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Advances in Immunology
- 1st Edition, Volume 157 - April 11, 2023
- Editors: Frederick W. Alt, Kenneth Murphy
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 3 2 8 - 6
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 3 2 9 - 3
Advances in Immunology, Volume 157, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immuno… Read more
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Request a sales quoteAdvances in Immunology, Volume 157, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Chapters in this new release include Antigen receptor structure and signaling, T cells in the brain inflammation, The molecular mechanism of RIG-I/MDA5 activation and signaling, GSDMD biology, cGAS-STING pathway, The CARD8 inflammasome in HIV infection, and much more.
- Presents current developments and comprehensive reviews in immunology
- Provides the latest in a longstanding and respected serial on the subject matter
- Focuses on recent advances in t cells and HIV infection
Immunologists and infectious disease specialists, cell biologists and hematologists
- Cover
- Title page
- Table of Contents
- Series page
- Copyright
- Contributors
- Chapter One: Antigen receptor structure and signaling
- Abstract
- 1: Introduction
- 2: The general properties of antigen receptor
- 3: B cell receptor, structure and its signaling
- 4: T-cell antigen receptor, structure and signaling transduction
- 5: Conclusion
- References
- Further reading
- Chapter Two: T cells in the brain inflammation
- Abstract
- 1: Introduction
- 2: Inflammation cascade after stroke
- 3: Resolution mechanism of inflammation after stroke
- 4: Role of microglia in resolution of inflammation and neural repair
- 5: Role of lymphocytes in post-ischemic brain inflammation at early phase
- 6: Accumulation of brain Tregs at the chronic phase of stroke
- 7: Molecules that are deeply involved in T cell-mediated neural recovery
- 8: T cells and neurodegenerative diseases
- 9: Tregs and neurodegenerative diseases
- 10: Conclusion
- References
- Chapter Three: The CARD8 inflammasome in HIV infection
- Abstract
- 1: Introduction
- 2: The CARD8 inflammasome
- 3: Activation of the CARD8 inflammasome by the HIV protease (PR)
- 4: HIV infection and other inflammasomes
- 5: Future directions
- Acknowledgments
- References
- No. of pages: 108
- Language: English
- Edition: 1
- Volume: 157
- Published: April 11, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780443193286
- eBook ISBN: 9780443193293
FA
Frederick W. Alt
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
Affiliations and expertise
Investigator and Director, Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USAKM
Kenneth Murphy
Kenneth M. Murphy works in Washington University School of Medecine, USA.
Affiliations and expertise
Washington University School of Medecine, USARead Advances in Immunology on ScienceDirect