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Elsevier

Books in Life sciences

  • Autoimmunity, COVID-19, Post-COVID19 Syndrome and COVID-19 Vaccination

    • 1st Edition
    • Volume 1
    • Yehuda Shoenfeld + 1 more
    • English
    Autoimmunity, COVID-19, Post-COVID-19 Syndrome and COVID-19 Vaccination covers all aspects of what is perhaps the most dramatic health crisis in the history of modern medicine. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raised major concerns about the association between the virus and various autoimmune manifestations. Over 15 distinct autoantibodies and above 10 different autoimmune diseases were found to develop in COVID-19 patients. Moreover, evidence about recovered COVID-19 patients demonstrates that persistent systemic symptoms, which are believed to have an autoimmune-related mechanism, do exist. As it is of great importance to recognize those autoimmune manifestations of COVID-19 and post-COVID-19 syndrome to properly cope with their outcomes in the ongoing pandemic and the long-term post-pandemic period, this book fulfills a vital need in the medical community.

  • Elemene Antitumor Drugs

    Molecular Compatibility Theory and its Applications in New Drug Development and Clinical Practice
    • 1st Edition
    • Tian Xie
    • English
    Elemene Antitumor Drugs: Molecular Compatibility Theory and its Applications in New Drug Development and Clinical Practice introduces natural anti-tumor drug elemene and systematic basic and clinical research. Basic principles of the compatibility theory of traditional Chinese medicine and the research and development process of the natural anti-tumor drug elemene under the guidance of this principle are introduced. In addition, the traditional extraction and separation of elemene and the new biosynthesis technology developed by the author's team are described. Then, the systematic anti-tumor mechanism research of elemene are introduced, including unique multi-target and comprehensive anti-tumor mechanisms and detailed mechanisms for treating specific tumors. Under the guidance of compatibility theory, clinical research on the combined application of elemene and different chemotherapeutic drugs has been further carried out, achieving positive results in clinical practice. Finally, the book also introduces the research and exploration of new drug delivery systems of elemene, as well as the structural modification and drug discovery progress taking elemene structure as the lead compound.

  • Biomedical Defense Principles to Counter DNA Deep Hacking

    • 1st Edition
    • Rocky Termanini
    • English
    Biomedical Defense Principles to Counter DNA Deep Hacking presents readers with a comprehensive look at the emerging threat of DNA hacking. Dr. Rocky Termanini goes in-depth to uncover the erupting technology being developed by a new generation of savvy bio-hackers who have skills and expertise in biomedical engineering and bioinformatics. The book covers the use of tools such as CRISPR for malicious purposes, which has led agencies such as the U.S. Office of the Director of National Intelligence to add gene editing to its annual list of threats posed by "weapons of mass destruction and proliferation." Readers will learn about the methods and possible effects of bio-hacking attacks, and, in turn the best methods of autonomic and cognitive defense strategies to detect, capture, analyze, and neutralize DNA bio-hacking attacks, including the versatile DNA symmetrical AI Cognitive Defense System (ACDS). DNA bio-hackers plan to destroy, distort and contaminate confidential, healthy DNA records and potentially create corrupted genes for erroneous diagnosis of illnesses, disease genesis and even wrong DNA fingerprinting for criminal forensics investigations.

  • Epigenetics in Organ Specific Disorders

    • 1st Edition
    • Volume 34
    • English
    **Selected for Doody’s Core Titles® 2024 in Clinical Genetics**Epigenetic... in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth.Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies.

  • Microbial Biomolecules

    Emerging Approach in Agriculture, Pharmaceuticals and Environment Management
    • 1st Edition
    • Ajay Kumar + 3 more
    • English
    Microbial Biomolecules: Emerging Approach in Agriculture, Pharmaceuticals and Environment Management explores and compiles new aspects of microbial-based biomolecules such as microbial enzymes, microbial metabolites, microbial surfactants, exopolysaccharides, and bioactive compounds and their potential applications in the field of health-related issues, sustainable agriculture and environment contamination management. Written for researchers, scientists, and graduate and PhD students in the areas of Microbiology, Biotechnology, Environmental Science and Pharmacology, this book covers the urgent need to explore eco-friendly and sustainable approaches to healthcare, agriculture and environmental contamination management.

  • Perinatal and Developmental Epigenetics

    • 1st Edition
    • Volume 35
    • Garima Singh
    • English
    Perinatal and Developmental Epigenetics, Volume 32, a new volume in the Translational Epigenetics series, provides a thorough overview of epigenetics in the early developmental and perinatal stages, illuminating pathways for drug discovery and clinical advances. Here, over 25 international researchers examine recent steps forward in our understanding of epigenetic programming during perinatal and early development. The book opens with an in-depth introduction to known and newly discovered epigenetic marks and how they regulate various cellular processes. Later sections examine various prenatal and perinatal environmental experiences and their ability to derail the normal developmental trajectory via epigenetic reprogramming. Insights and suggestions for future research illuminate approaches for identifying individual disease susceptibility. Concluding chapters highlight preventative and targeted therapeutic pathways to improve quality of life into adulthood.

