Translational Neuroimmunology, Volume 7
Neuroinflammation
- 1st Edition - June 16, 2023
- Imprint: Academic Press
- Editors: Nima Rezaei, Niloufar Yazdanpanah
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 8 4 1 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 0 0 7 1 - 3
Translational NeuroImmunology: Neuroinflammation updates on bench to bedside studies on neurological disorders that have immunological etiologies. The book covers neuroimmu… Read more
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Request a sales quoteTranslational NeuroImmunology: Neuroinflammation updates on bench to bedside studies on neurological disorders that have immunological etiologies. The book covers neuroimmunology and the principles of autoimmune and autoinflammatory neurological disorders, with multiple sclerosis as the main focus. The immunopathology, genetics and epigenetics, microbiome, diagnosis and treatment of multiple sclerosis will be explained in ten chapters. A chapter also examines distinct aspects of pericytes, with final discussions on the neurologic manifestations, diagnostic approaches and treatments of the various neuroimmune disorders and lessons learned from translational research on non-human primates and zebrafish.
All sections are presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research.
- Gives an introduction on neuroimmunological diseases, from bench to bedside
- Encourages the development of immunologic approaches to analyze the interaction and specific properties of nervous tissue elements during development and disease
- Focuses on understanding and therapeutically manipulating immunological responses to injury, degeneration and autoimmunity in the central nervous system
- Proves changes in relevant immune and inflammatory reactions at the cellular and molecular level during the development of nervous system diseases
Clinical immunologists, neurologists, Rheumatologist, Endocrinologists, Microbiologists, Oncologists, Rheumatologists, Clinicians, research scientists, and industry partners
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Series editor’s biography
- Abbreviations
- Chapter 1: Introduction on neuroinflammation
- Abstract
- 1: Introduction
- 2: Cellular contributors
- 3: Molecular contributors
- 4: Acute and chronic neuroinflammation
- 5: Consequences of neuroinflammation
- 6: Conclusion
- References
- Chapter 2: Neuroimmune interactions: From bench to bedside
- Abstract
- 1: Introduction
- 2: Immune to brain communication
- 3: The brain-immune crosstalk
- 4: Neuroimmune interaction in the gut: The gut microbiota
- 5: From bench to bedside: Perspectives
- 6: Conclusion
- References
- Chapter 3: Neuroimmunology: Translational lessons from zebrafish models
- Abstract
- 1: Introduction
- 2: Zebrafish immune system
- 3: Zebrafish neuroimmune models
- 4: Zebrafish models for studying gut microbiota-brain interplay
- 5: Conclusion
- References
- Chapter 4: The COVID-19–related neuroinflammation model may reveal relevant information on healthy longevity
- Abstract
- Funding
- 1: Introduction
- 2: Correlation among GCs and neuroinflammation, COVID-19, and AD
- 3: GCs, AD, and COVID-19
- 4: Conclusion
- References
- Chapter 5: Role of neural-immune dysregulation in the periphery in the development of age-associated immune dysfunctions
- Abstract
- 1: Introduction
- 2: Sympathetic innervations of lymphoid organs
- 3: Neuroimmunomodulation by norepinephrine
- 4: Neuroendocrine-immune interactions in aging
- 5: Neuroendocrine-immune modulations in autoimmune diseases
- 6: Sympathectomy and neuroendocrine-immune homeostasis
- 7: Mechanistic role of adrenoceptors in autoimmunity
- 8: Sympathetic regulation of autoimmune diseases
- 9: Conclusion
- References
- Chapter 6: Pericytes, a cell type contributing to autoimmunity and immune tolerance
- Abstract
- 1: Introduction
- 2: Physiological role
- 3: Pericytes in the immune system
- 4: Proinflammatory implications of pericytes in autoimmune diseases
- 5: Pericytes and immune tolerance in cancer
- 6: Conclusion
- References
- Chapter 7: Immunity and cognition
- Abstract
- Conflict of interest
- 1: Introduction
