Advances in Immunology
- 1st Edition, Volume 158 - July 13, 2023
- Imprint: Academic Press
- Editors: Frederick W. Alt, Kenneth Murphy
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 3 3 0 - 9
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 3 3 1 - 6
Advances in Immunology, Volume 158, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immuno… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteAdvances in Immunology, Volume 158, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.
- Presents current developments and comprehensive reviews in immunology
- Provides the latest in a longstanding and respected serial on the subject matter
- Focuses on recent advances in t cells and HIV infection
Immunologists and infectious disease specialists, cell biologists and hematologists
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Chapter One: RIG-I-like receptors: Molecular mechanism of activation and signaling
- Abstract
- 1: RIG-I-like receptors activate antiviral immune responses
- 2: MDA5 complements RIG-I in targeting a broad spectrum of viral infections
- 3: LGP2 shares more homology to MDA5 than to RIG-I
- 4: MAVS on mitochondria and its downstream interaction
- 5: Molecular basis of the genetic diseases associated with RLRs
- 6: Development of therapeutics targeting RLRs
- References
- Chapter Two: Regulation of gasdermins in pyroptosis and cytokine release
- Abstract
- 1: Introduction
- 2: Processing of gasdermins by host proteases
- 3: Regulation of GSDMB and GSDMD through ubiquitination
- 4: Cys modifications in gasdermins that regulate pyroptosis
- 5: Phosphorylation of gasdermins
- 6: The roles of gasdermins in cytokine release
- 7: Conclusions and future perspectives
- References
- Edition: 1
- Volume: 158
- Published: July 13, 2023
- No. of pages (Hardback): 114
- No. of pages (eBook): 198
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443193309
- eBook ISBN: 9780443193316
FA
Frederick W. Alt
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
Affiliations and expertise
Investigator and Director, Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USAKM
Kenneth Murphy
Kenneth M. Murphy works in Washington University School of Medecine, USA.
Affiliations and expertise
Washington University School of Medecine, USARead Advances in Immunology on ScienceDirect