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Nonlinear Dynamics of Parkinson’s Disease and the Basal Ganglia-Thalamic-Cortical System
- 1st Edition - June 20, 2023
- Authors: Erwin B. Montgomery Jr., Olivier Darbin
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 1 6 9 9 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 1 6 9 8 - 5
Nonlinear Dynamics of Parkinson’s Disease and the Basal Ganglia-Thalamic-Cortical System examines current research regarding the operations of the basal ganglia-tha… Read more
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Request a sales quoteNonlinear Dynamics of Parkinson’s Disease and the Basal Ganglia-Thalamic-Cortical System examines current research regarding the operations of the basal ganglia-thalamic-cortical system that causes neurological disorders like Parkinson’s disease. While there have been remarkable advances in the understanding of the anatomy, physiology and chemistry of these systems, there remains a significant degree of inconsistency and incompleteness between facts and advancements. This book introduces the novel concepts of nonlinear complex systems and their connection to Parkinsonism as well as hyperkinetic disorders. The actual mechanisms underlying the motor disorders of Parkinson’s disease at the level of the lower motor neuron are also discussed.
- Outlines phenomenological selectivity of pallidotomy and Deep Brain Stimulation
- Reviews the anatomical models of pathophysiology and physiology
- Discusses the instrumental and analytical misrepresentations and the inferences that misrepresent the data in Nonmonotonic Nonlinear Dynamics
Neurologists, neurosurgeons, neuroscientists, neurophysiologists, and students of these professions
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Epigraph
- Preface
- Chapter 1. Introduction
- Abstract
- Motivation
- Revisiting the centrality of dopamine deficiency—Deep Brain Stimulation
- Current theories
- What is being offered
- A brief note on nonlinearity, Chaos and Complexity by way of introduction
- Focus on pathophysiology and then physiology
- Evolution of past theories of pathophysiology and physiology
- Shaping the approach
- Dynamics
- Sensory stimulation versus perception
- Epistemic considerations
- Importance of theories for the physiology and pathophysiology of the basal ganglia–thalamic–cortical system
- Case study
- Evaluation of potential theories
- Traditional presumptions
- Translation of traditional presumptions to mathematical models
- Neurophysiology is fundamentally nonmonotonic nonlinear
- Mathematical metaphors
- Linearization of nonlinear phenomena
- Self-organization in nonlinear systems
- Networks of loosely coupled nonlinear oscillators
- Case study revisited
- Information theory
- Plan
- References
- Chapter 2. Conundrums
- Abstract
- The need to reassess current theories of basal ganglia–thalamic–cortical pathophysiology and physiology
- Increasing the Completeness of theories of basal ganglia–thalamic–cortical pathophysiology and physiology
- References
- Chapter 3. Anatomy
- Abstract
- Anatomical models of pathophysiology and physiology
- Reasoning from pathological–behavioral correlations
- Problems
- The Cajal–Golgi debates
- Anatomy is not physiology
- References
- Chapter 4. Physiology
- Abstract
- Realizing the challenge
- Basis of motor control
- Motor unit orchestration
- Conclusion
- References
- Chapter 5. Misrepresentation of nonmonotonic nonlinear dynamics
- Abstract
- How would one know if there is a misrepresentation?
- Instrumental misrepresentation
- Experimental design misrepresentations
- Analytical misrepresentations
- Inferences that misrepresent the data
- Advancing to nonmonotonic nonlinear experimental design and analyses
- References
- Chapter 6. Conceptual momentum of one-dimensional push–pull dynamics
- Abstract
- Persistence of one-dimensional push–pull dynamics as archetypical paradigm
- Historical legacy
- The Contraries as the origin of the one-dimensional push–pull dynamics paradigm
- One approach to the infinitesimal but not a resolution
- The nature of the legacy
- References
- Chapter 7. Acquiring and analyzing nonmonotonic nonlinear dynamics
- Abstract
- Recognizing nonmonotonic nonlinear dynamics in experimental observations
- Equilibrium and nonequilibrium dynamics
- Challenges to analysis of nonmonotonic nonlinear analyses
- Nonmonotonic nonlinear analyses
- Nonmonotonic nonlinear motifs
- References
- Chapter 8. Nonmonotonic nonlinear dynamical modeling
- Abstract
- The necessity of modeling
- Judging models
- Two general approaches to modeling
- Reductionism
- Mereology
- Mathematical versus computational
- References
- Chapter 9. Networks of nonmonotonic nonlinear oscillators
- Abstract
- Reconstruction of the anatomical architecture
- Reconstruction of the physiological architecture
- Unique oscillator mechanisms that contribute to the physiology and pathophysiology of the basal ganglia–thalamic–cortical system
- Anatomical and physiological tenets of the proposed theory
- Computational modeling and simulation
- Implications for the actual pathophysiology and physiology of the basal ganglia–thalamic–cortical system
- Extension to pathophysiology
- References
- Appendix A. Deep dive into neurophysiological epistemology
- Challenge
- Carving nature at its joints
- The mereology of distributed locality
- How to begin
- Knowledge versus understanding
- Principles of Causational and Informational Synonymy
- Epistemic response to the fundamental ontological problem
- Appendix B. Chance, randomness, and incompleteness
- Randomness
- Stochasticity or chance
- Incompleteness
- Appendix C. Unpredictability, dependence on initial conditions, and self-organization
- How can an equation be unpredictable?
- Equations of motion and activation
- Chaos and complexity
- Other forms of unpredictability
- Appendix D. Information theory
- Dimensionality
- Shannon Information Theory
- Synonymy of physical and informational entropy
- D.4 Shannon’s notion of order
- Index
- No. of pages: 404
- Language: English
- Edition: 1
- Published: June 20, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780443216992
- eBook ISBN: 9780443216985
EM
Erwin B. Montgomery Jr.
Dr. Montgomery has been an academic neurologist for over 40 years pursuing teaching, clinical and basic research at major academic medical centers. He has authored over 120 peer reviewed journal articles (available on PubMed) and 8 books on medicine (4 on the subject of Deep Brain Stimulation). The last two have been “Reproducibility in Biomedical Research” (Academic Press, 2024) and “The Ethics of Everyday Medicine” (Academic Press, 2023).
Affiliations and expertise
Emeritus Professor, Department of Medicine (Neurology), McMaster University, Hamilton, ON, CanadaOD
Olivier Darbin
Dr. Darbin pursues theoric, basic and translational research on the function of the basal ganglia and has worked at major centres in Europe, America and Japan. He has authored over 50 peer reviewed journal articles (available on PubMed) in biochemistry, neurophysiology and psychophysiology. His current research is on therapeutic on-demand for conditions with movement disorders (Nature Scientific Report, 2022).
Affiliations and expertise
Assistant Professor, Department of Neurosurgery, University of South Alabama, AL, United StatesRead Nonlinear Dynamics of Parkinson’s Disease and the Basal Ganglia-Thalamic-Cortical System on ScienceDirect