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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • Environmental Factors in Neurodegenerative Diseases

    • 1st Edition
    • Volume 1
    • English
    Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson’s disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike.

  • Chordomas and Chondrosarcomas of the Skull Base and Spine

    • 2nd Edition
    • Griffith R. Harsh IV + 1 more
    • English
    Chordomas and Chondrosarcomas of the Skull Base and Spine, Second Edition, is a major reference and guide for neurosurgeons, medical oncologists, neuroscientists, orthopedic surgeons, head and neck surgeons and radiation oncologists that treat patients and research chordomas and chondrosarcomas of the axial skeleton. This book is the unique result of the collaboration of multidisciplinary specialists from a wide variety of fields (neurological sciences, medical oncology, molecular biology, orthopedics and radiation oncology), offering the most relevant information about chordomas and chondrosarcomas of the axial skeleton from each of these fields condensed into one single volume. It contains new medical knowledge and scientific advances regarding the treatment of these types of tumors. Additionally, the book includes chapters written by the Chordoma Foundation and Sarcoma Foundation of America, providing the most valuable information and support for patients and their relatives.

  • The Complex Connection between Cannabis and Schizophrenia

    • 1st Edition
    • Michael T. Compton + 1 more
    • English
    The Complex Connection between Cannabis and Schizophrenia provides an in-depth overview of the current state of research into the role that cannabis plays in schizophrenia, covering both the pathophysiological and the pharmacological implications. It addresses the epidemiology of cannabis use and the risks associated with its use, the biological aspects of the drug, its effects on the brain and the pharmacological possibilities of using cannabidiol to treat schizophrenia. It is the only book on the market devoted exclusively to examining the links between this very commonly used (and misused) drug and a specific set of devastating psychiatric illnesses, providing a comprehensive guide to our current understandings of this relationship. Marijuana is the most commonly used illicit drug globally, and is becoming increasingly decriminalized and even legalized worldwide. Among the numerous mental-health concerns related to the drug, there is mounting evidence of an intricate link between cannabis use and schizophrenia and related psychotic disorders. At the same time, there is promising evidence to suggest that cannabidiol, one of the many compounds found in cannabis that activates the brain’s cannabinoid receptors, could prove to be an effective antipsychotic to treat schizophrenia.

  • Vital Models

    The Making and Use of Models in the Brain Sciences
    • 1st Edition
    • Volume 233
    • English
    The use of models has been important to the historical and contemporary study of the human brain, yet very little study by social scientists has been dedicated to how the brain sciences develop and use models to better understand what brains are and how they work, including the complex entanglements between brains, bodies and their environments. Vital Models: The Making and Use of Models in the Brain Sciences explores the history and use of brain models from clinical psychiatry to psychopharmacology and cybernetics, as well as developments in digital brain modeling, simulation, imaging and connectomics. This timely volume helps both scientists and students better understand the variety, strengths, weaknesses and applicability of models in neuroscience.

  • Neurobiology of Chinese Herb Medicine

    • 1st Edition
    • Volume 135
    • English
    Neurobiology of Chinese Herb Medicine, Volume 135 is a valuable book for anyone interested in alternative medicine or the scientific research surrounding ancient herbal medicine. This updated volume in the series includes chapters that delve into timely topics, including the Effects of Lycium Barbarum on the Visual System, the Effect of Chinese Herbal Medicine on Alzheimer’s Disease, the Effect and Mechanism of Chinese Herbal Medicine on Parkinson’s Disease, the Neurobiology of Chinese Herbal Medicine on Major Depressive Disorder, the Treatment of Insomnia with Traditional Chinese Herbal Medicine, and the Metabolic Factors and Adult Neurogenesis: Impacts of Chinese Herbal Medicine on Brain Repair in Neurological Diseases. This series is ideal for Chinese herbal medicine practitioners who are working in a clinical environment, although the clinical applications of Chinese medicinal herbs presented provide useful references and guidance for any clinical practice that specializes in the treatment of various conditions.

  • Nonmotor Parkinson's: The Hidden Face

    Management and the Hidden Face of Related Disorders
    • 1st Edition
    • Volume 134
    • English
    Non-motor Parkinson's: The Hidden Face-Management and the Hidden Face of Related Disorders, Volume 134, the latest release in the International Review of Neurobiology series, is an up-to-date and comprehensive textbook addressing non-motor aspects of Parkinson’s disease, a key unmet need. Specific chapters in this updated release include Therapeutics and NMS in PD, Non-motor effects of conventional and transdermal therapies in PD, Infusion therapy, CDD and NMS in PD, DBS and NMS in PD, TMS and implications for NMS in PD, Botulinum toxin therapy and NMS in PD, and Nutrition and NMS in PD, amongst others. Including practical tips for non-specialists and clinical algorithms, the book contains contributions from over 40 opinion leaders in the field of movement disorders. It provides practitioners and researchers with a laboratory, to bedside, to caregiver perspective.

