Environmental Contaminants and Endocrine Health
- 1st Edition - May 30, 2023
- Editors: Oliana Carnevali, Gary Hardiman
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 4 4 6 4 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 9 3 2 - 5
Environmental Contaminants and Endocrine Health focuses specifically on contaminants with hormonal disrupting activities. The book provides insights into the multiple effects o… Read more
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Request a sales quoteEnvironmental Contaminants and Endocrine Health focuses specifically on contaminants with hormonal disrupting activities. The book provides insights into the multiple effects of endocrine-disrupting chemicals (EDCs) and their mechanism of action (MoA) on metabolism, reproduction and the multiple physiological roles of the endocannabinoid system which has recently been indicated as new target. The content systematically covers EDC sources and effects, EDCs as sources of disease and health impairment in laboratory models, EDCs as the cause of disease and health impairment in humans and wild species, and the removal of hazardous pollutants from wastewaters to highlight intervention, mitigation and adaptation for reduced threat.
This content will be a foundational resource for academic and research staff in endocrinology and hormone toxicology as well as for professors, researchers and students in these areas.
- Includes important foundational coverage of the endocrine system, definitions of EDC sources and descriptions, model examples and mechanisms of action biological effects
- Provides coverage of EDC effects in humans and animals, from metabolic alterations to epidemiological studies of fertility and metabolism
- Presents insights into the confirmed and suspected human diseases spectrum with origins linked to EDC exposure, including cancers, intellectual disabilities, autism, birth defects of the urethra (hypospadias), decreased sperm count, increased rates of miscarriage, obesity, type 2 diabetes, and more
Academic/research staff in endocrinology and toxicology, professors, researchers, students (background content for Ecotoxicology courses), Chemical industry managers and researchers
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Foreword
- Preface
- Acknowledgments
- Chapter 1: Endocrine-disrupting chemical sources and effects
- Chapter 1.1: Endocrine system
- Abstract
- 1: Fundamentals of hormones
- 2: Vertebrate endocrine physiology: Organs, axes, and hormones
- References
- Further reading
- Chapter 1.2: Endocrine-disrupting chemicals (EDCs) in environmental matrices and human bodily fluids
- Abstract
- 1: Introduction
- 2: Endocrine-disrupting chemicals (EDCs)
- 3: EDCs sources, exposure and presence in tissues and body fluids
- 4: Plastics
- 5: Pesticides
- 6: Flame retardants
- 7: Poly- and perfluoroalkyl substances (PFASs)
- 8: Polychlorinated biphenyls (PCBs)
- 9: Sunscreen
- 10: Conclusion
- References
- Chapter 1.3: In vitro-, ecological-, murine, and human models for examining the effects of EDCs
- Abstract
- 1: Summary
- 2: In vitro models for examining the effects of EDCs
- 3: Ecological models for examining the effects of EDCs
- 4: Murine models for examining the effects of EDCs
- 5: Human models for examining the effects of EDCs
- 6: Overview
- References
- Chapter 1.4: Endocrine-disrupting chemicals and their mode of action: The case of nuclear receptors and the evolution of the Metazoa
- Abstract
- 1: Introduction
- 2: Evolution and nuclear receptors: A conceptual framework
- 3: Endocrine disruption via nuclear receptors
- 4: Conclusions
- References
- Chapter 1.5: EDCs impacts on human populations. Addressing multiple chemicals in human exposure and epidemiological studies
- Abstract
- 1: Background
- 2: Assessing chemical mixtures in a birth cohort study: A simulated example
- 3: Conclusions
- References
- Chapter 2: Endocrine-disrupting chemicals as source of disease and health impairment in laboratory models
- Chapter 2.1: EDCs: Focus on metabolic alteration of mammalian and nonmammalian models
- Abstract
- 1: Introduction
- 2: Approaches used to investigate the adverse actions of EDCs on the liver function
- 3: Hepatic metabolism alteration in nonmammalian model species: A 5-year survey
- 4: Hepatic metabolism alteration in mammalian species: A 5-year survey
- 5: Conclusions
- References
- Chapter 2.2: EDCs: Focus on reproductive alterations in mammalian and nonmammalian models
- Abstract
- 1: Introduction
- 2: Reproductive toxicity outcomes in nonmammalian and mammalian species: A 5-year survey
- 3: Are microplastics deleterious for reproduction in mammals?
