Dystonia
- 1st Edition, Volume 169 - July 21, 2023
- Imprint: Academic Press
- Editors: Hyder Jinnah, Kailash Bhatia, Alberto Albanese
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 0 2 6 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 0 2 7 - 1
Dystonia, Volume 169, the latest release in the International Review of Neurobiology serial, highlights new advances in the field with this new volume presenting interesting c… Read more
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Request a sales quoteDystonia, Volume 169, the latest release in the International Review of Neurobiology serial, highlights new advances in the field with this new volume presenting interesting chapters on topics including Clinical Features and the Science of Classification, What Can Epidemiological Studies Tell us About the Neurobiology of Dystonia, Dystonia Genes and Their Biological Pathways, Functional Anatomy of Dystonia, Physiology of Dystonia: Human Studies, Physiology of Dystonia: Animal Studies, Experimental Pharmacology: Targeting Neurotransmitters, Experimental Pharmacology: Targeting Metabolic Pathways, Adult-Onset Focal Dystonias: One Biology or Many?, Early-Onset Inherited vs Late-Onset Idiopathic Dystonias: Same or Different Biological Mechanisms?, and much more.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in International Review on Neurobiology serials
- Updated release includes the latest information on Dystonia
Undergraduates, graduates, academics, and researchers in the field of Dystonia
- Cover Image
- Title page
- Table of Contents
- International Review Of Neurobiology: Dystonia
- International Review Of Neurobiology
- Copyright
- Contributors
- Chapter One: Clinical features of dystonia and the science of classification
- Abstract
- 1 Early observations
- 2 Phenomenology
- 3 Motor features
- 4 Diagnosis
- 5 Classification
- 6 Current status and beyond
- References
- Chapter Two: What can epidemiological studies teach on the pathophysiology of adult-onset isolated dystonia
- Abstract
- 1 Introduction
- 2 Studies of birth sex in AOID: Suggestions for pathophysiology
- 3 How does age affect phenotype and natural history of AOID
- 4 Extra-genetic risk factors and mechanisms of AOID
- 5 Clinical and epidemiological studies of non-motor symptoms in AOID: Implications for pathophysiology
- 6 Brain-wide mechanisms and network dysfunction: Supporting evidence from epidemiologic data
- 7 Form-specific mechanisms: Supporting evidence from epidemiologic data
- 8 Where to go next investigating risk- and course-modifying factors of dystonia Conclusive remarks
- References
- Chapter Three: Dystonia genes and their biological pathways
- Abstract
- 1 Introduction
- 2 Concluding remarks and future perspectives
- References
- Chapter Four: The functional anatomy of dystonia: Recent developments
- Abstract
- 1 Introduction
- 2 Neuroimaging in idiopathic dystonia
- 3 Lesion studies
- 4 Animal studies in dystonia
- 5 Pathways of dystonia
- 6 Future directions
- 7 Conclusions
- Acknowledgements
- References
- Chapter Five: Physiology of dystonia: Human studies
- Abstract
- 1 Introduction
- 2 Inhibition
- 3 Plasticity
- 4 Limitations of inhibition and plasticity hypothesis
- 5 Peripheral contributions and disrupted sensorimotor integration
- 6 Oscillations in dystonia
- 7 Conclusions
- References
- Chapter Six: Physiology of Dystonia: Animal Studies
- Abstract
- 1 Introduction
- 2 Genetic mouse models with mutations in dystonia-associated genes that are affected in human patients
- 3 Spontaneous genetic models with dystonic movements
- 4 Neural circuit manipulations causing dystonia
- 5 Pharmacologically-induced dystonia models
- 6 Other models of induced dystonia
- 7 Conclusions
- References
- Chapter Seven: Advances in targeting neurotransmitter systems in dystonia
- Abstract
- 1 Introduction
- 2 Physiology of the principal brain neurotransmitters
- 3 Neurotransmitter-targeting pharmacological therapies
- 4 New evolving genetic therapies targeting neurotransmitter systems
- 5 Discussion
- Acknowledgements
- References
- Chapter Eight: Experimental pharmacology: Targeting metabolic pathways
- Abstract
- 1 Introduction
- 2 Genetic-metabolic conditions causing dystonia with available disease-specific treatment
- 3 Trace element metabolism disorders and NBIA disorders
- 4 Manganese transport disorders
- 5 Aceruloplasminemia
- 6 PKAN
- 7 Energetic metabolism alterations
- 8 Lysosomal disorders
- 9 Neurotransmitter defects
- 10 Channelopathies and synaptopathies
- 11 Conclusive remarks
- Acknowledgments
- References
- Chapter Nine: Adult-onset focal dystonias: To lump or split
- Abstract
- 1 Introduction
- 2 Lumping
- 3 Splitting
- 4 Resolving the paradox
- 5 Conclusions and future prospects
- References
- Chapter Ten: Early-onset inherited dystonias versus late-onset idiopathic dystonias: Same or different biological mechanisms
- Abstract
- 1 Introduction
- 2 Epidemiology, genetics and age at onset of dystonias
- 3 Age-related modifiers of genetic dystonias
- 4 Converging biochemical and physiologic abnormalities
- 5 Critical periods of vulnerability for the sensorimotor system: Does it apply to dystonia
- 6 A possible common framework: The double-hit hypothesis
- Disclosures
- References
- Chapter Eleven: Dystonia and Parkinson’s disease: Do they have a shared biology
