The Eye
- 1st Edition, Volume 4 - March 31, 2023
- Imprint: Academic Press
- Editors: Eman E. Taher, Mohamed Elalfy
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 9 8 7 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 8 3 1 6 - 7
The Eye, Volume Four, the latest release in the Stem Cell Innovation in Health and Disease series, addresses the recent data accumulated on the potential applications of… Read more
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Request a sales quoteThe Eye, Volume Four, the latest release in the Stem Cell Innovation in Health and Disease series, addresses the recent data accumulated on the potential applications of stem cells to treat eye diseases. This volume highlights the recent development of cutting-edge in vitro and in vivo research tools and approaches, including human and murine organoid cultures, genetic editing in vitro and in vivo, human iPSC models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure eye diseases.
The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field. This is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album on the fast-moving field of regenerative medicine and stem cell therapeutics.
- Provides cutting-edge research to understand stem cell functions used in disease treatments of the eye
- Develops processes to bring stem cells from bench to bedside
- Includes up-to-date references on stem cell biology and function in common eye diseases and disorders
Stem cell biology scientists, regenerative medicine scientists, physicians and surgeons, Graduate and undergraduate students, researchers and practitioners in these fields; Biomedicine, stem cell biology, regenerative medicine, and joint and bone biology, repair and regeneration, as well as translational regenerative medicine courses in the biomedical, biological and stem cell-related programs; These relevant courses are taught at schools of medicine, basic medicine and life sciences at a wide range of universities in the U.S. (e.g., University of South California), Europe (e.g. University of Edinburgh, Manchester, etc.), South East Asia (e.g. Zhejiang University, China) etc.
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- About the editors
- Foreword
- Preface
- Epigraph
- Chapter 1. Stem cell-based organoid cultures as innovative approaches for ocular repair and regeneration
- Abstract
- 1.1 Cornea
- 1.2 Retina
- 1.3 Retinal ganglion cells and the optic nerve
- Conflict of interest
- References
- Chapter 2. Organoid-based modality of eye function and cellular processes
- Abstract
- Abbreviations
- Brief description of the eye structure
- 2.1 The need for innovative tools for eye biology, function, and diseases
- 2.2 Roles of the organoid culture in the cornea
- 2.3 Retina
- 2.4 Lacrimal glands
- 2.5 Lacrimal gland organoid cultures
- 2.6 Lens
- 2.7 Discussion and conclusion
- References
- Chapter 3. Leveraging neural crest pluripotency to extend retinal and craniofacial niches for building neurovascular organoids—a theranostic and drug development perspective
- Abstract
- 3.1 Introduction
- 3.2 Summary, conclusion, and future perspective
- Acknowledgments
- Disclaimer
- References
- Further reading
- Chapter 4. Role of stem cell engineering and or gene-editing technologies in eye diseases degeneration, and therapy
- Abstract
- 4.1 Introduction
- 4.2 Introducing stem cells
- 4.3 Induced pluripotent stem cell
- 4.4 Retina, retinal pigment epithelium
- 4.5 Examples of iPSCs implications in eye diseases
- 4.6 AMD
- 4.7 Photoreceptor cell disorders
- 4.8 RPE disorders
- 4.9 Eye disease and stem cell therapy
- 4.10 Gene therapy
- 4.11 Eye-related disorders
- 4.12 Conclusion
- References
- Chapter 5. Stem cells and genetic engineering empower therapeutic development for blinding eye diseases
- Abstract
- 5.1 Introduction
- 5.2 Stem cell therapy in eye diseases
- 5.3 Gene therapy in eye diseases
- 5.4 Conclusion
- Acknowledgements
- References
- Chapter 6. Human stem cell-derived retinal pigment epithelial cells for retinal regeneration: differentiation and clinical translation
- Abstract
- 6.1 Introduction
- 6.2 Differentiation of retinal pigment epithelium cells from human stem cells
- 6.3 Characteristics of HSC-RPE cells
- 6.4 Clinical translation of HSC-RPE cells
- 6.5 Discussion
- Acknowledgments
- References
- Further reading
- Chapter 7. Mesenchymal stem cells therapy for retinal diseases
- Abstract
- Abbreviations
- 7.1 Introduction
- 7.2 Challenges and prospects
- 7.3 Summary and conclusions
- References
- Chapter 8. Retinal cone photoreceptors from pluripotent stem cells for macular regeneration
- Abstract
- 8.1 Introduction
- 8.2 Mouse ESCs and PSCs-derived cone photoreceptors
- 8.3 Human ESCs and PSCs-derived cone photoreceptors
- 8.4 Transplantation of PSC-derived cone photoreceptors
- 8.5 Conclusions
- Acknowledgments
- References
- Chapter 9. Update on stem/progenitor cell-based clinical trials for eye disease
- Abstract
- 9.1 Retinal stem cell studies
- 9.2 Limbal stem cells studies
- References
- Chapter 10. Stem cell innovation in eye disease, repair and regeneration: general conclusion, challenges and prospective
- Abstract
- Abbreviations
- 10.1 Introduction
- 10.2 Roles of the organoids in modeling and investigating eye diseases
- 10.3 Roles of stem cells and genetic engineering technologies in empowering therapeutic development for blinding eye diseases
- 10.4 Application of stem cell types in eye diseases
- Conflicts of interest
- References
- Index
- Edition: 1
- Volume: 4
- Published: March 31, 2023
- No. of pages (Paperback): 308
- No. of pages (eBook): 308
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323999878
- eBook ISBN: 9780323983167
ET
Eman E. Taher
Dr. Eman E. Taher is a Professor in the Department of Microbiology and Clinical Parasitology at the Research Institute of Ophthalmology. The institute studies and performs different diagnostic techniques for parasites especially those affecting the eyes.
Dr. Taher is the head of the Clinical Parasitology Unit. His extensive work has been on the diagnosis of Acanthamoeba, Toxoplasma, Toxocara and Schistosomiasis, as well as other different parasites, which has yielded over 20 papers, with different faculties, post-doctoral fellows and students. Additionally, Dr. Taher has also completed extensive research on different molecular diagnostic techniques for different parasites including electrophoresis, PCR, Western blot, DNA-extraction, ELISA and dot-ELISA. In addition, to stem cell preparation, characterization being a member of the stem cell laboratory at the Research Institute of Ophthalmology, he earned a six–month scholarship at the Eye and Ear Institute, Pittsburgh University, USA. His research portfolio includes variable papers on different parasites.
Affiliations and expertise
Professor, Department of Microbiology and Clinical Parasitology, Research Institute of Ophthalmology, Cairo, EgyptME
Mohamed Elalfy
Dr. Mohamed Elalfy is a fellow of the Royal College of Ophthalmologists in London, the Royal College of Surgeons in Edinburgh, the Royal College of Physicians and Surgeons in Glasgow, the European Board of Ophthalmology and the International Council of Ophthalmology. He is an active member of the European Society of Cataract and Refractive Surgery, and of The European Cornea Society and Refractive Surgery. Mr Elalfy travels abroad as an invited guest to share his expertise through teaching and live surgeries. He is Fellowship Programme Director in Corneoplastic Unit, Queen Victoria Hospital where he trains four fellows annually. Having obtained two academic qualifications through his career of more than 15 years in ophthalmology and with more than 30 peer-reviewed publications, Mr Elalfy puts evidence-based ophthalmology in the heart of his practice.
Affiliations and expertise
Ophthalmologist - Private Practice, UKRead The Eye on ScienceDirect