  • Rapid Sensory Profiling Techniques

    Applications in New Product Development and Consumer Research
    • 2nd Edition
    • Julien Delarue + 1 more
    • English
    Rapid Sensory Profiling Techniques: Applications in New Product Development and Consumer Research, Second Edition presents the latest findings and recommendations on the proper choice and use of rapid product profiling methods. Each chapter is written by a key opinion leader on a specific method with discussions on theory, pros, cons and the application of each method that is demonstrated through a case study. This valuable resource educates and empowers those working in research and development on how to meet shorter product turnaround times at lower cost and with no compromise on quality.This book is not just needed by the scientific community, it is an essential must have in an industry challenged by a "speed to market" mantra.

  • Omics Approaches and Technologies in COVID-19

    • 1st Edition
    • Debmalya Barh + 1 more
    • English
    The COVID-19 pandemic has affected the entire world in an unprecedented way since 2019. However, novel and innovative applications of various omics, computational, and smart technologies have helped manage the pandemic of the 21st century in a very effective manner. Omics approaches and technologies in COVID-19 presents up-to-date knowledge on omics, genetic engineering, mathematical and computational approaches, and advanced technologies in the diagnosis, prevention, monitoring, and management of COVID-19. This book contains 26 chapters written by academic and industry experts from more than 15 countries. Split into three sections (Omics; Artificial Intelligence and Bioinformatics; and Smart and Emerging Technologies), it brings an overview of novel technologies under omics such as, genomic, metagenomic, pangenomic, metabolomics and proteomics in COVID-19. In addition, it discusses hostpathogen interactions and interactomics, management options, application of genetic engineering, mathematical modeling andsimulations, systems biology, and bioinformatics approaches in COVID-19 drug discovery and vaccine development. This is a valuable resource for students, biotechnologists, bioinformaticians, virologists, clinicians, and pharmaceutical, biomedical, and healthcare industry people who want to understand the promising omics and other technologies used in combating COVID-19 from various aspects.

  • Cardiopulmonary Bypass

    Advances in Extracorporeal Life Support
    • 1st Edition
    • Kaan Kırali + 2 more
    • English
    Cardiopulmonary Bypass: Advancements in Extracorporeal Life Support provides comprehensive coverage on the technological developments and clinical applications of extracorporeal technologies, including the underlying basic science and the latest clinical advances in the field. Written by experts around the world, this book comprises all characteristics of cardiopulmonary bypass as well as chapters regarding equipment, physiology and pathology, pediatric aspects and clinical applications. Important highlights include the latest updates regarding minimal invasive cardiopulmonary bypass (MICPB), extracorporeal circulatory and respiratory support (ECCRS) in cardiac and non-cardiac patients, ECMO support in COVID-19, and updated guidelines of extracorporeal technologies. This book is an invaluable resource to clinicians, researchers and medical students in the fields of cardiothoracic surgery, cardiac anesthesiology, intensive care, and perfusion technology.

  • Mitochondrial Intoxication

    • 1st Edition
    • Marcos Roberto de Oliveira
    • English
    Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease.

  • Advances in Extraction and Applications of Bioactive Phytochemicals

    • 1st Edition
    • Mihir Kumar Purkait + 2 more
    • English
    Advances in Extraction and Applications of Bioactive Phytochemicals presents comprehensive and systematic coverage of extraction techniques for bioactive phytochemical compounds and their delivery and therapeutic effectiveness. Sections focus on the pharmaceutical industry’s perspective, aiming at compiling recent advances of natural products in the field of drug delivery, including a brief overview of plant-based bioactive molecules, utilization of different plant elements for the extraction of phytochemicals, a compilation of conventional extraction approaches, advanced extraction methods, including Supercritical carbon-dioxide extraction, computational methods to improve production, drug delivery aspects of bioactive phytochemicals, their therapeutic effectiveness, and more. This book is a complete reference targeted at pharma researchers in academic and corporate environments and those willing to apply the most current extraction methods and health applications. Researchers in medicinal chemistry and chemical engineering will also benefit from this comprehensive resource.

  • Animal Assisted Therapy Use Application by Condition

    • 1st Edition
    • Eric Altschuler
    • English
    Animal Assisted Therapy Use Application by Condition provides the most updated and comprehensive data knowledge on animal-assisted therapy. The book synthesizes historical information, theory, clinical practice, and data from recent clinical studies on animal-assisted therapy for post-traumatic stress disorder (PTSD) and other diseases. Written by international experts drawn from the fields of medicine, clinical psychology and therapy, speech therapy, clinical research, and animal training and welfare, this book employs a hypothesis driven, data rich approach to inform readers on current research and serve as a reference for clinical practice and use of animal-assisted therapy. This is an important resource for clinicians, researchers, animal trainers and handlers and students who want to understand and utilize animal-assisted therapy in theory and practice.

  • Genomic Data Sharing

    Case Studies, Challenges, and Opportunities for Precision Medicine
    • 1st Edition
    • Jennifer B. Mccormick + 1 more
    • English
    Genomic Data Sharing: Case Studies, Challenges, and Opportunities for Precision Medicine provides a comprehensive overview of current and emerging issues in genomic data sharing. In this book, international leaders in genomic data examine these issues in-depth, offering practical case studies that highlight key successes, challenges and opportunities. Sections discuss the eMERGE Network, Undiagnosed Disease Network, Vanderbilt Biobank, Marshfield Clinic Biobank, Minnesota Authorization, Rochester Epidemiology Project, NIH sponsored biobanks, GINA, and Global Alliance for Genomics and Health (GA4GH). In addition to these perspectives from the frontlines, the book also provides succinct overviews of ethical, legal, social and IT challenges.Clinician investigators, clinicians affiliated with academic medical centers, policymakers and regulators will also gain insights that will allow them to navigate the increasingly complex ethical, social and clinical landscape of genomic data sharing.

