Environmental Contaminants and Endocrine Health
- 1st Edition - May 31, 2023
- Latest edition
- Editors: Oliana Carnevali, Gary Hardiman
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 4 4 6 4 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 9 3 2 - 5
Environmental Contaminants and Endocrine Health focuses specifically on contaminants with hormonal disrupting activities. The book provides insights into the multiple effects o… Read more
Environmental Contaminants and Endocrine Health focuses specifically on contaminants with hormonal disrupting activities. The book provides insights into the multiple effects of endocrine-disrupting chemicals (EDCs) and their mechanism of action (MoA) on metabolism, reproduction and the multiple physiological roles of the endocannabinoid system which has recently been indicated as new target. The content systematically covers EDC sources and effects, EDCs as sources of disease and health impairment in laboratory models, EDCs as the cause of disease and health impairment in humans and wild species, and the removal of hazardous pollutants from wastewaters to highlight intervention, mitigation and adaptation for reduced threat.
This content will be a foundational resource for academic and research staff in endocrinology and hormone toxicology as well as for professors, researchers and students in these areas.
- Includes important foundational coverage of the endocrine system, definitions of EDC sources and descriptions, model examples and mechanisms of action biological effects
- Provides coverage of EDC effects in humans and animals, from metabolic alterations to epidemiological studies of fertility and metabolism
- Presents insights into the confirmed and suspected human diseases spectrum with origins linked to EDC exposure, including cancers, intellectual disabilities, autism, birth defects of the urethra (hypospadias), decreased sperm count, increased rates of miscarriage, obesity, type 2 diabetes, and more
Academic/research staff in endocrinology and toxicology, professors, researchers, students (background content for Ecotoxicology courses), Chemical industry managers and researchers
1. Endocrine-disrupting chemical sources and effects
1.1. Endocrine System
1.2 Definition of endocrine-disrupting chemicals (EDCs), EDC sources and description of the main EDCs found in the environment matrices (soil air and water) and human bodily fluids
1.3. In vitro-, ecological-, murine and human models for examining the effects of EDCs
1.4 MoA of EDCs and their biological effects
2. Endocrine-disrupting Chemicals as source of disease and health impairment in laboratory models
2.1. EDCs: focus on metabolic alterations of mammalian and non-mammalian models
2.2. EDCs: focus on reproductive alterations in mammalian and non-mammalian models
2.3 EDC: effects on the epigenetic process
2.4 EDCs: Transgenerational effects
2.4 Alterations of the endocannabinoid system by EDCs: effects on metabolism and reproduction
2.5 Effects of endocrine-disrupting chemicals on the gut microbiota
2.6 Adverse effects of mixtures of environmental pollutants in mammalian and non-mammalian models
3. Endocrine-disrupting chemicals; cause of disease and health impairment in human and wild species
3.1 EDC Effects in Humans
3.1.1 EDCs: focus on metabolic alterations
3.1.2 EDCs: focus on reproductive alterations in females
3.1.3 EDCs: Focus on reproductive alterations in males
3.1.4 EDCs impacts on embryonic development
3.1.5 Epidemiological studies on the effects of EDCs on fertility
3.1.6 Epidemiological studies on the effects of EDCs on metabolic disorders
3.2. EDC effects in Animals
3.2.1 EDCs: focus on metabolic alterations
3.2.2 EDCs: focus on female reproductive alterations
3.2.3 EDCs: focus on male reproductive alterations
4. Removal of Hazardous Pollutants from Wastewaters
4.1 Intervention, mitigation and adaptation to reduce environmental damage
4.2 Role of membranes and activated carbon in the removal of EDCs
4.3 Nanofiltration and ultrafiltration of endocrine disrupting compounds,
4.4 In situ sediment treatment using activated carbon
4.5 Effective controls of EDCs in wastewater effluent using constructed wetlands under anoxic condition
1.1. Endocrine System
1.2 Definition of endocrine-disrupting chemicals (EDCs), EDC sources and description of the main EDCs found in the environment matrices (soil air and water) and human bodily fluids
