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Navigating Non-coding RNA
From Biogenesis to Therapeutic Application
1st Edition - June 17, 2023
Editor: Joanna Sztuba-Solinska
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 4 0 6 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 7 0 0 - 2
Navigating Non-coding RNA: From Biogenesis to Therapeutic Application provides a concise overview of the field of non-coding RNA (ncRNA). Chapters cover the history of discoveries… Read more
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Navigating Non-coding RNA: From Biogenesis to Therapeutic Application provides a concise overview of the field of non-coding RNA (ncRNA). Chapters cover the history of discoveries that have occurred in the area of ncRNA, specific types of ncRNA, housekeeping ncRNAs such as ribosomal RNA, transfer RNA, small nuclear RNA and telomerase RNA, regulatory ncRNAs such as microRNA, small interfering RNA, long non-coding RNA and Y RNA. Biogenesis, structure, function, and regulation of each of these are also explored in addition to traditional and cutting-edge methods for the identification, functional characterization and structural characterization of ncRNA.
The book also focuses on the different types of epitranscriptomic modifications and their involvement in regulating ncRNA structure, stability and intermolecular interactions in addition to the role of ncRNAs in a range of diseases and potential therapeutic applications.
- Covers a wide range of non-coding RNAs, including ribosomal RNA, transfer RNA, telomerase RNA, microRNA, small interfering RNA and circular RNA
- Features both traditional and novel methodologies for investigating ncRNA, from microarray and conventional chemical probing to CAGE-seq and computational methods
- Includes chapters on ncRNAs in a range of diseases, including cancers, neurological disorders, cardiovascular conditions and infectious illnesses
- Discusses novel therapeutic strategies for targeting ncRNAs, including CRISP/Ca9 applications and RNAi-based strategies
- Explores the molecular mechanisms and intermolecular interactions of ncRNA
Researchers involved in RNA investigation, molecular biology and biochemistry, biomedicine, and related fields, Undergraduate, graduate and postdoctoral students in molecular biology, biochemistry, and related life science programs
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Chapter 1. History and definitions of ncRNAs
- The C-value paradox—there is more to a genome than protein-coding genes
- Protein synthesis, splicing, and RNA with catalytic function—the early days of ncRNA research
- Pervasive transcription
- Small ncRNAs
- Medium ncRNAs
- Long non-coding RNAs
- Conclusions
- Chapter 2. Regulatory non-coding RNAs-biogenesis, mechanisms of action and role in gene expression regulation
- Introduction
- microRNAs (miRNAs)
- Small interfering RNAs (siRNAs)
- Long non-coding RNAs (lncRNAs)
- Enhancer RNAs (eRNAs)
- Circular RNAs (circRNAs)
- Piwi RNAs (piRNAs)
- Vault RNAs (vRNAs)
- Concluding remarks
- Chapter 3. Non-coding RNAs: Mechanisms of action
- MicroRNAs
- PIWI-interacting RNAs
- Small nucleolar RNAs
- Small nuclear RNAs
- tRNA-derived fragments
- Long non-coding RNAs
- Circular RNAs
- Enhancer RNAs
- CRediT author statement
- Chapter 4. Functional characterization of lncRNAs
- Introduction
- Genomic features
- Transcriptomic features
- Subcellular localization
- Interacting partners (RNA/DNA/protein)
- RNA structure
- Perturbation experiments followed by phenotypic assessment
- High-throughput functional screening
- Outlook
- Chapter 5. Secondary structural characterization of non-coding RNAs
- Introduction
- In silico approaches for the characterization of non-coding RNA secondary structure
- Experimental approaches for the characterization of non-coding RNA secondary structure
- Example analysis of the human H19 long noncoding RNA
- Conclusion
- Author contributions
- Chapter 6. Regulation of non-coding RNAs
- Introduction
- Transcriptional regulation of ncRNAs
- Identification of promoter regions for miRNAs and lncRNAs
- Epitranscriptomic regulation of non-coding RNA
- A-to-I editing
- Funding
- Chapter 7. Non-coding RNAs in human non-infectious diseases
- Introduction
- Aberrant regulation of non-coding RNAs in rheumatoid arthritis
- Dysregulation of non-coding RNA in systemic lupus erythematosus
- Conclusions and perspectives: autoimmune and inflammatory diseases
- Cardiac and skeletal muscle
- Disease of cardiac muscle
- Atrophic conditions in skeletal muscle
- Conclusions and perspectives: cardiac and skeletal muscle diseases
- Chapter 8. Non-coding RNAs in human infectious diseases
- Introduction
- Biogenesis of non-coding RNA
- Innate immune response elicited by pathogens
- Non-coding RNAs in viral infections
- Non-coding RNAs in bacterial infections
- Non-coding RNAs in other infections
- Predisposition to infectious diseases due to genetic polymorphism
- Non-coding RNAs as therapeutics for infectious diseases
- Conclusion
- Chapter 9. Therapeutic targeting non-coding RNAs
- Introduction
- Non-coding RNA-based therapeutics
- Conclusions and perspectives
- Index
- No. of pages: 448
- Language: English
- Published: June 17, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780323904063
- eBook ISBN: 9780323907002
JS
Joanna Sztuba-Solinska
Joanna Sztuba-Solinska is an Assistant Professor at the Department of Biological Sciences, Auburn University, Alabama, US. She has more than ten years’ experience working across the fields of molecular virology and biochemistry, with specific training and expertise in the analysis of RNA structure, regulation, and function in different viral systems, including herpesviruses, filoviruses, and flaviviruses. Dr. Sztuba-Solinska is currently also Principal Investigator at Auburn University where she leads a laboratory team working at the interface of molecular biology and virology, where they use molecular, biochemical, and bioinformatic tools to study the structure, function, epitranscriptomic regulation of viral coding and non-coding RNAs. This research ultimately leads to understanding the viral RNAs structure-to-function relationship, and the potential identification of new antiviral targets and therapies.
Affiliations and expertise
Assistant Professor, Department of Biological Sciences, Auburn University, Auburn, Alabama, USA