  • Spinal Interneurons

    Plasticity after Spinal Cord Injury
    • 1st Edition
    • Lyandysha Viktorovna Zholudeva + 1 more
    • English
    The spinal cord is comprised of four types of neurons: motor neurons, pre-ganglionic neurons, ascending projection neurons, and spinal interneurons. Interneurons are neurons that process information within local circuits, and have an incredible ability for neuroplasticity, whether due to persistent activity, neural injury, or in response to disease. Although, by definition, their axons are restricted to the same structure as the soma (in this case the spinal cord), spinal interneurons are capable of sprouting and rewiring entire neural circuits, and contribute to some restoration of disrupted neural communication after injury to the spinal cord (i.e., “bypassing” the lesion site). Spinal Interneurons provides a focused overview of how scientists classify interneurons in general, the techniques used to identify subsets of interneurons, their roles in specific neural circuits, and the scientific evidence for their neuroplasticity. Understanding the capacity for neuroplasticity and identity of specific spinal interneurons that are optimal for recovery, may help determine cellular candidates for developing therapies. Spinal Interneurons provides neuroscientists, clinicians, and trainees a reference book exclusively concentrating on spinal interneurons, the techniques and experiments employed to identify and study these cells as part of normal and compromised neural circuits, and highlights the therapeutic potential of these cells by presenting the relevant pre-clinical and clinical work to date. People in industry will also benefit from this book, which compiles the latest in therapeutic strategies for targeting spinal interneurons, what considerations there are for the development and use of treatments, and how such treatments can not only be translated to the clinic, but how existing treatments should be appropriately reverse-translated to the bench.

  • Neglected and Underutilized Crops

    Future Smart Food
    • 1st Edition
    • Muhammad Farooq + 1 more
    • English
    Neglected and Underutilized Crops: Future Smart Food explores future food crops with climate resilience potential. Sections cover their botany, nutritional significance, global distribution, production technology, and tolerance to biotic and abiotic stresses of neglected and underutilized crops. By simply changing species in a crop rotation system, the cycle of some pests and diseases is disrupted and probabilities of infestations are reduced. Finally, the book provides case studies that highlight where the adaptation of crops to local environments, especially with regard to climate change, have been successful.These crops can help make agricultural production systems more resilient to climate change. Although a few books on neglected and underutilized crops are available, this comprehensive book covers the full scope of crop husbandry, nutritional significance and global distribution.

  • Neurocircuitry of Addiction

    • 1st Edition
    • Nicholas W. Gilpin
    • English
    People use drugs for many different reasons, including the pursuit of "high," social factors and self-medication of other conditions. Many millions of people are addicted to at least one substance, and the cost of addiction is immense, at both the individual and societal levels. Neurocircuitry of Addiction is the first book of its kind, with a focus on addiction neuroscience from a neural circuit perspective. This book begins with a primer on circuit-based neuroscience that equips the reader with an understanding of the applications described throughout the book. Each subsequent chapter positions a different brain region at the "center" of addiction neurocircuitry and goes on to describe the anatomical connectivity of that brain region, how those circuits are affected by drug exposure, and the role of those circuits in controlling addiction-related behaviors. All chapters of this book are written by content experts for a target audience that has some basic neuroscience background, but no prior in-depth knowledge regarding the neurocircuitry of addiction.

  • Agricultural Bioeconomy

    Innovation and Foresight in the Post-COVID Era
    • 1st Edition
    • Chetan Keswani + 3 more
    • English
    Agricultural Bioeconomy: Innovation and Foresight in the Post-COVID Era presents recent advancements in biotechnology, exploring the optimal utilization of technologies to provide rapid and impactful economic recovery and sustainable resources in a future that will bear the mark of COVID-19. Understanding that there is a necessary balance between risk and reward, this book provides a foundational hypothesis as well as operational direction for addressing the commercialization and regulatory issues in a bio-based economy where agricultural output is at the core. By presenting adaptable practices to successfully establish and progress agri-based global bioeconomies, the book features a new paradigm focused on technological foresight and response to future risks and disasters. Key considerations include assessing and managing the urban bioeconomy, climate change mitigation, biofuels and bioenergy, GMOs, and employment generation. This book provides the solid next step toward future-proofing global economies using a combination of agricultural technologies and economic goals. Professionals and advanced students focused on the production of renewable biological resources and their conversion into value-added products including food, feed, bio-based products, and bioenergy will find this book useful.

  • State of the Art in Neural Networks and Their Applications

    Volume 2
    • 1st Edition
    • Jasjit S. Suri + 1 more
    • English
    State of the Art in Neural Networks and Their Applications, Volume Two presents the latest advances in artificial neural networks and their applications across a wide range of clinical diagnoses. The book provides over views and case studies of advances in the role of machine learning, artificial intelligence, deep learning, cognitive image processing, and suitable data analytics useful for clinical diagnosis and research applications. The application of neural network, artificial intelligence and machine learning methods in biomedical image analysis have resulted in the development of computer-aided diagnostic (CAD) systems that aim towards the automatic early detection of several severe diseases. State of the Art in Neural Networks and Their Applications is presented in two volumes. Volume One: Neural Networks in Oncology Imaging covers lung cancer, prostate cancer, and bladder cancer. Volume Two: Neural Networks in Brain Disorders and Other Diseases covers autism spectrum disorder, Alzheimer’s disease, attention deficit hyperactivity disorder, hypertension, and other diseases. Written by experienced engineers in the field, these two volumes will help engineers, computer scientists, researchers, and clinicians understand the technology and applications of artificial neural networks.