- 4: Conclusion
- References
- Chapter 2.3: The EDCs as epigenetic disruptors: Implications for development and health
- Abstract
- 1: Introduction to epigenetics
- 2: Interference of EDCs with the epigenetic dynamics
- 3: The impact of epigenetic effects triggered by EDCs on health conditions
- 4: Concluding remarks
- References
- Chapter 2.4: Endocrine disrupting chemicals induce the epigenetic transgenerational inheritance of disease
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Molecular epigenetic mechanisms
- 3: Epigenetic transgenerational inheritance
- 4: Developmental etiology of epigenetic transgenerational inheritance
- 5: Germline epimutations
- 6: Transgenerational gene expression changes
- 7: Conclusion
- References
- Chapter 2.5: Endocrine disruption persistence through development and across generations can be mediated by environmental perturbations of the heterochromatin/euchromatin compartmentalization
- Abstract
- 1: Introduction
- 2: Environmental perturbation of genome organization as DIPE mediator
- 3: How do HEC perturbations determine the phenotypic manifestations of DIPE?
- 4: How are HEC perturbations propagated?
- 5: How are HEC perturbations originated?
- 6: Concluding remarks
- References
- Chapter 2.6: Alterations of the endocannabinoid system by endocrine-disrupting chemicals: Effects on metabolism and reproduction
- Abstract
- 1: The endocannabinoid system
- 2: Endocannabinoid system, endocrine-disrupting chemicals, and hepatic metabolism
- 3: Endocannabinoid system, endocrine-disrupting chemicals, and reproduction
- 4: Conclusions
- References
- Chapter 3: Endocrine-disrupting chemicals; cause of disease and health impairment in human and wild species
- Chapter 3.1: EDC effects in humans
- Chapter 3.1.1: Metabolism disrupting chemicals in the development of human diseases
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Common ground for MDC research
- 3: Organ and organ systems
- 4: MDC-related diseases
- 5: Type-II diabetes mellitus
- 6: Alzheimer's disease and “Type 3 diabetes”
- 7: Parkinson's disease
- 8: A slightly broader view of MDCs and the mitochondria
- 9: Expanding areas for MDC research
- 10: Looking backward and forward
- References
- Chapter 3.1.2: Focus on reproductive health and alterations in women
- Abstract
- 1: Introduction
- 2: Female reproductive health
- 3: EDCs and female reproductive health
- 4: Exposure in the womb
- 5: Effects on puberty
- 6: Polycystic ovary syndrome (PCOS)
- 7: Breast cancer
- 8: Endometriosis
- 9: Uterine fibroid (uterine leiomyoma)
- 10: Infertility
- 11: Pregnancy complications
- 12: Epigenetics and transgenerational effects
- 13: Conclusion and future perspectives
- References
- Chapter 3.1.3: EDCs: Focus on reproductive alterations in males
- Abstract
- 1: Introduction
- 2: Bisphenol A
- 3: Phthalates
- 4: Perfluoroalkyl substances
- 5: Dioxin and dioxin-like compounds
- 6: Conclusions
- References
- Chapter 3.1.4: A good start lasts a lifetime: Endocrine-disrupting chemicals and their impact on embryonic and fetal development
- Abstract
- 1: Introduction
- 2: Early embryonic development in the human
- 3: Measurements of early embryonic growth and development
- 4: Evidence that EDCs directly impact human early embryonic development
- 5: Late embryonic and fetal development in humans: A brief overview
- 6: Evaluating late embryonic and fetal development in humans
- 7: EDCs: Impact on organogenesis and fetal growth
- 8: Developmental origins of adult diseases
- 9: EDCs and the developmental origins of adult diseases
- 10: Conclusions
- References
- Chapter 3.1.5: Epidemiological studies on the effects of prenatal exposure to endocrine-disrupting compounds on fertility
- Abstract
- 1: Introduction
- 2: Male reproductive function
- 3: Discussion
- References
- Chapter 3.2: EDC effects in animals
- Chapter 3.2.1: Metabolism vs. metabolomics: Mechanisms of endocrine disruption
- Abstract
- 1: Metabolic transformations of chemical contaminants to active estrogenic targets
- 2: Metabolomics impacts of environmental contaminants
- References
- Chapter 3.2.2: Effects of EDCs on female reproductive system in reptiles
- Abstract
- 1: Introduction
- 2: Reptilian physiology
- 3: Reptilian reproductive strategy: Oviparous and viviparous
- 4: Parental nurturing behavior
- 5: Reptilian endocrine system
- 6: Endocrine disruption in wild reptile
- 7: Experimentally induced endocrine disruption in female reptile
- 8: Conclusions
- References
- Chapter 3.2.3: Effects of aquatic contaminants in female fish reproduction
- Abstract
- Acknowledgment
- 1: Neuroendocrine regulation of female fish reproduction
- 2: Example of contaminants affecting female fish reproduction
