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Books in Life sciences

  • Medicinal Chemistry of Chemotherapeutic Agents

    A Comprehensive Resource of Anti-infective and Anti-cancer Drugs
    • 1st Edition
    • Pratap Chandra Acharya + 1 more
    • English
    Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-infective and Anti-cancer Drugs focuses on the basics and fundamentals of chemistry involved in chemotherapeutic agents. Each chapter comprises distinct chemical classifications that include structure and IUPAC nomenclature, synthetic schemes and routes for each drug, mechanism of the drug action, metabolic pathway and structure–activity relationship (SAR) studies. The book covers current research focused on drug resistance and methods to overcome it, the development of newer drugs belonging to each category of the chemotherapeutic agents, molecules currently under clinical trials, and newly approved drugs, if any. This book will be a valuable resource for academics and researchers, helping them to understand the fundamentals of the medicinal chemistry of the chemotherapeutic agents.

  • Chitosan

    Novel Applications in Food Systems
    • 1st Edition
    • Ioannis Savvaidis
    • English
    Chitosan: Novel Applications in Food Systems is a practical resource for those looking to understand new applications of chitosan in the food industry. The content presented is written by experts in the field who have worked on the latest application of chitosan-based research to help researchers and scientists understand how recent applications combined with traditional food preservation hurdles, or novel hurdles such as active packaging, irradiation and essential oils can improve methods of controlling microorganisms in foods. With an emphasis of potential of chitosan in food safety this reference briefly summarizes what chitosan-based research has already done for the industry, including potential applications.

  • Conceptual Development of Industrial Biotechnology for Commercial Production of Vaccines and Biopharmaceuticals

    • 1st Edition
    • Basanta Kumara Behera
    • English
    Conceptual Development of Industrial Biotechnology for Commercial Production of Biopharmaceuticals and Vaccines provides insights on how to bring sustainability into biologic drug production. The cumulative facts and figures within in the book are helpful to promoters in monitoring value chain transfer process of super quality biologics for better return in profits. In addition, this is a useful reference for students, researchers and scientists in biotechnology, pharmaceutical science, medical sciences, and the R&D division of biotechnology-based industries. Conceptual development of biotechnology has taken new avenues with the integration of medical sciences, physical science, and engineering, hence this is a timely source. The current global market for vaccines, especially COVID-19, is tremendous. Bivalent oral polio vaccine, diphtheria, tetanus-containing, and measles-containing vaccines have a high demand internationally and recombinant DNA technology and protein engineering are helpful in the production of quality bio-products.

  • Smart Nanomaterials to Combat the Spread of Viral Infections

    Advanced Strategies for the Prevention of Viral Infections
    • 1st Edition
    • Raju Khan + 1 more
    • English
    Smart Nanomaterials to Combat the Spread of Viral Infections comprises nanotechnology-based approaches with detailed preventive and treatment methodology for enabling their application in antiviral systems. This book discusses the role of metal nanoparticles in the treatment of and prevention of viral infections and nanotechnology advancements in antiviral coatings to combat affected surfaces. It also covers the use of nanomaterials for the efficient intracellular delivery of antiviral agents to disinfect and treat viral infections. This is a timely coverage of how nanotechnologies and materials as well as the utilization of artificial intelligence and Internet of things–based smart nano-systems are used to control and manage viral infections during the COVID-19 pandemic. Advances in smart research and future antimicrobial applications round out the book. This book provides a comprehensive overview of smart nanomaterials and advanced nano-system applications to researchers and academics in virology, microbiology, chemistry, material science, nanotechnology, and biotechnology as well as those in industries interested in their virucidal properties to prevent viral infections.

  • Natural Products in Vector-Borne Disease Management

    • 1st Edition
    • Nagendra Singh Chauhan + 1 more
    • English
    Natural Products in Vector-Borne Disease Management explores the potential application of natural products in vector control and disease management. The chapters discuss the global impact of specific vector-borne diseases, gaps in management, and natural products in specific stages of development - discovery, optimization, validation, and preclinical/clinical development. Toxic effects and mechanisms of action are also discussed. This book also explores how therapeutic plant derivatives can be used to combat the vectors of infection and how natural products can be used to manage and treat vector-borne diseases like malaria, leishmaniasis, dengue, and trypanosomiasis. With the inclusion of case studies on field and clinical applications and the contributions from experts in the field, Natural Products in Vector-Borne Disease Management is an essential resource to researchers, academics, and clinicians in parasitology, virology, microbiology, biotechnology, pharmacology, and pharmacognosy working in the field of vector-borne diseases.

  • MRI/DTI Atlas of the Human Brainstem in Transverse and Sagittal Planes

    • 1st Edition
    • George Paxinos + 5 more
    • English
    **Selected for Doody’s Core Titles® 2024 in Neuroscience**MRI/DT... Atlas of the Human Brainstem in Transverse and Sagittal Planes presents a detailed view of the human brainstem in DTI/MRI. It is the first ever MRI or histological atlas to present detailed diagrams of sagittal views of the brainstem. Presenting data of unprecedented quality, images are juxtaposed with detailed diagrams in the transverse and sagittal planes. The atlas features a 50 micron resolution for the GRE and 200 microns for the FAC and DWI, 8000 times higher than that seen in a clinical MRI and 1000 times higher than that seen in a clinical DTI scan, all based on one brain.This atlas is important for neuroscientists, neurosurgeons, pathologists, anatomists, neurophysiologists, radiologists, radiotherapists (e.g., for cyberknife guidance), and graduate students in neuroscience.

