Advances in Accelerators and Medical Physics
- 1st Edition - May 25, 2023
- Imprint: Academic Press
- Editors: Toshiyuki Shirai, Teiji Nishio, Kiyokazu Sato
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 1 9 1 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 1 9 2 - 6
Radiotherapy is now one of the major cancer treatments. The field of accelerator and medical physics is important and growing to support high precision cancer radiotherapy. Ad… Read more
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Request a sales quoteRadiotherapy is now one of the major cancer treatments. The field of accelerator and medical physics is important and growing to support high precision cancer radiotherapy. Advances in Accelerators and Medical Physics provides in-depth and comprehensive coverage of the basic concepts in x-ray therapy, electron beam therapy, particle therapy, boron neutron capture therapy, and molecular imaging and therapy. Novel technologies such as FLASH therapy and laser ion accelerator are also introduced. Each section of the book presents the current state of accelerators, irradiation methods and therapy technologies, as well as future trends in advanced research. This book will serve as a key resource for researchers and students to find all information on latest cancer radiotherapy technologies and methods.
- Offers a deep dive into fundamental accelerator and medical physics techniques and technologies used in cancer radiotherapy
- Considers updated status at hospitals and clinical facilities, and future research trends
- Covers advanced research, development and novel technologies
- Chapters written by experts from the Particle Accelerator Society of Japan(PASJ) and the Japan Society of Medical Physics (JSMP)
Graduate students, researchers, and professionals in medical physics, medical dosimetry, radiation technology, radiotherapy technology, and radiology
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Foreword by Masao Kuriki
- References
- Foreword by Shigekazu Fukuda
- Section A: X-ray therapy and electron beam therapy
- Chapter One: Electron accelerator and beam irradiation system
- Abstract
- 1.1: History and prospects of radiation therapy
- 1.2: Electron linear accelerator (general description)
- 1.3: C-band linear accelerator and irradiation device
- 1.4: Summary
- References
- Chapter Two: External beam radiation therapy
- Abstract
- 2.1: Fixed gantry irradiation
- 2.2: Moving gantry irradiation
- 2.3: Conformal irradiation
- 2.4: Stereotactic irradiation
- 2.5: Intensity modulated radiation therapy
- Reference
- Chapter Three: Immobilization and patient positioning
- Abstract
- 3.1: Planar kV X-ray image
- 3.2: kV-CBCT/MV-CBCT
- 3.3: Optical surface imaging system
- 3.4: Ultrasound
- 3.5: Magnetic resonance image
- References
- Chapter Four: Respiratory motion management
- Abstract
- 4.1: Abdominal compression
- 4.2: Breath hold
- 4.3: Respiratory gating
- 4.4: Real-time tumor tracking
- References
- Chapter Five: Radiation treatment planning (photon and electron beam therapy)
- Abstract
- 5.1: Treatment planning parameter
- 5.2: Dose calculation algorithm
- References
- Chapter Six: Dosimetric verification
- Abstract
- 6.1: Introduction
- 6.2: Absolute dose-to-water verification
- 6.3: General QA test for medical linear accelerators
- 6.4: Patient-specific QA for the IMRT technique
- 6.5: Geometric and dosimetric verification for the MR-guided radiation therapy system
- References
- Chapter Seven: Adaptive radiotherapy
- Abstract
- 7.1: Imaging systems for the detection of patient-specific changes over the course of treatment
- 7.2: Three classes of ART
- 7.3: Commercial technologies for online ART
- References
- Section B: Particle therapy
- Chapter Eight: Proton cyclotron accelerator and line scanning irradiation system
- Abstract
- 8.1: Introduction
- 8.2: Accelerators for proton therapy
- 8.3: Scanning irradiation systems
- 8.4: Future prospects for the cyclotron
- 8.5: Conclusions
- References
- Chapter Nine: Proton synchrotron accelerator and spot scanning irradiation system
- Abstract
- Acknowledgments
- 9.1: Introduction
- 9.2: History of synchrotrons for proton beam therapy
- 9.3: Compact proton synchrotron
- 9.4: Spot scanning irradiation method in proton beam therapy
- 9.5: Compact proton therapy system with a single treatment room
- 9.6: Conclusion
- References