  • Nonmotor Parkinson's: The Hidden Face

    The Many Hidden Faces
    • 1st Edition
    • Volume 133
    • English
    Non-motor Parkinson's: The Hidden Face, Volume 133, the first part of the latest volume in the International Review of Neurobiology series, is an up-to-date, comprehensive textbook addressing the non-motor aspects of Parkinson’s disease, a key unmet need. Chapters in this new release include topics such as The hidden face of Parkinson's, JP and non-motor symptoms, Parkinson's: a complex non-motor disease, Neuropathology of NMS of PD, Neurophysiology and animal models related to NMS in PD, Epidemiology of NMS in PD (cohort studies), Genes and NMS in PD, NMS in genetic forms of PD, and Imaging the NMS in PD. Including practical tips for non-specialists and clinical algorithms, this book contains contributions from over 40 opinion leaders in the field of movement disorders, covering the topic from laboratory, to bedside, to caregiver.

  • Comprendre la paralysie cérébrale et les troubles associés

    Évaluations et traitements
    • 2nd Edition
    • Sylvain Brochard + 13 more
    • French
    Comprendre la paralysie cérébrale et les troubles associés est une refonte du livre précédent sur les infirmités motrices cérébrales. Son originalité réside dans le fait qu’il s’engage sur la voie du pronostic autant clinique qu’humain. L’approche médicale est large, de l’atteinte neuromotrice, orthopédique, des troubles de la santé aux facteurs de dysfonctionnement psychologique et/ou neuropsychologique. La recherche d’indices pronostiques dépend d’éléments cliniques déjà validés et s’appuie aussi sur des connaissances scientifiques récentes, comme la plasticité cérébrale.La parole donnée aux adultes en situation de handicap, voire aux familles, permet de suivre la pertinence de l’application des décisions thérapeutiques qu’ils ont vécues. Leurs témoignages indiquent leur dynamique pour trouver une qualité de vie personnalisée et leur volonté de trouver des contacts humains élargis. Des textes complémentaires, des références ainsi que des séquences vidéos montrant les divers aspects de la prise en charge en rééducation et en chirurgie orthopédique sont proposés en ligne. Coécrit par des équipes multidisciplinaires et référentes – médecins de médecine physique et de réadaptation (MPR), pédiatres, chirurgiens, rééducateurs, psychologues, scientifiques –, cet ouvrage a été coordonné par le docteur Danièle Truscelli.

  • Dual Energy CT: Applications in Head and Neck and Neurologic Imaging, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 27-3
    • Reza Forghani + 1 more
    • English
    This issue of Neuroimaging Clinics of North America focuses on Dual Energy CT: Applications in Neurologic, Head and Neck Imaging, and is edited by Drs. Reza Forghani and Hillary R. Kelly. Articles will include: Dual Energy CT: Physical Principles and Approaches to Scanning, Part 1; Dual Energy CT: Physical Principles and Approaches to Scanning, Part 2; Dual Energy CT Applications for Differentiation of Intracranial Hemorrhage, Calcium, and Iodine; Dual Energy CT Angiography of the Head and Neck and Related Applications; Miscellaneous and Emerging Applications of Dual Energy CT for the Evaluation of Intracranial Pathology; Applications of Dual Energy CT for the Evaluation of Head and Neck Squamous Cell Carcinoma; Dual Energy CT Applications for the Evaluation of Cervical Lymphadenopathy; Miscellaneous and Emerging Applications of Dual Energy CT for the Evaluation of Pathologies in the Head and Neck; Dual Energy CT Applications for the Evaluation of the Spine; Applications of Dual Energy CT for Artifact Reduction in the Head, Neck, and Spine; Advanced Tissue Characterization and Texture Analysis using Dual Energy CT: Horizons and Emerging Applications; and more!

  • Clinical Informatics Literacy

    5000 Concepts That Every Informatician Should Know
    • 1st Edition
    • Dean F. Sittig
    • English
    Clinical Informatics Literacy: 5000 Concepts That Every Informatician Should Know is about all aspects of clinical informatics, a subset of the larger field of biomedical informatics. Clinical Informatics is an applied field that exists at the intersection of the fields of medicine, computer science, information science, anthropology, human factors engineering, cognitive psychology and health services research. As such informaticians are required to have an extremely broad understanding of a considerable swath of the fields at the heart of the health-oriented knowledge economy. The author has collected and explained each one of the relevant concepts during his experience of 27 years working with many of the leaders in the field of clinical informatics at several of the leading academic healthcare institutions around the USA. The author’s experience and his didactic approach make this book an essential source of information for all participants in the clinical informatics field.

  • Neurological Problems

    • 1st Edition
    • Jerzy Choróbski
    • English
    Neurological Problems describes the clinical and pathological aspects of numerous neurological disorders. This book is organized into four parts encompassing 69 chapters. The opening part provides an introduction to the close relationship between the central nervous system and the categories of pathological reactions in man. The next parts deal first with certain problems concerning peripheral vasomotor activity, followed by discussions on neurophysiological mechanisms and chemical aspects of neurological problems. The last part presents considerable clinical manifestations and case studies of these problems. This book is of value to neurologists, neurophysiologists, pathologists, and clinicians.

  • Latent Syphilis and the Autonomic Nervous System

    • 2nd Edition
    • Griffith Evans
    • English
    Latent Syphilis and the Autonomic Nervous System, Second Edition describes the link between the pathogenesis of syphilis and the autonomic nervous system. This book is composed of 15 chapters, and begins with a brief introduction to the pathology of syphilis, followed by chapters on the physiologic changes in the thyroid gland, including thyroid enlargement and goiter formation, in early syphilis. The succeeding chapters are devoted to syphilis-related diseases, such as allergy, asthma, vasomotor disturbances, dysphagia, dyspepsia, cancer, and superficial ulceration of the mouth. A chapter describes some clinical features in latent syphilis. The final chapter examines the clinical manifestations of pes cavus, which is both an acquired and congenital disease. This book is of value to pathologists, endocrinologists, clinicians, and medical researchers.