  • Encyclopedia of Human Nutrition

    • 4th Edition
    • Benjamin Caballero
    • English
    **Selected for Doody’s Core Titles® 2024 in Nutrition**Encyclope... of Human Nutrition, Fourth Edition, a Four Volume Set, provides updated information on the foundations of nutrition science, along with the biology and functions of vitamins and other essential nutrients present in the human diet. The book's content offers a modern understanding of the links between diet and health effects, including diseases of recognized nutritional etiology. This overview of the genetic and molecular aspects of nutrient-health interrelationships includes important content on topics like nutrigenomics, metabolomics and the microbiome. In addition, the book provides global context, particularly on the issue of food production, sustainability and climate change.The new edition carries on the legacy of a reference work that comprehensively offers a one-source, integrated bank of information on all three areas – food, nutrition science and clinical nutrition.

  • Regulation of Downstream Targets

    • 1st Edition
    • Volume 134
    • Rossen Donev
    • English
    Regulation of Downstream Targets, Volume 134 in the Advances in Protein Chemistry and Structural Biology series, presents interesting chapters on topics such as Transcriptional regulatory mechanisms and signaling networks in Viral Infections, Identification of potential key genes associated with pathogenesis and prognosis of endometrial cancer based on Integrated Bioinformatics Approaches, Differential regulation of genes in stage IB pancreatic cancer associated with increased risk of metastasis, AMPK-related LKB1-downstream targets, A compilation of bioinformatic approaches to identify novel downstream targets for the detection and prophylaxis of cancer, Protein phosphatases and their targets: Critical determinants of signaling pathway in plants, and more. Other sections cover Calcium decoders and their targets: The holy alliance that regulate cellular responses, Importin alpha family NAAT/IBB domain: functions of a multi-faceted long chameleon sequence, Aurora Kinase A and related downstream molecules: A Potential Network for Cancer Therapy, Emerging Role of Heat Shock Proteins in Cardiovascular Diseases, Function, Structure, Evolution, Regulation and Drug Target Relevance of Arylalkylamine N-acetyltransferase, and Analysis of signaling cascades from myeloma cells treated with pristimerin.

  • DNA Interactions with Drugs and Other Small Ligands

    Single Molecule Approaches and Techniques
    • 1st Edition
    • Marcio Santos Rocha
    • English
    DNA Interactions With Drugs and Other Small Ligands: Single Molecule Approaches and Techniques provides the reader with all the main information, a "state-of-the-art" of sorts and an overall review of the field. There is no other book currently available that covers all these subjects together. On the contrary, the different subjects that are developed in this book are currently scattered in journal articles and other books.

  • Clinical Trials and Tribulations

    • 1st Edition
    • Gayathri De Lanerolle + 2 more
    • English
    Clinical Trials and Tribulations evaluates the multiple layers of complexities around research management, also exploring current practices, challenges and future directions. The book provides answers to readers questions and problems through extensive use of real-world examples, case studies and lessons learned. Following an approach to provide pragmatic viewpoints as well as concepts and methodologies and its alignment with specific practices, the book explores paradigms between planning and conducting research in academia vs. healthcare vs. industry in the UK vs. Europe vs. America. It highlights practical solutions to real-world complex issues that have been documented by independent regulators. This will be an indispensable book for all staff working in clinical research within healthcare, academia and industry, as well as students intending to work in clinical trials.

  • In Silico Approach Towards Magnetic Fluid Hyperthermia of Cancer Treatment

    Modeling and Simulation
    • 1st Edition
    • Muhammad Suleman
    • English
    In Silico Approach Towards Magnetic Fluid Hyperthermia in Cancer Treatment: Modeling and Simulation presents mathematical modeling and simulation approaches contrary to costly and time consuming in-vivo and in-vitro studies. Finite element method-based models of all hyperthermia processes of liver, brain and breast tumors are simulated on COMSOL Multiphysics software. Problems of constant versus variable heat sources, the backflow problem, the enhanced permeation and retention effect, the flow around Happel’s sphere in cells model structure, the deformation effect in poroelastic brain tumor, 3D flow through porous tissue, the reacting nanofluid flows, and optimization of parameters have been simulated for quantitative analysis. This important reference aids in hyperthermia treatment planning in clinical applications and provides an important compendium for practitioners as well as non-medical practicing scientists and engineers and is resource for both research and medical practice in hyperthermia treatment planning in clinical applications.

  • Nano/micro-Plastics Toxicity on Food Quality and Food Safety

    • 1st Edition
    • Volume 103
    • English
    Nano/micro-Plastics Toxicity on Food Quality and Food Safety, Volume 103 in the Advances in Food and Nutrition Research series, provides in-depth reviews on recent developments in nano/micro-plastics toxicity on food quality and food safety research. Topics covered in this volume include the sources and occurrence of nano/microplastics in terrestrial/marine environments, release mechanisms of microplastics from packaging into foods, influencing factors of microplastic on food products, their translocation and accumulations potential, microplastic as a critical vector for pollutant transfer, toxicology impact, cycling in the marine environment and seafood safety, and more. Moreover, microplastic migration by enhancing public awareness as well as improving waste management, complications and toxicity associated with the presence of nano/microplastics and quantification methods are highlighted. Finally, existing regulations and requirements of a robust framework of nano/microplastics are provided.

  • Hormones and Epigenetics

    • 1st Edition
    • Volume 122
    • Gerald Litwack
    • English
    Hormones and Epigenetics, Volume 122, the latest release in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting timely, interesting chapters written by an international board of authors.

