Phytopharmaceuticals and Herbal Drugs

Prospects and Safety Issues in the Delivery of Natural Products

1st Edition - July 15, 2023
Imprint: Academic Press
Editors: Manju Rawat Singh, Deependra Singh
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 1 2 5 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 3 6 9 - 2

Phytopharmaceuticals and Herbal Drugs: Prospects and Safety Issues in the Delivery of Natural Products explores the delivery aspects of plant-based drugs, providing insights… Read more

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Phytopharmaceuticals and Herbal Drugs: Prospects and Safety Issues in the Delivery of Natural Products explores the delivery aspects of plant-based drugs, providing insights into formulation constraints associated with plant-based drugs, the development of novel delivery systems based on polymers or lipids, and how combining natural products with technological advancements in drug delivery is making large strides. Some of the best-selling drugs for the treatment of diseases like cancer, ulcers and malaria are either natural products or their derivatives, all of which are covered in this comprehensive resource.

This book will be useful to researchers working in plant-derived medicines and the development of their delivery systems, including sections on their derivatives and analogs that represent over 50% of all drugs in clinical use. Active ingredients originated from plant resources generally exhibit compromised desired effects limited by issues such as stability, solubility, molecular size, bioavailability and toxicity.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
About the editors
Preface
Acknowledgments
Section I. Prospects of plant-based therapeutics
Chapter 1. Plant-based therapeutics: current status and future perspectives
1. Introduction
2. Phytopharmaceuticals: revival of traditional medicine in a modern way
3. Research in natural products
4. The market trend regarding natural product
5. Future perspectives
6. Conclusion
Chapter 2. Worldwide health scenario from the perspective of herbal medicine research
1. Introduction
2. Herbal drugs
3. Application of phytomedicine
4. Research efforts on herbal medicine
5. Safety and efficacy of herbal drugs
6. Conclusion and future prospects
Section II. Challenges and delivery aspects of phytomedicines and bioactives
Chapter 3. Challenges in delivery of plant actives
1. Natural compounds with therapeutic potential
2. Plant bioactives market and conventional pharmaceutical formulations
3. Limitations of plant bioactives
4. Innovative pharmaceutical formulations of plant bioactives
5. Nanotechnology as key strategy to deliver bioactives
6. Screening models for formulation development
7. Regulatory framework of isolated compounds from plants, extracts, or plant-derived products
8. Conclusions and future perspectives
Chapter 4. Lipid-based particulate systems for delivery of plant actives and extracts: Extraction, prospective carriers, and safety issues
1. Introduction
2. Issues related to the extraction of herbs and their safety
3. Lipid-based systems
4. Lipid-based system as carriers for plant actives and extracts
5. Conclusion
Chapter 5. Phyto-complexed systems as a versatile tool for the delivery of plant-based drugs
1. Introduction
2. Complexation
3. Methods for the preparation of phyto-complexes
4. Characterization of complexes
5. Applications
6. Conclusion
Chapter 6. Impact of nanotechnology on herbal bioactives: an overview
1. Introduction
2. Bioactivities of polyphenols
3. Hiccups for the efficient delivery of phytoconstituents/bioactives
4. Nanotechnology: Importance and application
5. Nanophytomedicines: Nanostructured drug delivery systems for bioactive
6. Understanding herbal nanoparticles
7. Conclusions
Chapter 7. Application of nanomedicine for efficient delivery of herbal bioactives
1. Introduction
2. Herbal bioactive compounds
3. Nanocarriers for control drug delivery
4. Conclusion and future prospects
Chapter 8. Nanophytomedicine: nanotechnology for herbal product development and value addition
1. Introduction
2. Phytomedicines
3. Nanotechnology-based herbal product development and value addition
4. Nanophytomedicines
5. Conclusion
Section III. Safety considerations, regulatory, and commercial aspects
Chapter 9. Phytopharmaceuticals and herbal drugs: prospects and safety issues in the delivery of natural products
1. Introduction
2. Safety issues
3. Role of novel delivery systems in overcoming some of these challenges
4. Storage and stability issues
5. Regulatory aspects
6. Concluding remarks and future prospects
Chapter 10. Herbal drug interaction and effects on phytopharmaceuticals
1. Introduction
2. Types of herb-drug interactions
3. Pharmacokinetic of herb-drug interaction
4. Pharmacodynamic of herb-drug interaction
5. Reasons and need of herb-drug interaction
6. How herbs interact with coadministered allopathic drugs
7. Enzymes responsible for herb-drug interaction
8. Mechanism of herb-drug interaction
9. Examples of herb-drug interaction
10. Conclusion
Chapter 11. Clinical, ethical, and regulatory issues of botanicals
1. Introduction
2. Need for regulation of botanicals
3. Clinical issues of botanicals
4. Ethical issues of botanicals
5. Regulatory issues of botanicals
6. Conclusion and future perspectives
Chapter 12. Commercial aspect and market potential of phytoactive products
1. Introduction
2. Health benefits of phytochemicals
3. Phytochemicals from plant to market
4. Classification of phytochemicals
5. Phenolic compounds
6. Carotenoids
7. Alkaloids
8. Nitrogen-containing compounds
9. Organosulfur compounds
10. Contemporary scenario and market demand of phytochemicals
11. Market potential of phytochemicals and phytoconstituents
12. Worldwide demands of phytochemicals
13. Segments of phytochemical global market
14. Other sector
15. International key players
16. Kemin industries Inc.
17. Naturex
18. Badische Anilin-und SodaFabrik
19. Organic herb Inc.
20. Chengdu biopurify phytochemicals Ltd.
21. Nektium
22. Demand in Indian market
23. Sydler
24. Alkaloids corporation
25. Kothari phytochemicals international
26. Conclusion
Section IV. Application aspects of phytopharmaceuticals
Chapter 13. Interactions between radiopharmaceutical products and herbal medicines
List of symbols and abbreviations
1. Introduction
2. Radiopharmaceuticals
3. Discussion and conclusion
Chapter 14. Use of microfluidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs
1. Introduction
2. Phytochemicals and herbal phytopharmaceuticals
3. Organ-on-a-chip systems
4. Herbochip
5. Current challenges and future directions
6. Conclusion
Chapter 15. New and revisited approaches on the transdermal delivery of polyphenols-loaded nanoparticles for melanoma prevention and treatment
List of abbreviations and acronyms
1. Introduction
2. Skin: anatomy and physiology
3. Melanoma: pathophysiology and therapeutic approaches
4. Conclusion and future perspectives
Chapter 16. Novel drug delivery approaches for improving therapeutic applications of berberine and berberine-rich herbal preparations
1. Introduction
2. Characteristics of BER
3. Delivery approaches
4. Conclusion
Chapter 17. Impact of phytomedicines and their novel delivery systems as an alternative for the treatment of neurodegenerative disorders
1. Introduction
2. Phytomedicines for neurodegenerative disorders (NDs): A neuropharmacological perspective
3. Delivery system for phytoconstituents to the CNS
4. Nanocarriers-based delivery of phytoconstituents for NDs
5. Conclusion
Chapter 18. Role of phytopharmaceuticals in inflammatory disorders
1. Introduction
2. Antiinflammatory phytochemicals
3. Phytopharmaceuticals regulate inflammatory markers and thus boost immunity to alleviate COVID-19 (SARS-CoV-2)
4. Resveratrol
5. Curcumin
6. Quercetin
7. Genistein
8. Butyrate
9. Licorice
10. Proanthocyanidins (PAC)
11. Bromelain
12. Naringenin
13. Naringin
14. Chrysin
15. Mangiferin
16. Conclusion
Index