  • Data Science for Genomics

    • 1st Edition
    • Amit Kumar Tyagi + 1 more
    • English
    Data Science for Genomics presents the foundational concepts of data science as they pertain to genomics, encompassing the process of inspecting, cleaning, transforming, and modeling data with the goal of discovering useful information, suggesting conclusions and supporting decision-making. Sections cover Data Science, Machine Learning, Deep Learning, data analysis, and visualization techniques. The authors then present the fundamentals of Genomics, Genetics, Transcriptomes and Proteomes as basic concepts of molecular biology, along with DNA and key features of the human genome, as well as the genomes of eukaryotes and prokaryotes. Techniques that are more specifically used for studying genomes are then described in the order in which they are used in a genome project, including methods for constructing genetic and physical maps. DNA sequencing methodology and the strategies used to assemble a contiguous genome sequence and methods for identifying genes in a genome sequence and determining the functions of those genes in the cell. Readers will learn how the information contained in the genome is released and made available to the cell, as well as methods centered on cloning and PCR.

  • The Veterinarian’s Guide to Animal Welfare

    • 1st Edition
    • Bonnie V. Beaver + 1 more
    • English
    The Veterinarian’s Guide to Animal Welfare provides an overview of various aspects of animal welfare that are particularly relative to the veterinary profession. The book explores various ways of viewing and assessing welfare, as well as the numerous factors that influence perceptions. Emphasis is placed on contemporary issues across, and within, major species groups. The book's authors are internationally known experts in the veterinary aspects of animal welfare and have written numerous articles on animal welfare, behavior, euthanasia and the human-animal bond. This book is written for the veterinary profession and was designed to be used as a textbook for animal welfare courses at colleges and schools of veterinary medicine. It complements the Model Curriculum for the Study of Animal Welfare (AVMA 2015) and its attendant course syllabus. This is an important resource for graduate veterinarians seeking to improve their understanding of the numerous aspects of animal welfare.

  • Frontiers in Aquaculture Biotechnology

    • 1st Edition
    • W.S. Lakra + 2 more
    • English
    Frontiers in Aquaculture Biotechnology presents a broad-spectrum of topics, covering different key aspects of aquaculture. With the rising importance of aquaculture research, evidence-based information is integral in advancing this field. This book provides a solid resource of information on DNA barcoding for fish species authentication and seafood labelling and cell culture, including stem cell culture, in vitro research using fish cell lines such as in vitro fish meat, reproductive biotechnology, including surrogate technology, gene editing and genetically modified aquaculture species, biofloc technology, and omic technologies such as proteomics, artificial intelligence and biobanking. This book will be a valuable resource to students, researchers a nd entrepreneurs interested in a better understanding of this emerging field of aquaculture.

  • Cardiopulmonary Bypass

    Advances in Extracorporeal Life Support
    • 1st Edition
    • Kaan Kırali + 2 more
    • English
    Cardiopulmonary Bypass: Advancements in Extracorporeal Life Support provides comprehensive coverage on the technological developments and clinical applications of extracorporeal technologies, including the underlying basic science and the latest clinical advances in the field. Written by experts around the world, this book comprises all characteristics of cardiopulmonary bypass as well as chapters regarding equipment, physiology and pathology, pediatric aspects, and clinical applications. Important highlights include the latest updates regarding minimal invasive cardiopulmonary bypass (MICPB), extracorporeal circulatory and respiratory support (ECCRS) in cardiac and non-cardiac patients, ECMO support in COVID-19 and updated guidelines of extracorporeal technologies. This book is an invaluable resource to clinicians, researchers and medical students in the fields of cardiothoracic surgery, cardiac anesthesiology, intensive care, and perfusion technology.

  • Principles of Cognitive Rehabilitation

    • 1st Edition
    • Vahid Nejati
    • English
    Principles of Cognitive Rehabilitation is designed to familiarize readers with the deep-rooted principles of cognitive rehabilitation and cognitive training. Presenting a new comprehensive framework in cognitive rehabilitation for therapeutic, educational, and research purposes, this volume introduces five components that are introduced for cognitive rehabilitation, including primary principles, patient, practitioner, program, and process (5Ps). Detailing the developmental stages of a program will help readers understand the logistics of cognitive interventions and also help them to design and evaluate their own therapeutic interventions.