  • Environmental Carcinogenesis

    • 1st Edition
    • Volume 96
    • English
    Environmental Carcinogenesis, Volume 96 in the Advances in Pharmacology series, reports on work done with carcinogenic metals and the mechanisms of their carcinogenicity, including Arsenic and Chromate. Chapters in this release include Breast cancer carcinogenesis by organophosphate pesticides, Polyadenylation of Canonical histone H3.1 in Carcinogenesis, Epigenomic reprogramming in iAs-mediated carcinogenesis, MicroRNAs and epigenetic regulation in metal-induced angiogenesis and carcinogenesis, Environmental epigenetics and new mechanistic markers of chemical exposure, Arsenic carcinogenesis by inhibition of DNA repair, Genetic and environmental reprogramming of the sarcoma epigenome, Mechanism of chromate carcinogenesis by chromatin alterations, and more. Other chapters cover Arsenic carcinogenesis and microRNAs, Epigenetic mechanism of Cr(VI)-induced cell malignant transformation and tumorigenesis, The dark side of NRF2 in arsenic carcinogenesis, and Chemical mechanisms of DNA damage by carcinogenic chromium(VI).

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 3: Environmental Toxicologic Pathology and Major Toxicant Classes

    • 4th Edition
    • Wanda M. Haschek + 3 more
    • English
    Haschek and Rousseaux's Handbook of Toxicologic Pathology, Fourth Edition, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, this book covers the toxicologic pathology of major classes of environmental toxicants. Volumes emphasize the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. This series comprises the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.

  • African Flora to Fight Bacterial Resistance, Part I

    Standards for the Activity of Plant-Derived Products
    • 1st Edition
    • Volume 106
    • English
    African Flora to Fight Bacterial Resistance, Part One: Standards for the Activity of Plant-Derived Products offers a glimpse into the potential of African medicinal plants to fight bacterial infections, with an emphasis on bacterial drug resistance. Sample chapters cover the Global Burden of bacterial infections and drug resistance, Bacterial drug resistance towards natural products, Harvesting and Processing Medicinal plants for antibacterial testing, Screening methods for antibacterial agents from plant source, Established antibacterial drugs from plants, Potential of African medicinal plants against Enterobacteria: classification of plants antibacterial agents, and much more. Based on collected data, the book offers a rationale classification basis for the antibacterial activity of plant-based products. General knowledge of state-of-the-art of drug resistance is globally described, with the book clearly identifying the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 113
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 113, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry with sections in this release focusing on Biosensors for saliva biomarkers, Biochemistry and pathophysiology of the Transient Potential Receptor Vanilloid 6 (TRPV6) calcium channel, Protein Glycation in Diabetes Mellitus, Biomarkers of Oxidative Stress and Reproductive Complications, Cortisol: Analytical and Clinical Determinants, and Hemophilia A: Emicizumab monitoring and impact on coagulation testing.

  • Mitochondria and Bacterial Pathogens - Part A

    • 1st Edition
    • Volume 374
    • English
    Mitochondria and Bacterial Pathogens, Volume 374, Part A. Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca2+ fluxes, bioenergetic metabolism, and cell death. Perhaps not surprisingly, multiple pathogenic bacteria have evolved strategies to subvert mitochondrial functions in support of their survival and dissemination. In the IRCMB volume 375, the authors discus different pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells.

  • Standardizing Pharmacology: Assays and Hormones

    Discoveries in Pharmacology, Volume 2
    • 2nd Edition
    • Michael J. Parnham + 2 more
    • English
    Standardizing Pharmacology: Assays and Hormones, Volume Two in the Discoveries in Pharmacology series, presents selected articles from historic discoveries that are enhanced with commentary from contemporary scholars who present discussions on the importance of each chapter, along with an updated bibliography on the subject and contributions from a Nobel Prize winner and other pioneers in pharmacology. Academic and industry researchers in pharmacology and medicine, as well as advanced students will find this series a useful teaching tool and launch to new discoveries. Sections cover key discoveries in receptor theory, pharmacological methods and the development of hormone therapy, including J. Parascandola on the development of receptor theory, R.S. Yalow on radioimmunoassay, M. van Rossum and J.T L.A. Hurkmans on bioassays, M. Tausk on androgen therapy and C. Djerassi on oral contraceptives, with commentaries from experts such as T. Hökfelt and V.C. Jordan.

  • From Fossils to Mind

    • 1st Edition
    • Volume 275
    • English
    From Fossils to Mind, Volume 275 in the Progress in Brain Research series, presents chapters on a variety of interesting topics, including What could our premammalian ancestors hear, see, smell, and touch? A review of ten years of research about cynodont paleoneurology, Endocasts of ornithopod dinosaurs: anatomy and comparison, Adaptationism and Structuralism in Brain Evolution Research, Genomic approaches for tracing the evolution of brain ageing and neurodegenerative diseases, Investigating the Coevolution of Language and Tools in the Brain: An ALE Meta-analysis of Neural Activation During Syntactic Processing and Tool Use, and more.

  • Algae Materials

    Applications Benefitting Health
    • 1st Edition
    • K. Arunkumar + 3 more
    • English
    Algae Materials: Applications Benefitting Health offers a comprehensive analysis of biosensors, algae materials for clinical applications, algae polymers, proteins and pigments, algae for food applications and packaging, blue economy, algae forming, cosmetics, and more. The book enlists the less explored areas of algal bioproducts, including how the application of genetic engineering is currently used to enhance bioproducts. Even though there are numerous reviews and scattered documents available, there are some recent fields yet to explore.