- References
- Chapter 3.2.4: EDCs: Focus on male fish reproductive alterations
- Abstract
- 1: Introduction
- 2: Male fish reproductive endocrinology
- 3: Environmental contaminants
- 4: Bisphenols
- 5: Metals
- 6: Pharmaceuticals
- 7: Insecticides
- 8: Alkylphenols
- References
- Chapter 3.2.5: Environmental endocrine-disrupting chemicals and their effects in marine mammals
- Abstract
- Acknowledgements
- 1: Introduction
- 2: Exposure to EDCs in marine mammals
- 3: Effects of EDCs in marine mammals
- 4: In vitro studies
- 5: Conclusion and future direction
- Appendix
- References
- Chapter 4: Removal of hazardous pollutants from wastewaters
- Chapter 4.1: Conventional wastewater treatment methods and their ability to remove EDCs
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Characteristics of EDCs
- 3: Conventional wastewater treatment: A brief overview
- 4: Factors influencing the fate of EDCs
- 5: Conclusions
- References
- Chapter 4.2: Nanofiltration and ultrafiltration of endocrine-disrupting compounds
- Abstract
- 1: EDCs in aquatic environment
- 2: Removal of EDCs by membrane processes
- 3: Membrane materials for EDC removal
- 4: Removal mechanism of EDCs with UF membranes
- 5: Removal mechanism of EDCs with NF membranes
- 6: Rejection of EDCs by UF membrane systems
- 7: Rejection of EDCs by NF membrane systems
- References
- Chapter 4.3: Advanced oxidation processes for wastewater treatment
- Abstract
- 1: Introduction
- 2: Ozonation for EDCs degradation
- 3: UV photolysis and UV/H2O2 for EDCs degradation
- 4: Fenton and Fenton-like reaction
- 5: TiO2-catalyzed UV oxidation (UV/TiO2)
- 6: Conclusions
- References
- Chapter 4.4: Endocrine-disrupting compounds (EDCs) in conventional wastewater treatment: State of art and future challenges
- Abstract
- Acknowledgments
- 1: Conventional wastewater treatment plants as a source of EDCs
- 2: Research trends in EDCs removal in wastewater treatment plants
- 3: Final comments and future perspectives
- References
- Index
- No. of pages: 392
- Language: English
- Edition: 1
- Published: May 30, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780128244647
- eBook ISBN: 9780323859325
OC
Oliana Carnevali
Dr. Oliana Carnevali, PhD, Professor of Developmental Biology, Polytechnic University of Marche, Italy
Dr. Carnevali’s research focuses on reproductive and developmental biology of fish models. Her focus is on the effects of probiotics on fish welfare. Her group also has substantial interest in reproductive toxicology to monitor environmental risk. A wide spectrum of aspects such as embryo development, reproduction, energy metabolism, immune system and genotoxic aspects, on different fish models are evaluated. She is a partner of the BioMedAqu project, supervisor of ESR10, a project focusing on skeletal pathologies in human and fish providing evidence on the effects of micronutrients and probiotics in bone cell differentiation in fish. In addition, the in vivo effects of vitamins and probiotic by parental and larval exposure on skeletal formation will be tested on zebrafish, seabream and meagre. A multidisciplinary approach including transcriptomic, histology, cell biology, infrared micro spectrometry and Raman, will be used.
Affiliations and expertise
Professor of Developmental Biology, Polytechnic University of Marche, ItalyGH
Gary Hardiman
Dr. Gary Hardiman, PhD, Professor, Faculty of Medicine, Health and Life Sciences, School of Biological Sciences, Queen’s University, Ireland
Dr. Hardman works in the field of systems biology the objective of which is the study of biological systems, including genes, RNAs, proteins, metabolites and cells in a focused manner, and organs, organisms and populations in a broader context. Areas of research focus include studying the effects of man-made contaminants on marine and human health; studying prostate cancer in the context of racial differences and nutritional deficiency; examining the impacts of long term space travel – specifically the effects of nutrition, torpor, space radiation and microgravity on hepatic and intestinal biology; developing a rat model of opioid abuse to better understand the biological basis for substance abuse disorders and advance development of preventive strategies and more efficacious treatments; and developing a robust toolkit for better integration of Omics data sets into genotype-phenotype predictions. He maintains active research collaborations with groups in the USA, Italy, Ireland and Scotland.
Affiliations and expertise
Professor, Faculty of Medicine, Health and Life Sciences, School of Biological Sciences, Queen’s University, IrelandRead Environmental Contaminants and Endocrine Health on ScienceDirect