Ionizing Radiation and the Immune Response - Part A
- 1st Edition, Volume 376 - March 29, 2023
- Imprint: Academic Press
- Editors: Lorenzo Galluzzi, Celine Mirjolet
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 5 2 3 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 5 2 4 - 9
Ionizing Radiation and the Immune Response, Volume 376, Part A reviews the latest updates on the immune response induced by ionizing radiations. Sections discuss NK functions… Read more
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Request a sales quoteIonizing Radiation and the Immune Response, Volume 376, Part A reviews the latest updates on the immune response induced by ionizing radiations. Sections discuss NK functions in radio-induced immune response, TRT and immune response, Radio-induced immune response and lipid metabolism, Effect of protons and heavy ions on immune response, Effect of flashtherapy and mini beam on immune response, Radio-induced lymphopenia, CT to potentiate radio-induced immune response, Impact of RT on healthy tissues (inflammation), Radio-induced macrophagic response, To use nanoparticles and ionizing radiations to modulate immune response: opinion of the chemist, biologist and clinician, and more.
Additional sections touch on the Effect of low dose radiation on radio-induced immune response, Role of Dendritic cells in radiation-induced immune response, Relationship between the tumor microenvironment and the efficacy of the radiotherapy/immunotherapy combination+A23, and Biomarkers of radiation induced response to optimize radio-immunotherapy combination.
- Covers the latest insights on the biological and physical parameters that modulate radio-induced immune response
- Provides an accurate review by selected experts of the impact on the immune response of new techniques delivering ionizing radiations
- Presents valuable information to clinicians to optimize radiotherapy and immunotherapy combinations
Radiation biologist, radiation oncologist and immunologists interested to use ionizing radiation to iprove combination with immunotherapy
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: Are charged particles a good match for combination with immunotherapy? Current knowledge and perspectives
- Abstract
- 1: Introduction
- 2: Charged particles: physics and biology
- 3: Impact of charged particles on the immune response
- 4: Future perspectives
- 5: Conclusions
- Reference
- Chapter Two: Radiation-induced immune response in novel radiotherapy approaches FLASH and spatially fractionated radiotherapies
- Abstract
- 1: Introduction
- 2: FLASH radiation therapy and the immune system
- 3: Spatially fractionated radiotherapy and radiation-induced immune response
- 4: Conclusions
- Acknowledgments
- References
- Chapter Three: Impact of radiation therapy on healthy tissues
- Abstract
- 1: Acute normal tissue reactions associated with an inflammatory response
- 2: Late normal tissue effects
- 3: Joined targets to improve the tumor vs normal tissue differential effect
- 4: Conclusion
- References
- Chapter Four: The various functions and phenotypes of macrophages are also reflected in their responses to irradiation: A current overview
- Abstract
- 1: Macrophage polarization and functionality
- 2: Macrophages in health and disease
- 3: Molecular effects of ionizing radiation on macrophages
- 4: Outlook
- 5: Conclusion
- Acknowledgments
- References
- Chapter Five: Fatty acid metabolism and radiation-induced anti-tumor immunity
- Abstract
- 1: Introduction
- 2: Overview of fatty acid metabolism
- 3: Fatty acid metabolism and immune regulation
- 4: Radiation therapy and fatty acid metabolism
- 5: Conclusions
- References
- Chapter Six: Chemotherapy to potentiate the radiation-induced immune response
- Abstract
- 1: Introduction
- 2: Immunostimulating effects of chemoradiation
- 3: Immune suppressive effects of chemoradiation therapy
- 4: Combining CRT with immunotherapy: A promising strategy
- 5: Conclusion
- References
- Edition: 1
- Volume: 376
- Published: March 29, 2023
- No. of pages (Hardback): 184
- No. of pages (eBook): 184
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780323955232
- eBook ISBN: 9780323955249
LG
Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
Affiliations and expertise
Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USACM
Celine Mirjolet
Dr. Céline Mirjolet is a radiobiologist with in-depth knowledge of the impact of radiotherapy fractionation on the radiation-induced immune response and on the effectiveness of the radiotherapy and immunotherapy combination. She obtained a doctorate in radiobiology at the anti-cancer center of Nancy (France). She then moved to Brussels at the University of Belgium to study epigenetic mechanisms in transcriptional activity and cancer. For ten years, she has been working in the radiotherapy department of the Dijon cancer center in close collaboration with clinicians and physicists to develop translational research projects on the combination of immunotherapy and radiotherapy. She leads the preclinical research team in radiotherapy and radiobiology and her programs focus on the validation of preclinical concepts leading to the design of clinical trials.
Affiliations and expertise
Radiobiologist, CGFL Dijon, FranceRead Ionizing Radiation and the Immune Response - Part A on ScienceDirect