  • Nanotechnology and Regenerative Medicine

    History, Techniques, Frontiers, and Applications
    • 1st Edition
    • Maria H. Santana + 2 more
    • English
    "Cell niches” are present in several human body tissues as a dynamic microenvironment essential to modulate stem cells’ behavior in health, under injury, and in regenerative processes. The interplay between stem cells and their niche is necessary for sustaining tissues. The extracellular matrix (ECM) is the crucial component of the stem cell. It defines the architectural space, physical binding to the cell membrane, and interactions with the neighborhood cells and supports physical stress. Domains with nano or micrometric sizes define the surface and topology of the ECM, mediating cell interactions and macrophage recruitment to injured sites. Over the last two decades, the integration of biomedicine with other engineering and biomaterial sciences promoted the development of nanotechnology and regenerative medicine toward mimicking the specialized stem cell niches to treat diseases with less invasive and efficient therapies. Innovative approaches in nanotechnology, such as targeting the immunological system, transporting drugs across blood–brain/BBB and blood–retinal barriers/BRB, directing active moiety to specific disease location/organs, encapsulation of multiple components, and promoting signalization and pathway-specific surfaces for cell interactions and growth, are indeed promising. On the other side, developments of biomaterial scaffolds to mimic the cell niches for interactions with stem cells in vitro or in vivo have tremendous potential. The three-dimensional printing technology offers a base for a wide array of applications, for example, developing tissue constructs, mimetic organs, organoids, and organ-on-a-chip, thus avoiding the differences between animal model species and humans. Aiming closer to the natural environments, fresh autologous products from the blood, such as platelet-rich plasma (PRP), contain platelets and leukocytes, providing growth factors, cytokines, and proteins for the resident stem cells in the stages of regeneration. PRP also provides pain relief, reducing disabilities in elderly or diseased people. This book brings thought-provoking multidisciplinary topics on the diverse aspects of basic and applied sciences. The prime focus of the compilation is to understand the challenges researchers encounter in combining nanotechnology and regenerative medicine, ultimately integrating both disciplines for the benefit of the patient and offering them a ray of hope to be cured.

  • Advances in Insect Physiology

    • 1st Edition
    • Volume 63
    • English
    Advances in Insect Physiology, Volume 63 in this longstanding series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of highly qualified authors.

  • Ultrasound and Microwave for Food Processing

    Synergism for Preservation and Extraction
    • 1st Edition
    • Gulzar Ahmad Nayik + 4 more
    • English
    Ultrasound and Microwave for Food Processing: Synergism for Preservation and Extraction analyzes the efficiency and validity of the combined effect of sonication and microwave in food processing, preservation, and extraction. This volume features novel food processing technologies for applications in meat, dairy, juice, and other food processing industries, and presents emerging research trends for future use development in food processing. This book is a comprehensive resource for experts and newcomers in the innovative food processing field, offering insight into physical principles of the technology, detailing the latest advancements, and linking them to current and potential applications in food and bioprocessing-relate... industries.

  • Microbiome in Neurological Disease

    • 1st Edition
    • Volume 167
    • English
    Microbiome in Neurological Disease, Volume 167 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Section in this new release cover Intersections of the microbiome and early neurodevelopment, Microbiome influences on neuro-immune interactions, The genomes of Parkinson’s disease, Experimental contributions of the microbiome to Parkinson’s disease, The foundations of microbiome contributions to Alzheimer’s disease, Immunologic pathways by which the gut microbiota influences Alzheimer’s disease, Role of the gut microbiome in Huntington’s Disease, and much more.

  • Side Effects of Drugs Annual

    A Worldwide Yearly Survey of New Data in Adverse Drug Reactions
    • 1st Edition
    • Volume 44
    • Sidhartha D. Ray
    • English
    Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 44, first published in 1977, presents clinicians and medical investigators with a critical survey of new data and trends in adverse drug reactions and interactions. Topics covered in this new release include Thyroid hormones, Iodine and Iodides, and Antithyroid Drugs, Side Effects of Antidepressant Medications, Side Effects of Lithium, Side Effects of Opioid Analgesics and Narcotic Antagonists, Side Effects of Beta-lactams and Tetracyclines, Side effects of Anti-diabetic Drugs, Vaccines, Side Effects of Neuromuscular Blockings Agents and Skeletal Muscle Relaxants, and much more. Other chapters cover General Anesthetics and Therapeutic Gases, Drugs that Act on the Respiratory Tract, Positive Inotropic Drugs and Drugs Used in Dysrhythmias, Metals and Metal Antagonists, Antiseptic Drugs and Disinfectants with special scrutiny of COVID-19 pandemic related side effects, Drugs in tuberculosis and leprosy, Anthelminthic drugs, Blood and blood treatments, and a variety of other topics.

  • The South African Herbal Pharmacopoeia

    Monographs of Medicinal and Aromatic Plants
    • 1st Edition
    • Alvaro Viljoen + 4 more
    • English
    The South African Herbal Pharmacopeia: Monographs of Medicinal and Aromatic Plants is a collection of 25 original monographs of medicinal plants that are currently under commercialization or have the potential for commercialization into herbal medicinal products for the global marketplace. Chapters include a general overview covering synonyms, common names, conservation status, botany, geographical distribution, ethnopharmacology, commercialization, pharmacological evaluation, chemical profiling and quality control, including HPTLC fingerprint analysis, UPLC analysis, gas chromatography and mid-infrared spectroscopy analysis. Academics researching pharmacy and analytical chemistry will benefit from the detailed chemical profile on each species presented. Industrial manufacturers of herbal products, herbal medicines, cosmetics, food supplements, and national and international policymakers and regulators will benefit from the overview provided at the beginning of each chapter.

