Multifaceted Role of IL-1 in Cancer and Inflammation
- 1st Edition - June 7, 2023
- Editor: Manisha Singh
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 4 2 7 3 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 9 6 7 - 7
Multifaceted Role of IL-1 in Cancer and Inflammation summarizes the existing literature and discusses future perspectives about the role of IL-1 in immune suppression, cancer pr… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteMultifaceted Role of IL-1 in Cancer and Inflammation summarizes the existing literature and discusses future perspectives about the role of IL-1 in immune suppression, cancer progression, angiogenesis, and resistance to immunotherapies. The book presents mechanisms to overcome IL-1 mediated immune suppression in tumor microenvironment and covers topics on the source of IL-1 in the tumor microenvironment, IL-1 mediated downstream pathway, mechanism of IL-1 mediated immune suppression in cancer, and its effect on immunotherapy of cancer. Those topics help readers understand the effect of IL-1 on cancer immunopathology and immunotherapy, and provide them with broader concepts to develop therapies for IL-1 enrichment tumors.
This is a valuable source for cancer researchers, clinicians and other members of the biomedical field who wants to learn more about mechanisms to improve outcome of cancer immunotherapies.
- Presents a summary in the beginning of each chapter to help readers to find the needed information and understand the content easily
- Encompasses detailed schematic diagrams and illustrations throughout the content to explain the complex immune mechanisms discussed
- Discusses future perspectives in all chapters to motivate researchers to work on emerging problems
- Includes contributions from internationally renown experts sharing their experiences on clinics and research
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. Role of IL-1 gene polymorphisms in common solid cancers
- Introduction
- Role of IL-1 in cancer initiation, progression, and immunosuppression
- The interleukin-1 gene cluster: structure and genetic polymorphisms
- IL1A, IL1B, and IL1RN polymorphism in various cancers
- Conclusion
- Abbreviations
- Chapter 2. The role of IL-1 in tumor growth and angiogenesis
- Introduction
- Concluding remarks
- Chapter 3. Interleukin-1-mediated immune suppression and resistance to immunotherapy in cancer
- Introduction
- Induction of IL-1 in the tumor microenvironment
- IL-1-mediated immune suppression and resistance to immunotherapy
- Conclusions and future perspectives
- Chapter 4. Strategies to overcome interleukin-1-mediated immune suppression and resistance to immunotherapy in cancer
- Introduction
- IL-1 biology
- IL-1's role in resistance to immunotherapy
- Future perspectives
- Chapter 5. Modulation of IL-1-mediated inflammation in cancer using a food-based approach: a preventive strategy
- Introduction
- IL-1-mediated cancer prognosis
- IL-1 in human health and disease
- Therapeutic targeting of IL-1 through dietary bioactive compounds
- Conclusion
- Chapter 6. IL-1-mediated inflammation in COVID-19
- Introduction
- Interleukin-1
- Protective and pathologic roles of IL-1 in viral diseases
- COVID-19: general introduction
- Respiratory distress and cytokine storm
- Immunomodulatory drugs and COVID-19 infection
- Conclusion and future perspectives
- Chapter 7. Role of IL-1 in bacterial infections
- Introduction
- Role of IL-1 in immunity
- IL-1α
- IL-1β
- IL-1 in bacterial infections
- IL-1 signaling and pathways involved
- IL-1 polymorphism associated with bacterial diseases
- IL-1 immunotherapy
- Concluding remarks
- Index
- No. of pages: 192
- Language: English
- Edition: 1
- Published: June 7, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780128242735
- eBook ISBN: 9780323859677
MS