Manju Rawat Singh

Dr. Manju Singh obtained her M.Pharm in Pharmaceutical biotechnology from the Department of Pharmaceutical sciences, Dr. H.S. Gour Central University, Sagar in 2004 and Ph.D from University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) India in 2009 where she is currently working as assistant professor. She has around 18 years of teaching and research experience. Her prime research area includes designing strategies for protein and peptide delivery, topical systems for autoimmune disorders like psoriasis, rheumatoid arthritis, inflammatory bowel disease and experimental designing using advanced statistical and mathematical modeling methods. She has 80 research and review papers published in national and international journals. She has citations more than 3000 with h-index 28 and i10 index of 49 (Google scholar) and scopus h-index 21; 4100 citations. She has 2 international and 1 Indian patent. She has successfully completed several projects funded by Indian council of medical research (ICMR), university grants commission (UGC), C.G. state council of science and technology (CGCOST), and Department of science and technology (DST). She is recipient of DHR-ICMR international fellowship 2014-15 and number of awards at national and state level for excellence in research viz. Young scientist award of the state of Chhattisgarh 2006 in biotechnology. She has been bestowed with Best Teacher award (Assistant Professor) of Pt. Ravishankar Shukla University in science section 2016. She is a life member of various professional bodies like Indian Pharmaceutical association (IPA), Association of Pharmacy teachers of India (APTI), Indian Pharmacy Graduates Association (IPGA). She had been visiting scientist at School of Pharmacy, Department of Pharmaceutics, University of Mississippi, Oxford, USA 2015. She is engaged in research projects focused on studying the role of plant bioactives in devising new treatments mainly for autoimmune disorders and inflammatory diseases in collaboration with various universities in India and abroad.

Affiliations and expertise

Assistant Professor (Senior), University Institute of Pharmacy, Pt. Ravishankar Shukla University, India

Deependra Singh

Dr. Deependra Singh is presently working as assistant professor at University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) India. He is a central member of the Pharmacy council of India. He has around 18 years of teaching and research experience. His prime research area includes formulation of multiple bioactive delivery systems like multiphase hydrogels, nanosystems, microspheres for wound management, advanced statistical and mathematical modelling methods, Tissue Culture Techniques, nutraceuticals and designing novel systems for plant actives and extracts. He has more than 90 research and review papers published in national and international journals. He has successfully completed projects funded by UGC, AICTE, DST and several industrial projects. He has citations more than 4000 with h-index 28 and i10 index of 49 (Google scholar) and scopus h-index 21; 4100 citations. He has 2 international and 1 Indian patent. He is recipient of prestigious Department of health research-ICMR young Indian biomedical scientist award 2019, UGC RAMAN international award 2014 and UGC Research Award 2012 by university Grants Commission, New Delhi. He has prestigious awards at state level for excellence in research viz.; Young scientist award of the state of Chhattisgarh 2006 in medical sciences. He is state evaluator and trainee for national children science congress. He is a life member of various professional bodies like Indian Pharmaceutical association (IPA), Association of Pharmacy teachers of India (APTI), Indian Society of Pharmacognosy (ISP) and serving as President, Chhattisgarh state branch APTI 2013 (Elected); Secretary, Chhattisgarh state branch IPA. He had been visiting scientist at National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Mississippi USA.

Affiliations and expertise

Assistant Professor (Senior), University Institute of Pharmacy, Pt. Ravishankar Shukla University, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health