  • A Paradigm Shift to Prevent and Treat Alzheimer's Disease

    From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols
    • 1st Edition
    • Howard Friel + 1 more
    • English
    A Paradigm Shift to Prevent and Treat Alzheimer’s Disease: From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols is the first book to systematically exhibit the powerful pleiotropic pharmacological effects on Alzheimer’s disease of plant-based compounds from ancient foods that humans have been consuming safely with substantial health benefits for thousands of years. These plant-based compounds include curcuminoids from turmeric, resveratrol from red wine and grape seed extract from other grape products, epigallocatechin-gal... (EGCG) from green tea, and oleocanthal and oleuropein from olive oil, in addition to a special extract, EGb 761, from the leaves of Ginkgo biloba, the oldest living species of tree on earth. This book also presents a new analytical framework that convincingly favors a multi-targeting ("pleiotropic") approach to the prevention and treatment of complex chronic diseases, in contrast to the mono-targeting of the pharmaceutical model. A Paradigm Shift to Prevent and Treat Alzheimer’s Disease is a unique and exciting resource for pharmaceutical scientists, pharmacologists, neurologists, general practitioners, research scientists in various medical and life sciences, healthcare professionals in clinical and executive positions, conventional medical schools, schools of naturopathic medicine, healthcare and medical journalists, executives in both national public healthcare systems and private insurers, and informed general readers.

  • Chronic Traumatic Encephalopathy

    Proceedings of the Boston University Alzheimer’s Disease Center Conference
    • 1st Edition
    • Andrew E. Budson + 3 more
    • English
    Get a thorough, expert overview of the many key facets of chronic traumatic encephalopathy (CTE) with this concise, practical resource by Drs. Andrew E. Budson, Ann C. McKee, Robert C. Cantu, and Robert A. Stern. This easy-to-read reference is based on lectures from Boston University’s Alzheimer’s Disease Center’s November 2016 two-day conference on CTE.

  • Neurobiological Background of Exploration Geosciences

    New Methods for Data Analysis Based on Cognitive Criteria
    • 1st Edition
    • Paolo Dell'Aversana
    • English
    Neurobiological Background of Exploration Geosciences: New Methods for Data Analysis Based on Cognitive Criteria examines the neurobiological background of earth science disciplines. It presents the fundamental features of the human brain that form the cognitive basis of exploration geophysics and investigates how their analysis can drive the development of new brain-based technologies. Crucial aspects of human cognition include the impulse to explore the environment, the ability of our brain to create mental maps and virtual images of the world, and the human ability to recognize, integrate and save patterns of information in a shared memory. Geoscience technology can be made more effective by taking the working neurobiological principles of our brains into account. This book is appropriate for multiple audiences, including neuroscientists, cognitive scientists and geoscientists, presenting both theoretical and experimental results.

  • Nanotechnology Methods for Neurological Diseases and Brain Tumors

    Drug Delivery across the Blood–Brain Barrier
    • 1st Edition
    • Yasemin Gürsoy Özdemir + 2 more
    • English
    Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategies for brain tumors and neurological diseases, in particular Alzheimer’s, Parkinson’s and stroke, those that bypass the blood/brain barrier. The current understanding of brain drug delivery and access is discussed in Chapter One, with the next section focusing on the implementation of the nose-to-brain intranasal route in brain-targeted drug delivery. In addition, nanotechnology-based brain drug delivery is covered in Chapter Three. This avenue offers impressive improvement in the treatment of neurological diseases and brain tumors by using bio-engineered systems that interact with biological systems at a molecular level. In Chapter Four, emphasis is placed on the need for brain-targeted experimental models that mimic disease conditions. Final chapters discuss the very latest advances in targeted treatment strategies for neurological diseases and brain tumors.

  • Noradrenergic Signaling and Astroglia

    • 1st Edition
    • Nina Vardjan + 1 more
    • English
    Noradrenergic Signaling and Astroglia integrates what is known about the active role of astroglia in the locus coeruleus-noradrener... system and outlines the most recent advances in the field. It discusses the molecular mechanisms underlying norepinephrine-induc... receptor activation in astroglia, cellular metabolism and CNS energy provision, in vitro, ex vivo, and in vivo models, gliosignalling and neuronal activity, and astroglial networks, gap junctions, and morphological plasticity. The book also addresses the role of astroglial adrenergic receptor activation in memory formation, cognition, regulation of sleep homeostasis, and lastly in neurological disorders, including trauma (cellular edema), neurodegeneration (Alzheimer’s disease), and neuroinflammation (multiple sclerosis). Noradrenergic Signaling and Astroglia is a valuable source of new knowledge for a wide audience, including graduate students, post-doctoral fellows, and researchers in neuroscience, life sciences, and the biological and biomedical sciences.

