New Horizons in Natural Compound Research

1st Edition - April 18, 2023
Editors: Surya Nandan Meena, Vinod Nandre, Kisan Kodam, Ram Swaroop Meena
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 2 3 2 - 0
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 2 3 3 - 7

New Horizons in Natural Compound Research provides the latest updates in natural compound research (plant, microbes, algae, fungi) and their novel applications in health, agricultu… Read more

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New Horizons in Natural Compound Research provides the latest updates in natural compound research (plant, microbes, algae, fungi) and their novel applications in health, agriculture and environment. The book gives recent advances in the extraction of natural compounds, cutting-edge approaches for natural compound purifications, and emerging trends in natural compound screening and identification. In addition, it provides a detailed explanation of the databases and libraries of natural compounds, as well as their significance. Sections focus on research and multidisciplinary practical techniques of natural product research, encouraging young scientists to pursue unique research while also generating strong research ideas.

From a future perspective, this book acts as a guide to identify potential areas and new research opportunities in the field of natural products and their service towards human beings, animals and the environment.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Biographies
Preface
Chapter 1. Natural compounds for health and environment: past, present, and future
1. Introduction
2. Vital natural compounds
3. Future of natural compounds
4. Conclusions
Chapter 2. Recent advances in extraction of natural compounds
1. Introduction
2. Extraction methodologies and their applications
3. Concluding remarks
Chapter 3. Cutting edge approaches for natural product purification
1. Introduction
2. Extraction
3. Pre-isolation
4. Isolation
5. Purification
6. A typical approach for isolation of anthocyanin monomers from red cabbage
7. Conclusion
Chapter 4. Mass spectrometry-based metabolomics for high-throughput natural products screening and compound discovery: an emerging trend
1. Introduction
2. MS-based metabolomics
3. Applications of MS-based metabolomics in NP research
4. Conclusions
Chapter 5. Green synthesis of natural compounds
1. Introduction
2. Conclusion
Chapter 6. Diversity of chemical skeletons: a practical strategy to benefit
1. Introduction
2. Structural diversity in natural products
3. Semisynthetic or modified NPs
4. Synthetic approaches for building chemical skeletons
5. Conclusion
Chapter 7. Modern approaches for mining of novel compounds from the microbes
1. Introduction
2. Traditional methods and techniques used for mining of novel compounds along with their limitations
3. Modern use of databases in hunting new compounds
4. Mining for novel compounds using genomic databases
5. Proteomics approach for the mining for NCs
6. Metabolomics and mass spectrometry approach in the discovery of NCs
7. Conclusion and future prospects
Chapter 8. Informatics and computational methods in natural product drug discovery
1. Introduction
2. Evolution of bioinformatics concept: a new vision
3. High-throughput virtual screening
Author contributions
Conflict of interest statement
Chapter 9. Compound synergy in natural crude extract: a novel concept in drug formulation
1. Introduction
2. What is the synergy effect?
3. Factors responsible for the synergetic effect
4. Synergistic effect on diabetes
5. Synergistic effect on antimicrobial activity
6. Synergistic effect of natural drugs on breast cancer cell
7. Conclusion
Chapter 10. Small molecules vs biologics
1. Introduction
Chapter 11. Introduction to enzymes and organocatalysis
1. Definition and classifications of enzymes
2. Introduction to organocatalysis
3. Conclusion
Suggestion
Chapter 12. Natural products for the prevention and management of nephrolithiasis
1. Introduction
2. Prospects for nephrolithiasis management and improvements in natural product approaches
Chapter 13. Enzymatic preparation, purification, and therapeutic applications of marine oligosaccharides
1. Introduction
2. Marine polysaccharides and their oligosaccharides
3. Enzymatic preparation of bioactive oligosaccharides from complex polysaccharides
4. Purification of oligosaccharides
5. Application of oligosaccharides in biomedicine
6. Conclusion and future prospects
Chapter 14. Marine microalgae: an emerging source of pharmaceuticals and bioactive compounds
1. Introduction
2. Bioactive compounds from microalgae
3. Applications of bioactive compounds
4. Microalgae as a source of pharmaceuticals
5. Enhancement of algal metabolites
6. Conclusion
Chapter 15. Natural compounds in chemopreventive foods for prevention and management of non-communicable diseases
Abbreviations
1. Introduction
2. Cause of civilization diseases
3. How oxidative stress cause NCDs and antioxidants can prevent NCDs
4. What are chemopreventive foods?
5. Antioxidants in chemopreventive foods to prevent or control civilization diseases
6. Challenges or loopholes in chemoprevention strategy
7. Conclusion and future perspective
Chapter 16. Insect metabolome: New paradigm of novel metabolites discovery and its potential applications
1. Introduction
2. Specialized methods for insect metabolome analysis
3. Insect metabolome: diversity and spatio-temporal dynamics
4. Uniqueness of insect metabolome
5. Insect-associated metabolome
6. Potential application of insect metabolites
7. Conclusion and future prospects
Chapter 17. New targets for old drugs: drug repurposing approach for accelerating the drug discovery engine with minimum financial inputs
1. Introduction to drug repurposing: beyond the “old wine in new bottle”
2. Experimental and computational approaches for drug repurposing
3. Repurposing the drugs for effective cancer management
4. Repurposing for cardiovascular diseases
5. Repurposing for neurodegenerative disorders
6. Drug repurposing in diabetes
7. Repurposing for viral diseases
8. Repurposing for microbial diseases
9. Conclusion
Chapter 18. Modern role of essential oils in drug discovery and medicinal products
1. Introduction
2. Methods of extraction of essential oils (EOs)
3. Medicinal plants as a source of essential oils
4. Essential oils as a source of medicine and drug discovery
5. Conclusions
Chapter 19. Cyclodextrins (CDs) derived from natural source as an essential component in biopharmaceutics
1. Introduction
2. Application of cyclodextrins in biopharmaceuticals
3. Regulatory aspects of CDs
4. Conclusion
Chapter 20. Natural compound-based scaffold to design in vitro disease systems
1. Introduction
2. 2D cell culture system
3. 3D system
4. Scaffold for 3D cell culturing
5. Types of scaffolds
6. Conclusion
7. Future perspective
Chapter 21. Natural compounds as pesticides, emerging trends, prospects, and challenges
1. Introduction
2. Different sources for biopesticides
3. Mode of action of different biopesticides
4. Challenges
5. Prospects
6. Conclusions
Chapter 22. Natural compounds as insecticides—a novel understanding
1. Introduction
2. Natural plant compounds as insecticides
3. Conclusion
Chapter 23. Nanoformulations of natural compounds for herbicide and agri-food application
1. Introduction
2. Nanotechnologies in agriculture
3. Nanotechnologies in food science
4. Summary and future prospect
Declaration of competing interest
Chapter 24. Natural compounds for bioremediation and biodegradation of pesticides
1. Introduction
2. Pesticides and their impacts on sustainability
3. Concerns related to pesticide pollution
4. Bioremediation of pesticides
5. Types of pesticide bioremediion based on the type of microbes/enzymes
6. Conclusions and future perspectives
Chapter 25. Role of natural compounds in metal removing strategies
1. Introduction
2. Natural compounds used in heavy metals removal
3. Conclusions
Chapter 26. Policies, regulatory requirements, and risks in natural product research
1. Introduction
2. Protection of new plant variety
3. Natural products and international protection
4. Natural resources and associated traditional knowledge
5. Bioprospecting and biopiracy
6. Conclusion
Index