- Chapter Ten: Carbon-ion synchrotron accelerator and raster scanning irradiation system
- Abstract
- 10.1: Introduction
- 10.2: Accelerator
- 10.3: Beam-delivery system
- 10.4: Respiratory gated irradiation
- 10.5: Superconducting rotating gantry
- References
- Chapter Eleven: Quantum scalpel
- Abstract
- 11.1: Introduction
- 11.2: Multi-ion source
- 11.3: Superconducting synchrotron
- References
- Chapter Twelve: Irradiation and therapy methods
- Abstract
- 12.1: Passive beam spreading
- 12.2: Lateral beam spreading
- 12.3: Range modulator
- 12.4: Range shifter
- 12.5: Collimator
- 12.6: Range compensator
- 12.7: Layer stacking technique
- 12.8: Applicable cases of proton beam therapy
- 12.9: Scanning
- 12.10: SFUD, MSFO, and IMPT
- 12.11: Interlock system
- References
- Chapter Thirteen: Management of patient position and respiratory motion
- Abstract
- 13.1: Introduction
- 13.2: Imaging techniques
- 13.3: Patient positioning
- 13.4: Treatment planning for organ motion
- 13.5: Motion management
- 13.6: Summary
- References
- Chapter Fourteen: Treatment planning
- Abstract
- 14.1: Dose calculation
- 14.2: Biological effect
- 14.3: Target definition and margin
- 14.4: Field design
- 14.5: Optimization algorithms
- References
- Chapter Fifteen: Dosimetric verification
- Abstract
- 15.1: Introduction
- 15.2: Verification of dose at a reference point
- 15.3: Verification of dose distributions
- 15.4: Dosimetric verification for clinical trial credentialing
- 15.5: Log-files as a tool for dosimetric verification
- 15.6: Monte Carlo simulations
- References
- Chapter Sixteen: Radiation protection
- Abstract
- 16.1: Medical exposure of patients
- 16.2: Occupational exposure
- 16.3: Radiation safety management
- References
- Section C: Boron neutron capture therapy (BNCT)
- Chapter Seventeen: Principle and current status
- Abstract
- 17.1: Introduction
- 17.2: Principle
- 17.3: Current status of BNCT facilities in Japan
- References
- Chapter Eighteen: Proton linear accelerator and lithium target system
- Abstract
- 18.1: Introduction
- 18.2: Accelerator BNCT system
- 18.3: Lithium target system
- 18.4: Moderator and reflector
- 18.5: Patient couch
- 18.6: Summary
- References
- Chapter Nineteen: Proton linear accelerator and beryllium target system
- Abstract
- 19.1: Concept of the Ibaraki boron neutron capture therapy system
- 19.2: Components of the accelerator
- 19.3: Recent performances of the iBNCT Linac
- 19.4: Summary
- References
- Chapter Twenty: Proton cyclotron accelerator and beryllium target system
- Abstract
- 20.1: Introduction
- 20.2: Neutron source
- 20.3: Performance tests
- 20.4: Medical device approval
- 20.5: Conclusion
- References
- Chapter Twenty-One: Irradiation method and the immobilization and positioning of patients (head and neck)
- Abstract
- 21.1: Introduction
- 21.2: Basic workflow of head and neck BNCT
- 21.3: Immobilizing and positioning patients
- 21.4: Treatment planning
- 21.5: Irradiation
- References
- Chapter Twenty-Two: Therapy method, irradiation method, and immobilization and positioning of patients (brain)
- Abstract
- 22.1: Therapy method
- 22.2: Irradiation method
- 22.3: Immobilizing and positioning patients
- References
- Chapter Twenty-Three: Therapy method, irradiation method, and immobilization and positioning (skin)
- Abstract
- 23.1: Introduction
- 23.2: The accelerator-based BNCT system at the NCCH
- 23.3: Therapy/irradiation method
- 23.4: Immobilization and positioning
- 23.5: Summary
- References
- Chapter Twenty-Four: Treatment planning
- Abstract
- 24.1: Introduction
- 24.2: Dose estimation method in BNCT
- 24.3: Dose calculation method
- 24.4: Treatment planning system for BNCT
- References
- Chapter Twenty-Five: Dosimetric verification
- Abstract
- 25.1: Radiation field in boron neutron capture therapy
- 25.2: Neutron energy spectrum at target
- 25.3: In-air irradiation
- 25.4: Beam monitor system
- 25.5: Phantom irradiation
- 25.6: Commissioning and quality assurance and quality control (QA/QC)
- References
- Chapter Twenty-Six: Future works
- Abstract
- 26.1: Introduction
- 26.2: Dose estimation
- 26.3: Dose planning system
- 26.4: Quality assurance/quality control
- References
- Section D: Molecular imaging and therapy
- Chapter Twenty-Seven: Electron linear accelerator for medical radionuclide production
- Abstract
- 27.1: Introduction
- 27.2: Medical radionuclide