  • Sports Neurology, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 35-3
    • Tad Seifert
    • English
    This issue of Neurologic Clinics, Edited by Dr. Tad Seifert, will do a comprehensive review of Sports Neurology. Some of the topics discussed in the issue include, but are not limited to: Biomechanical Aspects of Sports-Related Head Injuries; Peripheral Nerve Injuries in Sport; CNS Performance Enhancing Drugs in Sport, Sleep, Recovery, and Performance in Sport; Pathophysiology of Sports-Related Concussion; Neurologic Injuries in Noncontact Sports; Neuropsychological Screening in Concussion; Neurosurgical Emergencies in Sport; Psychiatric Comorbidities in Sport; and Biomarkers and Their Role in Sport-Related Head Trauma, among others.

  • Brain Edema

    From Molecular Mechanisms to Clinical Practice
    • 1st Edition
    • Jerome Badaut + 1 more
    • English
    Brain Edema: From Molecular Mechanisms to Clinical Practice brings together the most widely recognized experts in experimental and clinical brain edema research to review the current knowledge gathered on the molecular and cellular pathophysiology and clinical management of brain edema. This timely book also discusses future directions of research and treatment. Brain edema is an integral and acutely life-threatening part of the pathophysiology of multiple cerebral and non-cerebral disorders, including traumatic brain injury, cerebral ischemia, brain tumors, cardiac arrest, altitude sickness and liver failure. Affecting millions worldwide, research over the past few years has shown that a plethora of complex molecular and cellular mechanisms contribute to this pathological accumulation of water in the brain parenchyma. In parallel, the development of new neuroimaging tools has provided a new way to examine how edema develops longitudinally and in real time, both in pre-clinical models and in patients. Despite intense research over the past few decades, therapeutic options are still limited and sometimes not effective.

  • Learning and Memory: A Comprehensive Reference

    • 2nd Edition
    • John H. Byrne
    • English
    Learning and Memory: A Comprehensive Reference, Second Edition, Four Volume Set is the authoritative resource for scientists and students interested in all facets of learning and memory. This updated edition includes chapters that reflect the state-of-the-art of research in this area. Coverage of sleep and memory has been significantly expanded, while neuromodulators in memory processing, neurogenesis and epigenetics are also covered in greater detail. New chapters have been included to reflect the massive increase in research into working memory and the educational relevance of memory research. No other reference work covers so wide a territory and in so much depth.

  • Engineering Neural Tissue from Stem Cells

    • 1st Edition
    • Stephanie Willerth
    • English
    Engineering Neural Tissue from Stem Cells covers the basic knowledge needed to understand the nervous system and how existing cells can be used to create neural tissue. This book presents a broad range of topics related to the design requirements for engineering neural tissue from stem cells. It begins with the anatomy and function of the central and peripheral nervous system, also covering stem cells, their relation to the nervous system and their function in recovery after injury or disease. In addition, the book explores the role of the extracellular matrix and vasculature/immune system and biomaterials, including their suitability for neural tissue engineering applications.

  • Human Brain in Standard MNI Space

    A Comprehensive Pocket Atlas
    • 1st Edition
    • Juergen K Mai + 1 more
    • English
    Human Brain in Standard MNI Space: A Comprehensive Pocket Atlas is a thorough pocket atlas designed for easy reference and interpretation of medical and scientific MR-images. It is intended for both early career and advanced medical students, for residents in radiology and neurology, and those involved in neuroscience research, emphasizing anatomy’s relationship to radiology. In addition, the book is ideal for non-specialists interested in issues relating to the brain or the determination of imaging features.

  • Rhythmic Stimulation Procedures in Neuromodulation

    • 1st Edition
    • James R. Evans + 1 more
    • English
    Rhythmic Stimulation Procedures in Neuromodulation offers a unique approach to rhythm-related stimulation as it pertains to modulating neural functioning, with the goal of alleviating symptoms of mental disorder. Rhythm and related concepts (frequency, resonance, entrainment) are thought by many to be closely linked to human health and disease. Neurologists and clinical psychologists facilitate neuroplasticity by using pulsed (rhythmic) sensory or electromagnetic stimulation—a group of techniques broadly referred to as neuromodulation. This edited volume describes details of rhythm-related neuromodulation techniques, and experts in the field have detailed the pros and cons of each approach, citing both clinical and scientific support. Each technique chapter provides a detailed description of the procedure, a rationale for application with specific populations, discussion of similarities/differe... relative to other approaches, and support for efficacy. This volume offers readers a historical overview of the roles of rhythm and dysrhythmia in health and disease, including examples of past and present therapeutic uses of rhythmic stimulation, entrainment, and/or modification. It also facilitates speculation about potential developments in rhythm-related methods for the future of mental health. Few books published in the general area of rhythm have focused on the scientific study of the significance of biological rhythms.

  • Institutional Neurosis

    • 2nd Edition
    • Russell Barton
    • English
    Institutional Neurosis is a four-chapter text that systematically presents the dreadful mental changes that may result from institutional life and the steps that can be taken to cure them. The term “institutional neurosis” promotes the syndrome to the category of a disease, rather than a process, thereby encouraging the public to understand, approach, and deal with it in the same way as other diseases. The opening chapter describes the clinical features of the disorder in mental hospitals, its differential diagnosis, etiology, treatment, and prevention. The next chapters consider the etiology or factors associated with institutional neurosis, including apathy, loss of interest, lack of initiative, and sometimes a characteristic posture and gait. The last chapter reviews the various aspects of the treatment of institutional neurosis. This book is of value to neurologists, psychologists, psychiatrists, and researchers in the allied fields.

