Nonlinear Dynamics of Parkinson’s Disease and the Basal Ganglia-Thalamic-Cortical System

Nonlinear Dynamics of Parkinson’s Disease and the Basal Ganglia-Thalamic-Cortical System examines current research regarding the operations of the basal ganglia-thalamic-cortical system that causes neurological disorders like Parkinson’s disease. While there have been remarkable advances in the understanding of the anatomy, physiology and chemistry of these systems, there remains a significant degree of inconsistency and incompleteness between facts and advancements. This book introduces the novel concepts of nonlinear complex systems and their connection to Parkinsonism as well as hyperkinetic disorders. The actual mechanisms underlying the motor disorders of Parkinson’s disease at the level of the lower motor neuron are also discussed.

"...describes the dynamics of basal ganglia networks...[and] theories that express the dynamic interaction between these functional nuclei...[including] thalamus and cortical interactions....[A]pproaches the current therapeutic interventions and elaborates on the lack of clear theories that explain the current response to therapies....[D]elves into detailed mathematical and physical analyses, which makes it well suited for researchers interested in medical sciences… [W]ritten with detailed discussion of theoretical analysis of interactions between different brain areas involved in movement, particularly Parkinson’s disease....[A] good addition to the field of movement disorders. As the field is growing and interaction between complete logical machines is accomplished and understood (e.g., deep brain stimulation), the better automated this interaction can be achieved. This can be a game changer in deep brain stimulation for many patients to achieve a state-of-the-art automated therapy based on their symptoms."— ©Doody’s Review Service, 2024, Karim Makhoul, MD (Northwell Health)