Skip to main content
Elsevier

Environmental Factors in Neurodegenerative Diseases

  • 1st Edition, Volume 1 - September 19, 2017
  • Latest edition
  • Editors: Michael Aschner, Lucio G. Costa
  • Language: English

Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles… Read more

Description

Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson’s disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike.

Key features

  • Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology
  • Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers
  • Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America
  • Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government

Readership

<

Table of contents

1. Traffic-Related Air Pollution and Neurodegenerative Diseases: Epidemiological and Experimental Evidence, and Potential Underlying Mechanisms
Lucio G. Costa

2. The Catecholaminergic Neurotransmitter System in Methylmercury-Induced Neurotoxicity
Marcelo Farina, Michael Aschner and João B.T. da Rocha

3. Pesticides and Parkinson’s Disease: Current Experimental and Epidemiological Evidence
Samuel M. Goldman, Ruth E. Musgrove, Sarah A. Jewell and Donato A. Di Monte

4. Metals and Circadian Rhythms
Nancy L. Parmalee and Michael Aschner

5. Aluminum and Neurodegenerative Diseases
Stephen C. Bondy and Arezoo Campbell

6. Manganese Neurodegeneration
David C. Dorman

7. Roles of Microglia in Inflammation-Mediated Neurodegeneration: Models, Mechanisms, and Therapeutic Interventions for Parkinson’s Disease
Hui-Ming Gao, Dezhen Tu, Yun Gao, Qiyao Liu, Ru Yang, Yue Liu, Tian Guan and Jau-Shyong Hong

8. Mitochondrial Dynamics in Neurodegenerative Diseases
Jennifer Pinnell and Kim Tieu

9. Food Plant Chemicals Linked With Neurological and Neurodegenerative Disease
Peter S. Spencer and Valerie S. Palmer

Product details

  • Edition: 1
  • Latest edition
  • Volume: 1
  • Published: September 19, 2017
  • Language: English

About the editors

Michael Aschner

Serial Editor
Dr. Aschner serves as the Harold and Muriel Block Chair in Molecular Pharmacology at Albert Einstein College of Medicine. He served on numerous toxicology panels (Institute of Medicine, US Environmental Protection Agency, Center for Disease Control, FDA, National Academy of Sciences, US Department of Defense), and was a member and chair of the Neurotoxicology and Alcohol study section (NIH). He served as the President of the Society of Toxicology and has previously served as the President of the Academy of Toxicological Sciences and the International Neurotoxicology Association. He has authored (co-authored) >1,100 peer reviewed manuscripts and 110 book chapters, his h-index is 124, and he is a recipient of Honorary Doctorate from the University of Cordoba in Argentina. Research in his lab focuses on: (1) Modulation of C. elegans genes (aat, skn-1, daf-16) that are homologous to mammalian regulators of methylmercury (MeHg) uptake and cellular resistance will modify dopaminergic neurodegeneration in response to MeHg exposure. (2) Under conditions of MeHg-induced oxidative stress, Nrf2 (a master regulator of antioxidant responses) coordinates the upregulation of cytoprotective genes that combat MeHg-induced oxidative injury, and that genetic and biochemical changes that negatively impact upon Nrf2 function increase MeHg’s neurotoxicity. (3) PARK2, a strong PD genetic risk factor, alters neuronal vulnerability to modifiers of cellular Mn status, particularly at the level of mitochondrial dysfunction and oxidative stress. His studies are designed to (1) shed novel mechanistic insight into metal-induced neurodegeneration; (2) identify targets for genetic or pharmacologic modulation of neurodegenerative disorders; (3) increase knowledge of the pathway involved in oxidative stress; (4) develop improved research models for human disease using knowledge of environmental sciences.

Affiliations and expertise
Professor, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA

Lucio G. Costa

Serial Editor
Dr. Costa is Professor Emeritus of Toxicology in the Department of Environmental and Occupational Health Sciences at the University of Washington in Seattle. Before joining the University of Washington in 1983 he received a doctorate in Pharmacology from the University of Milano and was a postdoctoral fellow at the University of Texas at Houston. Over the years he served as the Director of the University of Washington Toxicology Program, Director of the Neurotoxicology Research Core of the NIEHS Center in Ecogenetics and Environmental Health, and a Core Faculty of the Environmental and Occupational Epidemiology Training Program and the Environmental Pathology/Toxicology Training Program at the University of Washington. He has also held professorial positions at various Universities in Italy (Parma, Bari, Roma, Pavia, Milano). He is a member of several national and international professional organizations, a Fellow of the Academy of Toxicological Sciences, and a European Certified Toxicologist. He received various awards for his scientific accomplishments, including the Achievement Award from the Society of Toxicology. Dr. Costa has been a member of several panels and committees at the national and international level dealing with toxicology and risk assessment issues. He has been teaching classes in pharmacology, toxicology, and neurotoxicology for over 35 years, and has kept an active research program in neurotoxicology, with >500 publications, books and book chapters. The primary focus of his research relates to the toxicology and neurotoxicology of pesticides, environmental contaminants, alcohol, air pollution, and on various aspects of gene-environment interactions in relationship to neurotoxicity and neurodegeneration.
Affiliations and expertise
Professor of Toxicology, University of Washington, Seattle, WA, USA

View book on ScienceDirect

Read Environmental Factors in Neurodegenerative Diseases on ScienceDirect