  • Sport and the Brain: The Science of Preparing, Enduring and Winning, Part A

    • 1st Edition
    • Volume 232
    • English
    Sport and the Brain: The Science of Preparing, Enduring and Winning, Part A, Volume 231 reflects recent advancements in the understanding of how elite athletes prepare for—and perform at—peak levels during competition. The latest release in this series focuses on a variety of topics, including chapters on Great British medalists: Psychosocial biographies of Super-Elite and Elite athletes from Olympic sports, a chapter on elite and super-elite Great British athletes: Some theoretical implications from Hardy et al.’s (2016) findings, and The psychosocial development of world class athletes: Additional considerations for understanding the whole person and salience of adversity. This series takes a multidisciplinary approach, focusing on aspects of psychology, neuroscience, skill learning, talent development and physiology.

  • The Rewiring Brain

    A Computational Approach to Structural Plasticity in the Adult Brain
    • 1st Edition
    • Arjen van Ooyen + 1 more
    • English
    The adult brain is not as hard-wired as traditionally thought. By modifying their small- or large-scale morphology, neurons can make new synaptic connections or break existing ones (structural plasticity). Structural changes accompany memory formation and learning, and are induced by neurogenesis, neurodegeneration and brain injury such as stroke. Exploring the role of structural plasticity in the brain can be greatly assisted by mathematical and computational models, as they enable us to bridge the gap between system-level dynamics and lower level cellular and molecular processes. However, most traditional neural network models have fixed neuronal morphologies and a static connectivity pattern, with plasticity merely arising from changes in the strength of existing synapses (synaptic plasticity). In The Rewiring Brain, the editors bring together for the first time contemporary modeling studies that investigate the implications of structural plasticity for brain function and pathology. Starting with an experimental background on structural plasticity in the adult brain, the book covers computational studies on homeostatic structural plasticity, the impact of structural plasticity on cognition and cortical connectivity, the interaction between synaptic and structural plasticity, neurogenesis-related structural plasticity, and structural plasticity in neurological disorders. Structural plasticity adds a whole new dimension to brain plasticity, and The Rewiring Brain shows how computational approaches may help to gain a better understanding of the full adaptive potential of the adult brain. The book is written for both computational and experimental neuroscientists.

  • Psychometrics and Psychological Assessment

    Principles and Applications
    • 1st Edition
    • Carina Coulacoglou + 1 more
    • English
    Psychometrics and Psychological Assessment: Principles and Applications reports on contemporary perspectives and models on psychological assessment and their corresponding measures. It highlights topics relevant to clinical and neuropsychological domains, including cognitive abilities, adaptive behavior, temperament, and psychopathology.More... the book examines a series of standard as well as novel methods and instruments, along with their psychometric properties, recent meta-analytic studies, and their cross-cultural applications.

  • Models of Seizures and Epilepsy

    • 2nd Edition
    • Asla Pitkänen + 3 more
    • English
    Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals.

  • Essentials of Noncoding RNA in Neuroscience

    Ontogenetics, Plasticity of the Vertebrate Brain
    • 1st Edition
    • Davide De Pietri Tonelli
    • English
    Essentials of Noncoding RNA in Neuroscience: Ontogenetics, Plasticity of the Vertebrate Brain focuses on the role of miRNAs in neurogenesis, gliogenesis, neuronal network formation, and the cell biology of forebrain development. The important role miRNAs play in neuronal maturation, neocortex function, and in some neurodevelopmental disorders is discussed, as are the computational challenges and methods used in the identification of miRNA targets. This book is a valuable reference for neuroscientists who wish to better understand the role of miRNAs in complex processes. It is of strong interest to those working to develop enabling technologies to detect and monitor miRNA expression and function, and to evaluate its roles in neural progenitor proliferation/differ... neuronal plasticity, and learning and memory.

  • Choroidal Disorders

    • 1st Edition
    • Jay Chhablani + 1 more
    • English
    Choroidal Disorders provides an overview on various chorioretinal disorders with a special emphasis on choroidal imaging. As our understanding of the choroid has significantly improved with the development of advanced optical coherence tomography (OCT) and its role in posterior segment diseases is gaining new significance, this book focuses on the related improvements, diagnostic capabilities, management and prognosis of various chorioretinal disorders. It covers conventional techniques, such as ultrasonography and indocyanine green angiography as well as the most advanced techniques, including enhanced depth imaging OCT, swept source OCT, and OCT angiography.

  • Parkinson's Disease

    • 1st Edition
    • Volume 132
    • English
    Parkinson's Disease, Volume 132 addresses new developments in the F33 study of this disease, highlighting how the lives of people with Parkinson’s have undergone dramatic changes in the last decade. New to this edition are chapters on the Hallmarks of clinical aspects PD throughout centuries, The motor syndrome of Parkinson disease, The non-motor features of Parkinson’s disease, The New Diagnostic Criteria for Parkinson's disease, Advances in the Clinical Differential diagnosis, Clinical assessments in PD : Scales and monitoring, Biomarkers of Parkinson’s disease: an Introduction, and the Genetics of Parkinson’s Disease: Genotype-Phenotype Correlations. The topics discussed in this comprehensive series provide a clearer understanding of the prodromal stage, genetics, strategies, routes of treatment, and development of non-dopaminergic therapies in Parkinson's Disease, both medical and surgical.

