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Books in Life sciences

  • Brain Rehabilitation in Psychiatric Disorders

    • 1st Edition
    • Volume 301
    • English
    Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Structural Studies of Amyloid-Forming Peptides

    • 1st Edition
    • Volume 729
    • English
    Structural Study of Amyloid-β, Volume 729 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on important topics such as the Extraction of Amyloids from Neurodegenerative Disease Tissues for Structural Analysis, Cryo-EM Structure Determination of Amyloid Fibrils: Methodology, Insights, and Practical Tools, Methods for studying molecular architecture of Ab aggregates in tissues using cryo-ET, Cryo-EM methods to study binding between amyloid fibrils and chemical compounds or ligan, Dynamics studies of side-chains and hydration shells in amyloid-beta fibrils using deuterium and oxygen-17 solid-state NMR, and much more.Additional chapters cover the Technical aspects of pressure jump NMR applied to the study of Abeta and protein oligomerization, Characterizations of the beta-amyloid-membran... interaction intermediates, Time-resolved solid-state NMR studies of oligomer formation, Methods for characterizing the individual filament structures of amyloid peptide assemblies using atomic force microscopy, Single-molecule fluorescence spectroscopy and imaging on heterogeneous amyloid beta aggregation, Two-dimensional FT-IR methods on amyloid aggregation and folding pathways, and much more.

  • Physiologie des maladies mentales

    Anomalies neurobiologiques et conséquences thérapeutiques en psychiatrie
    • 1st Edition
    • Bruno Millet
    • French
    Les monographies en Psychiatrie sont des ouvrages de référence sur les troubles psychiatriques et les grandes problématiques de la discipline. Elles permettent aux praticiens d’approfondir et d’actualiser leurs connaissances, en exposant les données fondamentales actuelles et leurs applications dansla pratique clinique. Quelles anomalies cérébrales observe-t-on chez les patients atteints de troubles psychiques ? Quels dysfonctionnements sont à l’oeuvre dans leur cerveau ? Cet ouvrage répond à ces questions essentielles en s’appuyant sur les recherches actuelles en neurosciences (neuroanatomie structurale et fonctionnelle, neurobiologie). Il démontre comment les avancées dans la compréhension de la physiologie cérébrale, des mécanismes pathologiques et des comorbidités permettent d’améliorer la psychopharmacologie et de développer de nouveaux traitements par neurostimulation. Après un chapitre sur le système limbique et son articulation avec les systèmes cognitif et sensorimoteur, l’ouvrage explore les grandes pathologies psychiatriques selon deux approches complémentaires :l’approche catégorielle : schizophrénie, troubles obsessionnels compulsifs, état de stress post-traumatique, dépression récurrente, bipolarité, trouble panique, anxiété généralisée, TDAH l’approche dimensionnelle : régulation émotionnelle, motivation, compulsivité, impulsivité, discernement.Chaque chapitre intègre connaissances fondamentales, données cliniques et perspectives thérapeutiques, offrant ainsi aux praticiens et chercheurs une vision complète pour l’évaluation et la prise en charge.POINTS CLÉSLes mécanismes neurobiologiques des troubles psychiquesLes applications diagnostiques et thérapeutiquesLa double perspective catégorielle et dimensionnelleBruno Millet est psychiatre, professeur des universités-praticie... hospitalier, faculté de médecine Sorbonne Université, Hôpital Saint-Antoine, AP-HP, Paris. Thibaut Dondaine est neuropsychologue, maître de conférences-HDR en neurosciences, Université de Lille, Lille Neuroscience et Cognition (UMR-S1172), Lille.

  • Autophagy – Part A

    • 1st Edition
    • Volume 403
    • English
    Autophagy – Part A, Volume 403 explores the fundamental biological process of autophagy. Beginning with the historical discovery and molecular mechanisms of autophagy, the book delves into its regulation, physiological roles, and significance in maintaining cellular homeostasis. Chapters in this new release include Ciliophagy: Maintaining Primary Cilium Homeostasis to Prevent Cilium-Related Diseases, Unraveling the interplay of glycolysis, lactylation, and autophagy, Autophagy and Type 2 Diabetes: Bridging the Gap in Metabolic Health, Autophagy in Cancer Cachexia: From Mechanisms to Therapeutic Opportunities, Glycophagy: A Selective Autophagy Pathway for Glycogen Degradation, Role of Autophagy in Adipose Tissue: Implications for Metabolic Health, and more.

  • Artificial Intelligence for Multi-omics Analysis Part B

    • 1st Edition
    • Volume 222
    • English
    Artificial Intelligence for Multi-omics Analysis Part B, Volume 222 in the Progress in Molecular Biology and Translational Science series, highlights recent advances, with this new volume presenting chapters on a variety of topics, including Artificial Intelligence in multi-omics analysis of small molecule drug discovery, AI in multi-omics analysis in antimicrobial resistance, Artificial Intelligence and multi-Omics Approach in Vaccine Development, Artificial Intelligence in multi-omics Analysis of heart diseases, Artificial Intelligence in multi-omics Analysis of Kidney Diseases, Artificial Intelligence in multi-omics Analysis of Gastrointestinal Diseases, AI in multi-omics analysis in Stem cell research, and AI in multi-omics analysis in cancer, and more.Additional sections cover AI in multi-omics analysis in obstructive lung diseases, AI in multi-omics analysis in neurodiseases, AI in multi-omics analysis in autoimmune diseases, AI in multi-omics analysis of liver diseases, AI in multi-omics analysis of COVID-19 patient data, and AI in multi-omics analysis of Type 2 diabetes.