  • Inflammasome Biology

    Fundamentals, Role in Disease States, and Therapeutic Opportunities
    • 1st Edition
    • Pablo Pelegrin
    • English
    Inflammasome Biology: Fundamentals, Role in Disease States, and Therapeutic Opportunities is a complete reference on the role of inflammasomes in health and disease. Sections cover the different types of inflammasomes, including cellular signaling, structural and evolutive aspects, overview the role of inflammasomes in key diseases, microbial infections and human body systems conditions, cover the interplay between Inflammasomes and cell death processes, and discuss current therapeutic opportunities driven by inflammasome research, including targeting, blocking and inhibiting the development of inflammasomes through both synthetic and natural compounds. This book is the perfect reference for cell biologists, immunologists and research clinicians to understand the foundations of inflammasomes and explore the therapeutic opportunities they present. Pharma researchers may also find this reference invaluable in devising new approaches to developing anti-inflammatory drugs.

  • Advances in Biomembranes and Lipid Self-Assembly

    • 1st Edition
    • Volume 36
    • Aleš Iglič︎ + 2 more
    • English
    Advances in Biomembranes and Lipid Self-Assembly, Volume 36 serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Functionality and Application of Colored Cereals

    Nutritional, Bioactive, and Health Aspects
    • 1st Edition
    • Sneh Punia + 1 more
    • English
    Functionality and Application of Colored Cereals: Nutritional, Bioactive and Health Aspects focuses on exploiting the full and functional possibilities of these grains. From their physical chemistry to their health benefits, this book highlights cereals with potential for enhanced products. Plant-based food colorants play an important role in conferring colors to food to increase attractiveness for consumers, improve appetite, minimize synthetic colorants, and conform to food culture. Over the last decades, the presence of anthocyanin and other bioactive compounds in colored cereal grains (maize, rice, wheat, barley, sorghum, millet, and rye) have attracted the attention of various food processors and researchers. Colored cereals are imperative for food processing industries as high-value pigments present in the bran layer can easily be extracted and utilized as functional foods and natural colorants. The extracted pigments such as anthocyanin can replace synthetic dyes currently used in foods, drugs and cosmetics. Additionally, natural additives improve the nutritional value, appearance, texture, flavor and storage properties of food products.

  • Esophageal Disease and the Role of the Microbiome

    • 1st Edition
    • David A. Johnson
    • English
    Esophageal Diseases and the Role of the Microbiome provides evidence on biomic influence in esophageal diseases. The book builds on the translational information on H pylori for ulcer disease as well as the explosive focus on biomic influence in virtually all areas of esophageal diseases. This important reference will help translational researchers by providing scientific understanding and hypothesis generation that is needed for furthering this field of study. It will also provide clinicians with disease management options for esophageal diseases (for GERD and PPI options/side effects) and present cutting-edge science to promote provider/patient understanding and options.

  • Handbook of Animal Models in Neurological Disorders

    • 1st Edition
    • Colin R. Martin + 2 more
    • English
    Handbook of Animal Models in Neurological Disorders will better readers’ understanding of a large variety of animal models and their applicability in studying a number of neurological disorders. Featuring sections on brain injury, stroke and neuroinflammation, this volume discusses in detail the utility, success and pitfalls of multiple models for each condition. Multiple disorders are covered, ranging from neurodegenerative diseases like Alzheimer’s, Parkinson’s, and ALS, to multiple sclerosis, headache, migraine, and others. With expert authors, this book has applicability for anyone pursuing neuroscience or biomedical research working to better understand, study and ultimately treat neurological dysfunction.

  • Bidirectional Gene Promoters

    Transcription system and chromosomal structure
    • 1st Edition
    • Fumiaki Uchiumi
    • English
    Recent studies in human genetics and in silico analyses have revealed that a number of genes are head-head orientated with other genes or non-coding RNAs. The expression of regulatory element-containing 5’-upstream regions of gene pairs are referred to as bi-directional promoters and are thought to have a key role in biological regulatory mechanisms. For example, tumor suppressor protein-encoding TP53 and BRCA1 genes are head-head bound with WRAP53 and NBR2, respectively. DNA-repair factor-encoding ATM and PRKDC (DNA-PKcs) genes have bidirectional partner NPAT and MCM4, respectively. Surveillance of the human DNA database has revealed that the numbers of DNA repair/mitochondrial function/immune response-associated genes are bound with other genes that are transcribed to opposite direction. The observations may encourage us to investigate in the molecular mechanisms how DNA repair/mitochondrial function/immune response-associated genes are regulated by bidirectional promoters. Not only protein-coding genes, but also quite a few ncRNAs, which play important roles in various cellular events, are transcribed under the regulation of the bidirectional promoters. More importantly, we know that dysregulation in the promoter activity and transcription initiation of genes might cause human diseases.

  • Antimicrobial Peptides

    Challenges and Future Perspectives
    • 1st Edition
    • K. Sreejith + 1 more
    • English
    Antimicrobial Peptides: Challenges and Future Perspectives covers the latest developments about antimicrobial peptides in the scenario of drug resistance. The book is divided into 16 chapters arranged in sequence and preceded by chapters on historical developments and their role as regulatory molecules in innate defense mechanism. Emphasis is given to purification techniques and characterization suitable for interdisciplinary research. Chapters provide an inventory of various antimicrobial peptides, from a diverse array of organisms such as bacteria, fungi, insects, amphibians, plants and mammals. A section on marine ecosystem broadens readers understanding on marine based antimicrobial peptides. Additional sections provide an informative overview on peptides with antiviral properties and those targeting multi-drug resistant bacteria. Recent reports and mechanism on resistance against antimicrobial peptides are also provided, along with key insights into the challenges and future perspectives of peptide drug development.

