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Multifaceted Role of IL-1 in Cancer and Inflammation
1st Edition - June 7, 2023
Editor: Manisha Singh
Paperback ISBN:9780128242735
9 7 8 - 0 - 1 2 - 8 2 4 2 7 3 - 5
eBook ISBN:9780323859677
9 7 8 - 0 - 3 2 3 - 8 5 9 6 7 - 7
Multifaceted Role of IL-1 in Cancer and Inflammation summarizes the existing literature and discusses future perspectives about the role of IL-1 in immune suppression, cancer… Read more
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Multifaceted Role of IL-1 in Cancer and Inflammation summarizes the existing literature and discusses future perspectives about the role of IL-1 in immune suppression, cancer progression, angiogenesis, and resistance to immunotherapies. The book presents mechanisms to overcome IL-1 mediated immune suppression in tumor microenvironment and covers topics on the source of IL-1 in the tumor microenvironment, IL-1 mediated downstream pathway, mechanism of IL-1 mediated immune suppression in cancer, and its effect on immunotherapy of cancer. Those topics help readers understand the effect of IL-1 on cancer immunopathology and immunotherapy, and provide them with broader concepts to develop therapies for IL-1 enrichment tumors.
This is a valuable source for cancer researchers, clinicians and other members of the biomedical field who wants to learn more about mechanisms to improve outcome of cancer immunotherapies.
Presents a summary in the beginning of each chapter to help readers to find the needed information and understand the content easily
Encompasses detailed schematic diagrams and illustrations throughout the content to explain the complex immune mechanisms discussed
Discusses future perspectives in all chapters to motivate researchers to work on emerging problems
Includes contributions from internationally renown experts sharing their experiences on clinics and research
Cancer researchers, oncologists, graduate students, medical scientists, Pharmacologists, immunologists
Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Chapter 1. Role of IL-1 gene polymorphisms in common solid cancers
Introduction
Role of IL-1 in cancer initiation, progression, and immunosuppression
The interleukin-1 gene cluster: structure and genetic polymorphisms
IL1A, IL1B, and IL1RN polymorphism in various cancers
Conclusion
Abbreviations
Chapter 2. The role of IL-1 in tumor growth and angiogenesis
Introduction
Concluding remarks
Chapter 3. Interleukin-1-mediated immune suppression and resistance to immunotherapy in cancer
Introduction
Induction of IL-1 in the tumor microenvironment
IL-1-mediated immune suppression and resistance to immunotherapy
Conclusions and future perspectives
Chapter 4. Strategies to overcome interleukin-1-mediated immune suppression and resistance to immunotherapy in cancer
Introduction
IL-1 biology
IL-1's role in resistance to immunotherapy
Future perspectives
Chapter 5. Modulation of IL-1-mediated inflammation in cancer using a food-based approach: a preventive strategy
Introduction
IL-1-mediated cancer prognosis
IL-1 in human health and disease
Therapeutic targeting of IL-1 through dietary bioactive compounds
Conclusion
Chapter 6. IL-1-mediated inflammation in COVID-19
Introduction
Interleukin-1
Protective and pathologic roles of IL-1 in viral diseases
COVID-19: general introduction
Respiratory distress and cytokine storm
Immunomodulatory drugs and COVID-19 infection
Conclusion and future perspectives
Chapter 7. Role of IL-1 in bacterial infections
Introduction
Role of IL-1 in immunity
IL-1α
IL-1β
IL-1 in bacterial infections
IL-1 signaling and pathways involved
IL-1 polymorphism associated with bacterial diseases
IL-1 immunotherapy
Concluding remarks
Index
No. of pages: 192
Language: English
Published: June 7, 2023
Imprint: Academic Press
Paperback ISBN: 9780128242735
eBook ISBN: 9780323859677
MS
Manisha Singh
Manisha Singh, PhD, is a trained human and mouse immunologist and during the last 10 years, she has specialized in cancer immunology. The main focus of her work has been to increase the efficacy and understand the molecular mechanisms of various cancer immunotherapies. She is serving as the principal investigator on a 2-year grant ($545,486), having been funded by the US Department of Defense. Dr. Singh's current research is focused on understanding the role of inflammation in immune suppression and resistance to immunotherapy in cancer. Recently, she has submitted the NIH-R01 grant in which she proposed to study the role of IL-1α in immunotherapy induced resistance. She has published 24 peer-reviewed articles and many abstracts in prestigious journals such as Nature Communication, Journal of Immunology, and Journal of Clinical Investigator. Her work has been cited by several prestigious, peer-reviewed, international journals.
Affiliations and expertise
Department of Lymphoma/ Myeloma, The University of Texas, MD Anderson Houston, Houston, Texes, United States