  • Functional Neural Transplantation IV

    Translation to Clinical Application, Part B
    • 1st Edition
    • Volume 231
    • English
    Functional Neural Transplantation IV: Translation to Clinical Application, Part B, Volume 231 provides the current status of cell transplantation in the nervous system, focusing on the conditions for achieving structural repair and functional recovery. New to this edition are chapters on Plasticity and Regeneration in the Injured Spinal Cord After Cell Transplantation Therapy, Transplantation of GABAergic Interneurons for Cell-Based Therapy, Rebuilding CNS Inhibitory Circuits to Control Chronic Neuropathic Pain and Itch, From Transplanting Schwann Cells in Experimental Rat Spinal Cord Injury to their Transplantation into Human Injured Spinal Cord in Clinical Trials, and the Recruitment of Endogenous CNS Stem Cells for Regeneration in Demyelinating Disease. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments in cellular and molecular science, providing the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, while also addressing the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.

  • Fragile X Syndrome

    From Genetics to Targeted Treatment
    • 1st Edition
    • Rob Willemsen + 1 more
    • English
    Fragile X Syndrome: From Genetics to Targeted Treatment provides a structured overview of the molecular and clinical background of the disorder as well as treatment options. The book discusses the detailed molecular information on each of the pathways involved with sufficient details for all whose research touches this pathway. It provides a state-of-the-art update on all clinical aspects associated with this syndrome, including phenotype, diagnostics and epidemiology. It also includes an overview of the lessons learned from the preclinical research and pioneering trials on the fragile X syndrome for the investigators involved in clinical trials of neurodevelopmental disorders. This book is written for academic researchers, pharmaceutical investigators, and clinicians in the field who work on the disorder, and for researchers involved in clinical trials of the fragile X syndrome or related disorders. “This fascinating book, edited by Rob Willemsen and Frank Kooy, summarizes the current knowledge of the molecular aspects of fragile X syndrome (FXS), andthe potential for therapies resulting from this knowledge...Particul... interesting is a review “fragile X research from a parental perspective,” which summarizes the results of an international survey of the attitudes of families with FXS relatives towards research…This book is also an essential reference book for genetic counselors...The book provides counselors with the necessary biological background for proper explanations to the relatives of FXS patients. Many parents acquire a substantial knowledge of the conditions afflicting their children. The book will be helpful for both families and counselors to manage the expectations of families participating in clinical trials…In conclusion, this book is essential for everyone who is involved in the diagnosis and treatment of FXS patients.” - European Journal of Human Genetics (September 2018)

  • Neuroscience Basics

    A Guide to the Brain's Involvement in Everyday Activities
    • 1st Edition
    • Jennifer L. Larimore
    • English
    Neuroscience Basics: A Guide to the Brain’s Involvement in Everyday Activities examines how our brain works in everyday activities like sleeping, eating, love, and exercise. Many want to better understand how the brain works, but the terminology and jargon of books can be overwhelming. The book covers the basics taught in an introductory neurobiology course designed for anyone new to the neuroscience field, including non-neuroscientists. While each of the chapters explore the brain in a normal state, Neuroscience Basics also discusses disruptions of the normal state—psychosis, Alzheimer’s, Parkinson’s, autism, learning disorders, etc. This book breaks down the topics into language that is more accessible while making the neuroscience topics fun and relevant.

  • Neurochemical Aspects of Alzheimer's Disease

    Risk Factors, Pathogenesis, Biomarkers, and Potential Treatment Strategies
    • 1st Edition
    • Akhlaq A. Farooqui
    • English
    Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists... and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders.

  • Designing EEG Experiments for Studying the Brain

    Design Code and Example Datasets
    • 1st Edition
    • Aamir Saeed Malik + 1 more
    • English
    Designing EEG Experiments for Studying the Brain: Design Code and Example Datasets details the design of various brain experiments using electroencephalogram (EEG). Providing guidelines for designing an EEG experiment, it is primarily for researchers who want to venture into this field by designing their own experiments as well as those who are excited about neuroscience and want to explore various applications related to the brain. The first chapter describes how to design an EEG experiment and details the various parameters that should be considered for success, while remaining chapters provide experiment design for a number of neurological applications, both clinical and behavioral. As each chapter is accompanied with experiment design codes and example datasets, those interested can quickly design their own experiments or use the current design for their own purposes. Helpful appendices provide various forms for one’s experiment including recruitment forms, feedback forms, ethics forms, and recommendations for related hardware equipment and software for data acquisition, processing, and analysis.

  • Functional Neural Transplantation IV

    Translation to Clinical Application, Part A
    • 1st Edition
    • Volume 230
    • English
    Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. New to this release are chapters that delve into the Mechanisms and Use of Neural Transplants for Brain Repair, Reprogramming of Somatic Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for the Treatment of Neurological Disorders, Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science, providing an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.

  • Arteriovenous and Cavernous Malformations

    • 1st Edition
    • Volume 143
    • English
    Arteriovenous and Cavernous Malformations, Volume 143, is the latest addition in the ongoing HCN series, an evidence-based compendium which addresses both the scientific and clinical aspects of this unique disease process. The volume covers didactic aspects, such as the epidemiology, etiology, and diagnosis of AVMs, while also providing expert clinical information on the management and treatment of these lesions. In addition, it provides coverage of modern-day advances in the genetics of cavernous malformations, as well as discussion regarding future open research questions. Readers from the laboratory bench to the bedside can expect a broad, yet objective, review of this pathology, with updates from the latest scientific literature and data supporting current practices.