- Abstract
- 1 Introduction
- 2 Pathophysiological considerations—Convergence and divergence
- 3 Dystonia and Parkinson’s disease
- 4 Dystonia and parkinsonism—Beyond PD
- 5 Conclusion and future directions—One pathway or many
- References
- Chapter Twelve: Dystonia and tremor: Do they have a shared biology
- Abstract
- 1 Introduction
- 2 Evidence in favor of shared biology
- 3 Evidence against a shared biology
- Conclusion and future perspectives
- References
- Chapter Thirteen: How does botulinum toxin really work
- Abstract
- 1 Background
- 2 What is the evidence for a central effect
- 3 Neurophysiological evidence of BoNT effects on brainstem excitability in humans
- 4 Neurophysiological evidence of BoNT effects on the sensory system in humans
- 5 Neuroimaging evidence of central effects of BoNT in humans
- 6 Conclusions
- References
- Chapter Fourteen: What have we learned about the biology of dystonia from deep brain stimulation
- Abstract
- References
- Edition: 1
- Volume: 169
- Published: July 21, 2023
- No. of pages (Hardback): 508
- No. of pages (eBook): 322
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780323990264
- eBook ISBN: 9780323990271
HJ
Hyder Jinnah
Dr. Hyder A Jinnah, MD, PhD, is a Professor in Departments of Neurology, Pediatrics, & Human Genetics, Emory University School of Medicine. His research group is interested in the biological basis of behavior, and translational research relating to treatment. He focus mostly on disorders of humans and animals that affect abilities to control movement, with a special interest in genetic causes. He is currently working on translational studies for human dystonia, as well as scientific studies of several neurogenic disorders including Lesch-Nyhan-Nyhan disease, dopa-responsive dystonia, and dystonia caused by defects in TOR1A.
Affiliations and expertise
Professor, Department of Neurology, Pediatrics, and Human Genetics, Emory University School of Medicine, GA, USAKB
Kailash Bhatia
Kailash Bhatia is a professor of clinical neurology in the Sobell Department of Movement Neuroscience at the Institute of Neurology, UCL, Queen Square, London and an honorary consultant neurologist at the affiliated National Hospital for Neurology, Queen Square.
Kailash obtained his basic medical degree and neurology training in Mumbai, India and further training in neurogenetics and movement disorders with the late Professors Anita Harding and David Marsden at the Institute of Neurology, London. In 2007 he was appointed senior lecturer and honorary consultant neurologist, and in 2002 was promoted to professor of clinical neurology.
Kailash is a fellow of the Royal College of Physicians and corresponding fellow of the American Academy of Neurology.
Professor Bhatia has over 500 publications, including 384 peer-reviewed papers. Kailash has just published “Marsden’s book of Movement disorders”, a comprehensive piece of work which has been highly acclaimed. He is the current Associate Editor of the Movement Disorders Journal. He is a grant reviewer for Telethon, Inserm France, UK PD society and a medical advisor to the UK Dystonia society and on the scientific board of the Bachman Struass trust. He is the current chairman of the Movement Disorders subcommittee of the European Neurological Society (ENS), and serves on various committees of the International Movement Disorders Society.
Affiliations and expertise
Professor of Clinical Neurology, Sobell Department of Movement Neuroscience, Institute of Neurology, UCL, Queen Square, London and Honorary Consultant Neurologist, National Hospital for Neurology, Queen Square, UKAA
Alberto Albanese
Mr Alberto Albanese is an accredited Cardiac Surgeon, currently works as a Consultant Cardiac Surgeon for both the NHS at the Essex Cardiothoracic Centre and in the private sector, including the prestigious Harley Street Clinic, in central London, which offers a world-leading acute care.
Alberto originally trained as heart surgeon in Italy and then moved to the United Kingdom, where, after more training and practice, has been appointed as a Consultant. During his training he has done dedicated fellowships in world renowned units like Harefield Hospital, St. George’s Hospital and the new Barts Heart Centre, which have given him a large experience in all aspects of cardiac surgery.
Alberto has performed several hundreds open heart operations with excellent results. He is extremely driven and motivated, and totally dedicated to his job and to his patients. His patients have a very high level of satisfaction.
His large working experience in both countries UK and Italy, all the national and international meetings and conferences attended, often as speaker, his publications in peer reviewed journals make Alberto a known surgeon with an international reputation.
Alberto currently works for the NHS at the Essex Cardiothoracic Centre. He also works in the private sector in central London and Essex. He likes to spend a good amount of time visiting other Cardiac units, for Multi Disciplinary Meetings with Cardiologists, to discuss complex patients or difficult clinical scenarios and to review patients who need attention and assiduous care.
Affiliations and expertise
Consultant Cardiac Surgeon, NHS, Essex Cardiothoracic Centre and Harley Street Clinic, London, UKRead Dystonia on ScienceDirect