The Cardiovascular Glycocalyx in Health and Disease
- 1st Edition, Volume 91 - April 11, 2023
- Imprint: Academic Press
- Editors: Ibra S. Fancher, Andreia Z. Chignalia
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 1 5 9 - 6
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 1 6 0 - 2
The Cardiovascular Glycocalyx in Health and Disease, Volume 91 gives updates on the glycocalyx function through the cardiovascular system and its integration in whole system physio… Read more
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Request a sales quoteThe Cardiovascular Glycocalyx in Health and Disease, Volume 91 gives updates on the glycocalyx function through the cardiovascular system and its integration in whole system physiology. Chapters address Endothelial surface layers in the kidney, Pharmacological targeting of the glycocalyx -- current status and prospects, The endothelial glycocalyx and the subtleties of female microcirculation, and much more targeted content.
- Provides a broad scope that reviews glycocalyx foundational studies to contemporary findings
- Includes Pharmacological and Translational Perspectives
- Discusses the glycocalyx in integrated system physiology
Those seeking to expand their knowledge on the glycocalyx through reviews of contemporary research and perspectives of recently identified roles of the glycocalyx in the cardiovascular system
- Cover
- Title page
- Table of Contents
- Series page
- Copyright
- Contributors
- Preface
- Chapter One: Impairment of endothelial glycocalyx in atherosclerosis and obesity
- Abstract
- 1: Introduction
- 2: Impairment of endothelial glycocalyx in atherosclerosis
- 3: Effects of obesity on endothelial glycocalyx
- 4: Conclusion
- Acknowledgments
- Reference
- Chapter Two: The glycocalyx and calcium dynamics in endothelial cells
- Abstract
- 1: The endothelial glycocalyx
- 2: The glycocalyx in endothelial cell physiology
- 3: Calcium signaling and endothelial function
- 4: Conclusions and perspectives
- References
- Chapter Three: Mechanotransduction and the endothelial glycocalyx: Interactions with membrane and cytoskeletal proteins to transduce force
- Abstract
- 1: Introduction
- 2: Regulation of membrane proteins by the glycocalyx
- 3: Regulation of cytoskeletal proteins by the glycocalyx
- 4: Conclusion
- Acknowledgments
- References
- Chapter Four: Setting the stage for universal pharmacological targeting of the glycocalyx
- Abstract
- 1: Introduction
- 2: The multifaceted nature of the glycocalyx in disease
- 3: The glycocalyx as a therapeutic target
- 4: Discussion and outlook
- References
- Chapter Five: The effects of female sexual hormones on the endothelial glycocalyx
- Abstract
- 1: Introduction
- 2: Effects of female hormones on the endothelial glycocalyx
- 3: Glycocalyx remodeling during pregnancy and the placental glycocalyx
- 4: Female-related diseases and glycocalyx injury/damage
- 5: Endothelial glycocalyx as a potential therapeutic target
- 6: Conclusions
- References
- Chapter Six: The role of hyaluronan in endothelial glycocalyx and potential preventative lifestyle strategy with advancing age
- Abstract
- 1: Introduction
- 2: Endothelial glycocalyx structure and function
- 3: Hyaluronan as a primary component of endothelial glycocalyx
- 4: Endothelial glycocalyx and hyaluronan with aging
- 5: Preventative lifestyle strategy to maintain healthy endothelial glycocalyx and hyaluronan
- 6: Conclusion
- References
- Edition: 1
- Volume: 91
- Published: April 11, 2023
- No. of pages (Hardback): 166
- No. of pages (eBook): 166
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443191596
- eBook ISBN: 9780443191602
IF
Ibra S. Fancher
Dr. Fancher is an Assistant Professor at the University of Delaware in the Department of Kinesiology and Applied Physiology, College of Health Sciences. Dr. Fancher’s immediate interests are in understanding how cardiovascular risk factors, such as obesity, impair vascular endothelial ion channel function which ultimately results in dysregulation of vascular function. His recent studies have detailed a link between damage to the endothelial glycocalyx and impaired K+ channel function in obesity; a mechanism he proposes contributes to obesity-induced vascular dysfunction. Ongoing studies in the lab are focused on determining the mechanistic link between elevated macronutrients associated with a poor Western diet and obesity, disruption of the glycocalyx, and K+ channel function.
Affiliations and expertise
Assistant Professor, Department of Kinesiology and Applied Physiology, University of Delaware, College of Health Sciences, DE, USAAC
Andreia Z. Chignalia
Dr. Andreia Z. Chignalia is an Assistant Professor at the University of Arizona, Department of Anesthesiology, College of Medicine-Tucson. The research in the Chignalia lab focuses on studying the redox mechanisms underlying cardiovascular diseases and associated pulmonary complications. Special emphasis is given to explore the differential redox-sensitive pathways activated by individual glycocalyx components during disease progression. Her research program utilizes a broad range of techniques that span from in vitro, in situ, and in vivo animal models of disease with a translational approach to advance the understanding of human disease with the goal to identify new targets for drug development.
Affiliations and expertise
Assistant Professor, Department of Anesthesiology, University of Arizona, College of Medicine-Tucson, Arizona, USARead The Cardiovascular Glycocalyx in Health and Disease on ScienceDirect