  • RNA Methodologies

    A Laboratory Guide for Isolation and Characterization
    • 6th Edition
    • Robert E. Farrell Jr.
    • English
    RNA Methodologies: A Laboratory Guide for Isolation and Characterization, Sixth Edition provides the most up-to-date ribonucleic acid lab techniques for seasoned scientists and graduate students alike. This edition features new material on RNA sequencing, RNA in Situ Hybridization, non-coding RNAs, computational RNA biology, transcriptomes and bioinformatics, along with the latest advances in methods and protocols across the field of RNA investigation. As a leader in the field, Dr. Farrell provides a wealth of knowledge on the topic of RNA biology while also giving readers helpful hints and troubleshooting techniques from his own personal experience in this subject area. This book presents the essential knowledge and techniques to use when working with RNA for the experienced practitioner, while also aiding the beginner in fully understanding this important branch of molecular biology.

  • Emerging Thermal Processes in the Food Industry

    Unit Operations and Processing Equipment in the Food Industry
    • 1st Edition
    • Seid Mahdi Jafari
    • English
    Emerging Thermal Processes in the Food Industry, a volume in the Unit Operations and Processing Equipment in the Food Industry series, explains the processing operations and equipment necessary for thermal processing, including infrared heating, microwave processing, sonication, UV processing, ohmic heating and dielectric processing. These processes and unit operations are very important in terms of achieving favorable sensory properties and energy usage. Chapters emphasize basic texts relating to experimental, theoretical, computational and/or applications of food engineering principles and relevant processing equipment for emerging thermal unit operations. Written by experts in the field of food engineering in a simple and dynamic way, this book targets industrial engineers working in the field of food processing and within food factories to make them more familiar with food processing operations and equipment.

  • Central Nervous System Infections, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 33-1
    • Tchoyoson Lim
    • English
    In this issue of Neuroimaging Clinics, guest editor Dr. Tchoyoson Lim Choie Cheio brings his considerable expertise to the topic of Central Nervous System Infections. Infections can involve any part of the CNS and often, multiple parts of the CNS are involved at the same time. The imaging surrounding them is constantly evolving, and in this issue, key international experts provide a thorough update of the imaging of these common and pervasive infections.

  • QTL Mapping in Crop Improvement

    Present Progress and Future Perspectives
    • 1st Edition
    • Shabir Hussain Wani + 2 more
    • English
    QTL Mapping in Crop Improvement: Present Progress and Future Perspectives presents advancements in QTL breeding for biotic and abiotic stresses and nutritional improvement in a range of crop plants. The book presents a roadmap for future breeding for resilience to various stresses and improvement in nutritional quality. Crops such as rice, wheat, maize, soybeans, common bean, and pigeon pea are the major staple crops consumed globally, hence fulfilling the nutritional requirements of global populations, particularly in the under-developed world, is extremely important. Sections cover the challenges facing maximized production of these crops, including diseases, insect damage, drought, heat, salinity and mineral toxicity. Covering globally important crops including maize, wheat, rice, barley, soybean, common bean and pigeon pea, this book will be an important reference for those working in agriculture and crop improvement.

  • Advances in Immunology

    • 1st Edition
    • Volume 156
    • English
    Advances in Immunology, Volume 156, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology, with this volume covering self-referential immune recognition through C-type lectin receptors, genetic susceptibility to autoimmunity, activation and regulation of the cGAS-STING pathway and the implications of IL-15 trans-presentation on the immune response.

  • Mathematical Approaches to Molecular Structural Biology

    • 1st Edition
    • Subrata Pal
    • English
    Mathematical Approaches to Molecular Structural Biology offers a comprehensive overview of the mathematical foundations behind the study of biomolecular structure. Initial chapters provide an introduction to the mathematics associated with the study of molecular structure, such as vector spaces and matrices, linear systems, matrix decomposition, vector calculus, probability and statistics. The book then moves on to more advanced areas of molecular structural biology based on the mathematical concepts discussed in earlier chapters. Here, key methods such as X-ray crystallography and cryo-electron microscopy are explored, in addition to biomolecular structure dynamics within the context of mathematics and physics. This book equips readers with an understanding of the fundamental principles behind structural biology, providing researchers with a strong groundwork for further investigation in both this and related fields.

  • Microbial Endophytes and Plant Growth

    Beneficial Interactions and Applications
    • 1st Edition
    • Manoj Kumar Solanki + 3 more
    • English
    Microbial Endophytes and Plant Growth: Beneficial Interactions and Applications explains how modern molecular tools can unlock the plant's microbial network, building the bridge between plant and environment. Chapters describe the usefulness of the endophytic microbiome of different crops, including cereals, vegetables and horticulture, and delve into the latest research surrounding the applications of plant-microbe interactions in improving plant growth. Other topics discussed include root endophytes and their role in plant fitness, seed associated endophytes and their functions, and microbial endophytes and nanotechnology. This is a one-stop resource for scientists wanting access to the latest research in plant microbiology. The book also provides advanced techniques for using multi-omics approaches to study plant-microbe interactions, providing readers with a practical approach.