  • The Neuroscience of Cocaine

    Mechanisms and Treatment
    • 1st Edition
    • Victor R. Preedy
    • English
    The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects of this drug, addressing the neurobiology behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse. This book provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms. Cocaine is one of the most highly abused illicit drugs worldwide and is frequently associated with other forms of drug addiction and misuse, but researchers are still struggling to understand cocaine’s neuropharmacological profile and the mechanisms of its effects and manifestations at the cognitive level. Cessation of cocaine use can lead to numerous adverse withdrawal conditions, from the cellular and molecular level to the behavioral level of the individual user. Written by worldwide experts in cocaine addiction, this book assists neuroscientists and other addiction researchers in unraveling the many complex facets of cocaine use and abuse.

  • The Endocannabinoid System

    Genetics, Biochemistry, Brain Disorders, and Therapy
    • 1st Edition
    • Eric Murillo-Rodriguez
    • English
    The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and Therapy examines the cellular, biochemical, genetic, and therapeutic aspects of the endocannabinoid system. The chapters cover significant conceptual advances in the endocannabinoid field and shed light on the many brain disorders in which this biological system is involved. Written by world-leading experts in the field, the topics covered in this book will have a positive impact on the area of molecular biology, including, but not limited to, cell biology, neuroscience, pharmacology, signaling, disease mechanisms, and therapeutics.

  • Biometals in Neurodegenerative Diseases

    Mechanisms and Therapeutics
    • 1st Edition
    • Anthony R. White + 3 more
    • English
    Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.

  • Blanco's Overview of Alpha-1 Antitrypsin Deficiency

    History, Biology, Pathophysiology, Related Diseases, Diagnosis and Treatment
    • 1st Edition
    • Ignacio Blanco
    • English
    Blanco’s Overview of Alpha-1 Antitrypsin Deficiency: History, Biology, Pathophysiology, Related Diseases, Diagnosis, and Treatment is a robust introduction to topics associated with Alpha-1 Antitrypsin Deficiency (AATD). Included are topics ranging from the history of the disease, biology, pathophysiology, related diseases, including the two major manifestations of the disease (liver disease and lung disease), and diagnosis and treatment. The book addresses the need for the amalgamation of current and novel concepts and practices in the field of AATD. AATD is under-recognized in the medical community and, as a result, it is underdiagnosed. The book provides increased awareness and understanding of the condition to improve diagnosis rates and enhance patient care. This book is an essential tool and reference, beneficial to clinicians who screen and treat AATD patients, as well as research scientists working in the AATD field at junior and senior levels.

  • A Roadmap for Curing Cancer, Alzheimer's, and Cardiovascular Disease

    • 1st Edition
    • Paul J. Marangos
    • English
    Cancer, dementia, and cardiovascular disease are responsible for almost two million deaths each year in the United States alone and represent the largest immediate threat to humanity. Over the last century, we have made spectacular advances that have transformed our society – splitting the atom, space travel, telecommunications, and the Internet – but with medical research focused mostly on science for the sake of science, it has yielded precious few cures. A Roadmap for Curing Cancer, Alzheimer’s, and Cardiovascular Disease represents a "first of its kind" effort to address both the reasons for this and to posit solutions to fix our broken system, in an effort to finally end this cure crisis. Dr. Marangos draws on 45 years of experience in every aspect of the biomedical R&D field, from basic drug discovery research at the NIH to the co-founding of five drug companies. He has published 252 research papers and edited four books on drug discovery, is co-inventor on 14 patents, and founded "The Journal of Molecular Neuroscience". He argues that from a development perspective, the regulatory, patent, and legal hurdles that force industry to pursue so-called "me-too" drugs rather than cures for terminal diseases must be re-thought. Leadership accountability, strategy, focus, and urgency need to be re-evaluated, and major reforms to the NIH, FDA, and patent codes are proposed.to remedy these impediments to cures. Written for anyone frustrated with the seemingly endless threat of terminal disease, this book seeks to inform, energize, and provide the rationale for the public and industry stakeholders, as well as clinicians and researchers, to resurrect the physician-patient relationship and demand that we get serious about ridding society of this scourge on humanity. This work contains the views and opinions of the author and are in no way intended to harm the reputation of any person, agency, organization, or commercial entity discussed herein. www.cureterminaldise...

  • Brain-Based Learning and Education

    Principles and Practice
    • 1st Edition
    • Yi-Yuan Tang
    • English
    Brain-Based Learning and Education presents a new type of education that uses brain-based and self-control theory-driven training. Leaving aside the current focus in education on content knowledge, it examines essential character strengths such as selfcontrol, persistence, creativity, attention, memory, and social learning, and relates their relevance to learning. By bridging the research and application gap in education, this text not only covers the latest findings related to learning and teaching but also provides insights for application and practice for brain-based methods in health and education. This integration of neuroscience and education takes us from a deep understanding of brain function to the frontline of the classroom.

