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Neurostimulation for Epilepsy
Advances, Applications and Opportunities
- 1st Edition - April 11, 2023
- Editor: Vikram R. Rao
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 7 0 2 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 8 5 6 4 - 2
**Association of American Publishers (AAP) PROSE Award Finalist in Biomedicine and Neuroscience, 2024**Neurostimulation for Epilepsy: Advances, Applications, and Opportunit… Read more
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Request a sales quote**Association of American Publishers (AAP) PROSE Award Finalist in Biomedicine and Neuroscience, 2024**
Neurostimulation for Epilepsy: Advances, Applications, and Opportunities comprehensively reviews the diverse array of neurostimulation technologies currently in use and in development for the treatment of epilepsy. The book covers basic mechanisms of neurostimulation, technical characteristics of approved and investigational neurostimulation devices, clinical applications and programming considerations of these devices, and progress toward next-generation device technology. Leading experts in the field provide a contemporary appraisal of neurostimulation in epilepsy, one that highlights recent advances, outlines unanswered questions, and proposes future directions.
Neurostimulation for Epilepsy: Advances, Applications, and Opportunities will be of high interest to clinical, basic, and translational researchers seeking to understand leading-edge applications of neurostimulation in epilepsy and to clinicians managing patients with epilepsy who are treated with implanted and external neurostimulation devices. This book will also be of interest to trainees, to physicians in other areas of neurology where neurostimulation is employed, such as Pain and Movement Disorders, and to general medical practitioners, neurobiologists, and engineers.
- Explains fundamental principles of neurostimulation in accessible terms
- Details technical characteristics and engineering considerations of neurostimulation devices
- Describes strengths and limitations of approved and investigational neurostimulation devices
- Overviews clinical applications of neurostimulation, including device selection and programming
- Highlights the patient experience with neurostimulation, with an emphasis on quality of life
- Provides a roadmap for the development of next-generation devices
Clinical basic and translational researchers in epilepsy, as well as clinicians who treat patients with epilepsy.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Acknowledgments
- Chapter 1: Principles of neurostimulation
- Abstract
- Introduction
- Technical and biophysical background of neurostimulation
- Targets for neurostimulation in epilepsy
- Antiepileptic effects of specific stimulus forms
- Stimulation of peripheral nerves: Vagus nerve stimulation
- Stimulation of network hubs: Anterior and centromedian nuclei of the thalamus
- Combining neuromodulatory approaches
- Closed-loop stimulation
- Cognitive tolerability of therapeutic brain stimulation
- References
- Chapter 2: Neurostimulation device technology
- Abstract
- Introduction
- Neuromodulation technology
- Commercially available implantable neuromodulation devices for epilepsy
- Direction of future neuromodulation technology
- References
- Chapter 3: Vagus nerve stimulation
- Abstract
- Introduction
- History
- Efficacy
- Mechanism of action
- Experimental studies
- Clinical studies
- Selection of candidates
- Initiation and maintenance
- Complications and adverse effects
- Advantages and disadvantages
- Future developments
- Addendum
- References
- Chapter 4: Responsive neurostimulation
- Abstract
- Acknowledgments
- Theoretical underpinnings
- RNS System
- Clinical data
- Targets for responsive neurostimulation
- Future directions
- Conclusions
- References
- Chapter 5: Deep brain stimulation (DBS) of thalamus for epilepsy
- Abstract
- Brief historical background
- Laboratory studies
- ANT DBS
- Other thalamic DBS targets
- Conclusions and future directions
- References
- Chapter 6: Epicranial focal cortex stimulation with the EASEE system
- Abstract
- Background
- Device components
- The implantable pulse generator—EASEE Power
- The electrode—EASEE Lead
- Electrical fields
- Device programming
- Patient controller
- Clinical trials
- Future avenues
- References
- Chapter 7: Noninvasive brain stimulation for epilepsy
- Abstract
- Introduction
- Transcranial magnetic stimulation (TMS)
- Low-intensity focused ultrasound (FUS)
- Vision for the future
- References
- Chapter 8: Applications of long-term data from neurostimulation devices
- Abstract
- Introduction
- Responsive Neurostimulation
- Deep brain stimulation (DBS) for epilepsy
- Conclusion
- References
- Chapter 9: Next-generation brain sensing, stimulation, and adaptive control devices for epilepsy
- Abstract
- Introduction
- Current state of ESB devices
- Solutions to some current clinical gaps and opportunities
- Conclusions
- References
- Chapter 10: Quality of life, neurocognitive outcomes, and mood effects with neurostimulation devices
- Abstract
- Introduction
- Vagus nerve stimulation (VNS)
- Responsive neurostimulation (RNS)
- Deep brain stimulation (DBS)
- References
- Index
- No. of pages: 268
- Language: English
- Edition: 1
- Published: April 11, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780323917025
- eBook ISBN: 9780323985642
VR
Vikram R. Rao
Vikram Rao, MD, PhD is a neurologist who specializes in epilepsy and is an Associate Professor of Clinical Neurology at UCSF. He is Chief of the Epilepsy Division at UCSF and also conducts research in epileptology. He takes a holistic approach to helping patients deal with the challenges of their seizures and works at multiple levels to improve their quality of life. He has a special interest in utilizing implanted neurostimulation devices to treat drug-resistant forms of epilepsy. Rao's research involves using direct brain electrical recordings made with implanted devices to understand how abnormal patterns of brain electricity give rise to seizures.
Affiliations and expertise
University of California, San Francisco, Comprehensive Epilepsy Center, San Francisco, CA, USA