  • African Flora to Fight Bacterial Resistance, Part II

    The Best Source of Herbal Drugs and Pharmaceuticals
    • 1st Edition
    • Volume 107
    • English
    African Flora to Fight Bacterial Resistance, Part Two: The Best Source of Herbal Drugs and Pharmaceuticals, Volume 107 offers detailed information on the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals to efficiently tackle bacterial drug resistance. Chapters cover Phytochemistry and antibacterial potential of the genus Allanblackia, Phytochemistry and antibacterial potential of the genus Beilschmiedia, Phytochemistry and antibacterial potential of the genus Fagara, Phytochemistry and antibacterial potential of the genus Garcinia, Harungana madagascariensis as a source of antibacterial agents, Hypericum roeperianum as a source of antibacterial agents, and much more.

  • Handbook of Arsenic Toxicology

    • 2nd Edition
    • Swaran Jeet Singh Flora
    • English
    Handbook of Arsenic Toxicology, Second Edition presents the latest findings on arsenic, including its chemistry, sources and effects on the environment and human health. The book discusses both acute and chronic effects, discussing many aspects of arsenic, from physical and chemical properties, exposure, epidemiology, organ toxicity, diagnosis, prevention and treatment. Fully updated and revised, this new edition includes new topics on risk assessment, molecular mechanisms of arsenic, advances in the integrated approach to testing, assessment and development, evaluation and application of high content predictive models, and new alternative methods (NAMS) in the context of Adverse Outcome Pathways (AOPs) to assess toxicology. This comprehensive resource allows readers to effectively assess the risks related to arsenic, providing them with all they need to know on arsenic exposure, toxicity and toxicity prevention.

  • 8-Membered Heterocycle Synthesis

    • 1st Edition
    • Navjeet Kaur
    • English
    8-Membered Heterocycle Synthesis focuses on both the new and established methods for the synthesis of various 8-membered heterocycles. 8-membered heterocyclic compounds act as target molecules for a wide range of synthetic studies and are present in a broad range of natural products, showing a wide variety of pharmaceutical and biological properties. Covering an important and rapidly growing branch of heterocyclic chemistry, this book brings together every protocol for the synthesis of 8-membered heterocycles in one place, allowing the reader to see all the possibilities for making a particular compound using one particular reagent. Providing up-to-date and comprehensive information about the synthesis of medium-ring heterocycles and the latest information on this fast-moving field, with easy access to the synthetic protocols for different 8-membered heterocycles, case studies, and application, this book will be essential reading for students, pharmacologists, biochemists, organic and medicinal chemists, researchers, and academic professionals.

  • Angiotensin

    From the Kidney to Coronavirus
    • 1st Edition
    • Paul M. Pilowsky
    • English
    Angiotensin: From the Kidney to Coronavirus, a new volume in the Molecular Mediators in Health and Disease series, presents the communication role of the hormone in both health and disease states. Beyond the most common conditions, the book also explores the role of Angiotensin in infectious diseases, like COVID-19. Sections provide background to its discovery and role in homeostasis, focus on molecular biology aspects, including genetics and measurements of its associated proteins, describe the specific actions of angiotensin in normal physiology with different organ systems, survey different classes of drugs that act on the Renin-angiotensin-al... system, cover non-angiotensin II peptides, and more. The final part of the book is dedicated to angiotensin’s role in disease states, making this the ideal reference for researchers in life sciences interested in understanding the physiological role of Angiotensin in a complete fashion. Research physicians will also benefit from the book’s complete coverage of organ systems and diseases where Angiotensin plays a key role.

  • Translational Autoimmunity, Volume 6

    Advances in Autoimmune Rheumatic Diseases
    • 1st Edition
    • Nima Rezaei
    • English
    Translational Autoimmunity: Advances in Autoimmune Rheumatic Diseases, Volume Six addresses autoimmune diseases classified under the category of rheumatic diseases. Rheumatic diseases are heterogeneous groups of disorders in which inflammation affects not only joints, but also tendons, ligaments and bones. This updated release focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, osteoarthritis and Sjogren’s syndrome, and will be of interest to researchers, students and clinicians interested in autoimmune diseases, especially rheumatic diseases. From an introduction to rheumatic diseases to diagnostic laboratory tests, and from the microbiota-immunity to cell-based therapies, the bench to bedside approach to rheumatic diseases is the main subject of discussion in this comprehensive resource.

  • Receptor Endocytosis and Signalling in Health and Disease - Part B

    • 1st Edition
    • Volume 196
    • English
    Receptor Endocytosis and Signalling in Health and Disease, Part B, Volume 196 highlights the different aspects of receptor endocytosis and signaling, covering several receptors which are associated with different organs and that play a key role in normal functioning in the body, including somatostatin, Mas receptor, AMPA, Dopamine, 5-HT1-2, GABA, GPCR, nuclear receptor, Integrin, BCR, CRHR1, etc. Chapters in this new release include Internalization of somatostatin receptors in brain and periphery, Mas receptor, signaling and trafficking in health and disease, Endocytosis of AMPA receptors: Role in neurological conditions, Endocytosis of dopamine receptor: Signaling in brain, and more. Additional chapters cover Endocytosis of LXRs: Signalling in liver, Endocytosis of LDL receptor: Importance in cardiovascular diseases, Advances in the molecular level understanding of G-protein-coupled receptor, Nuclear receptor: Structure and function, Integrin receptor trafficking in health and disease, B Cell Receptor (BCR) endocytosis,CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling, and much more.