  • Dementia, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 35-2
    • John M. Ringman
    • English
    This issue of Neurologic Clinics, edited by Dr. John Ringman, will cover a wider variety of topics and the latest updated on Demantia. Topics covered in this issue include, but are not limited to Updates on the basic science of AD; The role of neuropsychology in the assessment of the cognitively impaired elderly; Assessment of the Spanish-speaking cognitively impaired elderly; Early-Onset Alzheimer’s disease; Vascular dementia and vascular contributions to Alzheimer’s disease; Frontotemporal Degenerations; and Current and Experimental Treatments, among others.

  • Wilson Disease

    • 1st Edition
    • Volume 142
    • Anna Czlonkowska + 1 more
    • English
    Wilson Disease provides a comprehensive guide on this inherited genetic disorder that has devastating consequences for both the liver and neurologic/psychiatr... health. This disease is of increasing interest to neurologists, hepatologists, and geneticists, but when the disease is diagnosed early, it is treatable, with patients living normal lives. This volume describes the molecular pathophysiology of WD and the clinical and pathological effects of copper. Separate sections address both diagnosis and medical and surgical approaches to treatment. Both adult and pediatric perspectives on diagnosis and treatment are addressed, and a section on genetics highlights advances in molecular diagnostics. Patient support groups that can aid in coping with this disease are also discussed, as are animal models for those interested in basic research on cell biology, pathophysiology, and treatment.

  • Machine Dreaming and Consciousness

    • 1st Edition
    • J. F. Pagel + 1 more
    • English
    Machine Dreaming and Consciousness is the first book to discuss the questions raised by the advent of machine dreaming. Artificial intelligence (AI) systems meeting criteria of primary and self-reflexive consciousness are often utilized to extend the human interface, creating waking experiences that resemble the human dream. Surprisingly, AI systems also easily meet all human-based operational criteria for dreaming. These “dreams” are far different from anthropomorphic dreaming, including such processes as fuzzy logic, liquid illogic, and integration instability, all processes that may be necessary in both biologic and artificial systems to extend creative capacity. Today, multi-linear AI systems are being built to resemble the structural framework of the human central nervous system. The creation of the biologic framework of dreaming (emotions, associative memories, and visual imagery) is well within our technical capacity. AI dreams potentially portend the further development of consciousness in these systems. This focus on AI dreaming raises even larger questions. In many ways, dreaming defines our humanity. What is humanly special about the states of dreaming? And what are we losing when we limit our focus to its technical and biologic structure, and extend the capacity for dreaming into our artificial creations? Machine Dreaming and Consciousness provides thorough discussion of these issues for neuroscientists and other researchers investigating consciousness and cognition.

  • Advances in Imaging of Multiple Sclerosis, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 27-2
    • Alex Rovira
    • English
    This issue of Neuroimaging Clinics of North America focuses on Imaging of Multiple Sclerosis: Diagnosis and Management, and is edited by Dr. Àlex Rovira Cañellas. Articles will include: Multiple Sclerosis: Epidemiological, Clinical and Therapeutic Aspects; Brain and Spinal Cord MR Imaging Features in Multiple Sclerosis and Variants; Neuromyelitis Optica Spectrum Disorders; Radiologically Isolated Syndrome; MRI in Monitoring and Predicting Treatment Response in Multiple Sclerosis; Cortical Grey Matter MR Imaging in Multiple Sclerosis; Brain Atrophy in Multiple Sclerosis: Technical Aspects and Clinical Relevance; Iron Mapping in Multiple Sclerosis; Microstructural MR Techniques in Multiple Sclerosis; Molecular and Metabolic Imaging in Multiple Sclerosis; Insights from Ultra-high Field Imaging in Multiple Sclerosis; Pediatric Multiple Sclerosis: Distinguishing Clinical and MRI Features, and more!

  • Network Functions and Plasticity

    Perspectives from Studying Neuronal Electrical Coupling in Microcircuits
    • 1st Edition
    • Jian Jing
    • English
    Network Functions and Plasticity: Perspectives from Studying Neuronal Electrical Coupling in Microcircuits focuses on the specific roles of electrical coupling in tractable, well-defined circuits, highlighting current research that offers novel insights for electrical coupling‘s roles in sensory and motor functions, neural computations, decision-making, regulation of network activity, circuit development, and learning and memory. Bringing together a diverse group of international experts and their contributions using a variety of approaches to study different invertebrate and vertebrate model systems with a focus on the role of electrical coupling/gap junctions in microcircuits, this book presents a timely contribution for students and researchers alike.

  • Systems Factorial Technology

    A Theory Driven Methodology for the Identification of Perceptual and Cognitive Mechanisms
    • 1st Edition
    • Daniel Little + 3 more
    • English
    Systems Factorial Technology: A Theory Driven Methodology for the Identification of Perceptual and Cognitive Mechanisms explores the theoretical and methodological tools used to investigate fundamental questions central to basic psychological and perceptual processes. Such processes include detection, identification, classification, recognition, and decision-making. This book collects the tools that allow researchers to deal with the pervasive model mimicry problems which exist in standard experimental and theoretical paradigms and includes novel applications to not only basic psychological questions, but also clinical diagnosis and links to neuroscience. Researchers can use this book to begin using the methodology behind SFT and to get an overview of current uses and future directions. The collected developments and applications of SFT allow us to peer inside the human mind and provide strong constraints on psychological theory.

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