1.3. In vitro-, ecological-, murine and human models for examining the effects of EDCs
1.4 MoA of EDCs and their biological effects
2. Endocrine-disrupting Chemicals as source of disease and health impairment in laboratory models
2.1. EDCs: focus on metabolic alterations of mammalian and non-mammalian models
2.2. EDCs: focus on reproductive alterations in mammalian and non-mammalian models
2.3 EDC: effects on the epigenetic process
2.4 EDCs: Transgenerational effects
2.4 Alterations of the endocannabinoid system by EDCs: effects on metabolism and reproduction
2.5 Effects of endocrine-disrupting chemicals on the gut microbiota
2.6 Adverse effects of mixtures of environmental pollutants in mammalian and non-mammalian models
3. Endocrine-disrupting chemicals; cause of disease and health impairment in human and wild species
3.1 EDC Effects in Humans
3.1.1 EDCs: focus on metabolic alterations
3.1.2 EDCs: focus on reproductive alterations in females
3.1.3 EDCs: Focus on reproductive alterations in males
3.1.4 EDCs impacts on embryonic development
3.1.5 Epidemiological studies on the effects of EDCs on fertility
3.1.6 Epidemiological studies on the effects of EDCs on metabolic disorders
3.2. EDC effects in Animals
3.2.1 EDCs: focus on metabolic alterations
3.2.2 EDCs: focus on female reproductive alterations
3.2.3 EDCs: focus on male reproductive alterations
4. Removal of Hazardous Pollutants from Wastewaters
4.1 Intervention, mitigation and adaptation to reduce environmental damage
4.2 Role of membranes and activated carbon in the removal of EDCs
4.3 Nanofiltration and ultrafiltration of endocrine disrupting compounds,
4.4 In situ sediment treatment using activated carbon
4.5 Effective controls of EDCs in wastewater effluent using constructed wetlands under anoxic condition
- Edition: 1
- Latest edition
- Published: May 31, 2023
- Language: English
OC
Oliana Carnevali
Dr. Oliana Carnevali, PhD, Professor of Developmental Biology, Polytechnic University of Marche, Italy
Dr. Carnevali’s research focuses on reproductive and developmental biology of fish models. Her focus is on the effects of probiotics on fish welfare. Her group also has substantial interest in reproductive toxicology to monitor environmental risk. A wide spectrum of aspects such as embryo development, reproduction, energy metabolism, immune system and genotoxic aspects, on different fish models are evaluated. She is a partner of the BioMedAqu project, supervisor of ESR10, a project focusing on skeletal pathologies in human and fish providing evidence on the effects of micronutrients and probiotics in bone cell differentiation in fish. In addition, the in vivo effects of vitamins and probiotic by parental and larval exposure on skeletal formation will be tested on zebrafish, seabream and meagre. A multidisciplinary approach including transcriptomic, histology, cell biology, infrared micro spectrometry and Raman, will be used.
Affiliations and expertise
Professor of Developmental Biology, Polytechnic University of Marche, ItalyGH
Gary Hardiman
Dr. Gary Hardiman, PhD, Professor, Faculty of Medicine, Health and Life Sciences, School of Biological Sciences, Queen’s University, Ireland
Dr. Hardman works in the field of systems biology the objective of which is the study of biological systems, including genes, RNAs, proteins, metabolites and cells in a focused manner, and organs, organisms and populations in a broader context. Areas of research focus include studying the effects of man-made contaminants on marine and human health; studying prostate cancer in the context of racial differences and nutritional deficiency; examining the impacts of long term space travel – specifically the effects of nutrition, torpor, space radiation and microgravity on hepatic and intestinal biology; developing a rat model of opioid abuse to better understand the biological basis for substance abuse disorders and advance development of preventive strategies and more efficacious treatments; and developing a robust toolkit for better integration of Omics data sets into genotype-phenotype predictions. He maintains active research collaborations with groups in the USA, Italy, Ireland and Scotland.
Affiliations and expertise
Professor, Faculty of Medicine, Health and Life Sciences, School of Biological Sciences, Queen’s University, IrelandRead Environmental Contaminants and Endocrine Health on ScienceDirect