Control of Cell Cycle and Cell Proliferation

1st Edition, Volume 135 - April 11, 2023
Editor: Rossen Donev
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 8 2 2 - 3
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 8 2 3 - 0

Control of Cell Cycle and Cell Proliferation, Volume 135 in the Advances in Protein Chemistry and Structural Biology series, presents chapters on a variety topics, including Exp… Read more

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Control of Cell Cycle and Cell Proliferation, Volume 135 in the Advances in Protein Chemistry and Structural Biology series, presents chapters on a variety topics, including Exploiting pivotal mechanisms behind the senescence-like cell cycle arrest, Viral infection on through Cell Cycle Regulation, Analyzing drug resistant mutation in CDK4 gene and identification of potential inhibitors through structure based virtual screening approach, Controlling cell proliferation by targeting CDK6 using drug repurposing approach, The role of the nucleolus in regulating cell cycle, Chromatin regulators in DNA replication and genome stability maintenance during S-phase, Role of macrophage in cancer cell progression and targeted immunotherapies, and much more.

Cover
Title page
Table of Contents
Copyright
Contributors
Chapter One: Exploiting pivotal mechanisms behind the senescence-like cell cycle arrest in cancer
Abstract
1: Introduction
2: Senescence-like cell cycle arrest in cancer
3: General signaling pathways engaged in senescence-like cell cycle arrest
4: Conclusion
5: Future perspective
References
Chapter Two: Cyclin-dependent kinases in cancer: Role, regulation, and therapeutic targeting
Abstract
1: Introduction
2: Cyclins and cyclin-dependent kinases in cell cycle progression
3: Cyclin-dependent kinase inhibitors (CDKIs) in cancer therapeutics
4: Conclusion
Ethical approval and consent to participate
Consent for publication
Availability of supporting data
Competing interests
References
Chapter Three: Computational screening and structural analysis of Gly201Arg and Gly201Asp missense mutations in human cyclin-dependent kinase 4 protein
Abstract
1: Introduction
2: Materials and methods
3: Results and discussion
4: Conclusion
References
Chapter Four: Controlling cell proliferation by targeting cyclin-dependent kinase 6 using drug repurposing approach
Abstract
1: Introduction
2: Methodology
3: Results
4: Discussion
5: Conclusion
References
Chapter Five: CDK regulators—Cell cycle progression or apoptosis—Scenarios in normal cells and cancerous cells
Abstract
1: Introduction
2: CDK regulators
3: Comparison between normal cells and cancerous cells
4: CDKI as therapeutics
5: Conclusion
6: Future prospects
References
Chapter Six: Insights into the aberrant CDK4/6 signaling pathway as a therapeutic target in tumorigenesis
Abstract
1: Introduction
2: Aberrant cell cycle checkpoints cooperate with cancer progression
3: AMBRA1 destabilizes cyclin D protein
4: Immunomodulatory function of cell cycle regulators
5: Cell cycle-based targeted cancer therapies
6: Targeting CK1ɛ for overcoming resistance to CDK4/6 inhibitors
7: Discussion
Acknowledgment
References
Chapter Seven: The role of the nucleolus in regulating the cell cycle and the DNA damage response
Abstract
1: Introduction
2: Nucleolus structure
3: The nucleolar proteome
4: Nucleolar assembly and disassembly during the cell cycle
5: The role of the nucleolus in regulating p53-dependent cell cycle events
6: p53-independent cell cycle regulation by nucleolar proteins
7: Nucleolar stress and DNA repair
8: The role of NPM1 in protecting from genomic instability
9: The nucleolus and cell death pathways
10: Nucleolar proteins in cancer
11: Conclusions
References
Chapter Eight: Chromatin regulators in DNA replication and genome stability maintenance during S-phase
Abstract
1: Replication of chromatin
2: Cellular response to replication stress
3: Chromatin factors involved in DNA replication initiation
4: Chromatin in the maintenance of DNA replication elongation and replication stress protection
5: Chromatin events at stalled forks
6: Transcription-induced replication stress
7: Exploiting replication stress
8: Concluding remarks
Acknowledgments
References
Chapter Nine: Role of macrophages in cancer progression and targeted immunotherapies
Abstract
1: Overview of tumor-associated macrophages
2: Polarization of TAMs
3: TAMs involvement in tumor progression
4: Role of TAMs in immune response
5: Cell cycle regulation in TAMs and cancer cells
6: Therapies targeting cancer cell cycle progression by targeting TAMs
7: Future directions
References
Chapter Ten: Therapeutic targets in cancer treatment: Cell cycle proteins
Abstract
1: Introduction
2: Tumor cell cycle phase analysis
3: Cell-cycle checkpoint
4: Targeting cell cycle kinases in cancer therapy
5: Role of D-type cyclins in cancer
6: Role of cyclin E in cancer
7: Role of cyclin B and CDK1 in cancer
8: Role of polo-like kinases (Plks) family members in cancer
9: Plks in cancer development
10: DNA damage checkpoint kinases
11: Currently used cyclin inhibitors
12: Concluding remarks
References
Chapter Eleven: Anti-cancer drug molecules targeting cancer cell cycle and proliferation
Abstract
1: Introduction
2: Overview of cell cycle checkpoints
3: Disturbance in cancer cell cycle checkpoints
4: Anti-cancer drugs
5: Drugs that target cell cycle proteins
6: Cancer cell proliferation inhibitors
7: Conclusion
References
Chapter Twelve: Cellular signals integrate cell cycle and metabolic control in cancer
Abstract
1: Growth factors in cancer
2: Growth factor signal transduction and biological responses
3: Growth factor-dependent signaling and cell cycle progression
4: The cell cycle controls the metabolism
5: Conclusion
References
Chapter Thirteen: Therapeutic targeting and HSC proliferation by small molecules and biologicals
Abstract
1: Introduction
2: Cell cycle kinetics of hematopoietic stem cells
3: Hematopoietic stem cells expansion technologies
4: Small molecule-induced HSC expansion
5: Clinical perspective on HSC expansion
6: Conclusion
References
Chapter Fourteen: Mechanism of cell cycle regulation and cell proliferation during human viral infection
Abstract
1: Introduction
2: Cell cycle: An overview
3: Brief account of viruses involved in the regulation of the cell cycle
4: Mechanistic account of virus mediated cell regulation
5: Conclusions
References

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Rossen Donev