- 27.3: Photonuclear reaction
- 27.4: Targetry
- 27.5: Electron linear accelerator
- 27.6: Postirradiation processing
- 27.7: Beyond production
- References
- Chapter Twenty-Eight: Cyclotron accelerators for the production of medical radionuclides
- Abstract
- 28.1: Compact cyclotron for PET nuclides production
- 28.2: Cyclotrons for manufacturing nuclides for targeted radioisotope therapy
- 28.3: Solid target systems
- 28.4: RI purification system
- 28.5: Drug synthesis equipment for PET
- References
- Chapter Twenty-Nine: Dosimetry in therapy using radiopharmaceuticals
- Abstract
- 29.1: Introduction
- 29.2: Pharmacokinetic data collection
- 29.3: Time-integrated activity
- 29.4: Absorbed dose calculation
- 29.5: Clinical dosimetry methods for targeted radioisotope therapy
- References
- Section E: Novel technologies
- Chapter Thirty: FLASH radiotherapy
- Abstract
- 30.1: Introduction
- 30.2: Radiochemical reactions
- 30.3: Biological response and effect
- 30.4: Dosimetry
- 30.5: FLASH beam irradiation facility
- References
- Chapter Thirty-One: Laser-driven ion accelerator
- Abstract
- 31.1: Advantage of laser-driven ion accelerators
- 31.2: The physics of laser-driven ion acceleration
- 31.3: Extreme light infrastructure and the Quantum Scalpel project
- References
- Index
- Edition: 1
- Published: May 25, 2023
- No. of pages (Paperback): 384
- No. of pages (eBook): 384
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323991919
- eBook ISBN: 9780323991926
TS
Toshiyuki Shirai
Dr. Toshiyuki Shirai is the Director of the Department of Accelerator and Medical Physics at the National Institutes for Quantum and Radiological Science and Technology (QST). He received his PhD degree from the Faculty of Science, Kyoto University. After graduation, he worked in the accelerator and beam physics at the Institute for Chemical Research, Kyoto University. At QST, his research interests are in medical physics and medical accelerators for particle therapy, especially carbon-ion radiotherapy. He has served as a Councilor of the Particle Accelerator Society of Japan.
Affiliations and expertise
Director, Department of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institute for Quantum Science and Technology, Chiba, JapanTN
Teiji Nishio
Dr. Teiji Nishio is Professor and Director of the Medical Physics Laboratory, Division of Health Science, Graduate School of Medicine, Osaka University, Osaka, Japan. He received his Ph.D. in Science from the Department of Physics, Graduate School of Science, Rikkyo University for his research in nuclear astrophysics. He also received his Ph.D. in Medicine from the Department of Biophysics and Medicine, Graduate School of Medicine, The University of Tokyo for his research in medical physics. So far, he has been working on research and development of proton therapy, especially, Beam On-Line PET system, which visualize the proton irradiation area, at the National Cancer Center Japan. He is currently engaged in research and education on X-ray therapy, proton therapy, and heavy particle therapy in the Medical Physics Laboratory at Osaka University. He is also a board member of the Japan Society of Medical Physics (JSMP).
Affiliations and expertise
Professor and Director of the Medical Physics Laboratory, Division of Health Science, Graduate School of Medicine, Osaka University, Osaka, Japan.KS
Kiyokazu Sato
Kiyokazu Sato is the Senior Consultant of Keihin Product Operations Toshiba Energy Systems & Solutions Corporation. He is responsible for improving technologies and the quality of Keihin Product Operations which is the core factory in Toshiba for energy related equipments such as steam and hydro turbines, turbine-generators, heat exchangers, nuclear reactor internals and new energy equipment. Prior to his current role, he was the Senior Manager of Machinery and Equipment Department and in charge of designing and fabricating new energy equipment such as particle accelerators, superconducting magnets, equipment for fusion reactors, and special remote handling systems.
Dr. Sato holds a PhD in Engineering for his work on heavy ion linear accelerators from Tokyo Institute of Technology, Tokyo, Japan.
Affiliations and expertise
Senior Consultant, Keihin Product Operations, Toshiba Energy Systems & Solutions Co., Kanagawa, JapanRead Advances in Accelerators and Medical Physics on ScienceDirect