Mitochondria and Bacterial Pathogens - Part B
- 1st Edition, Volume 377 - May 31, 2023
- Imprint: Academic Press
- Editors: Lorenzo Galluzzi, Saverio Marchi
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 1 2 3 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 1 2 4 - 4
Mitochondria and Bacterial Pathogens, Part B, Volume 375 discusses different pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compar… Read more
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Request a sales quoteMitochondria and Bacterial Pathogens, Part B, Volume 375 discusses different pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells. Chapters in this new release include Interaction between host cell mitochondria and Coxiella Burnetii, Control of mitochondrial functions by Pseudomonas aeruginosa in cystic fibrosis, Mitochondrial and bacterial ATP synthase: Structural similarities and divergences to exploit in the battle against M. tuberculosis, Role of mitochondria in the enteropathogenic Escherichia coli disease, Mitochondria dynamics and antibiotic resistance, and more.
- Provides a collection of articles reporting on the role of mitochondria during bacterial infection
- Covers Mitochondria, the evolutionary successors of an ancient endosymbiotic prokaryote, occupy a central position in the biology of modern eukaryotic cells
- Includes content on numerous pathogenic bacteria and how they have evolved strategies to subvert the mitochondrial functions of host cells in support of proliferation and dissemination
Researchers interested in mitochondrial dynamics and bacterial infections
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Chapter One: Interaction between host cell mitochondria and Coxiella burnetii
- Abstract
- 1: Coxiella burnetii—The causative agent of Q fever
- 2: The Coxiella-containing vacuole
- 3: The Dot/Icm effector repertoire
- 4: Mitochondria—Key players in host-pathogen interactions
- 5: AnkG—A nuclear effector with affection for mitochondria
- 6: MceA—A mitochondrial effector that gets lost when ectopically expressed
- 7: Complexities of elucidating effector function
- 8: The host perspective
- 9: Outstanding questions in the field
- References
- Chapter Two: Control of mitochondrial functions by Pseudomonas aeruginosa in cystic fibrosis
- Abstract
- 1: Introduction
- 2: The physiopathology of cystic fibrosis
- 3: P. aeruginosa is the major pathogen in the CF
- 4: Effects of P. aeruginosa on mitochondrial functions in cystic fibrosis
- 5: Conclusion
- Conflicts of interest
- References
- Chapter Three: Bacterial and mammalian F1FO-ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis
- Abstract
- 1: Introduction
- 2: Structure and function of F1Fo-ATPase in bacteria and mitochondria
- 3: Inhibition mechanism of mycobacterial F1Fo-ATPase by BDQ
- 4: Conclusion
- References
- Chapter Four: Attaching and effacing pathogens modulate host mitochondrial structure and function
- Abstract
- 1: Introduction
- 2: Role of mitochondria in the intestinal epithelium
- 3: A/E pathogens and host cell mitochondria—In vivo studies
- 4: A/E pathogens and host cell mitochondria—Mechanistic studies
- 5: Relevance of A/E pathogen mitochondrial impacts to virulence and pathogenesis
- 6: Caveats and considerations
- References
- Chapter Five: Mycobacterial infection alters host mitochondrial activity
- Abstract
- 1: Introduction
- 2: Transport of factors across the mitochondrial membrane
- 3: Mitochondrial immunometabolism as the link between metabolism and innate immunity
- 4: Mitochondria as a target of mycobacterial infection
- 5: Mycobacterial interaction with the host immune system
- 6: Mycobacteria alters macrophage effector functions by targeting mitochondria
- 7: Mycobacterial proteins are targeted to host mitochondria
- 8: Metabolite promiscuity in macrophage reprogramming
- 9: Concluding remarks
- References
- Chapter Six: Side effects of antibiotics and perturbations of mitochondria functions
- Abstract
- 1: Introduction
- 2: Antibiotics targeting protein synthesis
- 3: Other antibiotics
- 4: Antibiotics targeting DNA
- 5: Conclusion
- Conflict of interest
- References
- Edition: 1
- Volume: 377
- Published: May 31, 2023
- No. of pages (Hardback): 150
- No. of pages (eBook): 150
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443191237
- eBook ISBN: 9780443191244
LG
Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
Affiliations and expertise
Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USASM
Saverio Marchi
Saverio Marchi obtained his PhD in ‘Pharmacology and Molecular Oncology’ from University of Ferrara (Italy), under the supervision of Prof. Rosario Rizzuto, where he investigated the role of Ca2+ signalling and mitochondrial dynamics in cancer. He did a short term research stay at the Gustave Roussy Institute (Paris, France) in the Guido Kroemer’s lab, for the study of the mechanisms of autophagy regulation. On 2011 he joined the Laboratory of Dr. Paolo Pinton at the University of Ferrara (Italy) where he carried out his postdoctoral studies. During his postdoctoral training, he studied the implications of Endoplasmic Reticulum-mitochondria connection in diseases, especially cancer. In 2014, he was the recipient of the Young Researcher award, which allowed him to work at the Cancer Center, University of Hawai’i (Prof. Michele Carbone’s lab), where he was introduced to the study of the signalling pathways regulating mesothelioma progression. Now, he is associate professor at the Marche Polytechnic University, where he leads his own group. He is interested in the involvement of the MCU complex and mitochondrial Ca2+ in the evolution of cancer. More recently, he has become interested in the alteration of mitochondrial dynamics during bacterial infection.
He published 77 papers on “peer-reviewed” journals (h-index: 41; n° of citations > 5800. Source: Scopus).
Affiliations and expertise
Dept. of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, ItalyRead Mitochondria and Bacterial Pathogens - Part B on ScienceDirect