  • Mathematics for Physical Chemistry

    • 5th Edition
    • Robert G. Mortimer + 1 more
    • English
    Mathematics for Physical Chemistry, Fifth Edition includes exercises that enable readers to test their understanding and put theory into practice. Chapters are constructed around a sequence of mathematical topics, progressing gradually into more advanced material, before discussing key mathematical skills, including the analysis of experimental data and—new to this edition—complex variables. Includes additional new content on Mathematica and its advanced applications. Drawing on the experience of its expert authors, this book is the ideal supplementary text for practicing chemists and students wanting to sharpen their mathematics skills and understanding of key mathematical concepts for applications across physical chemistry.

  • Mitochondrial Diseases

    • 1st Edition
    • Volume 194
    • English
    Mitochondrial Diseases, Volume 194 presents the most common clinical manifestations, providing an up-to-date summaries on the clinical presentations, diagnostic processes, genetic counseling and treatment options in mitochondrial diseases. Contents include specialist biochemical analyses and targeted molecular genetic testing, as well as first-line genome-wide sequencing to accelerate speed of diagnosis while avoiding time-consuming, expensive and invasive investigations. Establishing a genetic diagnosis allows patients with mitochondrial diseases to have reproductive options, all of which are covered within.This book is intended for neurologists to help them recognize and manage patients with mitochondrial diseases.

  • Computational Methods and Deep Learning for Ophthalmology

    • 1st Edition
    • D. Jude Hemanth
    • English
    Computational Methods and Deep Learning for Ophthalmology presents readers with the concepts and methods needed to design and use advanced computer-aided diagnosis systems for ophthalmologic abnormalities in the human eye. Chapters cover computational approaches for diagnosis and assessment of a variety of ophthalmologic abnormalities. Computational approaches include topics such as Deep Convolutional Neural Networks, Generative Adversarial Networks, Auto Encoders, Recurrent Neural Networks, and modified/hybrid Artificial Neural Networks. Ophthalmological abnormalities covered include Glaucoma, Diabetic Retinopathy, Macular Degeneration, Retinal Vein Occlusions, eye lesions, cataracts, and optical nerve disorders. This handbook provides biomedical engineers, computer scientists, and multidisciplinary researchers with a significant resource for addressing the increase in the prevalence of diseases such as Diabetic Retinopathy, Glaucoma, and Macular Degeneration.

  • Covid-19 and Vaccine Nationalism

    Managing the Politics of Global Pandemics
    • 1st Edition
    • Eric E. Otenyo
    • English
    Covid-19 and Vaccine Nationalism: Managing the Politics of Global Pandemics provides an in-depth overview of the complex nature politics played in vaccine production and distribution. The book ensures international and domestic politics, governance, and mechanisms of vaccine production and administration are understandable through insightful discussions. The book aims to solve several problems, including the essence of vaccine nationalism in a context of international politics, the discourse of vaccine nationalism outside popular media, historical documentation of the problem of vaccine inequality and low access of Covid-19 vaccines in developing countries of Africa, the Caribbean, parts of Asia, and more. Final sections cover the global blueprint of solving the problem of the Covid-19 pandemic through vaccines and an in-depth analysis of the politics of Covid-19 vaccines in the United States, China, Europe, the United Kingdom and India.

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 2: Safety Assessment and Toxicologic Pathology

    • 4th Edition
    • Wanda M. Haschek + 3 more
    • English
    Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 2: Toxicologic Pathology in Safety Assessment is an essential part of the most authoritative reference on toxicologic pathology principles and techniques for assessing product safety and human risk. Volume 2 describes the integration of product-induced structural and functional changes in tissues and the interpretation of their biological implications. Completely revised with many new chapters, Volume 2 of the Fourth Edition covers product safety assessment from many angles including current and emerging issues in toxicologic pathology for many product classes. Volume 2 of the Handbook of Toxicologic Pathology is a key resource for pathologists, toxicologists, research scientists, and regulators who use toxicologic pathology methods to study and make decisions on product safety.

  • The Thinking Healthcare System

    Artificial Intelligence and Human Equity
    • 1st Edition
    • Dominique J. Monlezun
    • English
    The Thinking Healthcare System: Artificial Intelligence and Human Equity is the first comprehensive book detailing the historical, global, and technical trends shaping the evolution of the modern healthcare system into its final form—an AI-driven thinking healthcare system, structured and functioning as a global digital health ecosystem. Written by the world’s first triple doctorate trained physician-data scientist and ethicist, and author of three AI textbooks and over 350 scientific and ethics papers, this indispensable resource makes sense of how technology, economics, and ethics are already producing the future’s health system—and how to ensure it works for every patient, community, and culture in our globalized, digitalized, and divided world. Providing clear descriptions and concrete examples, this book brings together AI-accelerated digital health ecosystems, data architecture, cloud and edge computing, precision medicine, public health, telemedicine, patient safety, health political economics, multicultural global ethics, blockchain, and quantum health computing, among other topics. Healthcare and business executives, clinicians, researchers, government leaders, policymakers, and students in the fields of healthcare management, data science, medicine, public health, informatics, health and public policy, political economics, and bioethics will find this book to be a groundbreaking resource on how to create, nourish, and lead AI-driven health systems for the future that can think, adapt, and so care in a manner worthy of the world’s patients.

