Epigenetics in Health and Disease

1st Edition, Volume 197 - April 3, 2023
Editors: Vijai Singh, Indra Mani
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 6 6 9 - 1
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 6 7 0 - 7

Epigenetics in Health and Disease, Volume 197 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume… Read more

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Epigenetics in Health and Disease, Volume 197 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on An Introduction to epigenetics in health and disease, State-of-the-art techniques for epigenetics study, Computational biology in epigenetics, Artificial intelligence and machine learning in epigenetics, CRISPR-Cas systems in epigenetics modification for health, Mechanisms of DNA methylation and histone modifications, Non-coding RNA in epigenetics, Role of DNA Methylation in cardiovascular diseases, Role of epigenetics in renal diseases, and much more.

Additional chapters update on Histone modifications in fat metabolism and obesity, Role of DNA methylation in diabetes and obesity, Epigenetic regulons in Alzheimer’s disease, Epigenetics in heredity disease, Epigenetics of aging, Epigenetics in cancer development, diagnosis and therapy, Microbiota and epigenetics: health impact, Epigenetics in Fetal Alcohol Spectrum disorder, and much more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Insight into epigenetics and human diseases
Abstract
1: Introduction
2: Epigenetic mechanisms
3: Epigenetics and human diseases
4: Conclusion and future perspectives
Conflict of interest
References
Chapter Two: State-of-the-art techniques to study epigenetics
Abstract
1: Introduction
2: Histone modification analysis
3: DNA methylation profile analytic techniques
4: Conclusion and future perspectives
Conflict of interests
References
Chapter Three: Mechanisms of DNA methylation and histone modifications
Abstract
1: Introduction
2: DNA methylation sites
3: DNA demethylation and hydroxymethylation
4: DNA methylation and diseases
5: Importance of DNA methylation
6: Modification in histone
7: Histone modifications and diseases
8: Conclusion
References
Chapter Four: Epigenetics, genomics imprinting and non-coding RNAs
Abstract
1: Introduction
2: Genomic imprinting and epigenetic alterations
3: Immunity and epigenetic changes between generations
4: Non-coding RNAs
5: Conclusions and the way forward
Competing interests
References
Chapter Five: Epigenetics in cardiovascular health and disease
Abstract
1: Introduction
2: Methodologies in the study of cardiovascular epigenetics
3: The landscape of epigenetic research in cardiovascular disease
4: Conclusion
References
Chapter Six: Histone modifications in fat metabolism and obesity
Abstract
1: Introduction
2: Histone modifications in fat metabolism
3: Histone modifications in obesity
4: Conclusion and future direction
Acknowledgment
References
Chapter Seven: Role of DNA methylation in diabetes and obesity
Abstract
1: Introduction
2: DNA methylation and diabetes
3: DNA methylation and obesity
4: Conclusion and future direction
References
Chapter Eight: Aging: Epigenetic modifications
Abstract
1: Introduction
2: Key hallmarks of aging
3: Epigenetics, aging and aging-related diseases
4: Anti-aging strategies to improve the health span
5: Conclusions
References
Chapter Nine: Epigenetics in fetal alcohol spectrum disorder
Abstract
1: Introduction
2: DNA methylation changes in FASD
3: Histone proteins post-translational modification (PTM) in FASD
4: Regulation of microRNAs in FASD
5: Conclusions
References
Chapter Ten: Epigenetic regulation of pluripotency inducer genes NANOG and SOX2 in human prostate cancer
Abstract
1: Introduction
2: An overview of epigenetic modifications
3: Pluripotency factors involved in benign prostatic hyperplasia and prostate cancer
4: Crosstalk of epigenetic machinery with signaling in prostate cancer
5: CRISPR enables detecting reprogramming to pluripotency
6: Conclusion
References
Chapter Eleven: Mechanistic aspects of reversible methylation modifications of arginine and lysine of nuclear histones and their roles in human colon cancer
Abstract
1: Introduction
2: General insights into histone arginine and lysine methylation and demethylation
3: Mechanisms of histone arginine and lysine methylation and demethylation
4: Connecting reversible histone arginine and lysine methylations to cellular events
5: Histone arginine and lysine methylation-based epigenetic plasticity and transcriptional regulation
6: Interplay of arginine and lysine methylation with other histone marks at chromatin territory
7: Impact of reversible arginine and lysine methylation of nuclear histones in colon cancer
8: Conclusions and future prospects
References
Index

Vijai Singh

Dr Vijai Singh is a Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Associate Professor in the Department of Biosciences, School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. Prior this this, he was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 11 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 100 articles, 70 chapters, 15 books and 3 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.

Affiliations and expertise

Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, India

Indra Mani

Dr. Indra Mani is an Assistant Professor in the Department of Microbiology, Gargi College, University of Delhi (DU), New Delhi, India. He received M.Sc. in Microbiology from Bundelkhand University (BU), Jhansi, UP, India and Ph.D. in Biochemistry from Banaras Hindu University (BHU), Varanasi, UP, India. He completed postdoctoral training in the Department of Physiology, School of Medicine, Tulane University, New Orleans, USA. He has also worked as a Senior Research Officer (SRO) in the Department of Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India. He has more than 10 years of research and teaching experience in Microbiology, Molecular Genetics, Cell Signaling, and Bioinformatics. He has published 49 articles in peer reviewed journals and 22 book chapters. He has presented several papers in the different national and international conferences. He has extensive experience in fluorescence/confocal microscopy, receptor internalization, trafficking and signaling, molecular cytogenetics, microbial characterization, and in silico analysis. He serves as a reviewer of peer-reviewed journals and also a member of national and international societies.

Affiliations and expertise

Assistant Professor, Department of Microbiology, Gargi College, University of Delhi (DU), New Delhi, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health