- 2: The biological basis of memory and cognition
- 3: The immune system and synaptic function
- 4: Immune system activation and cognitive dysfunction: Translational lessons from multiple sclerosis
- 5: Conclusion
- References
- Chapter 8: Neuroimmunology and sleep
- Abstract
- 1: Introduction
- 2: Sleep and EEG power spectra
- 3: Cytokines
- 4: Interleukin-1β
- 5: Tumor necrosis factor alpha
- 6: Extracellular ATP
- 7: Adenosine
- 8: Oxidative stress
- 9: Cyclooxygenases and prostaglandins
- 10: Nuclear transcription factor kappa B
- 11: Nitric oxide
- 12: Stress
- 13: Neurovascular unit and cerebral blood flow
- 14: Conclusion
- Funding
- References
- Chapter 9: The impact of systemic inflammation on neuroinflammation
- Abstract
- 1: Introduction
- 2: Detrimental role of peripheral inflammation
- 3: Systemic inflammatory pathways to reach CNS
- 4: Systemic inflammation and brain innate immunity response
- 5: Role of systemic inflammation on inflammaging
- 6: Contribution of systemic inflammation and neuroinflammation on neurodegeneration
- 7: Conclusion
- References
- Chapter 10: Rare autoimmune and autoinflammatory neurologic disorders
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Autoimmune encephalitis
- 3: CNS vasculitis
- 4: Hashimoto’s encephalopathy
- 5: Autoimmune epilepsy
- 6: Morvan syndrome
- 7: Isaacs’ syndrome
- 8: Neuromyelitis optica spectrum disorders
- 9: Autoimmune optic neuritis
- 10: Neurosarcoidosis
- 11: Neuro-Behçet’s disease
- 12: CNS lupus
- 13: Myasthenia gravis
- 14: Chronic inflammatory demyelinating polyradiculoneuropathy
- 15: Lambert-Eaton Myasthenic syndrome
- 16: Socioeconomic impact autoimmune and autoinflammatory rare neurologic disorders
- 17: Conclusion
- References
- Chapter 11: Epstein-Barr virus and neuroinflammation
- Abstract
- Acknowledgments
- 1: Introduction
- 2: EBV disrupts the homeostasis of peripheral immune components
- 3: The fine line between CNS immunity and neuroinflammation
- 4: Translational immune control of EBV
- 5: Conclusion
- References
- Chapter 12: The potential role of dietary intervention for the treatment of neuroinflammation
- Abstract
- 1: Introduction
- 2: Neurotoxic triad
- 3: High-fat, high-sugar Western diet
- 4: Mediterranean diet
- 5: Omega-3 fatty acids
- 6: Phytochemicals
- 7: Vitamins
- 8: Minerals
- 9: Amino acids
- 10: Conclusion
- References
- Chapter 13: Immune dysregulation and neurodegenerative diseases
- Abstract
- 1: Introduction
- 2: Immunosenescence and neuroinflammation in dementia syndromes
- 3: Alzheimer’s disease
- 4: Dementia with Lewy bodies
- 5: Frontotemporal dementia
- 6: Role of brain barriers
- 7: Peripheral inflammatory biomarkers
- 8: Therapeutic perspectives
- 9: Conclusion
- References
- Chapter 14: Inflammatory and immunological aspects of glaucoma, optic neuritis, and neuromyelitis optica impacting eyesight
- Abstract
- 1: Introduction
- 2: Primary open-angle glaucoma and the eye
- 3: Key retinal cells involved in glaucoma pathogenesis
- 4: Inflammatory and immune-mediated retinoaxonal damage in glaucoma
- 5: Autoimmunity and glaucoma
- 6: OHT and glaucoma treatment options
- 7: Neuroprotection to combat and overcome glaucoma
- 8: Uveitic and pigmentary glaucoma
- 9: Optic neuritis related to multiple sclerosis
- 10: Neuromyelitis optica/neuromyelitis optica spectrum disorder
- 11: Conclusion
- References
- Further reading
- Chapter 15: Imaging characteristics of neuroimmunological disorders
- Abstract
- 1: Introduction
- 2: Multiple sclerosis
- 3: Radiologically isolated syndrome
- 4: Clinically isolated syndrome
- 5: Optic neuritis
- 6: Transverse myelitis
- 7: Neuromyelitis optica
- 8: Acute disseminated encephalomyelitis
- 9: Progressive multifocal leukoencephalopathy
- 10: Fulminant/Marburg variant MS
- 11: Tumefactive MS and tumefactive demyelinating lesions
- 12: Primary angiitis of the central nervous system
- 13: Neurosarcoidosis
- 14: Hashimoto encephalopathy
- 15: Neuro-Behçet disease
- 16: Limbic encephalitis
- 17: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids
- 18: Bickerstaff brainstem encephalitis
- 19: Neuropsychiatric systemic lupus erythematous
- 20: Susac syndrome
