Conceptual Breakthroughs in The Evolutionary Biology of Aging
- 1st Edition - July 10, 2023
- Imprint: Academic Press
- Authors: Kenneth R. Arnold, Michael R. Rose
- Editor: John C. Avise
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 5 4 5 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 5 4 6 - 3
Conceptual Breakthroughs in the Evolutionary Biology of Aging continues the innovative Conceptual Breakthroughs series by providing a comprehensive outline of the major breakt… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteConceptual Breakthroughs in the Evolutionary Biology of Aging continues the innovative Conceptual Breakthroughs series by providing a comprehensive outline of the major breakthroughs that built the evolutionary biology of aging as a leading scientific field. Following the evolutionary study of aging from its humble origins to the present, the book's chapters treat the field’s breakthroughs one at a time. Users will find a concise and accessible analysis of the science of aging viewed through an evolutionary lens. Building upon widely-cited studies conducted by author Michael Rose, this book covers 30 subsequent years of growth and development within the field.
The book highlights key publications for those who are not experts in the field, providing an important resource for researchers. Given the prevailing interest in changing the aging process dramatically, it is a powerful tool for readers who have a vested interest in understanding its causes and future control measures.
The book highlights key publications for those who are not experts in the field, providing an important resource for researchers. Given the prevailing interest in changing the aging process dramatically, it is a powerful tool for readers who have a vested interest in understanding its causes and future control measures.
- Reviews cell-molecular theories of aging in the light of evolutionary biology
- Offers an evolutionary analysis of prospects for mitigating aging not commonly discussed within private and public sectors
- Provides readers with a radically different perspective on contemporary biological gerontology, specifically through the lens of evolutionary biology
Researchers in evolutionary biology, human evolution studies, and aging studies
Advanced undergraduate and graduate students in evolutionary biology studies
Advanced undergraduate and graduate students in evolutionary biology studies
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Foreword from the Series Editor, John C. Avise
- Chapter One. Introduction
- Chapter Two. 384–322B.C: The first biologist on aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 6
- Chapter Three. 1645: A tale of two Bacons
- The standard paradigm
- The conceptual breakthrough
- Impact: 4
- Chapter Four. 1881: Natural selection is the ultimate determinant of aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Five. 1922: Early laboratory experiments on demography
- The standard paradigm
- The conceptual breakthrough
- Impact: 6
- Chapter Six. 1928: Basic mathematics of selection with age-structure
- The standard paradigm
- The conceptual breakthrough
- Impact: 8
- Chapter Seven. 1930: First explanation of aging by age-specific patterns of selection
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Eight. 1941: First proposal of the general idea of declining force of natural selection
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Nine. 1946–57: Verbal hypotheses for the evolutionary genetics of aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 8
- Chapter Ten. 1953: Absence of a Lansing effect in inbred Drosophila
- The standard paradigm
- The conceptual breakthrough
- Impact: 5
- Chapter Eleven. 1961: Presence of aging in a fish with continued adult growth
- The standard paradigm
- The conceptual breakthrough
- Impact: 4
- Chapter Twelve. 1966: Mathematical derivation of the forces of natural selection
- The standard paradigm
- The conceptual breakthrough
- Impact: 9
- Chapter Thirteen. 1960s: Falsification of the somatic mutation theory
- The standard paradigm
- The conceptual breakthrough
- Impact: 4
- Chapter Fourteen. 1960s: Falsification of the translation error catastrophe theory
- The standard paradigm
- The conceptual breakthrough
- Impact: 5
- Chapter Fifteen. 1968: Proposal of experimental designs to test evolutionary theories of aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Sixteen. 1968: Accidental evolutionary postponement of aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 6
- Chapter Seventeen. 1970: Experimental evolution of accelerated aging in Tribolium
- The standard paradigm
- The conceptual breakthrough
- Impact: 6
- Chapter Eighteen. 1970–74: Development of evolutionary genetics of age-structured populations
- The standard paradigm
- The conceptual breakthrough
- Impact: 10
- Chapter Nineteen. 1975: Application of Charlesworth's theory to the evolution of aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 10
- Chapter Twenty. 1980: Full development of evolutionary genetic theory for aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 10
- Chapter Twenty One. 1980–81: Quantitative genetic tests of hypotheses for the evolution of aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 8
- Chapter Twenty Two. 1980–84: Mitigation of aging by postponing the decline in forces of natural selection
- The standard paradigm
- The conceptual breakthrough
- Impact: 9
- Chapter Twenty Three. 1977–1988: Characterization of Caenorhabditis elegans mutants with extended lifespan
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Twenty four. 1982–85: Further mathematical characterization of evolution with antagonistic pleiotropy
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Twenty Five. 1984: Genetic covariation is shifted to positive values by inbreeding
- The standard paradigm
- The conceptual breakthrough
- Impact: 6
- Chapter Twenty Six. 1984: Direct demonstration of nonaging in fissile species
- The standard paradigm
- The conceptual breakthrough
- Impact: 9
- Chapter Twenty seven. 1989: Additional experiments support antagonistic pleiotropy
- The standard paradigm
- The conceptual breakthrough
- Impact: 6
- Chapter Twenty eight. 1985: Genotype-by-environment interaction shown for aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Twenty nine. 1985–onward: Evolutionary physiology of aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Thirty. 1987: Accelerated senescence explained in terms of mutation accumulation with inbreeding depression
