: Introduction
- 2: Complement system in the CNS
- 3: Complement cascade in MS
- 4: Conclusion
- References
- Index
- No. of pages: 270
- Language: English
- Edition: 1
- Published: June 16, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780443185786
- eBook ISBN: 9780443185793
NR
Nima Rezaei
Professor Nima Rezaei gained his medical degree (MD) from Tehran University of Medical Sciences and subsequently obtained an MSc in Molecular and Genetic Medicine and a PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Pediatric Clinical Immunology and Bone Marrow Transplantation in the Newcastle General Hospital. Professor Rezaei is now the Full Professor of Immunology and Vice Dean of Research, School of Medicine, Tehran University of Medical Sciences, and the co-founder and Head of the Research Center for Immunodeficiencies. He is also the founding President of the Universal Scientific Education and Research Network (USERN). Professor Rezaei has already been the Director of more than 55 research projects and has designed and participated in several international collaborative projects. Professor Rezaei is an editorial assistant or board member for more than 30 international journals. He has edited more than 35 international books, has presented more than 500 lectures/posters in congresses/meetings, and has published more than 1,000 scientific papers in the international journals.
Affiliations and expertise
Professor, Department of Immunology, School of Medicine; Head, Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences; Founding President, Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA),Universal Scientific Education and Research Network (USERN),Tehran, IranNY
Niloufar Yazdanpanah
Affiliations and expertise
Managing Director, Network of Immunity in Infection,
Malignancy and Autoimmunity (NIIMA)
Universal Scientific Education and Research Network (USERN); and School of Medicine,
Tehran University of MEdical Sciences,
Tehran, Iran