- 21: Childhood/developmental
- 22: Neurological paraneoplastic syndromes
- 23: Acute inflammatory demyelinating polyneuropathy
- 24: COVID-19 and neuroinflammatory disorders
- 25: Conclusion
- References
- Chapter 16: Contribution of neuroimaging studies to the understanding of immunology and inflammation in epilepsy
- Abstract
- 1: Introduction
- 2: Neuroinflammation and epilepsy
- 3: Contributions of neuroimaging
- 4: Positron emission tomography
- 5: 1H-magnetic resonance spectroscopy
- 6: Brain thermometry
- 7: Structural and diffusion MRI
- 8: Autoimmune epilepsy and neuroimaging
- 9: Conclusion
- References
- Chapter 17: Bedside to benchside translation with the targeting of the BAFF/APRIL axis in neurological autoimmune disorders
- Abstract
- 1: Introduction
- 2: B cells and autoimmune diseases in the CNS
- 3: The success of B cell depletion by anti-CD20 and anti-CD19 monoclonal antibodies
- 4: The BAFF/APRIL axis and autoimmune diseases in the CNS
- 5: Conclusion
- References
- Chapter 18: New insights on granulocyte-macrophage colony-stimulating factor (GM-CSF) as potential therapeutic target for immune-mediated neurological disorders
- Abstract
- 1: Introduction
- 2: GM-CSF in MS
- 3: GM-CSF in experimental autoimmune encephalomyelitis
- 4: GM-CSF in other immune-mediated neurological disorders
- 5: Chimeric antigen receptor-T cell therapy and immune effector cell-associated neurotoxicity syndrome
- 6: GM-CSF and Alzheimer’s disease
- 7: Clinical trials targeting GM-CSF in MS
- 8: Immunometabolism and GM-CSF
- 9: Conclusion
- References
- Chapter 19: Inflammasome elements in epilepsy and seizures
- Abstract
- 1: Introduction
- 2: Epilepsy and seizures; definition, classification, and neuroimmunopathology
- 3: Role of inflammasomes in epilepsy; NLRPs, NLRCs, AIMs, and noncanonical mechanisms
- 4: Insights for future research
- 5: Conclusion
- References
- Chapter 20: Neuroinflammation as a potential therapeutic target in neuroimmunological diseases
- Abstract
- 1: Introduction
- 2: Medicinal herbs and organic compounds
- 3: Endogenous neuroactive substances
- 4: Drug repurposing targeting neuroimmunological diseases
- 5: Nonpharmacological targets affecting neuroinflammation
- 6: Conclusion
- References
- Index
- Edition: 1
- Published: June 16, 2023
- Imprint: Academic Press
- No. of pages: 540
- Language: English
- Paperback ISBN: 9780323858410
- eBook ISBN: 9780323900713
NR
Nima Rezaei
Professor Nima Rezaei gained his medical degree (MD) from Tehran University of Medical Sciences and subsequently obtained an MSc in Molecular and Genetic Medicine and a PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Pediatric Clinical Immunology and Bone Marrow Transplantation in the Newcastle General Hospital. Professor Rezaei is now the Full Professor of Immunology and Vice Dean of Research, School of Medicine, Tehran University of Medical Sciences, and the co-founder and Head of the Research Center for Immunodeficiencies. He is also the founding President of the Universal Scientific Education and Research Network (USERN). Professor Rezaei has already been the Director of more than 55 research projects and has designed and participated in several international collaborative projects. Professor Rezaei is an editorial assistant or board member for more than 30 international journals. He has edited more than 35 international books, has presented more than 500 lectures/posters in congresses/meetings, and has published more than 1,000 scientific papers in the international journals.
Affiliations and expertise
Professor, Department of Immunology, School of Medicine; Head, Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences; Founding President, Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA),Universal Scientific Education and Research Network (USERN),Tehran, IranNY
Niloufar Yazdanpanah
Affiliations and expertise
Managing Director, Network of Immunity in Infection,
Malignancy and Autoimmunity (NIIMA)
Universal Scientific Education and Research Network (USERN); and School of Medicine,
Tehran University of MEdical Sciences,
Tehran, IranRead Translational Neuroimmunology, Volume 7 on ScienceDirect