  • Outpatient Neurology, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 41-1
    • Doris Kung + 1 more
    • English
    In this issue of Neurologic Clinics, guest editors Drs. Doris Kung and Everton A. Edmondson bring their considerable expertise to Outpatient Neurology. Top experts in the field cover key topics such as neck pain; how to read neurophysiology reports for the non-neurophysiologis... trigeminal neuralgia; epilepsy: choosing the best AED for your patient; insomnia: differential diagnosis and treatment options; dementia: management of psychiatric symptoms; and more.

  • Herbs, Spices and Their Roles in Nutraceuticals and Functional Foods

    • 1st Edition
    • Augustine Amalraj + 3 more
    • English
    Herbs, Spices and Their Roles in Nutraceuticals and Functional Foods gives an overview of the many pharmacological activities associated with herbs and spices, including detailed coverage on their mechanisms and formulations for the food industry. Chapters focus on key ingredients such as Curcuma longa, Piper Nigrum and Trigonella foenum-graecum, with contributors across the globe providing the latest research and advances for each. This is an essential read for scientists who want to understand the fundamental mechanisms behind the bioactive compounds within herbs and spices. The numerous phytochemicals present in plant extracts have multiple pharmacological activities so there is extensive research into new bioactive compounds. The pharmacological activities of herbs and spices have been thoroughly investigated, and it is crucial that the latest research is organized into a comprehensive resource.

  • Food Quality Analysis

    Applications of Analytical Methods Coupled With Artificial Intelligence
    • 1st Edition
    • Ashutosh Kumar Shukla
    • English
    Food Quality Analysis: Applications of Analytical Methods Coupled With Artificial Intelligence provides different spectroscopic techniques and their application to food quality analysis, with the unique approach of adding multivariate analysis as well as artificial intelligence applications. It also brings chromatographic methods for the analysis of a wide range of food items including wheat flours, oils and fats. Written by a team of interdisciplinary experts, this is a valuable resource for researchers and personnel involved in food industries.　　

  • Food Process Engineering Principles and Data

    • 1st Edition
    • Michael Lewis
    • English
    Food Process Engineering Principles and Data provides an overview of topics surrounding safety and quality in processing foods. The book covers a range of physical properties of foods, providing background information on the physical, chemical and engineering properties of foods to ensure food safety and perform engineering calculations. Chapters are self-contained, with comprehensive charts of food properties, making this unique a great reference for scientists who need a single, handy source of information. Written by an authority on the physical properties of foods and food engineering, this book is ideal for food scientists, technologists, manufacturers and processors.In addition, chemical engineers and biotechnologists will also benefit from the content of this comprehensive title.

  • Immediately Sequential Bilateral Cataract Surgery (ISBCS)

    Global History and Methodology
    • 1st Edition
    • Steve A. Arshinoff + 6 more
    • English
    Immediately Sequential Bilateral Cataract Surgery (ISBCS): Global History and Methodology is a comprehensive guide for the safe and efficient performance of ISBCS. It provides an overview of the history, recommended protocols, necessary precautions, exclusion criteria, benefits and risks associated with this procedure, organizational standards, and more. Written by the most prominent ISBCS surgeons in the world, chapters recount the arguments for and against bilateral surgery that have been made throughout the ages, up to the present, and deliver achieved and proposed resolutions to all problems discussed. Topics such as ethics and medico-legal issues surrounding ISBCS are also discussed, and a chapter on the global evolution of bilateral cataract surgery provides readers with a complete overview of the development of ISBCS practices in countries from all continents.

  • Bacterial Physiology and Biochemistry

    • 1st Edition
    • Ivan Kushkevych
    • English
    Bacterial Physiology and Biochemistry provides the most current, authoritative, and relevant presentation of bacterial physiology and biochemistry on subject, chemical composition and functional bacterial cell structure, nutrition and growth, the process of cell differentiation, metabolism and the influence of environmental factors. The book helps the reader learn and obtain modern knowledges on bacterial physiology and biochemistry, including chemical composition and functional cell structures, bacterial nutrition and growth, and the processes of cell differentiation, bacterial metabolism and microbial growth in nature, and the effect of environmental factors on bacterial cells. This book is an educational resource designed for use in advanced bachelor's and master's courses in biology, including microbiology, biochemistry and molecular biology. It contains curriculum taught to biology students specializing in microbiology.

  • Conservation Physiology for the Anthropocene - Issues and Applications

    • 1st Edition
    • Volume 39B
    • English
    Conservation Physiology for the Anthropocene – A Systems Approach, Volume 39B in the Fish Physiology series, is a comprehensive synthesis related to the physiology of fish in the Anthropocene. This volume helps solve knowledge gaps by considering the many ways in which different physiological systems (e.g., sensory physiology, endocrine, cardio-respiratory, bioenergetics, water and ionic balance and homeostasis, locomotion/biomechan... gene function) and physiological diversity are relevant to the management and conservation of fish and fisheries. Chapters in this release include Using physiology for recovering imperiled species – the Delta smelt, Conservation hatcheries – the Sturgeon story, Aquatic pollutants and stressors, and more. Other sections discuss Fisheries interactions in a multi-stressor world, Environmental change in riverine systems - Amazon basin stressors, Environmental change in lakes and wetlands – East African basin stressors, Coral reef fish in a multi-stressor world, Polar fish in a multi-stressor world, Physiology informs fisheries restoration and habitat management, A physiological perspective on fish passage and entrainment, Invasive species control and management – the sea lamprey story, and On the conservation physiology of fishes for tomorrow.

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