  • Encyclopedia of Child and Adolescent Health

    • 1st Edition
    • Bonnie Halpern-Felsher
    • English
    **Association of American Publishers (AAP) PROSE Award Winner in Clinical Medicine, 2024 and Reference Works & Textbooks Multivolume, 2024**Informed by the Biopsychosocial Model, this Encyclopedia of Child and Adolescent Health examines multiple aspects of child and adolescent development and physical and mental health. According to the Biopsychosocial Model, health is determined by the reciprocal interactions between biological (e.g., genetics, physical development, family health history), psychological (e.g., mental health, identity developmental, attitudes), and social (e.g., family, peers, school, social supports) factors. This theory posits that each one of these factors alone is not sufficient to understand health; instead, it is important to understand how these interactive components ultimately influence health outcomes.In addition to the Biopsychosocial Model, this Encyclopedia of Child and Adolescent Health has a translational approach. Each section and all applicable entries include a discussion of prevention or intervention efforts that can inform health and health promotion, and prevent health risks.

  • Lantibiotics as Alternative Therapeutics

    • 1st Edition
    • Sanket Joshi + 3 more
    • English
    Lantibiotics as Alternative Therapeutics explores alternative therapeutics, lantibiotics and other novel drugs. This book provides concrete information to readers regarding lantibiotics and various types of antimicrobial peptides with their mode of actions in treating various multidrug resistant organisms. It explains various techniques that are involved in analyzing antimicrobial peptides and their mode of actions. The development of antibiotic resistance has now reached a point of crisis where innovative methods and application of novel compounds and methods are required to prevent the spread of drug resistant infections. Novel compounds exhibit different modes of action to the currently used mechanism of therapeutics in order to combat against the resistant organisms. Lantibiotics hold considerable potential as a consequence of their unusual structure, unique mechanisms of action and their potency against multi-drug resistant bacteria. This book will be useful for pharmaceutical industry scientists and researchers in microbial and biomedical research as well as graduate and advanced students in microbiology, medical biotechnology, health, and pharmaceutical sciences.

  • Recent Developments in Anti-Inflammatory Therapy

    • 1st Edition
    • Parteek Prasher + 4 more
    • English
    Advances in Anti-inflammatory Therapy explores the cutting-edge in anti-inflammation therapy in clear and concise language, with insights from academia and industry. Sections cover key regulatory pathways that mediate acute and chronic inflammation and disease onset. Further chapters are devoted to advanced anti-inflammatory pharmaceuticals, including chemical moieties, pharmacophores, APIs, natural products, herbal therapies, molecular nanomedicine and advanced drug delivery vectors. Systematically planned chapters and illustrations enable potential readers to gain essential insights on the most recent advancements in the field. Arranged with systematic chapters covering a broad range of inflammatory diseases, discussions on past, current and future therapeutics and advanced anti-inflammatory pharmaceuticals, this book will be useful to a wide range of researchers, especially medicinal chemists, drug design experts, and biological and translational researchers working in the field of inflammation.

  • Precision Medicine in Neurodegenerative Disorders

    Part II
    • 1st Edition
    • Volume 193
    • English
    Precision Medicine in Neurodegenerative Disorders, Part Two, Volume 193 in the Handbook of Clinical Neurology deals with the "How" in the reconfiguration of our approach to slow accelerated brain aging. The book rethinks animal models on which therapies are tested, outlines the progress and expected changes in biological subtyping efforts using lysosomal, endosomal, mitochondrial, immune dysregulation, and inflammatory mechanisms of disease pathophysiology, and the growing role of microbiome in shaping disease. The volume separates the potentially disease-modifying neurorescue and neurorestoration, (e.g., gene therapy and cell replacement therapy) from true precision "medicine"–matching biology with the mechanism of intervention of interest. Specific chapters are dedicated to the promise and challenges of extracellular vesicles for both diagnosis and treatment, the growing application of digital measures and other evaluations of clinical response, the nuts and bolts of novel adaptive clinical trial designs, and the regulatory changes needed to facilitate drug development for disease-modification purposes.

  • The Chlamydomonas Sourcebook

    Volume 2: Organellar and Metabolic Processes
    • 3rd Edition
    • Arthur Grossman + 1 more
    • English
    Originally published as the stand-alone Chlamydomonas Sourcebook, then expanded as the second volume in a three-part comprehensive gold-standard reference, The Chlamydomonas Sourcebook: Organellar and Metabolic Processes has been fully revised and updated to include a wealth of new knowledge and resources for the Chlamydomonas community. It details the tremendous progress recently made with respect to imaging the ultrastructure of cells, dissecting acclimation and biosynthetic responses, and elucidating molecular processes underlying the biology of organelles. In particular, this volume includes exciting new developments in the use of imaging technologies for examining supramolecular organization of the chloroplast, defining mechanisms of branched electron transfer pathways in photosynthesis, dissecting the organization of pyrenoids and CO2 concentration mechanisms, presenting the intricacies associated with acclimation to environmental conditions and providing new insights into dark metabolism and the network of fermentative metabolism. This book thus presents the latest advances in both the research and uses of new experimental approaches and technologies, making this a must-have resource for researchers and students working in plant science and photosynthesis, fertility, mammalian vision, aspects of human disease, acclimation to environmental change, and the biogenesis of cellular complexes.

