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Multifaceted Role of IL-1 in Cancer and Inflammation
1st Edition - June 7, 2023
Editor: Manisha Singh
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 2 7 3 - 5
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 9 6 7 - 7
Multifaceted Role of IL-1 in Cancer and Inflammation summarizes the existing literature and discusses future perspectives about the role of IL-1 in immune suppression, cancer… Read more
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Multifaceted Role of IL-1 in Cancer and Inflammation summarizes the existing literature and discusses future perspectives about the role of IL-1 in immune suppression, cancer progression, angiogenesis, and resistance to immunotherapies. The book presents mechanisms to overcome IL-1 mediated immune suppression in tumor microenvironment and covers topics on the source of IL-1 in the tumor microenvironment, IL-1 mediated downstream pathway, mechanism of IL-1 mediated immune suppression in cancer, and its effect on immunotherapy of cancer. Those topics help readers understand the effect of IL-1 on cancer immunopathology and immunotherapy, and provide them with broader concepts to develop therapies for IL-1 enrichment tumors.
This is a valuable source for cancer researchers, clinicians and other members of the biomedical field who wants to learn more about mechanisms to improve outcome of cancer immunotherapies.
- Presents a summary in the beginning of each chapter to help readers to find the needed information and understand the content easily
- Encompasses detailed schematic diagrams and illustrations throughout the content to explain the complex immune mechanisms discussed
- Discusses future perspectives in all chapters to motivate researchers to work on emerging problems
- Includes contributions from internationally renown experts sharing their experiences on clinics and research
Cancer researchers, oncologists, graduate students, medical scientists, Pharmacologists, immunologists
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. Role of IL-1 gene polymorphisms in common solid cancers
- Introduction
- Role of IL-1 in cancer initiation, progression, and immunosuppression
- The interleukin-1 gene cluster: structure and genetic polymorphisms
- IL1A, IL1B, and IL1RN polymorphism in various cancers
- Conclusion
- Abbreviations
- Chapter 2. The role of IL-1 in tumor growth and angiogenesis
- Introduction
- Concluding remarks
- Chapter 3. Interleukin-1-mediated immune suppression and resistance to immunotherapy in cancer
- Introduction
- Induction of IL-1 in the tumor microenvironment
- IL-1-mediated immune suppression and resistance to immunotherapy
- Conclusions and future perspectives
- Chapter 4. Strategies to overcome interleukin-1-mediated immune suppression and resistance to immunotherapy in cancer
- Introduction
- IL-1 biology
- IL-1's role in resistance to immunotherapy
- Future perspectives
- Chapter 5. Modulation of IL-1-mediated inflammation in cancer using a food-based approach: a preventive strategy
- Introduction
- IL-1-mediated cancer prognosis
- IL-1 in human health and disease
- Therapeutic targeting of IL-1 through dietary bioactive compounds
- Conclusion
- Chapter 6. IL-1-mediated inflammation in COVID-19
- Introduction
- Interleukin-1
- Protective and pathologic roles of IL-1 in viral diseases
- COVID-19: general introduction
- Respiratory distress and cytokine storm
- Immunomodulatory drugs and COVID-19 infection
- Conclusion and future perspectives
- Chapter 7. Role of IL-1 in bacterial infections
- Introduction
- Role of IL-1 in immunity
- IL-1α
- IL-1β
- IL-1 in bacterial infections
- IL-1 signaling and pathways involved
- IL-1 polymorphism associated with bacterial diseases
- IL-1 immunotherapy
- Concluding remarks
- Index
- No. of pages: 192
- Language: English
- Published: June 7, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780128242735
- eBook ISBN: 9780323859677
MS
Manisha Singh
Manisha Singh, PhD, is a trained human and mouse immunologist and during the last 10 years, she has specialized in cancer immunology. The main focus of her work has been to increase the efficacy and understand the molecular mechanisms of various cancer immunotherapies. She is serving as the principal investigator on a 2-year grant ($545,486), having been funded by the US Department of Defense. Dr. Singh's current research is focused on understanding the role of inflammation in immune suppression and resistance to immunotherapy in cancer. Recently, she has submitted the NIH-R01 grant in which she proposed to study the role of IL-1α in immunotherapy induced resistance. She has published 24 peer-reviewed articles and many abstracts in prestigious journals such as Nature Communication, Journal of Immunology, and Journal of Clinical Investigator. Her work has been cited by several prestigious, peer-reviewed, international journals.
Affiliations and expertise
Department of Lymphoma/ Myeloma, The University of Texas, MD Anderson Houston, Houston, Texes, United States