  • 2D and 3D Cellular Screening Models and AI Guided Analysis

    • 1st Edition
    • Volume 204
    • English
    2D and 3D Cellular Screening Models and AI Guided Analysis, Volume 204 explores the development, application, and comparative benefits of 2D monolayer cultures and 3D organoids, spheroids, and tissue-engineered constructs for biomedical research and drug discovery. Chapters in this new release include High throughput CellTiter-glo viability assessment, Assessing viability of cancer cell spheroids in 3D drug screening, 3D killing assay of cancer spheroids by cytotoxic T lymphocytes in anchored microfluidic droplets, Use of micropatterning for 3D cell culture, Use of microfluidic chip devices for assessing the effect of radiation on 3D cell culture models, and much more.Additional chapters cover A 3D model for assessing regulated cell death modalities, YOLO detection model for Cell Viability assessment, Bioinformatics and AI/ML approaches using multi-omics data to accelerate diagnosis and delivery of precision care, Automated image analysis and machine learning for the assessment of mitochondrial membrane potential, Assessing cancer cell heterogeneity in patient-derived tumoroids, Assessment of lysosomal drug sequestration and release using fluorescence microscopy, Assessment of T cell toxicity in ex-vivo models of cancer, Three-dimensional Organoid Screening using Leica Thunder Microscope, Using vascularized organoids-on-chip for assessing systemic drug delivery, and many more interesting and timely topics.

  • Epigenetic Regulation of Cancer - Part E

    • 1st Edition
    • Volume 400
    • English
    Epigenetic Regulation of Cancer, Part E, Volume 400 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic regulation of cancer, Phytochemicals with epigenetic properties and their role in melanoma therapy, Epigenetic Insights of MicroRNAs: Pioneering Cancer Detection via Advanced Biosensors, Epigenetic Regulation of Autophagy in Cancer: A Double-Edged Sword in Tumor Progression and Therapy Resistance, Epigenetic Regulation via Histone Modifications in Ovarian Cancer, The current findings and potential applications of breast cancer epigenetics, and much more.Other chapters cover the Application of bioinformatics and data science in studies of cancer epigenetics, and much more.

  • Cytoskeletal Proteins in Neurodegenerative Diseases

    • 1st Edition
    • Volume 150
    • English
    Cytoskeletal Proteins in Neurodegenerative Diseases, Volume 150 covers the pivotal roles that cytoskeletal proteins play in the onset and progression of neurodegenerative disorders. The book explores the structure, function, and dynamics of key cytoskeletal components—including microtubules, actin filaments, and intermediate filaments—and examines how their dysfunction contributes to diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis (ALS). Chapters in this new release include Cytoskeletal proteins regulates Tau in Alzheimer's Disease, "Sticks with whips in neurodegenerative diseases: On the roles of intrinsic disorder in (dis)function of cytoskeletal proteins", Glial Fibrillary Protein is potential biomarker For AD, and much more. Additional chapters cover Cytoskeletal disintegration in cardiovascular disease-related neurodegeneration, Cytoskeletal Proteins in Neurodegeneration, Extracellular matrix degradation proteins in Neurodegenerative disease, GPCRs regulates Cytoskeletal remodeling in microglia, Understanding the impact of cytoskeleton disruption on synaptic plasticity in Alzheimer's Disease, Chemokine receptors modulates Cytoskeletal proteins in Alzheimer’s disease, Cytoskeletal Intermediate Filament proteins in Neurodegeneration, Mechanism of tau proteins differentially regulating the motility of different families of kinesin motors, The Quest to Restore Neuronal Structure: Targeting Cytoskeletal Proteins in Neurodegenerative Diseases, and many more timely topics.

  • Growth Hormone and Related Disorders: From Clinics to Diagnosis

    • 1st Edition
    • Volume 131
    • English
    Growth Hormone and Related Disorders: From Clinics to Diagnosis, Volume 131 covers various topics related to growth hormone and its associated disorders when there is a GH excess, including their pathophysiology, clinical presentation and diagnosis. Chapters in this new release include Growth hormone: synthesis and regulation, GH and GnRH-gonadotropin secretion, Co-Secreting Pituitary Adenomas in Acromegaly: Classification, Diagnosis, and Treatment Strategies, Growth hormone and glycemic metabolism, Acromegaly: pathophysiology and etiology, Acromegaly: biochemical diagnosis, Acromegaly and clinical manifestations, and more.Additional sections discuss Gigantism, Acromegaly and genetics, Molecular markers of response to medical therapy in acromegaly, and Acromegaly and histopathology.

  • Sensory Approaches to Mental Health Practice

    • 1st Edition
    • Tawanda Machingura + 1 more
    • English
    Sensory Approaches to Mental Health Practice presents the latest research on the relationship between sensory processing and a range of mental health conditions, along with coverage of relevant sensory-based programs. This book includes real life case studies to support practical and clinical application. Organised into sections on theory, specific diagnoses, clinical settings, interventions, and tools to practice, it explores key topics such as sensory processing, sensory integration, sensory modulation, and the intersection of these with recovery-oriented and trauma-informed care, in mental health practice. This comprehensive resource equips readers with the knowledge, practical skills, and tools to apply sensory approaches effectively and in a recovery-focused manner across diverse client needs and settings.

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