Surya Nandan Meena

Dr. Surya Nandan Meena is currently a DSK PDF at Department of Chemistry, Savitribai Phule Pune University, Pune, India. Earlier Dr. Meena has secured the National Postdoctoral Fellowship through Department of Science and Technology (DST), India and worked at National Institute of Oceanography, Goa for two years. He has completed his MSc (Agri) Plant Biotechnology from University of Agriculture Sciences, Dharwad, India and Ph.D. in Biotechnology from the Department of Biotechnology, Goa University, Goa India through research fellowship of Department of Biotechnology (DBT). Dr. Meena has more than 5 years of postdoctoral research experience in natural products chemistry which resulted in more than 10 peer reviewed research papers in international journals, three book chapters and editors of two books in Elsevier. Dr. Meena has presented his research work in different national and international conferences.

Affiliations and expertise

DSK PDF at Department of Chemistry, Savitribai Phule Pune University, Pune, India

Vinod Nandre

Dr. Vinod Nandre is working as a postdoctoral fellow in the Department of Chemistry, Savitribai Phule Pune University, Pune, India. His postdoctoral work is based on silica extraction from e-waste and rice husk. He has obtained his PhD from Savitribai Phule Pune University, Pune on the topic of arsenic metabolism in prokaryotic system and arsenic removal from waste. He has 21 international publications and 1 patent based on phosphate removal from industrial waste sample. He also has two book chapters to his credit. He has teaching experience in Medical Biochemistry and industrial experience.

Affiliations and expertise

Postdoctoral Fellow, Department of Chemistry, Savitribai Phule Pune University, Pune, India

Kisan Kodam

Dr. Kisan M. Kodam is Professor of Biochemistry at the Department of Chemistry, Savitribai Phule Pune University, Pune, India. Dr. Kodam’s research interests are focused on environmental biotechnology. In particular, his research team is working on biodegradation of organic pollutants, arsenic and metal bioremediation. He has 27 years of teaching and research experiences and he has supervised 16 students for their doctoral studies and mentored five postdoctoral fellows. He has published around 100 research publications and 4 book chapters. His citations are 2704 with a h-index of 29. He is also working on biotransformation reactions for synthesis of natural products and cytotoxicity analysis. He has reported two novel bacterial species, namely Alishewanella solinquinati and Microvirga indica isolated from dyes and metal contaminated soils, respectively. His research work has been presented in many international conferences. He has been awarded as Fellow of Maharashtra Academy of Sciences, India for his valuable contributions in the field of environmental biotechnology.

Affiliations and expertise

Professor of Biochemistry at the Department of Chemistry, Savitribai Phule Pune University, Pune, India

Ram Swaroop Meena

Dr. Ram Swaroop Meena is an Agronomist working in the Department of Agronomy, Institute of Agricultural Sciences, Banaras Hindu University (BHU), Varanasi, India. Dr. Meena has been awarded Raman Research Fellowship by the Ministry of Education, Government of India. He has completed his postdoctoral research on soil carbon sequestration under Padma Shri Prof. Rattan Lal, World Food Prize Laureate, Columbus, USA. Dr. Meena has completed 10 external funded projects including, MHRD, ICAR, DST, etc.

Affiliations and expertise

Institute of Agricultural Sciences, Banaras Hindu University, Varanasi-221005, (UP), India

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New Horizons in Natural Compound Research

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Surya Nandan Meena

Vinod Nandre

Kisan Kodam

Ram Swaroop Meena