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Thirty one. 1988: Reverse evolution of aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 8
- Chapter Thirty two. 1985–88: Genetic analysis of aging in males
- The standard paradigm
- The conceptual breakthrough
- Impact: 6
- Chapter Thirty three. 1987–1991: Quantitative genetic analysis of how many genes determine aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Thirty four. 1988: Evidence for senescence in the wild
- The standard paradigm
- The conceptual breakthrough
- Impact: 6
- Chapter Thirty five. 1989–onward: Molecular genetic variation at selected loci in the evolution of aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 8
- Chapter Thirty six. 1988–89: The evolutionary logic of extending lifespan by dietary restriction
- The standard paradigm
- The conceptual breakthrough
- Impact: 4
- Chapter Thirty seven. 1992: Selection for stress resistance increases lifespan
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Thirty eight. 1992: In late adult life, mortality rates stop increasing
- The standard paradigm
- The conceptual breakthrough
- Impact: 10
- Chapter Thirty nine. 1993–1995: Evolution of increased longevity among mammals, in the wild and the lab
- The standard paradigm
- The conceptual breakthrough
- Impact: 6
- Chapter Forty. 1993: Evolutionary physiology of dietary restriction
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Forty one. 1993: Genetic association between dauer metabolic arrest and increased lifespan
- The standard paradigm
- The conceptual breakthrough
- Impact: 8
- Chapter Forty two. 1992–95: Experimental evolution of aging is connected to development
- The standard paradigm
- The conceptual breakthrough
- Impact: 8
- Chapter Forty three. 1994–96: Evidence for mutation accumulation affecting virility and aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 8
- Chapter Forty four. 1996–98: Physiological research on evolution of aging supports organismal mechanisms
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Forty five. 1996: Late-life mortality plateaus explained using evolutionary theory
- The standard paradigm
- The conceptual breakthrough
- Impact: 9
- Chapter Forty six. 1998–2003: Falsification of lifelong heterogeneity models for the cessation of aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 8
- Chapter Forty seven. 1998–2000: Discovery of Drosophila mutants that sometimes increase longevity
- The standard paradigm
- The conceptual breakthrough
- Impact: 3
- Chapter Forty eight. 1999–2004: Nematode longevity mutants show antagonistic pleiotropy
- The standard paradigm
- The conceptual breakthrough
- Impact: 8
- Chapter Forty nine. 2002–06: Evolution of life-history fits evolutionary analysis of late life
- The standard paradigm
- The conceptual breakthrough
- Impact: 10
- Chapter Fifty. 2003–2005: Breakdown in correlations between stress resistance and aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Fifty one. 2007–11: Development of demographic models that separate aging from dying
- The standard paradigm
- The conceptual breakthrough
- Impact: 9
- Chapter Fifty two. 2010: Studying the evolutionary origins of aging in bacteria
- The standard paradigm
- The conceptual breakthrough
- Impact: 8
- Chapter Fifty three. 2010: Genome-wide sequencing of evolved aging reveals many sites
- The standard paradigm
- The conceptual breakthrough
- Impact: 9
- Chapter Fifty four. 2011–19: Evolutionary transcriptomics also reveal complex physiology of aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 9
- Chapter Fifty five. 2012: Late life is physiologically different from aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Fifty six. 2014: Genomic studies of centenarians have low scientific power
- The standard paradigm
- The conceptual breakthrough
- Impact: 3
- Chapter Fifty seven. 2015: Evolutionary genetic effects produce two evolutionary biologies of aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 6
- Chapter Fifty eight. 2016: Experimental evolution can produce nonaging young adults
- The standard paradigm
- The conceptual breakthrough
- Impact: 8
- Chapter Fifty nine. 2017: The heart is implicated in the evolution of aging
- The standard paradigm
- The conceptual breakthrough
- Impact: 7
- Chapter Sixty. 2020: Evolutionary adaptation to diet and its impact on healthspan
- The standard paradigm
- The conceptual breakthrough
- Impact: 9
- Conclusion
- Glossary
- Author Index
- Index
- Edition: 1
- Published: July 10, 2023
- Imprint: Academic Press
- No. of pages: 308
- Language: English
- Paperback ISBN: 9780128215456
- eBook ISBN: 9780128215463
JA
John C. Avise
John C. Avise is a Distinguished Professor at the University of California at Irvine, and an elected member of the National Academy of Sciences, the American Academy of Arts and Sciences, and the American Philosophical Society. His research utilizes molecular markers to study the ecology and evolution of wild animals on topics ranging from genetic parentage and mating behaviors to gene flow, hybridization, phylogeography, speciation, and phylogeny. He has published more than 340 scientific articles and 25 books on a wide variety of evolutionary genetic topics.
Affiliations and expertise
Professor, Department of Ecology and Evolutionary Biology, University of California at Irvine, CA, USAKA
Kenneth R. Arnold
Kenneth R. Arnold is a Graduate Researcher at the University of California at Irvine, working with Dr. Michael Rose in the Department of Ecology and Evolutionary Biology. He is also the Laboratory Stock Manager in the Laboratory of Dr. Michael Rose and Dr. Laurence Mueller at UCI. His studies and area of expertise deal with evolutionary biology and genomic trajectories
Affiliations and expertise
Graduate Researcher, University of California at Irvine, USAMR
Michael R. Rose
Michael Rose is a Distinguished Professor of Ecology and Evolutionary Biology at the University of California at Irvine. Since 2006, he also serves as the Director of the Network for Experimental Research on Evolution. Dr. Rose is widely recognized as a leading researcher in evolutionary biology, specifically the effects of this on aging humans; he published a groundbreaking book on this subject in 1991. In addition to this book publication, Dr. Rose has written hundreds of academic journal papers on evolution, evolutionary biology, and the evolution of aging.
Affiliations and expertise
Professor of Ecology and Evolutionary Biology, University of California at Irvine, USARead Conceptual Breakthroughs in The Evolutionary Biology of Aging on ScienceDirect