  • Atomic Force Microscopy for Nanoscale Biophysics

    From Single Molecules to Living Cells
    • 1st Edition
    • Mi Li
    • English
    Atomic Force Microscopy for Nanoscale Biophysics: From Single Molecules to Living Cells summarizes the applications of atomic force microscopy for the investigation of biomolecules and cells. The book discusses the methodology of AFM-based biomedical detection, diverse biological systems, and the combination of AFM with other complementary techniques. These state-of-the-art chapters empower researchers to address biological issues through the application of atomic force microscopy. Atomic force microscopy (AFM) is a unique, multifunctional tool for investigating the structures and properties of living biological systems under aqueous conditions with unprecedented spatiotemporal resolution.

  • The Chlamydomonas Sourcebook

    Volume 1: Introduction to Chlamydomonas and Its Laboratory Use
    • 3rd Edition
    • Ursula Goodenough
    • English
    The Chlamydomonas Sourcebook, 3rd Edition Introduction to Chlamydomonas and Its Laboratory Use (Volume 1) The gold-standard reference covering the basic biology of the Chlamydomonas alga and techniques for its laboratory analysis Originally published as the standalone Chlamydomonas Sourcebook, then expanded as the first volume in a three-part comprehensive gold-standard reference, The Chlamydomonas Sourcebook: Introduction to Chlamydomonas and Its Laboratory Use has been fully revised and updated to include a wealth of new resources for the Chlamydomonas community. Early chapters cover current understandings of its taxonomy, ultrastructure, cell and life cycles, and nuclear and organelle genomes, followed by technique-oriented chapters covering such topics as cell culture, mutagenesis, genetic analysis, construction of mutant libraries, and protein localization using immunofluorescence. This volume presents the latest in research and best practices, making it a must-have resource for researchers and students working in plant science and photosynthesis, fertility, mammalian vision, and biochemistry; crop scientists; plant physiologists; and plant, molecular, and human disease biologists.

  • The Chlamydomonas Sourcebook

    Volume 3: Cell Motility and Behavior
    • 3rd Edition
    • Susan Dutcher
    • English
    The Chlamydomonas Sourcebook, 3rd Edition Cell Motility and Behavior (Volume 3) The gold-standard reference introducin... this multidisciplinary science, fully revised and updated with the latest discoveries Originally published as the standalone Chlamydomonas Sourcebook, then expanded as the third volume in a three-part comprehensive gold-standard reference, The Chlamydomonas Sourcebook: Cell Motility and Behavior has been fully revised and updated to include the wealth of new resources for the Chlamydomonas community. Reflecting the significant advancement in the understanding of the role of basal bodies and cilia play in human diseases, this volume employs quantitative proteomics and mass spectroscopy as well as cryo EM tomography and single particle cryo EM. Other topics such as current insights on mitosis and cytokinesis, ciliary assembly and motility, intraflagellar trans... and more help build an understanding of human diseases of the cilium. Cell Motility and Behavior presents the latest in research and best practices, making this a must-have resource for researchers and students working in plant science and photosynthesis, fertility, mammalian vision, and biochemistry; crop scientists; plant physiologists; and plant, molecular, and human disease biologists.

  • Polysaccharide Degrading Biocatalysts

    • 1st Edition
    • Rosana Goldbeck + 1 more
    • English
    The transformation of polysaccharides into valuable compounds for health and industry requires the careful application of enzyme protocols and controlled biocatalysis. Polysaccharide-Degra... Biocatalysts provides a thorough grounding in these biocatalytic processes and their growing role in the depolymerization of polysaccharides, empowering researchers to discover and develop new enzyme-based approaches across pharmaceuticals, fuels, and food engineering. Here, over a dozen leading experts offer a close examination of structural polysaccharides, genetic modification of polysaccharides, polysaccharide degradation routes, pretreatments for enzymatic hydrolysis, hemicellulose-degrad... enzymes, biomass valorization processes, oligosaccharide production, and enzyme immobilization for the hydrolysis of polysaccharides, among other topics and related research protocols. A final chapter considers perspectives and challenges in an evolving, carbohydrate-based economy.

  • Proteomics

    A Promising Approach for Cancer Research
    • 1st Edition
    • Shafat Ali + 2 more
    • English
    Proteomics: A Promising Approach for Cancer Research provides an updated overview of scientific knowledge, achievements and findings in the field of cancer proteomics. The book discusses topics such as the use of proteomics in cancer biology and drug discovery, its role in surgical oncology, applications of mass spectrometry, target proteomics, single-cell proteomics, and next-generation proteomics. In addition, it discusses proteomics and phosphor-proteomics in cancer precision medicine; translation of proteomics research into clinical application; and challenges and future developments of the field. This will be a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical field who are interested in the potential of proteomics in cancer research and treatment. The field of cancer proteomics is very dynamic, with emerging trends related to clinical solutions developed in recent years, therefore this book's content helps readers get up-to-speed on the topic to easily apply learnings into their research or clinical practice.

  • Precision Medicine in Neurodegenerative Disorders

    Part I
    • 1st Edition
    • Volume 192
    • English
    Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 in the Handbook of Clinical Neurology deals with the "Why" in the approach to slow the progression of accelerated brain aging. This volume is intended to provide a scholarly background on the framework, basic science and conceptual pitfalls related to disease-modifying efforts in Parkinson's, Alzheimer's and other neurodegenerative disorders. Among topics covered are different models of precision medicine, the lumping-versus-split... tension in biomarker development and therapeutics, and the rationale for replacing the convergence of the prevailing autopsy-based nosology of neurodegenerative diseases with the divergence of a systems biology approach to human diseases. Specific chapters are dedicated to the promise of genetic subtypes and the lessons in disease modification offered by the fields of oncology and cystic fibrosis that can be adapted to the field of neurodegeneration. Matching a biology-correcting therapy with those biologically suitable to benefit from such therapy represents the vision and mission of precision medicine, the highest level of personalized medicine.

