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Basic Immunology
Functions and Disorders of the Immune System
- 7th Edition - April 20, 2023
- Authors: Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 0 5 1 9 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 0 5 5 0 - 0
Meticulously reviewed and updated for today's medical students, Basic Immunology, 7th Edition, is a concise text expertly written by the same distinguished author team as the… Read more
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Request a sales quoteMeticulously reviewed and updated for today's medical students, Basic Immunology, 7th Edition, is a concise text expertly written by the same distinguished author team as the best-selling, comprehensive text, Cellular and Molecular Immunology. This focused, easy-to-understand volume has been fully revised to include recent important advances in our understanding and knowledge of the immune system. A student favorite through six outstanding editions, this new edition uses full-color illustrations and clinical images, useful tables, and practical features such as Summary Point boxes, end-of-chapter review questions, glossary terms, and clinical cases—all designed to help you master this complex topic in the most efficient, effective manner possible.
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Emphasizes clinical aspects of immunology, including disease pathogenesis, the development of novel therapies based on basic science, and an appendix of clinical cases for real-world application.
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Contains new and expanded content on pandemics, COVID-19, and herd immunity; resistance and susceptibility to COVID-19; RNA vaccines and hybrid viral vaccines; tumor immunotherapy; innate immune responses to viruses; mechanisms of immunologic tolerance; and immunotherapy for autoimmune, allergic, and other inflammatory diseases, and cancer.
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Provides unrivalled instruction from an expert author team, all of whom are experienced teachers, course directors, and lecturers.
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Features a highly readable writing style and practical organization, now with fully revised content and updated images to cover new information and improve reader understanding of complex concepts.
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Provides additional online features such as answers to in-book chapter review questions and self-assessment questions.
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Presents information in a format and style that maximizes usefulness to students and teachers of medicine, allied health fields, and biology.
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Contains numerous features designed to help students understand key immunologic concepts: high-quality illustrations, practical tables, chapter outlines, bolded key points, and focus questions in every chapter for self-assessment and review.
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An eBook version is included with purchase. The eBook allows you to access all the text and figures, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Medical and allied health students
- Instructions for online access
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Preface
- 1. Introduction to the Immune System: Nomenclature, General Properties, and Components
- Infections and Immunity
- Immunologic Disorders
- Stages of Host Defense: Innate and Adaptive Immunity
- Properties of Adaptive Immune Responses
- Cells of the Adaptive Immune System
- Tissues of the Immune System
- Summary
- 2. Unlabeled image.Innate Immunity: The Early Defense Against Infections
- General Features and Specificity of Innate Immune Responses
- Cellular Receptors for Microbes and Damaged Cells
- Components of Innate Immunity
- Innate Immune Reactions
- Role of Innate Immunity in Stimulating Adaptive Immune Responses
- Summary
- 3. Antigen Presentation to T Lymphocytes and the Functions of Major Histocompatibility Complex Molecules: What T Lymphocytes See
- Antigens Recognized by T Lymphocytes
- Capture of Protein Antigens by Antigen-Presenting Cells
- Structure and Function of Major Histocompatibility Complex Molecules
- Processing and Presentation of Protein Antigens
- Functions of Antigen-Presenting Cells in Addition to Antigen Display
- Antigen Recognition by Other T Lymphocytes
- Summary
- 4. Antigen Recognition in the Adaptive Immune System: Structure of Lymphocyte Antigen Receptors and Development of Immune Repertoires
- Antigen Receptors of Lymphocytes
- Development of B and T Lymphocytes
- Summary
- 5. T Cell–Mediated Immunity: Activation of T Lymphocytes
- Steps in T Cell Responses
- Antigen Recognition and Costimulation
- Biochemical Pathways of T Cell Activation
- Functional Responses of T Lymphocytes to Antigen and Costimulation
- Regulation of T Cell Responses by Inhibitory Receptors (Coinhibitors)
- Migration of T Lymphocytes in Cell-Mediated Immune Reactions
- Decline of the Immune Response
- Summary
- 6. Effector Mechanisms of T Cell–Mediated Immunity: Functions of T Cells in Host Defense
- Types of T Cell–Mediated Immune Reactions
- Development and Functions of CD4+ Effector T Lymphocytes
- Differentiation and Functions of CD8+ Cytotoxic T Lymphocytes
- Resistance of Pathogenic Microbes to Cell-Mediated Immunity
- Summary
- 7. Humoral Immune Responses: Activation of B Lymphocytes and Production of Antibodies
- Phases and Types of Humoral Immune Responses
- Stimulation of B Lymphocytes by Antigen
- Functions of Helper T Lymphocytes in Humoral Immune Responses
- Antibody Responses to T-Independent Antigens
- Regulation of Humoral Immune Responses
- Summary
- 8. Effector Mechanisms of Humoral Immunity: Elimination of Extracellular Microbes and Toxins
- Properties of Antibodies That Determine Effector Functions
- Neutralization of Microbes and Microbial Toxins
- Opsonization and Phagocytosis
- Antibody-Dependent Cellular Cytotoxicity
- Immunoglobulin E– and Mast Cell–Mediated Reactions
- The Complement System
- Functions of Antibodies at Special Anatomic Sites
- Evasion of Humoral Immunity by Microbes
- Vaccination
- Summary
- 9. Immunologic Tolerance and Autoimmunity: Self–Nonself Discrimination in the Immune System and Its Failure
- Immunologic Tolerance: General Priniciples and Significance
- Central T Lymphocyte Tolerance
- Peripheral T Lymphocyte Tolerance
- B Lymphocyte Tolerance
- Tolerance to Commensal Microbes and Fetal Antigens
- Autoimmunity
- Summary
- 10. Tumor and Transplantation Immunology: Immune Responses to Cancer Cells and Normal Foreign Cells
- Immune Responses Against Tumors
- Immune Responses Against Transplants
- Summary
- 11. Hypersensitivity: Disorders Caused by Immune Responses
- Types of Hypersensitivity Reactions
- Immediate Hypersensitivity
- Diseases Caused by Antibodies Specific for Cell and Tissue Antigens
- Diseases Caused by Antigen-Antibody Complexes
- Diseases Caused by T Lymphocytes
- Summary
- 12. Immunodeficiency Diseases: Disorders Caused by Defective Immunity
- Primary (Congenital) Immunodeficiencies
- Acquired (Secondary) Immunodeficiencies
- Acquired Immunodeficiency Syndrome (AIDS)
- Summary
- Appendix I. Principal Features of Selected CD Molecules
- Appendix II. Cytokines
- Appendix III. Clinical Cases
- Answers to Review Questions
- Index
- No. of pages: 352
- Language: English
- Edition: 7
- Published: April 20, 2023
- Imprint: Elsevier
- Paperback ISBN: 9780443105197
- eBook ISBN: 9780443105500
AA
Abul K. Abbas
Abul K. Abbas, MBBS, Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California
Affiliations and expertise
Emeritus Professor, Department of Pathology, University of California San FranciscoAL
Andrew H. Lichtman
Affiliations and expertise
Professor of Pathology, Brigham and Women's Hospital, Harvard Medical SchoolSP
Shiv Pillai
Affiliations and expertise
Professor of Medicine and Health Sciences and Technology, Harvard Medical School, Ragon Institute of MGH, MIT and Harvard