  • Computational Modeling of Infectious Disease

    With Applications in Python
    • 1st Edition
    • Chris von Csefalvay
    • English
    Computational Modeling of Infectious Disease: With Applications in Python provides an illustrated compendium of tools and tactics for analyzing infectious diseases using cutting-edge computational methods. From simple S(E)IR models, and through time series analysis and geospatial models, this book is both a guided tour through the computational analysis of infectious diseases and a quick-reference manual. Chapters are accompanied by extensive practical examples in Python, illustrating applications from start to finish. This book is designed for researchers and practicing infectious disease forecasters, modelers, data scientists, and those who wish to learn more about analysis of infectious disease processes in the real world.

  • Security and Privacy Issues in Internet of Medical Things

    • 1st Edition
    • Rajkumar Buyya + 4 more
    • English
    Security and Privacy Issues in Internet of Medical Things addresses the security challenges faced by healthcare providers and patients. As IoMT devices are vulnerable to cyberattacks, and a security breach through IoMT devices may act as a pathway for hackers to enter hospital networks, the book covers a very timely topic. The incorporation of blockchain in the healthcare environment has given birth to the Internet of Medical Things (IoMT), which consists of a collection of healthcare systems that espouse groundbreaking technologies. Systems consist of inter-linked sensors, wearable technology devices and clinical frameworks that perform explicit, secure machine-to-machine and cloud platform communications. The significance of IoMT in the field of healthcare is undoubtedly a win-win situation for patients through technology enhancements and a collection of analytics that helps in better diagnosis and treatment. Due to higher accuracy levels, IoMT devices are more reliable in reporting and data tracking and help avoid human errors and incorrect reporting.

  • Sex and Cohabitation Among Early Humans

    Anthropological and Genetic Evidence for Interbreeding Among Early Humans
    • 1st Edition
    • Rene J. Herrera + 1 more
    • English
    Sex and Cohabitation Among Early Humans: Anthropological and Genetic Evidence for Interbreeding Among Early Humans explores the available information regarding interbreeding among different ancestral human species. In addition, it reviews evidence in support of cohabitation as well as cultural and technological interactions and exchanges among early humans, particularly Neanderthal-sapiens interactions. The fields of archaeology, anthropology, genetics, linguistics and molecular evolution have provided a wealth of information on the complex processes involved in human evolution. The book will help readers will develop knowledge on the complexity and multiplicity of hominins, including Homo heidelbergensis, Homo sapiens, and Homo floresiensis. Moreover, the book will help them reach a greater understanding of major topics, such as introgression, migration from Africa, the origin, development and extinction of Neanderthals, interbreeding between Neanderthals and humans, and trait continuity.

  • Plant Hormones in Crop Improvement

    • 1st Edition
    • M. Iqbal R. Khan + 2 more
    • English
    Plant Hormones in Crop Improvement examines the signaling pathways and mechanisms associated with phytohormones, with particular focus on stress resilience. The growing population of world and unpredictable climate puts pressure on the agriculture production. Current constraints such as increasing temperatures, drought, salinity, cold, nutrient deficiency, along with biotic interactions trigger exquisitely tuned responsive mechanisms in plants. The main coordinators of all stress-related mechanisms are phytohormones, which can be transported over long distances and play a significant role in controlling physiological, agronomic and growth traits, metabolites and sustained crop productivity. Therefore, understanding the mechanisms influencing the stress responses mediated by phytohormones is crucial to ensure the continuity of agricultural production and food security.　 This book aims to address sustainable agricultural approaches to improve biotic and abiotic stress resilience in crop plants, covering different topics from perception and signaling plant hormones to physiological and molecular changes under different cues. Plant Hormones in Crop Improvement is an essential read for students, researchers and agriculturalists interested in plant physiology, plant genetics and crop yield improvement.

  • Distilled Spirits

    • 1st Edition
    • Annie Hill + 1 more
    • English
    Distilled Spirits is the “go-to” guide for identifying the best practices and options available for distilled spirits product development. The book is a valuable reference for current and prospective distillers, including researchers in distilling and chemical engineering and students brewing and distilling programs. With an increase in the number of new start distilleries, the need for guidance on distilled spirits production has risen dramatically. This book examines the impact of raw materials and production processes on spirit quality, flavor and aroma compounds, and as indicators of poor quality. The book covers the entire production process, derivation of flavor and aroma compounds, definition of spirit quality, and identification of defects for Scotch whiskey, vodka, rum, and gin.

  • Comprehensive Guide to Hepatitis Advances

    • 1st Edition
    • Wai-Kay Seto + 1 more
    • English
    The Comprehensive Guide to Hepatitis Advances provides the most up-to-date information on all types of hepatitis in one resource. Coverage spans hepatitis in all forms (viral, alcoholic, metabolic, drug, autoimmune, etc.), showing the implications of current research in clinical practice and discussing future research directions. Discussions focus on the scientific advancements in understanding the disease process and in the treatment of different groups of hepatitis.This reference is perfect for basic science researchers in the field of hepatology; practicing gastroenterologists and hepatologists as well as primary care physicians attending to liver disease; and medical residents undergoing specialist training in gastroenterology and hepatology.

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